Dr. Rajesh Khanna of the KhannaLabUF
@khannalabuf.bsky.social
We are unraveling a QR code for chronic pain | Prof. of Pharmacology & Therapeutics, Univ. of Florida COM | Director, Center for Advanced Pain Therapeutics and Research (CAPTOR) | Mayday Pain Fellow | 🇮🇳🇴🇲🇨🇦🇺🇸
ORCID: 0000-0002-9066-2969
ORCID: 0000-0002-9066-2969
Reposted by Dr. Rajesh Khanna of the KhannaLabUF
In this week’s #PAIN Featured Image, Gomez et al. describe how the SARS-CoV-2 nucleocapsid (N) protein enhances pathological pain through NaV1.7 modulation. Learn more at bit.ly/4piitaH
December 19, 2025 at 2:00 PM
In this week’s #PAIN Featured Image, Gomez et al. describe how the SARS-CoV-2 nucleocapsid (N) protein enhances pathological pain through NaV1.7 modulation. Learn more at bit.ly/4piitaH
Reposted by Dr. Rajesh Khanna of the KhannaLabUF
Applications for the North American Pain School (NAPS) @napainschool.bsky.social are open until 31 January. Join leading experts for an immersive training experience 28 June – 3 July 2026 in Quebec. bit.ly/4rAEHWO
December 17, 2025 at 2:00 PM
Applications for the North American Pain School (NAPS) @napainschool.bsky.social are open until 31 January. Join leading experts for an immersive training experience 28 June – 3 July 2026 in Quebec. bit.ly/4rAEHWO
Reposted by Dr. Rajesh Khanna of the KhannaLabUF
Have you seen the new evidence that allosteric modulation of P2X7R can be governed by long-range influences from extracellular domains, as shown in Yu et al. in Neuropharmacology bit.ly/4aJP4BB #PapersoftheWeek #EditorsPick
December 15, 2025 at 1:00 PM
Have you seen the new evidence that allosteric modulation of P2X7R can be governed by long-range influences from extracellular domains, as shown in Yu et al. in Neuropharmacology bit.ly/4aJP4BB #PapersoftheWeek #EditorsPick
Reposted by Dr. Rajesh Khanna of the KhannaLabUF
A preprint from my lab @yalepharm.bsky.social: doi.org/10.1101/2025...
show molecular mechanisms of uncoupling nociceptive and neurotrophic TrkA signaling, using #singleMolecule #microscopy, #cryoEM, #electrophysiology, #signaling, offering a clear blueprint to target this long sought-after pathway!
show molecular mechanisms of uncoupling nociceptive and neurotrophic TrkA signaling, using #singleMolecule #microscopy, #cryoEM, #electrophysiology, #signaling, offering a clear blueprint to target this long sought-after pathway!
A painless nerve growth factor variant uncouples nociceptive and neurotrophic TrkA signaling
Nerve growth factor (NGF) binding to the receptor tyrosine kinase, TrkA, drives neurotrophic signaling essential for neuronal development and survival. This interaction simultaneously drives periphera...
doi.org
December 15, 2025 at 10:04 PM
A preprint from my lab @yalepharm.bsky.social: doi.org/10.1101/2025...
show molecular mechanisms of uncoupling nociceptive and neurotrophic TrkA signaling, using #singleMolecule #microscopy, #cryoEM, #electrophysiology, #signaling, offering a clear blueprint to target this long sought-after pathway!
show molecular mechanisms of uncoupling nociceptive and neurotrophic TrkA signaling, using #singleMolecule #microscopy, #cryoEM, #electrophysiology, #signaling, offering a clear blueprint to target this long sought-after pathway!
Reposted by Dr. Rajesh Khanna of the KhannaLabUF
Center for Pain Therapeutics and Addiction Research. @uthealthsa.bsky.social is searching for a tenure-track faculty recruit. Outstanding Envt and colleagues. Please apply or share widely. #neuroscience #painresearch #addictionresearch #orofacialpain uthscsa.referrals.selectminds.com/faculty/jobs...
CPTAR - Open Rank (Assistant/Associate/Professor) in San Antonio
The University of Texas Health Science Center San Antonio, School Dentistry, is seeking applications for a full-time position of a tenure...
uthscsa.referrals.selectminds.com
December 10, 2025 at 11:09 PM
Center for Pain Therapeutics and Addiction Research. @uthealthsa.bsky.social is searching for a tenure-track faculty recruit. Outstanding Envt and colleagues. Please apply or share widely. #neuroscience #painresearch #addictionresearch #orofacialpain uthscsa.referrals.selectminds.com/faculty/jobs...
Reposted by Dr. Rajesh Khanna of the KhannaLabUF
Register now for the 2026 USASP Annual meeting! Held March 23-26 2026 at the Loews Philadelphia Hotel.
December 9, 2025 at 11:34 PM
Register now for the 2026 USASP Annual meeting! Held March 23-26 2026 at the Loews Philadelphia Hotel.
Reposted by Dr. Rajesh Khanna of the KhannaLabUF
"The only reason I don’t have this funding is because my last name is Rodriguez,” he said. “It has nothing to do with the science."
STAT on the betrayal of early-career researchers:
www.statnews.com/2025/12/08/t...
STAT on the betrayal of early-career researchers:
www.statnews.com/2025/12/08/t...
NIH shut out hundreds of young scientists from funding to start their own labs
Special Report: The NIH has shut out hundreds of young scientists from funding to start their own labs.
www.statnews.com
December 8, 2025 at 11:43 AM
"The only reason I don’t have this funding is because my last name is Rodriguez,” he said. “It has nothing to do with the science."
STAT on the betrayal of early-career researchers:
www.statnews.com/2025/12/08/t...
STAT on the betrayal of early-career researchers:
www.statnews.com/2025/12/08/t...
Reposted by Dr. Rajesh Khanna of the KhannaLabUF
Are you an #earlycareer pain researcher with distinguished achievement or extraordinary promise in basic research in pain? Apply by 10 December to the Rita Allen Foundation’s Scholars Award in Pain bit.ly/4afvqNv #PRF
December 5, 2025 at 1:00 PM
Are you an #earlycareer pain researcher with distinguished achievement or extraordinary promise in basic research in pain? Apply by 10 December to the Rita Allen Foundation’s Scholars Award in Pain bit.ly/4afvqNv #PRF
Reposted by Dr. Rajesh Khanna of the KhannaLabUF
Meyer et al. find that the kinase GCN2 regulates neuronal sensitization and mechanical allodynia in response to a reactive glycolytic metabolite. Learn more in #PAIN bit.ly/43SpEgM
December 5, 2025 at 9:00 PM
Meyer et al. find that the kinase GCN2 regulates neuronal sensitization and mechanical allodynia in response to a reactive glycolytic metabolite. Learn more in #PAIN bit.ly/43SpEgM
Reposted by Dr. Rajesh Khanna of the KhannaLabUF
Applications for the North American Pain School (NAPS) @napainschool.bsky.social are open until 31 January. Join leading experts for an immersive training experience 28 June – 3 July 2026 in Quebec. bit.ly/4rAEHWO
December 4, 2025 at 7:41 PM
Applications for the North American Pain School (NAPS) @napainschool.bsky.social are open until 31 January. Join leading experts for an immersive training experience 28 June – 3 July 2026 in Quebec. bit.ly/4rAEHWO
Reposted by Dr. Rajesh Khanna of the KhannaLabUF
The review process will be overseen by JGP Associate Editors Teresa Giraldez (@giraldezt.bsky.social) and Jeanne Nerbonne, with Guest Editor and subject experts Angelika Lampert (@lampertlab.bsky.social), Hugues Abriel, and Rajesh Khanna (@khannalabuf.bsky.social) 👉 rupress.org/jgp/pages/ca...
December 4, 2025 at 3:15 PM
The review process will be overseen by JGP Associate Editors Teresa Giraldez (@giraldezt.bsky.social) and Jeanne Nerbonne, with Guest Editor and subject experts Angelika Lampert (@lampertlab.bsky.social), Hugues Abriel, and Rajesh Khanna (@khannalabuf.bsky.social) 👉 rupress.org/jgp/pages/ca...
Reposted by Dr. Rajesh Khanna of the KhannaLabUF
A budget request is a request, not a requirement of award, don’t dream too big just yet.
🚨The #NIH will no longer require an over-the-cap request for applications over $499,999.99/year. Furthermore, we will no longer require letters of intent.🚨
NOT-OD-26-019: Updated Application Policies: NIH Administrative Burden Reduction Effort Removal of Requirements for Letters of Intent and Unsolicited Applications Requesting $500,000 or More in Dire...
NIH Funding Opportunities and Notices in the NIH Guide for Grants and Contracts: Updated Application Policies: NIH Administrative Burden Reduction Effort Removal of Requirements for Letters of Inten...
grants.nih.gov
December 3, 2025 at 7:04 PM
A budget request is a request, not a requirement of award, don’t dream too big just yet.
Reposted by Dr. Rajesh Khanna of the KhannaLabUF
Is no one even going to mention the craziness of paying a football coach (one that is likely to leave or be fired well within his contract, if history is any guide) an amount of money that would fund entire science and humanities departments?
December 3, 2025 at 4:52 AM
Is no one even going to mention the craziness of paying a football coach (one that is likely to leave or be fired well within his contract, if history is any guide) an amount of money that would fund entire science and humanities departments?
Reposted by Dr. Rajesh Khanna of the KhannaLabUF
🚨 New Job Alert in Our Lab!
We’re hiring a full-time Research Assistant/Technician with experience in rodent stereotaxic surgery 🧠 and behavioral testing 🐁.
Please help us spread the word!
🔗 Apply: umb.taleo.net/careersectio...
@umsomneurosci.bsky.social @um-mind.bsky.social
We’re hiring a full-time Research Assistant/Technician with experience in rodent stereotaxic surgery 🧠 and behavioral testing 🐁.
Please help us spread the word!
🔗 Apply: umb.taleo.net/careersectio...
@umsomneurosci.bsky.social @um-mind.bsky.social
CII - Laboratory Animal Research Assistant
Click the link provided to see the complete job description.
umb.taleo.net
November 28, 2025 at 11:43 PM
🚨 New Job Alert in Our Lab!
We’re hiring a full-time Research Assistant/Technician with experience in rodent stereotaxic surgery 🧠 and behavioral testing 🐁.
Please help us spread the word!
🔗 Apply: umb.taleo.net/careersectio...
@umsomneurosci.bsky.social @um-mind.bsky.social
We’re hiring a full-time Research Assistant/Technician with experience in rodent stereotaxic surgery 🧠 and behavioral testing 🐁.
Please help us spread the word!
🔗 Apply: umb.taleo.net/careersectio...
@umsomneurosci.bsky.social @um-mind.bsky.social
Reposted by Dr. Rajesh Khanna of the KhannaLabUF
🚀 NAPS applications open this week!
The North American Pain School (@napainschool.bsky.social) brings together leading experts in #PainResearch for an immersive #SummerSchool training and networking experience in Québec.
📍 Apply Nov 28–Jan 31
👉 northamericanpainschool.com/registration/
The North American Pain School (@napainschool.bsky.social) brings together leading experts in #PainResearch for an immersive #SummerSchool training and networking experience in Québec.
📍 Apply Nov 28–Jan 31
👉 northamericanpainschool.com/registration/
November 25, 2025 at 12:30 AM
🚀 NAPS applications open this week!
The North American Pain School (@napainschool.bsky.social) brings together leading experts in #PainResearch for an immersive #SummerSchool training and networking experience in Québec.
📍 Apply Nov 28–Jan 31
👉 northamericanpainschool.com/registration/
The North American Pain School (@napainschool.bsky.social) brings together leading experts in #PainResearch for an immersive #SummerSchool training and networking experience in Québec.
📍 Apply Nov 28–Jan 31
👉 northamericanpainschool.com/registration/
Reposted by Dr. Rajesh Khanna of the KhannaLabUF
Updated guidance on NIH grant application due dates (10/1/2025-12/5/2025), along with some other Info. grants.nih.gov/grants/guide...
NOT-OD-26-012: Updated Guidance on Reopening of NIH Extramural Activities Following the October 1, 2025 - Lapse in Appropriations
NIH Funding Opportunities and Notices in the NIH Guide for Grants and Contracts: Updated Guidance on Reopening of NIH Extramural Activities Following the October 1, 2025 - Lapse in Appropriations NOT-...
grants.nih.gov
November 24, 2025 at 5:54 PM
Updated guidance on NIH grant application due dates (10/1/2025-12/5/2025), along with some other Info. grants.nih.gov/grants/guide...
Reposted by Dr. Rajesh Khanna of the KhannaLabUF
“Summary statements will be simplified. Narrative paragraphs summarizing committee discussion will not be used. Instead, summaries will have a sentence describing the degree of consensus in the committee vote, plus bullets listing the main score driving points.” FYI
Updated guidance on NIH grant application due dates (10/1/2025-12/5/2025), along with some other Info. grants.nih.gov/grants/guide...
NOT-OD-26-012: Updated Guidance on Reopening of NIH Extramural Activities Following the October 1, 2025 - Lapse in Appropriations
NIH Funding Opportunities and Notices in the NIH Guide for Grants and Contracts: Updated Guidance on Reopening of NIH Extramural Activities Following the October 1, 2025 - Lapse in Appropriations NOT-...
grants.nih.gov
November 24, 2025 at 6:25 PM
“Summary statements will be simplified. Narrative paragraphs summarizing committee discussion will not be used. Instead, summaries will have a sentence describing the degree of consensus in the committee vote, plus bullets listing the main score driving points.” FYI
Reposted by Dr. Rajesh Khanna of the KhannaLabUF
Excited to share that the main work of my PhD has been published!
We found that having control over pain makes expectations more precise, and changes pain perception. This is accompanied by activation changes in the PAG, SMA and ACC.
You can read the full version of the paper here: rdcu.be/eQy6X
We found that having control over pain makes expectations more precise, and changes pain perception. This is accompanied by activation changes in the PAG, SMA and ACC.
You can read the full version of the paper here: rdcu.be/eQy6X
Controllability changes pain perception by increasing the precision of expectations
Nature Communications - Control over pain changes how intense it is perceived. Here, the authors show that this effect results from increased expectation precision with control, which changes...
rdcu.be
November 22, 2025 at 1:50 PM
Excited to share that the main work of my PhD has been published!
We found that having control over pain makes expectations more precise, and changes pain perception. This is accompanied by activation changes in the PAG, SMA and ACC.
You can read the full version of the paper here: rdcu.be/eQy6X
We found that having control over pain makes expectations more precise, and changes pain perception. This is accompanied by activation changes in the PAG, SMA and ACC.
You can read the full version of the paper here: rdcu.be/eQy6X
Reposted by Dr. Rajesh Khanna of the KhannaLabUF
Big new paper from us published yesterday: The synaptic ectokinase VLK triggers the EphB2–NMDAR interaction to drive injury-induced pain
www.science.org/doi/10.1126/...
Led by @hajisciencebaji.bsky.social in my lab and a wonderful collaboration with Matthew Dalva's lab at Tulane
www.science.org/doi/10.1126/...
Led by @hajisciencebaji.bsky.social in my lab and a wonderful collaboration with Matthew Dalva's lab at Tulane
The synaptic ectokinase VLK triggers the EphB2–NMDAR interaction to drive injury-induced pain
Phosphorylation of hundreds of protein extracellular domains is mediated by two kinase families but the functional role of these kinases is underexplored. We find that the presynaptic release of the t...
www.science.org
November 21, 2025 at 6:13 PM
Big new paper from us published yesterday: The synaptic ectokinase VLK triggers the EphB2–NMDAR interaction to drive injury-induced pain
www.science.org/doi/10.1126/...
Led by @hajisciencebaji.bsky.social in my lab and a wonderful collaboration with Matthew Dalva's lab at Tulane
www.science.org/doi/10.1126/...
Led by @hajisciencebaji.bsky.social in my lab and a wonderful collaboration with Matthew Dalva's lab at Tulane
Reposted by Dr. Rajesh Khanna of the KhannaLabUF
Dont call it a payline grants.nih.gov/news-events/...
Implementing a Unified NIH Funding Strategy to Guide Consistent and Clearer Award Decisions | Grants & Funding
grants.nih.gov
November 21, 2025 at 5:23 PM
Dont call it a payline grants.nih.gov/news-events/...
Reposted by Dr. Rajesh Khanna of the KhannaLabUF
New preprint: Exploring the neuroimmune cellular landscape in the skin of subjects with fibromyalgia www.biorxiv.org/content/10.1...
www.biorxiv.org
November 20, 2025 at 7:43 AM
New preprint: Exploring the neuroimmune cellular landscape in the skin of subjects with fibromyalgia www.biorxiv.org/content/10.1...
Reposted by Dr. Rajesh Khanna of the KhannaLabUF
Looking forward to reading this!! Painless NGF seems to have moved away from p75 and onto TrkA biased signaling. www.biorxiv.org/content/10.1...
www.biorxiv.org
November 18, 2025 at 9:47 PM
Looking forward to reading this!! Painless NGF seems to have moved away from p75 and onto TrkA biased signaling. www.biorxiv.org/content/10.1...
Reposted by Dr. Rajesh Khanna of the KhannaLabUF
Game changer, no doubt. Commercial systems will have expensive consumables I suppose, but huge savings to be made in cell culture, and many important but sparse native targets come into play.
Crispr-tagged targets from iPSC neurons, for example.
TRPC6 blind? 🤯
Crispr-tagged targets from iPSC neurons, for example.
TRPC6 blind? 🤯
MISO: microfluidic protein isolation enables single-particle cryo-EM structure determination from a single cell colony.
Or from a single dish of HEK cell culture in the case of two membrane proteins.
Out in Nature Methods now! lnkd.in/gpyBSceg
Wonderful collaboration with the Efremov lab.
Or from a single dish of HEK cell culture in the case of two membrane proteins.
Out in Nature Methods now! lnkd.in/gpyBSceg
Wonderful collaboration with the Efremov lab.
November 15, 2025 at 2:46 PM
Game changer, no doubt. Commercial systems will have expensive consumables I suppose, but huge savings to be made in cell culture, and many important but sparse native targets come into play.
Crispr-tagged targets from iPSC neurons, for example.
TRPC6 blind? 🤯
Crispr-tagged targets from iPSC neurons, for example.
TRPC6 blind? 🤯
Reposted by Dr. Rajesh Khanna of the KhannaLabUF
Ready to talk to cells?
📖 Read the paper: doi.org/10.1038/s415...
🧬 Try the web app with public datasets: cellwhisperer.bocklab.org
🖥️ Analyze your own datasets: github.com/epigen/cellw...
(9/11)
📖 Read the paper: doi.org/10.1038/s415...
🧬 Try the web app with public datasets: cellwhisperer.bocklab.org
🖥️ Analyze your own datasets: github.com/epigen/cellw...
(9/11)
Multimodal learning enables chat-based exploration of single-cell data - Nature Biotechnology
CellWhisperer uses multimodal learning of transcriptomes and text to answer questions about single-cell RNA-sequencing data.
doi.org
November 11, 2025 at 12:52 PM
Ready to talk to cells?
📖 Read the paper: doi.org/10.1038/s415...
🧬 Try the web app with public datasets: cellwhisperer.bocklab.org
🖥️ Analyze your own datasets: github.com/epigen/cellw...
(9/11)
📖 Read the paper: doi.org/10.1038/s415...
🧬 Try the web app with public datasets: cellwhisperer.bocklab.org
🖥️ Analyze your own datasets: github.com/epigen/cellw...
(9/11)