Andrew Plested
@andrewplested.bsky.social
Glutamate
ORCID: 0000-0001-6062-0832
ORCID: 0000-0001-6062-0832
Pinned
Andrew Plested
@andrewplested.bsky.social
· Oct 12
iGlu3Fast and iGlu3Slow, improved fluorescent reporters for detection of spontaneous glutamate activity in the brain
The genetically-encoded fluorescent glutamate sensor, iGluSnFR3, characterised by a high dynamic range and rapid on-kinetics, is an attractive sensor for glutamate imaging in the central nervous syste...
www.biorxiv.org
The latest version of our collaboration with Katalin Torok and her lab is up. We report some new glutamate sensors. Great work from Sara Bertelli in Berlin and the whole team in London (Holly & Oanh particularly).
www.biorxiv.org/content/10.1...
1/6
1/6
Reposted by Andrew Plested
Again, and with emphasis: it is not the purported advent of superintelligence that threatens the human race; it is the exponential proliferation of superstupidity.
An essential development over the past decade-plus is that the ignorant went from feeling chastened when their ignorance was revealed to banding together and deciding that, actually, they were right. They might disagree at times, but they agreed that ignorance itself was an indicator of trust.
December 29, 2025 at 9:06 PM
Again, and with emphasis: it is not the purported advent of superintelligence that threatens the human race; it is the exponential proliferation of superstupidity.
Reposted by Andrew Plested
As @stephenjacobsmith.com @shahidkhan.bsky.social @alonlevy.bsky.social and others are asking about why Paris-Barcelona takes 6 hours 45 mins by train, a quick thread
December 30, 2025 at 2:49 PM
As @stephenjacobsmith.com @shahidkhan.bsky.social @alonlevy.bsky.social and others are asking about why Paris-Barcelona takes 6 hours 45 mins by train, a quick thread
I did it!
I ran 1000 km in 2025, with a day to spare. I was welcomed home and received a certificate from my daughter.
Thanks to @superkash.bsky.social for the inspiration!
I ran 1000 km in 2025, with a day to spare. I was welcomed home and received a certificate from my daughter.
Thanks to @superkash.bsky.social for the inspiration!
December 30, 2025 at 3:33 PM
I did it!
I ran 1000 km in 2025, with a day to spare. I was welcomed home and received a certificate from my daughter.
Thanks to @superkash.bsky.social for the inspiration!
I ran 1000 km in 2025, with a day to spare. I was welcomed home and received a certificate from my daughter.
Thanks to @superkash.bsky.social for the inspiration!
More goodies- from Castroni in Rome.
Something something Europe in decline something something.
Something something Europe in decline something something.
December 29, 2025 at 9:48 AM
More goodies- from Castroni in Rome.
Something something Europe in decline something something.
Something something Europe in decline something something.
Reposted by Andrew Plested
I'm just grateful to be alive at the same time as these Berliners.
December 28, 2025 at 9:00 PM
I'm just grateful to be alive at the same time as these Berliners.
Amazing present from my son- an Italian #cheese to mature at home, sealed in an earthenware container that you have to smash when you reach the desired age. I think we’ll choose 4 months (will be Feb).
December 28, 2025 at 5:43 PM
Amazing present from my son- an Italian #cheese to mature at home, sealed in an earthenware container that you have to smash when you reach the desired age. I think we’ll choose 4 months (will be Feb).
Reposted by Andrew Plested
Crazy that there are so many of them. 90s were an amazing time for music.
December 28, 2025 at 1:06 PM
Crazy that there are so many of them. 90s were an amazing time for music.
Reposted by Andrew Plested
Thank you Germany www.statnews.com/2025/12/26/p... #pubmed
PubMed has competition from Germany. That’s a very good thing
Germany’s new ZB MED is “about ensuring that a single fragile pipeline doesn’t bottleneck good science,” experts write.
www.statnews.com
December 28, 2025 at 1:25 PM
Thank you Germany www.statnews.com/2025/12/26/p... #pubmed
Reposted by Andrew Plested
Buttons are back. Knobs are back. Dumb devices are back. Own-it-forever software is back. Print is back. Personal websites and chronological feeds are back. Touching grass is back. People keep saying 2015, but it’s not far enough. The entire 2010s were a mistake. We must retvrn to… 2009.
Amazingly, reaction times using screens while driving are worse than being drunk or high—no wonder 90 percent of drivers hate using touchscreens in cars. Finally the auto industry is coming to its senses.
Rejoice! Carmakers Are Embracing Physical Buttons Again
Amazingly, reaction times using screens while driving are worse than being drunk or high—no wonder 90 percent of drivers hate using touchscreens in cars. Finally the auto industry is coming to its…
wrd.cm
December 28, 2025 at 3:54 AM
Buttons are back. Knobs are back. Dumb devices are back. Own-it-forever software is back. Print is back. Personal websites and chronological feeds are back. Touching grass is back. People keep saying 2015, but it’s not far enough. The entire 2010s were a mistake. We must retvrn to… 2009.
Reposted by Andrew Plested
descend upon the monster’s back for the special purpose referred to
December 28, 2025 at 5:47 AM
descend upon the monster’s back for the special purpose referred to
Sorry for the boosters, who I’m sure are sincere, but this vid is an apt metaphor for the transition that we’re going through right now in #science.
Keep a prudent distance, or AI might kick you in the family jewels!
Keep a prudent distance, or AI might kick you in the family jewels!
another robot highlight for 2025: man wearing humanoid mocap suit kicks himself in the balls
December 27, 2025 at 7:06 PM
Sorry for the boosters, who I’m sure are sincere, but this vid is an apt metaphor for the transition that we’re going through right now in #science.
Keep a prudent distance, or AI might kick you in the family jewels!
Keep a prudent distance, or AI might kick you in the family jewels!
It’s a Christmas miracle! 3 empty paper #recycling bins!
And the ghost of Christmas past: an overstuffed plastic/metal bin (‘Wertstoff’ aka ‘Gelbe Sack’).
And the ghost of Christmas past: an overstuffed plastic/metal bin (‘Wertstoff’ aka ‘Gelbe Sack’).
December 27, 2025 at 11:15 AM
It’s a Christmas miracle! 3 empty paper #recycling bins!
And the ghost of Christmas past: an overstuffed plastic/metal bin (‘Wertstoff’ aka ‘Gelbe Sack’).
And the ghost of Christmas past: an overstuffed plastic/metal bin (‘Wertstoff’ aka ‘Gelbe Sack’).
Reposted by Andrew Plested
have yourself a little merry Christmas
let your heart be light
ordering the adjectives, but not quite right
let your heart be light
ordering the adjectives, but not quite right
December 26, 2025 at 10:36 PM
have yourself a little merry Christmas
let your heart be light
ordering the adjectives, but not quite right
let your heart be light
ordering the adjectives, but not quite right
Reposted by Andrew Plested
most cutting thing you can say is "who's this clown?" because it implies they're a) a clown & b) not even one of the better-known clowns
April 27, 2023 at 7:19 PM
most cutting thing you can say is "who's this clown?" because it implies they're a) a clown & b) not even one of the better-known clowns
A Lego set fit for DJ Shadow.
December 25, 2025 at 9:23 AM
A Lego set fit for DJ Shadow.
Bookmakers in Touraine (France) will have to pay out!
December 25, 2025 at 9:11 AM
Bookmakers in Touraine (France) will have to pay out!
Reposted by Andrew Plested
In Germany, Christmas is celebrated TODAY so Merry Christmas to everyone who’s out there waiting for Santa 🎅🏻 and/or Christkind 👼🏻 to bring presents 🎁 and I’m wishing you and your loved ones wonderful holidays 💫
December 24, 2025 at 8:55 AM
In Germany, Christmas is celebrated TODAY so Merry Christmas to everyone who’s out there waiting for Santa 🎅🏻 and/or Christkind 👼🏻 to bring presents 🎁 and I’m wishing you and your loved ones wonderful holidays 💫
Reposted by Andrew Plested
Solange niemand neue Wagen baut, kommen wir nicht weit.
Eine vernünftige Strategie muss auch die Beschaffung von Rollmaterial umfassen.
Eine vernünftige Strategie muss auch die Beschaffung von Rollmaterial umfassen.
Mehr #Nachtzüge! 🌙 🚆
Deutschland sollte mit seiner Lage mitten in Europa 🇪🇺 aktiver werden, um mehr Nachtzüge anzureizen.
Dazu haben @gruene-bundestag.de einen Antrag mit entsprechenden Vorschlägen ins Parlament eingebracht.
Nachtzüge stellen eine wunderbare, klimaverträgliche Form der #Reise dar.
Deutschland sollte mit seiner Lage mitten in Europa 🇪🇺 aktiver werden, um mehr Nachtzüge anzureizen.
Dazu haben @gruene-bundestag.de einen Antrag mit entsprechenden Vorschlägen ins Parlament eingebracht.
Nachtzüge stellen eine wunderbare, klimaverträgliche Form der #Reise dar.
December 23, 2025 at 6:32 PM
Solange niemand neue Wagen baut, kommen wir nicht weit.
Eine vernünftige Strategie muss auch die Beschaffung von Rollmaterial umfassen.
Eine vernünftige Strategie muss auch die Beschaffung von Rollmaterial umfassen.
Reposted by Andrew Plested
“Pray tell, the Baron, what sort of gentleman is he?”
“Well…”
“Well…”
December 23, 2025 at 9:17 PM
“Pray tell, the Baron, what sort of gentleman is he?”
“Well…”
“Well…”
Reposted by Andrew Plested
banner year for teaching evals, in which I got several comments that my lectures were funny and only one that the way I talk is annoying
December 24, 2025 at 3:28 PM
banner year for teaching evals, in which I got several comments that my lectures were funny and only one that the way I talk is annoying
Reposted by Andrew Plested
The UK has been exporting loads of its old Intercity 125s with flimsy fibreglass cabs to Cancun. Unfortunately it seems Mexico has slightly different attitude to the question “is it acceptable to have a car on a level crossing as a train approaches”, creating quite a stream of content.
December 22, 2025 at 11:25 AM
The UK has been exporting loads of its old Intercity 125s with flimsy fibreglass cabs to Cancun. Unfortunately it seems Mexico has slightly different attitude to the question “is it acceptable to have a car on a level crossing as a train approaches”, creating quite a stream of content.
Reposted by Andrew Plested
“The most worthless of mankind are not afraid to condemn in others the same disorders which they allow in themselves; and can readily discover some nice difference in age, character, or station, to justify the partial distinction.”
-Edward Gibbon
-Edward Gibbon
December 18, 2025 at 4:01 PM
“The most worthless of mankind are not afraid to condemn in others the same disorders which they allow in themselves; and can readily discover some nice difference in age, character, or station, to justify the partial distinction.”
-Edward Gibbon
-Edward Gibbon
Reposted by Andrew Plested
December 22, 2025 at 9:04 PM
Reposted by Andrew Plested
Piran, Slovenia 🇸🇮
December 22, 2025 at 4:43 PM
Piran, Slovenia 🇸🇮
Reposted by Andrew Plested
Great opportunity for a Postdoc interested in cellular high resolution imaging: amazing lab & team, amazing campus & resources! And summer times starts early in DC ☀️I can highly recommend 👇
My lab in the NIH Intramural Program (Bethesda, MD) will be recruiting postdoctoral fellows over the next year with flexible start dates. We work on nanoscale cellular imaging of the plasma membrane and related organelles. Please reach out if you’re interested. www.training.nih.gov/jobs/pdp-053...
December 22, 2025 at 4:29 PM
Great opportunity for a Postdoc interested in cellular high resolution imaging: amazing lab & team, amazing campus & resources! And summer times starts early in DC ☀️I can highly recommend 👇