Andrew Plested
@andrewplested.bsky.social
Glutamate
ORCID: 0000-0001-6062-0832
ORCID: 0000-0001-6062-0832
Pinned
Andrew Plested
@andrewplested.bsky.social
· Oct 12
iGlu3Fast and iGlu3Slow, improved fluorescent reporters for detection of spontaneous glutamate activity in the brain
The genetically-encoded fluorescent glutamate sensor, iGluSnFR3, characterised by a high dynamic range and rapid on-kinetics, is an attractive sensor for glutamate imaging in the central nervous syste...
www.biorxiv.org
The latest version of our collaboration with Katalin Torok and her lab is up. We report some new glutamate sensors. Great work from Sara Bertelli in Berlin and the whole team in London (Holly & Oanh particularly).
www.biorxiv.org/content/10.1...
1/6
1/6
Reposted by Andrew Plested
It *literally* does.
Thats what it is. A document which says youre British.
Thats what it is. A document which says youre British.
February 15, 2026 at 1:38 PM
It *literally* does.
Thats what it is. A document which says youre British.
Thats what it is. A document which says youre British.
Reposted by Andrew Plested
Whole plasmid sequencing (in my opinion) soooo beats Sanger for checking your molecular cloning (and do be sure to check your plasmids!!!!). youtu.be/RJmBxwEoFHw
Whole plasmid sequencing with nanopore technology (ONT)
YouTube video by the bumbling biochemist
youtu.be
February 15, 2026 at 1:29 AM
Whole plasmid sequencing (in my opinion) soooo beats Sanger for checking your molecular cloning (and do be sure to check your plasmids!!!!). youtu.be/RJmBxwEoFHw
Reposted by Andrew Plested
just realized Crusher must have gone to med school at NYU
February 15, 2026 at 5:30 AM
just realized Crusher must have gone to med school at NYU
Reposted by Andrew Plested
If I was a student at Yale I'd be *sorely* tempted to take the course just to ask him about this, and then drop the class.
David Brooks: Boo-Boos in Paradise
The classic 2004 examination of David Brooks’s “Bobos in Paradise” by Philadelphia magazine’s Sasha Issenberg.
www.phillymag.com
February 14, 2026 at 11:12 PM
If I was a student at Yale I'd be *sorely* tempted to take the course just to ask him about this, and then drop the class.
Reposted by Andrew Plested
So great! Mechanical engineers study the physics of elephant whiskers. Unlike mice, elephants don’t whisk. The physics of their whiskers suggests they amplify touch.
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Functional gradients facilitate tactile sensing in elephant whiskers
Keratin composites enable animals to hike with hooves, fly with feathers, and sense with skin. Mammalian whiskers are elongated keratin rods attached to tactile skin structures that extend the animal’...
www.science.org
February 14, 2026 at 1:54 PM
So great! Mechanical engineers study the physics of elephant whiskers. Unlike mice, elephants don’t whisk. The physics of their whiskers suggests they amplify touch.
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Reposted by Andrew Plested
don't you, uh, hate when that happens
And when it comes to sleeping with an unknown stranger, in a strange inn, in a strange town, and that stranger a harpooneer, then your objections indefinitely multiply
February 15, 2026 at 7:49 AM
don't you, uh, hate when that happens
Reposted by Andrew Plested
"I've hooked the synthetic text extruding machine up to other systems that take that text as input and impact the world" != "The synthetic text extruding machine knows how to use tools."
February 15, 2026 at 4:43 AM
"I've hooked the synthetic text extruding machine up to other systems that take that text as input and impact the world" != "The synthetic text extruding machine knows how to use tools."
Reposted by Andrew Plested
It’s so funny to think about the fact that there’s people out there deferring every life decision to this
February 14, 2026 at 9:53 AM
It’s so funny to think about the fact that there’s people out there deferring every life decision to this
Reposted by Andrew Plested
It’s just lovely they did that without a warning after I’ve just flown out to Asia.
Is the Home Office in their right mind to change rules like that without anytime for its own citizens to adjust to them?
Honestly.
Is the Home Office in their right mind to change rules like that without anytime for its own citizens to adjust to them?
Honestly.
February 14, 2026 at 7:20 AM
It’s just lovely they did that without a warning after I’ve just flown out to Asia.
Is the Home Office in their right mind to change rules like that without anytime for its own citizens to adjust to them?
Honestly.
Is the Home Office in their right mind to change rules like that without anytime for its own citizens to adjust to them?
Honestly.
Reposted by Andrew Plested
People who know me know that I am… not an uncritical fan of aging and longevity research.
This is *deeply* interesting.
This is *deeply* interesting.
Here is a robust biochemical & functional difference between young and old mammalian cells:
- The fraction of new amino acids incorporated into proteins.
The difference is consistent, quantitative, cell-type specific, and deeply intriguing.
What aging mechanisms cause it ?
1/
- The fraction of new amino acids incorporated into proteins.
The difference is consistent, quantitative, cell-type specific, and deeply intriguing.
What aging mechanisms cause it ?
1/
February 13, 2026 at 7:22 PM
People who know me know that I am… not an uncritical fan of aging and longevity research.
This is *deeply* interesting.
This is *deeply* interesting.
Reposted by Andrew Plested
We are finally online 🥳 What a fantastic adventure with @rrsims, the @emilianilab.bsky.social and all co-authors from IdV Paris #TwoPhoton #Voltagers #Holography #Rhodopsins
February 13, 2026 at 9:06 PM
We are finally online 🥳 What a fantastic adventure with @rrsims, the @emilianilab.bsky.social and all co-authors from IdV Paris #TwoPhoton #Voltagers #Holography #Rhodopsins
Reposted by Andrew Plested
Sigh … Science win; scicomm fail. (To start, prefrontal cortex is in the front not back of the brain ….). Unis *must* lead truth telling - great that NYU has trainees like @andrewbahle.bsky.social to help with that (follow Andrew!)
Wow AI is so amazing we should use it for all our scientific diagrams
February 13, 2026 at 1:26 AM
Sigh … Science win; scicomm fail. (To start, prefrontal cortex is in the front not back of the brain ….). Unis *must* lead truth telling - great that NYU has trainees like @andrewbahle.bsky.social to help with that (follow Andrew!)
Reposted by Andrew Plested
We’re hiring a Group Leader!
Join us to lead a transformative initiative in human systems neuroscience.
Find out more and apply ⤵️
www.sainsburywellcome.org/content/curr...
Join us to lead a transformative initiative in human systems neuroscience.
Find out more and apply ⤵️
www.sainsburywellcome.org/content/curr...
February 13, 2026 at 1:41 PM
We’re hiring a Group Leader!
Join us to lead a transformative initiative in human systems neuroscience.
Find out more and apply ⤵️
www.sainsburywellcome.org/content/curr...
Join us to lead a transformative initiative in human systems neuroscience.
Find out more and apply ⤵️
www.sainsburywellcome.org/content/curr...
Reposted by Andrew Plested
Important.
In other words, interchangeable techbro with a theory of mind on level with a concussed toddler thinks the Beep Boop Man what lives in their computer is sentient. Truly a philosophical juggernaut of our time
February 11, 2026 at 10:01 PM
Important.
Reposted by Andrew Plested
Why do some scientists say "Bluesky is dead. I have no engagement. I have more engagement on X"? My TL is full of cool science, queer art, weird history facts, politics and whimsy. You're just not doing it right, man. Plus the fascism
February 10, 2026 at 8:10 PM
Why do some scientists say "Bluesky is dead. I have no engagement. I have more engagement on X"? My TL is full of cool science, queer art, weird history facts, politics and whimsy. You're just not doing it right, man. Plus the fascism
Reposted by Andrew Plested
New paper by Kay Grobe and Seraphine Wegner @sfb1348.bsky.social @uni-muenster.de shows that the soluble factor Scube recruits proteases, protease inhibitors, and lipoproteins to the cell surface, where they release the #Sonic #Hedgehog morphogen
www.nature.com/articles/s42... @commsbio.nature.com
www.nature.com/articles/s42... @commsbio.nature.com
February 9, 2026 at 9:17 AM
New paper by Kay Grobe and Seraphine Wegner @sfb1348.bsky.social @uni-muenster.de shows that the soluble factor Scube recruits proteases, protease inhibitors, and lipoproteins to the cell surface, where they release the #Sonic #Hedgehog morphogen
www.nature.com/articles/s42... @commsbio.nature.com
www.nature.com/articles/s42... @commsbio.nature.com
Reposted by Andrew Plested
A delegation of German academic leadership and council visited Shenzhen labs. Strong interest in concrete collaborations @unibonn.bsky.social @unileipzig.bsky.social @uniheidelberg.bsky.social
@uni-freiburg.de @unituebingen.bsky.social
@lmu.de @unistuttgart.bsky.social @kit.edu
@tuda.bsky.social
@uni-freiburg.de @unituebingen.bsky.social
@lmu.de @unistuttgart.bsky.social @kit.edu
@tuda.bsky.social
February 10, 2026 at 3:50 AM
A delegation of German academic leadership and council visited Shenzhen labs. Strong interest in concrete collaborations @unibonn.bsky.social @unileipzig.bsky.social @uniheidelberg.bsky.social
@uni-freiburg.de @unituebingen.bsky.social
@lmu.de @unistuttgart.bsky.social @kit.edu
@tuda.bsky.social
@uni-freiburg.de @unituebingen.bsky.social
@lmu.de @unistuttgart.bsky.social @kit.edu
@tuda.bsky.social
Reposted by Andrew Plested
Zukünftig sollten zuerst die Geh- und Radwege geräumt werden und dann die Straßen, fordert @antjekapek.bsky.social.
"Wenn wir schauen, wie es andere Städte machen, beispielsweise
Stockholm oder Helsinki, da habe ich kostenneutral einfach nur die
Reihenfolge der Räumpriorität geändert."
"Wenn wir schauen, wie es andere Städte machen, beispielsweise
Stockholm oder Helsinki, da habe ich kostenneutral einfach nur die
Reihenfolge der Räumpriorität geändert."
Nach Glatteis-Chaos in Berlin: CDU und SPD schreiben neue Regeln für Streusalz und Winterdienst ins Gesetz
Nach den Problemen mit Glatteis in Berlin haben sich CDU und SPD verständigt, wann künftig Streusalz auch auf Gehwegen eingesetzt werden darf. Auch für den Winterdienst soll es neue Zuständigkeiten ge...
www.tagesspiegel.de
February 9, 2026 at 10:56 AM
Zukünftig sollten zuerst die Geh- und Radwege geräumt werden und dann die Straßen, fordert @antjekapek.bsky.social.
"Wenn wir schauen, wie es andere Städte machen, beispielsweise
Stockholm oder Helsinki, da habe ich kostenneutral einfach nur die
Reihenfolge der Räumpriorität geändert."
"Wenn wir schauen, wie es andere Städte machen, beispielsweise
Stockholm oder Helsinki, da habe ich kostenneutral einfach nur die
Reihenfolge der Räumpriorität geändert."
Reposted by Andrew Plested
'The European Research Executive Agency (REA) received 17,066 applications for this call, of which 16,836 were eligible and were evaluated. 1610 projects were selected. This result corresponds to a 9,6% success rate.'
marie-sklodowska-curie-actions.ec.europa.eu/news/msca-aw...
marie-sklodowska-curie-actions.ec.europa.eu/news/msca-aw...
MSCA awards €404.3 million to postdoctoral researchers
1610 outstanding postdoctoral researchers were selected for funding among 17,066 applicants.
marie-sklodowska-curie-actions.ec.europa.eu
February 9, 2026 at 2:50 PM
'The European Research Executive Agency (REA) received 17,066 applications for this call, of which 16,836 were eligible and were evaluated. 1610 projects were selected. This result corresponds to a 9,6% success rate.'
marie-sklodowska-curie-actions.ec.europa.eu/news/msca-aw...
marie-sklodowska-curie-actions.ec.europa.eu/news/msca-aw...
Reposted by Andrew Plested
🚨 Nerd Alert! 🚨
Guildford Cathedral was the location for the scene in The Omen where Damien freaks out with his Mum and Dad (Lee Remick and Gregory Peck) in the limo on the drive up to the entrance.
Guildford Cathedral was the location for the scene in The Omen where Damien freaks out with his Mum and Dad (Lee Remick and Gregory Peck) in the limo on the drive up to the entrance.
February 7, 2026 at 6:43 PM
🚨 Nerd Alert! 🚨
Guildford Cathedral was the location for the scene in The Omen where Damien freaks out with his Mum and Dad (Lee Remick and Gregory Peck) in the limo on the drive up to the entrance.
Guildford Cathedral was the location for the scene in The Omen where Damien freaks out with his Mum and Dad (Lee Remick and Gregory Peck) in the limo on the drive up to the entrance.
Reposted by Andrew Plested
I just looked at the source code of a friend's vibecoded game, and it is probably the ugliest code I have seen in my life.
E.g.: EVERY modal (pop up) in the game is hundreds of lines of repeated code, and the game state is a 1000 line (!!!) arrow function.
It was made with the latest Claude model.
E.g.: EVERY modal (pop up) in the game is hundreds of lines of repeated code, and the game state is a 1000 line (!!!) arrow function.
It was made with the latest Claude model.
February 7, 2026 at 9:47 AM
I just looked at the source code of a friend's vibecoded game, and it is probably the ugliest code I have seen in my life.
E.g.: EVERY modal (pop up) in the game is hundreds of lines of repeated code, and the game state is a 1000 line (!!!) arrow function.
It was made with the latest Claude model.
E.g.: EVERY modal (pop up) in the game is hundreds of lines of repeated code, and the game state is a 1000 line (!!!) arrow function.
It was made with the latest Claude model.
Reposted by Andrew Plested
Symbiotic entrenchment through ecological Catch-22: Cell www.cell.com/cell/fulltex...
Symbiotic entrenchment through ecological Catch-22
A symbiotic rove beetle develops a stealth phenotype by silencing production of its
hydrocarbon pheromones, enabling it to infiltrate ant colonies, steal ant pheromones,
and achieve social acceptance ...
www.cell.com
February 7, 2026 at 3:45 PM
Symbiotic entrenchment through ecological Catch-22: Cell www.cell.com/cell/fulltex...
Reposted by Andrew Plested
And formally provably so because to drive you need theory of mind. You can indeed show with maths the limits of maths since it's a formal engineered system with knowable limits, see Gödel etc. We created trains which ban humans from tracks so the system can be safely automated, not so for roads. 1/n
These companies are always lying about the extent of their automation because some things cannot be fully automated in principle
futurism.com/advanced-tra...
futurism.com/advanced-tra...
It Turns Out That When Waymos Are Stumped, They Get Intervention From Workers in the Philippines
During a Congressional hearing, Waymo's chief safety officer, Mauricio Peña, was grilled over the company's reliance on overseas workers.
futurism.com
February 7, 2026 at 1:30 AM
And formally provably so because to drive you need theory of mind. You can indeed show with maths the limits of maths since it's a formal engineered system with knowable limits, see Gödel etc. We created trains which ban humans from tracks so the system can be safely automated, not so for roads. 1/n
Reposted by Andrew Plested
I don’t want to laugh at a small business but also VERY funny
February 6, 2026 at 1:40 PM
I don’t want to laugh at a small business but also VERY funny