Holly Sullivan-Toole
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hollysully.bsky.social
Holly Sullivan-Toole
@hollysully.bsky.social
2K followers 1.1K following 120 posts
Dev Affective Neuro, Reward, Reinforcement Learning, Anhedonia, Dopaminergic Circuitry, Brain Iron
she/her
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Reposted by Holly Sullivan-Toole
laurenshallion.bsky.social
Just accepted at Nature Mental Health:

Crises and Opportunities for Psychological Science under Fascism

https://doi.org/10.31234/osf.io/nz42x_v3

1/9
This manuscript has been provisionally accepted for publication at Nature Mental Health. Please cite as: Hallion, L. S., Lorenzo-Luaces, L., Crowell, S., Gruber, J., Boisseau, C. L.., Perillo, A. D., Perillo, J. T., Delawalla, C. (in press). Crises and opportunities for psychological science under fascism. Nature Mental Health. Abstract Psychopathology research and treatment is at a crucial juncture. Particularly within the United States, funding for scientific research has been cut drastically; academic freedom is under attack; and efforts to diversify our workforce and mitigate our field's contributions to systemic oppression have been banned outright. Ideologies vie for dominance, with reactionary centrism and institutional capitulation increasingly evident. Gaslighting plays a central role in our politics (academic, national, and beyond), but it is virtually unacknowledged within our science. At the same time, diamonds are formed under pressure. Our collective reckoning brings with it the potential for non-incremental improvements in our ability to assess, diagnose, and treat patients. These improvements arrive in the form of opportunities for paradigm shifts, particularly those involving acknowledging the gaslighting our field perpetuates; resourcefulness in conducting research; values-realignment; coalition-building within and across fields and institutions; and dissemination and outreach.
November 7, 2025 at 7:26 PM
Reposted by Holly Sullivan-Toole
drugmonkey.bsky.social
In the olden dayes we would know by now the relative force impact of a fully laden subway sandwich fired at point blank range by an inebriated individual who hasn’t thrown anything in 15 years. Academic tweetersky is a pale shadow. 🙁
November 5, 2025 at 6:33 PM
Reposted by Holly Sullivan-Toole
ajshackman.bsky.social
sciety-discovery.elifesciences.org/articles/by?...
Efficacy and target engagement of dopamine agonist pramipexole for anhedonic depression - the PRIME-PRAXOL randomized controlled trial
Here, we examined the efficacy and target engagement of dopamine agonist pramipexole in treating a cross-diagnostic sample of mood disorders characterized by severe anhedonia. Patients with major depr...
sciety-discovery.elifesciences.org
November 3, 2025 at 5:00 PM
Reposted by Holly Sullivan-Toole
ajshackman.bsky.social
www.thelancet.com/journals/ebi...
Pro-dopaminergic pharmacological interventions for anhedonia in depression: a living systematic review and network meta-analysis of human and animal studies
Our findings provide some support for the role of dopamine in anhedonia. However, the precise neurobiological mechanisms of anhedonia in major depression are still poorly understood and we posit that ...
www.thelancet.com
November 3, 2025 at 5:02 PM
Reposted by Holly Sullivan-Toole
latimes.com
US citizen shot from behind as he warned ICE agents children would be coming to get bus, lawyers say
U.S. citizen shot from behind as he warned ICE agents about children gathering at bus stop, lawyers say
Lawyers for Carlos Jimenez said he was in fear after an agent threatened him with chemical spray, then pointed a gun at him.
www.latimes.com
November 2, 2025 at 11:25 PM
Reposted by Holly Sullivan-Toole
caitlindeangelis.bsky.social
ICE kidnapped a 7th-grader with a pending asylum claim and spirited him out of state without notifying his parents, seemingly with the cooperation of the local police in Everett, MA.

www.bostonglobe.com/2025/10/12/m...
Everett 13-year-old arrested by ICE and sent to Virginia detention facility By Marcela Rodrigues Globe Staff,Updated October 12, 2025, 44 minutes ago 31 A 13-year-old boy was arrested by ICE in Everett and sent to a juvenile detention facility in Virginia. A 13-year-old boy was arrested by ICE in Everett and sent to a juvenile detention facility in Virginia. A 13-year-old boy was arrested by Immigration and Customs Enforcement agents in Everett after an interaction with members of the Everett Police Department and sent to a juvenile detention facility in Virginia, according to his mother and immigration lawyer Andrew Lattarulo. The boy’s mother, Josiele Berto, was called to pick her son up from the Everett Police Department on Thursday, the day he was arrested. After waiting for about an hour and a half, she was told her son was taken by ICE, Berto told the Globe in a phone interview. “My world collapsed,” Berto said in Portuguese. From the police department, the boy was taken to ICE’s holding facility in Burlington on Thursday evening, where he spent a night before being transferred by car to the Northwestern Regional Juvenile Detention Center in Winchester, Va., on Friday morning, his mother said. The juvenile facility is more than 500 miles away from Everett. The boy is a 7th-grader at Albert N. Parlin School in Everett, his mother said. The teen and his family, who are Brazilian nationals, have a pending asylum case and are authorized to work legally in the United States, Lattarulo said.
October 12, 2025 at 9:43 PM
Reposted by Holly Sullivan-Toole
dlknowles.bsky.social
I visited the apartment building ICE raided on Tuesday today. Story to come, but you can walk right in. Half of the apartments have no doors on them. Children's stuff abandoned in some flats. *Citizen* residents told me they were arrested and held for hours in zipties. This is America
October 4, 2025 at 8:49 PM
Reposted by Holly Sullivan-Toole
kjobson.bsky.social
Thank you so much to all of my co-authors on this paper; I certainly would not have received this award without all of the brilliant support I have gotten!
September 13, 2025 at 2:16 PM
hollysully.bsky.social
Awesome work on dense sampling of reward response from @mattmattoni.bsky.social!!! with a great thread detailing findings!!
mattmattoni.bsky.social Matt Mattoni @mattmattoni.bsky.social · Sep 29
🚨🚨New precision imaging study and open dataset 🚨🚨 Featuring almost 200 functional runs acquired in 3-4d intervals and behavioral manipulations focused on intraindividual study of the reward response - The Night Owls Scan Club (NOSC) With @dvsmith.bsky.social and @olinotom.bsky.social!
September 29, 2025 at 5:19 PM
Reposted by Holly Sullivan-Toole
dmihalopoulos.bsky.social
In which a top US Border Patrol official, incredibly, tells my tall and Anglo colleague @chipmitchell1.bsky.social that he's not the type they're looking for as they go about downtown Chicago arresting people based on "how they look"

chicago.suntimes.com/immigration/...
Feds in military gear flood downtown Chicago; top border official says arrests based on 'how they look'
The immigration agents were spotted making arrests in downtown Chicago and River North neighborhood early Sunday.
chicago.suntimes.com
September 28, 2025 at 11:49 PM
Reposted by Holly Sullivan-Toole
philcorlett.bsky.social
somehow I missed this!

Dopamine represents a domain-general teaching signal:

www.science.org/doi/full/10....
Striatal dopamine signals errors in prediction across different informational domains
Dopamine reflects prediction errors not only about reward but also about valueless stimuli, challenging many current theories.
www.science.org
September 16, 2025 at 7:44 PM
hollysully.bsky.social
Corn bread in a waffle iron is next level!!!
September 26, 2025 at 12:00 AM
Reposted by Holly Sullivan-Toole
mclem.org
This is a real photograph of Washington, DC this week, where the United States president has ordered military occupation in peacetime, and ordered the display of colossal portraits of himself.

www.wsj.com/politics/pol...
Washington, DC under military occupation in last August 2025, with banners proclaiming the absolute power of the primus inter pares
August 28, 2025 at 10:24 AM
Reposted by Holly Sullivan-Toole
bsamjournal.bsky.social
Do late adolescents and emerging adults who live in a communities with higher violent crime rates exhibit altered reward-related neural activation? This question was recently investigated in a sample of 101 adolescents.

Read more in BSAM, free for the week!
#healthpsych #psychscicky
Residence in Communities With Higher Violent Crimes... : Biopsychosocial Science and Medicine
dequately understood. Furthermore, most of the adversity literature examines individual-level exposure (eg, crime victimization), whereas efforts to consider neighborhood-level factors (eg, neighborho...
journals.lww.com
August 20, 2025 at 10:46 PM
Reposted by Holly Sullivan-Toole
ariellekeller.bsky.social
✨ New paper ✨ in JAMA Pediatrics! We discuss how understanding the timing ⏰ of stressful events relative to neurodevelopment can help us better identify risk factors (looking backward) and predict future psychopathology (looking forward) at the individual level
#neuroskyence #devpsych #PsychSciSky
August 19, 2025 at 5:56 PM
Reposted by Holly Sullivan-Toole
drugmonkey.bsky.social
Underrepresented minority faculty in the USA face a double standard in promotion and tenure decisions
August 16, 2025 at 12:54 AM
Reposted by Holly Sullivan-Toole
sromeropinto.bsky.social
My first paper with @naoshigeuchida.bsky.social is finally out in @natcomms.nature.com ! rdcu.be/eACGf

TL;DR: asymmetric learning rates can be induced by shifts in tonic dopamine giving rise to pessimistic/optimistic biases in agents or animals undergoing reinforcement learning .
Tonic dopamine and biases in value learning linked through a biologically inspired reinforcement learning model
Nature Communications - Accurate future predictions are essential for guiding behavior, and disruptions in this process are associated with psychiatric disorders. Here the authors show that changes...
rdcu.be
August 13, 2025 at 9:55 PM
Reposted by Holly Sullivan-Toole
dpmoriarity.bsky.social
I will be interviewing for a clinical psychology PhD student in the Precision Psychopathology + Dynamic Immunopsychiatry Lab this interview cycle.

Please see our website for more info about what we do + share with applicants you think might be a good fit.

share.google/uJRyS3NY9Kdo...
Precision Psychopathology + Dynamic Immunopsychiatry Lab – University of Pennsylvania, Department of Psychology
share.google
August 7, 2025 at 11:23 AM
Reposted by Holly Sullivan-Toole
imagingneurosci.bsky.social
New paper in Imaging Neuroscience by Matthew Mattoni, Thomas M. Olino, et al:

Functional connectivity heterogeneity and consequences for clinical and cognitive prediction: Stage 2 registered report

doi.org/10.1162/IMAG...
August 13, 2025 at 8:09 AM
Reposted by Holly Sullivan-Toole
carinaheller.bsky.social
We wrote a piece for @naturemedicine.bsky.social 🧠

Menstrual cycle irregularities can be both cause and consequence of wide-ranging health issues.
Embracing this complexity could reveal novel brain–body interactions and advance neuroscience.

Check out our commentary www.nature.com/articles/s41...
Why menstrual cycle irregularities belong in brain research - Nature Medicine
The menstrual cycle requires tight orchestration between the brain and body, and irregularities can be both the cause and the consequence of wide-ranging health issues. Embracing this complexity, inst...
www.nature.com
August 13, 2025 at 9:27 AM
hollysully.bsky.social
Read this whole thread 👇
richardfbetzel.bsky.social Rick Betzel @richardfbetzel.bsky.social · Aug 11
I've been thinking a lot about the preprint in terms of my own career. I grew up academically in computational labs. My papers were abstract early on and they only got more abstract as I progressed. The model was: find a new exciting mathematical tool. Apply it to brain imaging data. Write it up. 1/
drdamienfair.bsky.social Damien Fair @drdamienfair.bsky.social · Aug 10
I still get chills

Meet Mike
*30+ years severe depression
*first hospitalized @ 13y
*20 meds
*3 rounds of ECT
*2 near-fatal suicide attempts

Mike felt joy for the first time in decades after we turned on his new brain pacemaker or PACE

see videos, read paper, follow thread
doi.org/10.31234/osf...
August 13, 2025 at 3:11 AM
Reposted by Holly Sullivan-Toole
drjuliamoser.bsky.social
What an amazing demonstration of why Precision Functional Mapping matters 🧠It’s been an honor to support the team in this huge endeavor!
drdamienfair.bsky.social Damien Fair @drdamienfair.bsky.social · Aug 10
I still get chills

Meet Mike
*30+ years severe depression
*first hospitalized @ 13y
*20 meds
*3 rounds of ECT
*2 near-fatal suicide attempts

Mike felt joy for the first time in decades after we turned on his new brain pacemaker or PACE

see videos, read paper, follow thread
doi.org/10.31234/osf...
August 10, 2025 at 9:28 PM
Reposted by Holly Sullivan-Toole
roberthermosillo.bsky.social
When nothing worked, this did. Precision functional mapping is here for treatment-resistant depression. This is what hope looks like. 💡
drdamienfair.bsky.social Damien Fair @drdamienfair.bsky.social · Aug 10
I still get chills

Meet Mike
*30+ years severe depression
*first hospitalized @ 13y
*20 meds
*3 rounds of ECT
*2 near-fatal suicide attempts

Mike felt joy for the first time in decades after we turned on his new brain pacemaker or PACE

see videos, read paper, follow thread
doi.org/10.31234/osf...
August 11, 2025 at 12:19 AM
Reposted by Holly Sullivan-Toole
drdamienfair.bsky.social
I still get chills

Meet Mike
*30+ years severe depression
*first hospitalized @ 13y
*20 meds
*3 rounds of ECT
*2 near-fatal suicide attempts

Mike felt joy for the first time in decades after we turned on his new brain pacemaker or PACE

see videos, read paper, follow thread
doi.org/10.31234/osf...
August 10, 2025 at 6:23 PM
Reposted by Holly Sullivan-Toole
richardfbetzel.bsky.social
Personalized Adaptive Cortical Electro-stimulation (PACE) in Treatment-Resistant Depression

Punchline: PERSONALIZED network neuroscience works.

*Easily* the most important paper I’ve been part of.

Read the manuscript for details. Watch the movies for *amazing* testimonial.

1/2
August 10, 2025 at 5:25 PM