David Seminowicz
@daspainbrain.bsky.social
Brain imaging pain researcher.
Professor, Medical Biophysics at University of Western Ontario.
https://www.daslab.org/
https://www.knowpain.ca/
Professor, Medical Biophysics at University of Western Ontario.
https://www.daslab.org/
https://www.knowpain.ca/
Pinned
Predicting Individual Pain Sensitivity Using a Novel Cortical Biomarker Signature
This cohort study analyzes electroencephalography data from healthy participants to analyze and validate a cortical biomarker signature for pain, which comprised the measures sensorimotor peak alpha f...
jamanetwork.com
our NIH HEAL initiative funded biomarkers study now out @jama.com JAMA Neurology
open access, open data and code
w/ @drsmschabrun.bsky.social
jamanetwork.com/journals/jam...
open access, open data and code
w/ @drsmschabrun.bsky.social
jamanetwork.com/journals/jam...
Reposted by David Seminowicz
In 1956, Jim Watson told my father, a brown man, that he would never get a job at Harvard and it was a miracle he had been admitted . Harvard's Board of Trustees saw it differently & appointed dad as an Assistant Professor and Director of the Harvard Agassiz Observatory BEFORE he finished his Ph.D!
James Watson, infamous racist and sexist who try to deny Rosalind Franklin credit for her role in discovering the structure of DNA, has died at age 97.
apnews.com/article/jame...
apnews.com/article/jame...
James Watson, co-discoverer of the double-helix shape of DNA, has died at age 97
Scientist James Watson, who shared a Nobel prize for helping discover the double-helix shape of the DNA molecule, has died. He was 97.
apnews.com
November 7, 2025 at 9:20 PM
In 1956, Jim Watson told my father, a brown man, that he would never get a job at Harvard and it was a miracle he had been admitted . Harvard's Board of Trustees saw it differently & appointed dad as an Assistant Professor and Director of the Harvard Agassiz Observatory BEFORE he finished his Ph.D!
Reposted by David Seminowicz
Check out our newest demonstrating feasabilty of sub-mm whole brain EEG-fMRI at 7T.
Happy to have been part of this amazing collaboration and thank you so much to Cristina and João for leading this project 😊👍.
Happy to have been part of this amazing collaboration and thank you so much to Cristina and João for leading this project 😊👍.
New paper in Imaging Neuroscience by C. Sainz Martinez, J. Jorge, et al:
An optimized framework for simultaneous EEG-fMRI at 7T enabling safe, high-quality human brain imaging with millisecond temporal resolution and sub-millimeter spatial resolution
doi.org/10.1162/IMAG...
An optimized framework for simultaneous EEG-fMRI at 7T enabling safe, high-quality human brain imaging with millisecond temporal resolution and sub-millimeter spatial resolution
doi.org/10.1162/IMAG...
November 7, 2025 at 9:06 AM
Check out our newest demonstrating feasabilty of sub-mm whole brain EEG-fMRI at 7T.
Happy to have been part of this amazing collaboration and thank you so much to Cristina and João for leading this project 😊👍.
Happy to have been part of this amazing collaboration and thank you so much to Cristina and João for leading this project 😊👍.
Reposted by David Seminowicz
The BIG DRG paper is now up on @biorxiv-neursci.bsky.social www.biorxiv.org/content/10.1... so many people worked so hard to make this happen. Props to the whole PRECISION Human Pain Network.
A Reference Atlas of the Human Dorsal Root Ganglion
Somatosensory perception largely emerges from diverse peripheral sensory neurons whose cell bodies reside in dorsal root ganglia (DRG). Damage or dysfunction of DRG neurons is a major cause of chronic...
www.biorxiv.org
November 7, 2025 at 11:16 AM
The BIG DRG paper is now up on @biorxiv-neursci.bsky.social www.biorxiv.org/content/10.1... so many people worked so hard to make this happen. Props to the whole PRECISION Human Pain Network.
Reposted by David Seminowicz
Join us on November 13th for a free talk, hosted by the kNOw-PAIN Group, featuring Marco Loggia, Ph.D. titled "Towards a whole-person study of inflammation in human chronic pain."
This talk is available in-person with Zoom available on request. Please see below for more details!
This talk is available in-person with Zoom available on request. Please see below for more details!
November 6, 2025 at 8:47 PM
Join us on November 13th for a free talk, hosted by the kNOw-PAIN Group, featuring Marco Loggia, Ph.D. titled "Towards a whole-person study of inflammation in human chronic pain."
This talk is available in-person with Zoom available on request. Please see below for more details!
This talk is available in-person with Zoom available on request. Please see below for more details!
Reposted by David Seminowicz
Join us for our next #a2cps Journal Club featuring @ghasemloulab.bsky.social to discuss circadian rhythms as a #biomarker of #chronicpain conditions. Thurs Dec 4 noon ET, registration is free through the PURPOSE Network
painresearchers.com/topics/22512...
painresearchers.com/topics/22512...
Log in | PURPOSE: Positively Uniting Researchers of Pain to Opine, Synthesize, and Engage
painresearchers.com
November 6, 2025 at 4:57 PM
Join us for our next #a2cps Journal Club featuring @ghasemloulab.bsky.social to discuss circadian rhythms as a #biomarker of #chronicpain conditions. Thurs Dec 4 noon ET, registration is free through the PURPOSE Network
painresearchers.com/topics/22512...
painresearchers.com/topics/22512...
Reposted by David Seminowicz
This is 🤯
All publicly available. Looks like an amazing new histology-based human probabilistic atlas and parcellation tool.
#neuroskyence #mri #brainmapping
A probabilistic histological atlas of the human brain for MRI segmentation | Nature share.google/5AD0iW7pxgb4...
All publicly available. Looks like an amazing new histology-based human probabilistic atlas and parcellation tool.
#neuroskyence #mri #brainmapping
A probabilistic histological atlas of the human brain for MRI segmentation | Nature share.google/5AD0iW7pxgb4...
A probabilistic histological atlas of the human brain for MRI segmentation - Nature
NextBrain is an open source, probabilistic atlas of the entire human brain, assembled using artificial-intelligence-enabled registration and segmentation methods to reconstruct the multimodal serial h...
share.google
November 6, 2025 at 5:35 AM
This is 🤯
All publicly available. Looks like an amazing new histology-based human probabilistic atlas and parcellation tool.
#neuroskyence #mri #brainmapping
A probabilistic histological atlas of the human brain for MRI segmentation | Nature share.google/5AD0iW7pxgb4...
All publicly available. Looks like an amazing new histology-based human probabilistic atlas and parcellation tool.
#neuroskyence #mri #brainmapping
A probabilistic histological atlas of the human brain for MRI segmentation | Nature share.google/5AD0iW7pxgb4...
Reposted by David Seminowicz
This new prospective study followed 108 individuals with acute low back pain. Their immune profiles predicted transition from acute to chronic low back pain in a sex- and age-specific manner with some pretty impressive AUCs.
journals.lww.com/pain/abstrac...
#neuroskyence #painresearch #physio
journals.lww.com/pain/abstrac...
#neuroskyence #painresearch #physio
October 20, 2025 at 1:00 PM
This new prospective study followed 108 individuals with acute low back pain. Their immune profiles predicted transition from acute to chronic low back pain in a sex- and age-specific manner with some pretty impressive AUCs.
journals.lww.com/pain/abstrac...
#neuroskyence #painresearch #physio
journals.lww.com/pain/abstrac...
#neuroskyence #painresearch #physio
Reposted by David Seminowicz
Linking Electrophysiological Metrics to Oxidative Metabolism: Implications for EEG-fMRI Association https://www.biorxiv.org/content/10.1101/2025.11.04.686568v1
November 5, 2025 at 8:15 PM
Linking Electrophysiological Metrics to Oxidative Metabolism: Implications for EEG-fMRI Association https://www.biorxiv.org/content/10.1101/2025.11.04.686568v1
Reposted by David Seminowicz
Finally out in J Neurophysiology led by @daspainbrain.bsky.social with @andpru.bsky.social: journals.physiology.org/doi/abs/10.1...
November 5, 2025 at 3:50 AM
Finally out in J Neurophysiology led by @daspainbrain.bsky.social with @andpru.bsky.social: journals.physiology.org/doi/abs/10.1...
Reposted by David Seminowicz
And that’s a wrap. Our second annual AGM for @tridentpct.bsky.social is over. Thank you to all our trainees, faculty and advisors. And a HUGE ❤️ to my admin core (L-R) Sarah, Sriram and Sherry for pulling this off at the Ivey DKJ Centre in Toronto. Take a few days off !
November 5, 2025 at 12:00 AM
And that’s a wrap. Our second annual AGM for @tridentpct.bsky.social is over. Thank you to all our trainees, faculty and advisors. And a HUGE ❤️ to my admin core (L-R) Sarah, Sriram and Sherry for pulling this off at the Ivey DKJ Centre in Toronto. Take a few days off !
Reposted by David Seminowicz
We wrote a blog post about common misconceptions of basic EPI parameters.
Test your knowledge of EPI myths. layerfmri.com/epimyths/ 1/3
Test your knowledge of EPI myths. layerfmri.com/epimyths/ 1/3
November 4, 2025 at 9:28 PM
We wrote a blog post about common misconceptions of basic EPI parameters.
Test your knowledge of EPI myths. layerfmri.com/epimyths/ 1/3
Test your knowledge of EPI myths. layerfmri.com/epimyths/ 1/3
Reposted by David Seminowicz
Register for our November seminar now! Check out the link in our bio for more information.
October 21, 2025 at 6:34 PM
Register for our November seminar now! Check out the link in our bio for more information.
Reposted by David Seminowicz
PEPR is proud to support the Putting the Pieces Together Conference. Tune in now, and throughout the week. You can find more information here: www.paincanada.ca/events/putti...
Putting the Pieces Together | Pain Canada
www.paincanada.ca
November 3, 2025 at 6:23 PM
PEPR is proud to support the Putting the Pieces Together Conference. Tune in now, and throughout the week. You can find more information here: www.paincanada.ca/events/putti...
Reposted by David Seminowicz
🧵The Canadian House of Commons Standing Committee on Science and Research has put forward a motion to release ALL data in relation to federal research funding applications.
This motion was put forward by conservative MPs who are skeptical of funding being allocated "fairly."
This motion was put forward by conservative MPs who are skeptical of funding being allocated "fairly."
November 2, 2025 at 10:43 PM
🧵The Canadian House of Commons Standing Committee on Science and Research has put forward a motion to release ALL data in relation to federal research funding applications.
This motion was put forward by conservative MPs who are skeptical of funding being allocated "fairly."
This motion was put forward by conservative MPs who are skeptical of funding being allocated "fairly."
Reposted by David Seminowicz
From November 2 to 8, it’s National Pain Awareness Week.
A week to shed light on the reality of chronic pain and the people dedicated to understanding and addressing it.
Follow #NPAW2025 to stay tuned!
#PrioritizePain @paincanada.bsky.social @painbc.bsky.social
A week to shed light on the reality of chronic pain and the people dedicated to understanding and addressing it.
Follow #NPAW2025 to stay tuned!
#PrioritizePain @paincanada.bsky.social @painbc.bsky.social
November 2, 2025 at 3:01 PM
From November 2 to 8, it’s National Pain Awareness Week.
A week to shed light on the reality of chronic pain and the people dedicated to understanding and addressing it.
Follow #NPAW2025 to stay tuned!
#PrioritizePain @paincanada.bsky.social @painbc.bsky.social
A week to shed light on the reality of chronic pain and the people dedicated to understanding and addressing it.
Follow #NPAW2025 to stay tuned!
#PrioritizePain @paincanada.bsky.social @painbc.bsky.social
Reposted by David Seminowicz
The latest work from our PRECISION Human Pain Center project is now up on @biorxivpreprint.bsky.social led by Katherin Gabriel and @oliviadavis.bsky.social with a huge contribution from @allanhpool.bsky.social's lab and, of course, the Southwest Transplant Alliance: www.biorxiv.org/content/10.1...
A molecular map of the human spinal dorsal and ventral horn defines arrangement of neuronal types and glial sex differences
The spinal cord is the gateway for sensory information from the body as it ascends to the brain, as well as a major motor output center of the nervous system. It is also a key location for sensory-mot...
www.biorxiv.org
November 1, 2025 at 12:10 PM
The latest work from our PRECISION Human Pain Center project is now up on @biorxivpreprint.bsky.social led by Katherin Gabriel and @oliviadavis.bsky.social with a huge contribution from @allanhpool.bsky.social's lab and, of course, the Southwest Transplant Alliance: www.biorxiv.org/content/10.1...
Reposted by David Seminowicz
We are seeking a senior tenured professor in our Department working on affective and/or motivational neuroscience (defined in the ad, but pretty broad). The idea is that this person is going help lead our growth in this area alongside our excellent Centers. jobs.utdallas.edu/postings/30693
Associate/Full Professor - Affective Motivational Neuroscience
Position DescriptionThe Department of Neuroscience in the School of Behavioral and Brain Sciences at The University of Texas at Dallas seeks a late-stage Associate or Full Professor faculty member to ...
jobs.utdallas.edu
October 31, 2025 at 9:15 PM
We are seeking a senior tenured professor in our Department working on affective and/or motivational neuroscience (defined in the ad, but pretty broad). The idea is that this person is going help lead our growth in this area alongside our excellent Centers. jobs.utdallas.edu/postings/30693
Reposted by David Seminowicz
Reward-induced endogenous pain inhibition scales with action-outcome certainty in humans https://www.biorxiv.org/content/10.1101/2025.10.31.685818v1
November 1, 2025 at 10:17 AM
Reward-induced endogenous pain inhibition scales with action-outcome certainty in humans https://www.biorxiv.org/content/10.1101/2025.10.31.685818v1
Reposted by David Seminowicz
A new season of OHBM Neurosalience has started. Here's our kickoff episode where I talk with Lead Producer, Michelle Li about highlights from the past season, reaching our 100th episode, the controversial DIANA paper from last year, and what to expect.
www.youtube.com/watch?v=qFcq...
www.youtube.com/watch?v=qFcq...
Neurosalience #S6E1 - Highlights of season 5 and looking ahead to season 6
YouTube video by Organization for Human Brain Mapping
www.youtube.com
October 30, 2025 at 4:15 PM
A new season of OHBM Neurosalience has started. Here's our kickoff episode where I talk with Lead Producer, Michelle Li about highlights from the past season, reaching our 100th episode, the controversial DIANA paper from last year, and what to expect.
www.youtube.com/watch?v=qFcq...
www.youtube.com/watch?v=qFcq...
Reposted by David Seminowicz
.@andpru.bsky.social CRC in Sensorimotor Neuroscience and @schulichmeddent.bsky.social professor and his collaborators recently published in Nature on how our brains not only plan out our actions, but they actually anticipate unexpected disturbances.
Learn more: news.westernu.ca/2025/10/sens...
Learn more: news.westernu.ca/2025/10/sens...
October 30, 2025 at 2:35 PM
.@andpru.bsky.social CRC in Sensorimotor Neuroscience and @schulichmeddent.bsky.social professor and his collaborators recently published in Nature on how our brains not only plan out our actions, but they actually anticipate unexpected disturbances.
Learn more: news.westernu.ca/2025/10/sens...
Learn more: news.westernu.ca/2025/10/sens...
Reposted by David Seminowicz
One in four comatose (behaviourally non-responsive) patients in the ICU following a serious brain injury show us they are aware using fNIRS - published today. onlinelibrary.wiley.com/doi/10.1002/...
onlinelibrary.wiley.com
October 28, 2025 at 4:04 PM
One in four comatose (behaviourally non-responsive) patients in the ICU following a serious brain injury show us they are aware using fNIRS - published today. onlinelibrary.wiley.com/doi/10.1002/...
Reposted by David Seminowicz
Variability in #NeuralActivity is associated with cognition, but how does it relate to pain? @li-bo-zhang.bsky.social &co show that neural variability correlates with how individuals perceive #pain intensity in different contexts @plosbiology.org 🧪 plos.io/48QPR2S
![Neural variability does not encode interindividual sensory sensitivity but reflects intraindividual sensory perception. (A) Point-by-point partial correlations between trial-averaged SD ([High + Low]/2) and sensitivity measured by mean ratings ([High + Low]/2) to sensory stimuli of four modalities in Dataset 1 (N = 141). No significant correlations were found in any modality. Note that no gray bars are shown because none of the partial correlation coefficients survived FDR correction (all P values > 0.05). The color bars underneath display the corresponding Bayes factor values for the correlations. Note that part-corr is short for partial correlation. The light-colored “bursty” curves represent the subject-averaged residuals of mean SD after regressing out mean amplitude. (B) Point-by-point intraindividual correlations between neural variability and ratings to sensory stimuli for each trial in Dataset 1 (N = 141). The gray bars represent t-statistics at time points where significant differences were observed after FDR correction. (C) Point-by-point partial correlations between trial-averaged SD and mean ratings to sensory stimuli of four modalities in Datasets 2&3 (N = 225). (D) Point-by-point intraindividual correlations between neural variability and ratings to sensory stimuli for each trial in Datasets 2&3 (N = 225). These results illustrate that neural variability encodes sensory perception at the intraindividual level, but does not encode sensory sensitivity at the interindividual level.](https://cdn.bsky.app/img/feed_thumbnail/plain/did:plc:5522ztebtekoor5efelihqhb/bafkreibkwvpnw2iome7ah4acvcmfp3bfihj6y4ga6drnzrrpz5sumwfjzu@jpeg)
October 28, 2025 at 5:25 PM
Variability in #NeuralActivity is associated with cognition, but how does it relate to pain? @li-bo-zhang.bsky.social &co show that neural variability correlates with how individuals perceive #pain intensity in different contexts @plosbiology.org 🧪 plos.io/48QPR2S
Reposted by David Seminowicz
Stoked to see our study out in final form! Big kudos to @jonathanamichaels.bsky.social for driving this along for the past 5 years.
Thrilled that our paper is out today in Nature!
www.nature.com/articles/s4...
www.nature.com/articles/s4...
Sensory expectations shape neural population dynamics in motor circuits
Nature - Experiments with human volunteers and macaques show that expectations produced by probabilistic cueing of future sensory inputs shape motor circuit dynamics in order to increase the...
www.nature.com
October 29, 2025 at 4:47 PM
Stoked to see our study out in final form! Big kudos to @jonathanamichaels.bsky.social for driving this along for the past 5 years.
Reposted by David Seminowicz
Check out our latest work led by @joeyzhou.bsky.social on alpha oscillatory networks in PLOS Biology!
➡️ journals.plos.org/plosbiology/...
Do ongoing alpha activity fluctuations influence perceptual sensitivity or criterion?
➡️ journals.plos.org/plosbiology/...
Do ongoing alpha activity fluctuations influence perceptual sensitivity or criterion?
Distinct alpha networks modulate different aspects of perceptual decision-making
Fluctuations in alpha-band neural oscillations influence whether we perceive faint stimuli, but how these oscillations relate to different perceptual processes is not clear. This study shows that alph...
journals.plos.org
October 23, 2025 at 7:27 PM
Check out our latest work led by @joeyzhou.bsky.social on alpha oscillatory networks in PLOS Biology!
➡️ journals.plos.org/plosbiology/...
Do ongoing alpha activity fluctuations influence perceptual sensitivity or criterion?
➡️ journals.plos.org/plosbiology/...
Do ongoing alpha activity fluctuations influence perceptual sensitivity or criterion?
Reposted by David Seminowicz
Papadomanolakis-Pakis et al. developed 2 risk tools to preoperatively predict moderate-to-severe and severe acute postsurgical pain in the postanesthesia care unit. Both demonstrated acceptable predictive performance and clinical utility. #PainReports bit.ly/46VQdnw
October 22, 2025 at 12:00 PM
Papadomanolakis-Pakis et al. developed 2 risk tools to preoperatively predict moderate-to-severe and severe acute postsurgical pain in the postanesthesia care unit. Both demonstrated acceptable predictive performance and clinical utility. #PainReports bit.ly/46VQdnw