Nivedita Sarveswaran
@neuroniv.bsky.social
Postdoc in pain genetics & nociceptor biology @TheCIMR | via @biokent @UCLQSIoN @YaleMed | 🇦🇺🇬🇧🇱🇰
Pinned
Lots of writing on the cards over the next few months but thoroughly enjoying all the advice and memes I have saved from PhD thesis time. Might start a thread, but for now, keeping this one front and centre
Reposted by Nivedita Sarveswaran
ScienceWrite is a mentoring scheme for aspiring and early-career minoritised and marginalised UK-based STEM writers, supported by @royalsociety.org and co-founded by @hanaayoob.co.uk @romatheengineer.bsky.social.
There's just a week to go until this year's deadline >>
There's just a week to go until this year's deadline >>
ScienceWrite 2026 is open for applications! 🧪
Our programme for minoritised/marginalised science writers based in the UK is running again!
Have an idea for a book, article or other writing project for a lay audience? This is for you!
Apply & find out more at sciencewrite.co.uk
Our programme for minoritised/marginalised science writers based in the UK is running again!
Have an idea for a book, article or other writing project for a lay audience? This is for you!
Apply & find out more at sciencewrite.co.uk
November 10, 2025 at 9:43 AM
ScienceWrite is a mentoring scheme for aspiring and early-career minoritised and marginalised UK-based STEM writers, supported by @royalsociety.org and co-founded by @hanaayoob.co.uk @romatheengineer.bsky.social.
There's just a week to go until this year's deadline >>
There's just a week to go until this year's deadline >>
Reposted by Nivedita Sarveswaran
Her sister wrote my favorite essay about her. She points out that RF would have been famous even if she'd never looked at DNA
www.thelancet.com/journals/lan...
www.thelancet.com/journals/lan...
Remembering my sister Rosalind Franklin
Rosalind Franklin died of ovarian cancer in 1958 aged 37 years. Sympathy and feminism
have combined to give us her familiar image as a downtrodden woman scientist, brilliant
but neglected, a heroine t...
www.thelancet.com
November 7, 2025 at 11:20 PM
Her sister wrote my favorite essay about her. She points out that RF would have been famous even if she'd never looked at DNA
www.thelancet.com/journals/lan...
www.thelancet.com/journals/lan...
Reposted by Nivedita Sarveswaran
#NIHfunding via the HEAL initiative for the PRECISION Human Pain Network has yielded a massive increase in data on human sensory neurons. One of the most amazing collaborations I've been part of. Data sharing across 4 centers, insights from experts across the network that really moved the needle.
The BIG DRG paper is now up on @biorxiv-neursci.bsky.social www.biorxiv.org/content/10.1... so many people worked so hard to make this happen. Props to the whole PRECISION Human Pain Network.
A Reference Atlas of the Human Dorsal Root Ganglion
Somatosensory perception largely emerges from diverse peripheral sensory neurons whose cell bodies reside in dorsal root ganglia (DRG). Damage or dysfunction of DRG neurons is a major cause of chronic...
www.biorxiv.org
November 7, 2025 at 8:17 PM
#NIHfunding via the HEAL initiative for the PRECISION Human Pain Network has yielded a massive increase in data on human sensory neurons. One of the most amazing collaborations I've been part of. Data sharing across 4 centers, insights from experts across the network that really moved the needle.
Reposted by Nivedita Sarveswaran
Also happy to see that our rat DRG dataset is now online at Journal of Pain. www.jpain.org/article/S152... Big thanks to Sydney Caparaso and Becky Wachs for leading this effort along with @ish1789.bsky.social and I. Rats and mice and humans are not the same, oh my!
Single-nuclei RNA Sequencing Reveals Distinct Transcriptomic Signatures of Rat Dorsal Root Ganglia in a Chronic Discogenic Low Back Pain Model
Chronic low back pain (LBP), often correlated with intervertebral disc degeneration,
is a leading source of disability worldwide, yet remains poorly understood. Current
treatments often fail to provid...
www.jpain.org
November 7, 2025 at 5:51 PM
Also happy to see that our rat DRG dataset is now online at Journal of Pain. www.jpain.org/article/S152... Big thanks to Sydney Caparaso and Becky Wachs for leading this effort along with @ish1789.bsky.social and I. Rats and mice and humans are not the same, oh my!
New human DRG atlas just dropped! 🌟
The BIG DRG paper is now up on @biorxiv-neursci.bsky.social www.biorxiv.org/content/10.1... so many people worked so hard to make this happen. Props to the whole PRECISION Human Pain Network.
A Reference Atlas of the Human Dorsal Root Ganglion
Somatosensory perception largely emerges from diverse peripheral sensory neurons whose cell bodies reside in dorsal root ganglia (DRG). Damage or dysfunction of DRG neurons is a major cause of chronic...
www.biorxiv.org
November 7, 2025 at 11:26 AM
New human DRG atlas just dropped! 🌟
Reposted by Nivedita Sarveswaran
"The UK cannot become a science superpower unless it exploits the full range of talent that we have" - @nramnani.bsky.social
We are now welcoming applications to our BNA Scholars Programme.
🔗 Find out more and apply: www.bna.org.uk/policy-advoc...
#BNAScholars #DiversityInSTEM #Mentorship
We are now welcoming applications to our BNA Scholars Programme.
🔗 Find out more and apply: www.bna.org.uk/policy-advoc...
#BNAScholars #DiversityInSTEM #Mentorship
November 7, 2025 at 9:09 AM
"The UK cannot become a science superpower unless it exploits the full range of talent that we have" - @nramnani.bsky.social
We are now welcoming applications to our BNA Scholars Programme.
🔗 Find out more and apply: www.bna.org.uk/policy-advoc...
#BNAScholars #DiversityInSTEM #Mentorship
We are now welcoming applications to our BNA Scholars Programme.
🔗 Find out more and apply: www.bna.org.uk/policy-advoc...
#BNAScholars #DiversityInSTEM #Mentorship
Reposted by Nivedita Sarveswaran
🚨New paper from the NIH PRECISION Human Pain Network! We built a human DRG reference atlas: >500K cells from 126 donors to reveal 22 neuronal & 10 non-neuronal cell types. New insights into human sensory biology!
Paper: biorxiv.org/content/10.1...
Data: humandrg.painseq.com
Paper: biorxiv.org/content/10.1...
Data: humandrg.painseq.com
biorxiv.org
November 7, 2025 at 4:43 AM
🚨New paper from the NIH PRECISION Human Pain Network! We built a human DRG reference atlas: >500K cells from 126 donors to reveal 22 neuronal & 10 non-neuronal cell types. New insights into human sensory biology!
Paper: biorxiv.org/content/10.1...
Data: humandrg.painseq.com
Paper: biorxiv.org/content/10.1...
Data: humandrg.painseq.com
Reposted by Nivedita Sarveswaran
A fantastic opportunity to join our department! Our work spans from molecular mechanisms of organelle trafficking, receptor biophysics, circuit dissection, and metabolic regulation, to behaviour, reinforcement learning, and neural computation. All extremely collaborative and interdisciplinary!
Calling aspiring group leaders! We've just opened applications for group leader fellowship sponsorship to start a lab in UCL NPP. Deadline 5 Jan. @uclnpp.bsky.social tinyurl.com/3h33dvev
UCL – University College London
UCL is consistently ranked as one of the top ten universities in the world (QS World University Rankings 2010-2022) and is No.2 in the UK for research power (Research Excellence Framework 2021).
tinyurl.com
November 6, 2025 at 10:13 AM
A fantastic opportunity to join our department! Our work spans from molecular mechanisms of organelle trafficking, receptor biophysics, circuit dissection, and metabolic regulation, to behaviour, reinforcement learning, and neural computation. All extremely collaborative and interdisciplinary!
Reposted by Nivedita Sarveswaran
Our mission is to determine the molecular mechanisms of disease in order to advance human health.
Want to join our vibrant and diverse research institute as a funded PhD or taught MPhil student? Apply by the 2nd December 2025.
More information here: www.cimr.cam.ac.uk/postgraduate...
Want to join our vibrant and diverse research institute as a funded PhD or taught MPhil student? Apply by the 2nd December 2025.
More information here: www.cimr.cam.ac.uk/postgraduate...
November 6, 2025 at 10:40 AM
Our mission is to determine the molecular mechanisms of disease in order to advance human health.
Want to join our vibrant and diverse research institute as a funded PhD or taught MPhil student? Apply by the 2nd December 2025.
More information here: www.cimr.cam.ac.uk/postgraduate...
Want to join our vibrant and diverse research institute as a funded PhD or taught MPhil student? Apply by the 2nd December 2025.
More information here: www.cimr.cam.ac.uk/postgraduate...
Reposted by Nivedita Sarveswaran
Induced proximity-based therapeutic modalities
nature.com/articles/s41...
rdcu.be/eOfBH
This new Review by @dannomura.bsky.social et al. discusses the rapidly expanding landscape of therapeutic approaches based on inducing proximity between proteins, including targeted protein degraders and more
nature.com/articles/s41...
rdcu.be/eOfBH
This new Review by @dannomura.bsky.social et al. discusses the rapidly expanding landscape of therapeutic approaches based on inducing proximity between proteins, including targeted protein degraders and more
Induced proximity-based therapeutic modalities - Nature Reviews Drug Discovery
Induced proximity modalities encompass monovalent and bifunctional agents, such as molecular glues and proteolysis-targeting chimeras, that induce an interaction between biomolecules to functionally m...
nature.com
November 4, 2025 at 4:12 PM
Induced proximity-based therapeutic modalities
nature.com/articles/s41...
rdcu.be/eOfBH
This new Review by @dannomura.bsky.social et al. discusses the rapidly expanding landscape of therapeutic approaches based on inducing proximity between proteins, including targeted protein degraders and more
nature.com/articles/s41...
rdcu.be/eOfBH
This new Review by @dannomura.bsky.social et al. discusses the rapidly expanding landscape of therapeutic approaches based on inducing proximity between proteins, including targeted protein degraders and more
Reposted by Nivedita Sarveswaran
Nature suggests you use their "Manuscript Adviser" bot to get advice before submitting
I uploaded the classic Watson & Crick paper about DNA structure, and the Adviser had this to say about one of the greatest paper endings of the century:
I uploaded the classic Watson & Crick paper about DNA structure, and the Adviser had this to say about one of the greatest paper endings of the century:
November 3, 2025 at 1:55 PM
Nature suggests you use their "Manuscript Adviser" bot to get advice before submitting
I uploaded the classic Watson & Crick paper about DNA structure, and the Adviser had this to say about one of the greatest paper endings of the century:
I uploaded the classic Watson & Crick paper about DNA structure, and the Adviser had this to say about one of the greatest paper endings of the century:
Reposted by Nivedita Sarveswaran
As a regular train passenger, the attack and horrific injuries are shocking. But it took only 8 minutes (long ones) from the first emergency call to the attackers being arrested; all respect to the passengers, train driver, police, and emergency services that it was over so fast.
Cambridgeshire train attack: what we know so far
Two British men held in custody after ‘major incident’ on Saturday that resulted in 11 hospital admissions
www.theguardian.com
November 2, 2025 at 4:44 PM
As a regular train passenger, the attack and horrific injuries are shocking. But it took only 8 minutes (long ones) from the first emergency call to the attackers being arrested; all respect to the passengers, train driver, police, and emergency services that it was over so fast.
Reposted by Nivedita Sarveswaran
Research aims and objectives aren’t the same thing but are related It helps to understand the differences and connections patthomson.net/2025/11/01/r...
research aims vs. objectives – what’s the difference?
You’re finally sitting down to write your research proposal and you’ve hit that section where you need to outline your aims and objectives. You stare at the page. Aren’t these bas…
patthomson.net
November 2, 2025 at 6:32 AM
Research aims and objectives aren’t the same thing but are related It helps to understand the differences and connections patthomson.net/2025/11/01/r...
Being an absolute herby nerd, working on my plating game: lemon, parsley and fennel risotto with honey & thyme pancetta 🍽️
November 1, 2025 at 7:57 PM
Being an absolute herby nerd, working on my plating game: lemon, parsley and fennel risotto with honey & thyme pancetta 🍽️
Reposted by Nivedita Sarveswaran
The latest work from our PRECISION Human Pain Center project is now up on @biorxivpreprint.bsky.social led by Katherin Gabriel and @oliviadavis.bsky.social with a huge contribution from @allanhpool.bsky.social's lab and, of course, the Southwest Transplant Alliance: www.biorxiv.org/content/10.1...
A molecular map of the human spinal dorsal and ventral horn defines arrangement of neuronal types and glial sex differences
The spinal cord is the gateway for sensory information from the body as it ascends to the brain, as well as a major motor output center of the nervous system. It is also a key location for sensory-mot...
www.biorxiv.org
November 1, 2025 at 12:10 PM
The latest work from our PRECISION Human Pain Center project is now up on @biorxivpreprint.bsky.social led by Katherin Gabriel and @oliviadavis.bsky.social with a huge contribution from @allanhpool.bsky.social's lab and, of course, the Southwest Transplant Alliance: www.biorxiv.org/content/10.1...
Reposted by Nivedita Sarveswaran
Do you know a Year 12 student from a Black African, Caribbean or mixed race background who is thinking about applying to Cambridge?
Target Oxbridge is a free mentoring programme that has helped over 500 students to secure Oxbridge offers.
Apply at targetoxbridge.app.candidx.io/roles before 23 Nov.
Target Oxbridge is a free mentoring programme that has helped over 500 students to secure Oxbridge offers.
Apply at targetoxbridge.app.candidx.io/roles before 23 Nov.
October 30, 2025 at 9:09 AM
Do you know a Year 12 student from a Black African, Caribbean or mixed race background who is thinking about applying to Cambridge?
Target Oxbridge is a free mentoring programme that has helped over 500 students to secure Oxbridge offers.
Apply at targetoxbridge.app.candidx.io/roles before 23 Nov.
Target Oxbridge is a free mentoring programme that has helped over 500 students to secure Oxbridge offers.
Apply at targetoxbridge.app.candidx.io/roles before 23 Nov.
Thanks to John Oliver and Andy Zaltzman - we'll be using "The Louvre Manouvre" as the standard for good news shenanigan stories we need in the world right now www.youtube.com/watch?v=B2g7...
The Louvre Manoeuvre - With John Oliver and Andy Zaltzman
YouTube video by The Bugle
www.youtube.com
October 31, 2025 at 6:54 PM
Thanks to John Oliver and Andy Zaltzman - we'll be using "The Louvre Manouvre" as the standard for good news shenanigan stories we need in the world right now www.youtube.com/watch?v=B2g7...
Reposted by Nivedita Sarveswaran
Funders must recognise that great discoveries often come from studies that seeks to advance knowledge for its own sake
go.nature.com/47zrzYZ
go.nature.com/47zrzYZ
From MRI to Ozempic: breakthroughs that show why fundamental research must be protected
In these financially straitened times, funders must recognize that great discoveries often arise from work that was looking for something completely different.
go.nature.com
October 29, 2025 at 12:11 PM
Funders must recognise that great discoveries often come from studies that seeks to advance knowledge for its own sake
go.nature.com/47zrzYZ
go.nature.com/47zrzYZ
Reposted by Nivedita Sarveswaran
This is the news I've dreaded all my life, and it's here: Humanity has failed to avoid dangerous climate change.
We have now entered the overshoot era.
Our new goal is to prevent as many irreversible tipping points from taking hold as we can.
www.theguardian.com/environment/...
We have now entered the overshoot era.
Our new goal is to prevent as many irreversible tipping points from taking hold as we can.
www.theguardian.com/environment/...
‘Change course now’: humanity has missed 1.5C climate target, says UN head
Exclusive: ‘Devastating consequences’ now inevitable but emissions cuts still vital, says António Guterres in sole interview before Cop30
www.theguardian.com
October 28, 2025 at 4:30 AM
This is the news I've dreaded all my life, and it's here: Humanity has failed to avoid dangerous climate change.
We have now entered the overshoot era.
Our new goal is to prevent as many irreversible tipping points from taking hold as we can.
www.theguardian.com/environment/...
We have now entered the overshoot era.
Our new goal is to prevent as many irreversible tipping points from taking hold as we can.
www.theguardian.com/environment/...
Reposted by Nivedita Sarveswaran
Calling all #Membrane enthusiasts!
Our #MembraneTrafficking online seminar series is back for the 2025-26 season: 8 fantastic speakers from Nov'25 to Feb'26.
The first talks are already next Thursday (Nov 6, 5pm CET) with @agatawitkowska.bsky.social and @abdourachidthiam.bsky.social !
Our #MembraneTrafficking online seminar series is back for the 2025-26 season: 8 fantastic speakers from Nov'25 to Feb'26.
The first talks are already next Thursday (Nov 6, 5pm CET) with @agatawitkowska.bsky.social and @abdourachidthiam.bsky.social !
October 27, 2025 at 5:02 PM
Calling all #Membrane enthusiasts!
Our #MembraneTrafficking online seminar series is back for the 2025-26 season: 8 fantastic speakers from Nov'25 to Feb'26.
The first talks are already next Thursday (Nov 6, 5pm CET) with @agatawitkowska.bsky.social and @abdourachidthiam.bsky.social !
Our #MembraneTrafficking online seminar series is back for the 2025-26 season: 8 fantastic speakers from Nov'25 to Feb'26.
The first talks are already next Thursday (Nov 6, 5pm CET) with @agatawitkowska.bsky.social and @abdourachidthiam.bsky.social !
Reposted by Nivedita Sarveswaran
Happy to share our new preprint
doi.org/10.1101/2025...
We present a protocol to generate Parasympathetic neurons from hiPSC. They express key parasympathetic/autonomic markers, #ephys features and respond to nicotine. They can also form functional connections with hiPSC-atrial cardiomyocytes.
doi.org/10.1101/2025...
We present a protocol to generate Parasympathetic neurons from hiPSC. They express key parasympathetic/autonomic markers, #ephys features and respond to nicotine. They can also form functional connections with hiPSC-atrial cardiomyocytes.
Generation of parasympathetic neurons from hiPSC that reproduce the electrophysiological properties of native neurons and modulate the activity of hiPSC-atrial cardiomyocytes
Peripheral parasympathetic ganglia lie adjacent to their target organs; their dysfunction contributes to diseases like atrial fibrillation. Due to their challenging accessibility for primary culture, ...
doi.org
October 27, 2025 at 4:54 PM
Happy to share our new preprint
doi.org/10.1101/2025...
We present a protocol to generate Parasympathetic neurons from hiPSC. They express key parasympathetic/autonomic markers, #ephys features and respond to nicotine. They can also form functional connections with hiPSC-atrial cardiomyocytes.
doi.org/10.1101/2025...
We present a protocol to generate Parasympathetic neurons from hiPSC. They express key parasympathetic/autonomic markers, #ephys features and respond to nicotine. They can also form functional connections with hiPSC-atrial cardiomyocytes.
Pretty fun antique find this rainy weekend 🍺
October 26, 2025 at 4:24 PM
Pretty fun antique find this rainy weekend 🍺
Reposted by Nivedita Sarveswaran
Further to this, it’s actually reducing the amount of research we do. Imagine what would happen if we were doing research instead of writing grant after grant after grant after grant…
It doesn't matter how many grant writing workshops you put on, or how much pressure you put on academics to apply - if the money isn't there, the money simply isn't there.
After submitting a FOIA request UKRI, I obtained success rates by three grant call scheme and I can only say that I am disheartened by the results:
- AHRC Responsive Mode 2025: 2%
- ESRC New Investigator Grant 2025: 1%
- ESRC Research Grant Round 2025: 1%
- AHRC Responsive Mode 2025: 2%
- ESRC New Investigator Grant 2025: 1%
- ESRC Research Grant Round 2025: 1%
October 23, 2025 at 1:58 PM
Further to this, it’s actually reducing the amount of research we do. Imagine what would happen if we were doing research instead of writing grant after grant after grant after grant…
Reposted by Nivedita Sarveswaran
It doesn't matter how many grant writing workshops you put on, or how much pressure you put on academics to apply - if the money isn't there, the money simply isn't there.
After submitting a FOIA request UKRI, I obtained success rates by three grant call scheme and I can only say that I am disheartened by the results:
- AHRC Responsive Mode 2025: 2%
- ESRC New Investigator Grant 2025: 1%
- ESRC Research Grant Round 2025: 1%
- AHRC Responsive Mode 2025: 2%
- ESRC New Investigator Grant 2025: 1%
- ESRC Research Grant Round 2025: 1%
October 23, 2025 at 12:20 PM
It doesn't matter how many grant writing workshops you put on, or how much pressure you put on academics to apply - if the money isn't there, the money simply isn't there.
Ratatouille night 🧑🍳
October 24, 2025 at 8:30 PM
Ratatouille night 🧑🍳