Perhaps even more incredible are the full field of view synchronised events, measured with our high-affinity sensor iGlu3-Slow2. (No we don't know what they are, thanks for asking). We also see them (less often) with iGluSnFR3, and basically never with iGlu3Fast (once after damage to slice). 



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Katalin made some mutants of iGluSnFR3 that have improved properties. They end up being similar to (although not the same as) the new iGluSnFR4 variants.


iGlu3Fast is quite incredible in 2-Photon. This is a hippocampal dendrite, spontaneous activity. 

A world away from 1 Hz fluctuations! 



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