Valentin Riedl
@vavatin.bsky.social
Brain scientist asking: How do we spend metabolic energy on processing information?
https://valentinriedl.de/
| Professor for multiscale neuroimaging @FAU
| NeuroEnergetics-lab @TUM
| Award-winning documentary LOST IN FACE about Carlotta and her brain
Reposted by Valentin Riedl
Our new review is out today!
𝗧𝗵𝗲 𝗘𝗻𝗲𝗿𝗴𝗲𝘁𝗶𝗰 𝗖𝗼𝗹𝗹𝗮𝗽𝘀𝗲 𝗼𝗳 𝘁𝗵𝗲 𝗔𝗹𝘇𝗵𝗲𝗶𝗺𝗲𝗿’𝘀 𝗕𝗿𝗮𝗶𝗻: 𝗠𝗲𝘁𝗮𝗯𝗼𝗹𝗶𝗰 𝗜𝗻𝗳𝗹𝗲𝘅𝗶𝗯𝗶𝗹𝗶𝘁𝘆 𝗔𝗰𝗿𝗼𝘀𝘀 𝗖𝗲𝗹𝗹𝘀 𝗮𝗻𝗱 𝗡𝗲𝘁𝘄𝗼𝗿𝗸𝘀
We argue that Alzheimer’s disease is not just a problem of brain hypometabolism, but a disorder of metabolic inflexibility.
onlinelibrary.wiley.com/doi/10.1111/...
𝗧𝗵𝗲 𝗘𝗻𝗲𝗿𝗴𝗲𝘁𝗶𝗰 𝗖𝗼𝗹𝗹𝗮𝗽𝘀𝗲 𝗼𝗳 𝘁𝗵𝗲 𝗔𝗹𝘇𝗵𝗲𝗶𝗺𝗲𝗿’𝘀 𝗕𝗿𝗮𝗶𝗻: 𝗠𝗲𝘁𝗮𝗯𝗼𝗹𝗶𝗰 𝗜𝗻𝗳𝗹𝗲𝘅𝗶𝗯𝗶𝗹𝗶𝘁𝘆 𝗔𝗰𝗿𝗼𝘀𝘀 𝗖𝗲𝗹𝗹𝘀 𝗮𝗻𝗱 𝗡𝗲𝘁𝘄𝗼𝗿𝗸𝘀
We argue that Alzheimer’s disease is not just a problem of brain hypometabolism, but a disorder of metabolic inflexibility.
onlinelibrary.wiley.com/doi/10.1111/...
The Energetic Collapse of the Alzheimer's Brain: Metabolic Inflexibility Across Cells and Networks
Metabolic inflexibility in Alzheimer's disease. Schematic illustrating the biphasic trajectory of metabolic activity relative to canonical Alzheimer's disease (AD) biomarkers. In the presymptomatic p...
onlinelibrary.wiley.com
November 13, 2025 at 8:17 PM
Our new review is out today!
𝗧𝗵𝗲 𝗘𝗻𝗲𝗿𝗴𝗲𝘁𝗶𝗰 𝗖𝗼𝗹𝗹𝗮𝗽𝘀𝗲 𝗼𝗳 𝘁𝗵𝗲 𝗔𝗹𝘇𝗵𝗲𝗶𝗺𝗲𝗿’𝘀 𝗕𝗿𝗮𝗶𝗻: 𝗠𝗲𝘁𝗮𝗯𝗼𝗹𝗶𝗰 𝗜𝗻𝗳𝗹𝗲𝘅𝗶𝗯𝗶𝗹𝗶𝘁𝘆 𝗔𝗰𝗿𝗼𝘀𝘀 𝗖𝗲𝗹𝗹𝘀 𝗮𝗻𝗱 𝗡𝗲𝘁𝘄𝗼𝗿𝗸𝘀
We argue that Alzheimer’s disease is not just a problem of brain hypometabolism, but a disorder of metabolic inflexibility.
onlinelibrary.wiley.com/doi/10.1111/...
𝗧𝗵𝗲 𝗘𝗻𝗲𝗿𝗴𝗲𝘁𝗶𝗰 𝗖𝗼𝗹𝗹𝗮𝗽𝘀𝗲 𝗼𝗳 𝘁𝗵𝗲 𝗔𝗹𝘇𝗵𝗲𝗶𝗺𝗲𝗿’𝘀 𝗕𝗿𝗮𝗶𝗻: 𝗠𝗲𝘁𝗮𝗯𝗼𝗹𝗶𝗰 𝗜𝗻𝗳𝗹𝗲𝘅𝗶𝗯𝗶𝗹𝗶𝘁𝘆 𝗔𝗰𝗿𝗼𝘀𝘀 𝗖𝗲𝗹𝗹𝘀 𝗮𝗻𝗱 𝗡𝗲𝘁𝘄𝗼𝗿𝗸𝘀
We argue that Alzheimer’s disease is not just a problem of brain hypometabolism, but a disorder of metabolic inflexibility.
onlinelibrary.wiley.com/doi/10.1111/...
Reposted by Valentin Riedl
🧵 What does it take to build a small, scrappy, and successful communication neuroscience lab? Our lab, @gongxuanjun.bsky.social, @rachaelkee.bsky.social, Allyson Snyder, Ziyu Zhao, and I put out heads together to answer this question. Here's what we came up with: link.springer.com/chapter/10.1...
November 2, 2025 at 4:21 PM
🧵 What does it take to build a small, scrappy, and successful communication neuroscience lab? Our lab, @gongxuanjun.bsky.social, @rachaelkee.bsky.social, Allyson Snyder, Ziyu Zhao, and I put out heads together to answer this question. Here's what we came up with: link.springer.com/chapter/10.1...
Reposted by Valentin Riedl
Ever wonder how you read so fast? Your brain gets a head start—processing the next word before your eyes move. Our MEG + eye tracking study out in Nature Communications study from @thechbh.bsky.social reveals orthographic & semantic previews predicting reading speed www.nature.com/articles/s41...
Fast hierarchical processing of orthographic and semantic parafoveal information during natural reading - Nature Communications
Combining MEG, eye-tracking, and representational similarity analysis, this study shows that readers rapidly and sequentially extract orthographic and semantic information from upcoming words before fixation, supporting efficient reading.
www.nature.com
October 11, 2025 at 12:42 PM
Ever wonder how you read so fast? Your brain gets a head start—processing the next word before your eyes move. Our MEG + eye tracking study out in Nature Communications study from @thechbh.bsky.social reveals orthographic & semantic previews predicting reading speed www.nature.com/articles/s41...
Reposted by Valentin Riedl
Hello! It has been a while, but for the Hector Fellow Academy I created a small project at the interface of neuroscience and music. In short, it is like a neuro-jukebox of projects of friends and colleagues integrating music and art. I thought it would be nice to share here
cng-lab.github.io/kiosk
cng-lab.github.io/kiosk
NEUROSONICS
cng-lab.github.io
September 19, 2025 at 9:02 AM
Hello! It has been a while, but for the Hector Fellow Academy I created a small project at the interface of neuroscience and music. In short, it is like a neuro-jukebox of projects of friends and colleagues integrating music and art. I thought it would be nice to share here
cng-lab.github.io/kiosk
cng-lab.github.io/kiosk
Reposted by Valentin Riedl
Your brain doesn’t just passively track time ⏳ - it structures it.
In @Science.org we show that activity in 🧠 memory circuits (LEC) drifts constantly, but makes sharp jumps at key moments, segmenting life into meaningful events. (1/2)
👉 www.science.org/doi/10.1126/...
In @Science.org we show that activity in 🧠 memory circuits (LEC) drifts constantly, but makes sharp jumps at key moments, segmenting life into meaningful events. (1/2)
👉 www.science.org/doi/10.1126/...
Event structure sculpts neural population dynamics in the lateral entorhinal cortex
Our experience of the world is a continuous stream of events that must be segmented and organized at multiple timescales. The neural mechanisms underlying this process remain unknown. In this work, we...
www.science.org
June 26, 2025 at 6:06 PM
Your brain doesn’t just passively track time ⏳ - it structures it.
In @Science.org we show that activity in 🧠 memory circuits (LEC) drifts constantly, but makes sharp jumps at key moments, segmenting life into meaningful events. (1/2)
👉 www.science.org/doi/10.1126/...
In @Science.org we show that activity in 🧠 memory circuits (LEC) drifts constantly, but makes sharp jumps at key moments, segmenting life into meaningful events. (1/2)
👉 www.science.org/doi/10.1126/...
Reposted by Valentin Riedl
At today's layer-fMRI seminar, @ofgulban.bsky.social presented stunning high resolution vein mapping tools.
It left me quite excited.
youtu.be/0V8fSjo2T2w?...
It left me quite excited.
youtu.be/0V8fSjo2T2w?...
Faruk Gulban: Meso Veins Meet Layer fMRI in High-Speed Data Exploration for the New Mesoscopic Era
YouTube video by Layer fMRI
youtu.be
May 27, 2025 at 7:22 PM
At today's layer-fMRI seminar, @ofgulban.bsky.social presented stunning high resolution vein mapping tools.
It left me quite excited.
youtu.be/0V8fSjo2T2w?...
It left me quite excited.
youtu.be/0V8fSjo2T2w?...
Reposted by Valentin Riedl
Your brain functions not only as a thinking organ but also as a miniature water factory. We here calculate how much water neuronal mitochondria produce by glucose oxidation: 300-400 ml. Of that amount, 100 ml go into brain's interstitial fluid. fluidsbarrierscns.biomedcentral.com/articles/10....
A budget for brain metabolic water production by glucose catabolism during rest, rises in activity and sleep - Fluids and Barriers of the CNS
Maintaining brain fluid homeostasis is of critical importance for creating a stable environment conducive to optimal neuronal functioning, nutrient distribution, and waste product removal. In this stu...
fluidsbarrierscns.biomedcentral.com
May 6, 2025 at 6:21 PM
Your brain functions not only as a thinking organ but also as a miniature water factory. We here calculate how much water neuronal mitochondria produce by glucose oxidation: 300-400 ml. Of that amount, 100 ml go into brain's interstitial fluid. fluidsbarrierscns.biomedcentral.com/articles/10....
truely multiscale brain data on neuroenergetics
Cubing the brain into 703 tiny pieces reveals that not all mitochondria in the brain are alike.
By @claudia-lopez.bsky.social
#neuroskyence
www.thetransmitter.org/mitochondria...
By @claudia-lopez.bsky.social
#neuroskyence
www.thetransmitter.org/mitochondria...
Mitochondrial ‘landscape’ shifts across human brain
Evolutionarily newer regions sport mitochondria with a higher capacity for energy production than older regions, according to the first detailed map of the organelles in a tissue slice…
www.thetransmitter.org
April 30, 2025 at 8:10 PM
truely multiscale brain data on neuroenergetics
The brain’s energy landscape as a potential window into brain health
www.nature.com/articles/d41...
(study led by Martin Picard and Michel Thiebaut de Schotten)
www.nature.com/articles/d41...
(study led by Martin Picard and Michel Thiebaut de Schotten)
First map of human brain mitochondria is ‘groundbreaking’ achievement
Hundreds of cubes of human brain tissue help scientists to chart the energy-making capabilities of various brain regions.
www.nature.com
March 27, 2025 at 9:08 AM
The brain’s energy landscape as a potential window into brain health
www.nature.com/articles/d41...
(study led by Martin Picard and Michel Thiebaut de Schotten)
www.nature.com/articles/d41...
(study led by Martin Picard and Michel Thiebaut de Schotten)
Reposted by Valentin Riedl
Have questions about the ISMRM MiniHub in Lille, France? Get all your questions answered in an informal drop-in Zoom session with the Organizing Committee. Whether you're already registered or considering attending, stop by and ask us anything!
Register now: ow.ly/8Rgx50V6Xgr
#ISMRM #ISMRMMiniHub
Register now: ow.ly/8Rgx50V6Xgr
#ISMRM #ISMRMMiniHub
February 28, 2025 at 5:01 PM
Have questions about the ISMRM MiniHub in Lille, France? Get all your questions answered in an informal drop-in Zoom session with the Organizing Committee. Whether you're already registered or considering attending, stop by and ask us anything!
Register now: ow.ly/8Rgx50V6Xgr
#ISMRM #ISMRMMiniHub
Register now: ow.ly/8Rgx50V6Xgr
#ISMRM #ISMRMMiniHub
Reposted by Valentin Riedl
Thanks to all of the NIHers and their friends who reached out to me. I am still here (DM me or Signal jeremymberg.78)
I still have a very incomplete picture but based on what I have been told, the damage to NIH and to many wonderful people who work(ed) there is/was impossible for me to imagine
1/n
I still have a very incomplete picture but based on what I have been told, the damage to NIH and to many wonderful people who work(ed) there is/was impossible for me to imagine
1/n
February 16, 2025 at 6:32 AM
Thanks to all of the NIHers and their friends who reached out to me. I am still here (DM me or Signal jeremymberg.78)
I still have a very incomplete picture but based on what I have been told, the damage to NIH and to many wonderful people who work(ed) there is/was impossible for me to imagine
1/n
I still have a very incomplete picture but based on what I have been told, the damage to NIH and to many wonderful people who work(ed) there is/was impossible for me to imagine
1/n
Reposted by Valentin Riedl
Synaptome architecture shapes regional dynamics in the mouse brain | www.biorxiv.org/content/10.1...
Led by Justine Hansen
Big news: there are all sorts of different synapse types in the brain 👀‼️⤵️
Led by Justine Hansen
Big news: there are all sorts of different synapse types in the brain 👀‼️⤵️
February 12, 2025 at 6:23 PM
Synaptome architecture shapes regional dynamics in the mouse brain | www.biorxiv.org/content/10.1...
Led by Justine Hansen
Big news: there are all sorts of different synapse types in the brain 👀‼️⤵️
Led by Justine Hansen
Big news: there are all sorts of different synapse types in the brain 👀‼️⤵️
Reposted by Valentin Riedl
Neurons primarily rely on glucose—rather than lactate from astrocytes—to generate energy,
according to recent findings in mice.
By @giorgiag-sciwriter.bsky.social
www.thetransmitter.org/metabolism/f...
according to recent findings in mice.
By @giorgiag-sciwriter.bsky.social
www.thetransmitter.org/metabolism/f...
Food for thought: Neuronal fuel source more flexible than previously recognized
The cells primarily rely on glucose—rather than lactate from astrocytes—to generate energy, according to recent findings in mice.
www.thetransmitter.org
February 7, 2025 at 7:36 PM
Neurons primarily rely on glucose—rather than lactate from astrocytes—to generate energy,
according to recent findings in mice.
By @giorgiag-sciwriter.bsky.social
www.thetransmitter.org/metabolism/f...
according to recent findings in mice.
By @giorgiag-sciwriter.bsky.social
www.thetransmitter.org/metabolism/f...
Reposted by Valentin Riedl
📢 New preprint from the lab:
We are very excited to report the discovery of an oscillation in the Central Thalamus using rare direct recordings of human thalamic electrophysiology.
The novel oscillation is tightly coupled to specific, natural states of consciousness.🧵
We are very excited to report the discovery of an oscillation in the Central Thalamus using rare direct recordings of human thalamic electrophysiology.
The novel oscillation is tightly coupled to specific, natural states of consciousness.🧵
Thalamic oscillations distinguish natural states of consciousness in humans https://www.biorxiv.org/content/10.1101/2025.01.28.635248v1
January 29, 2025 at 3:05 PM
📢 New preprint from the lab:
We are very excited to report the discovery of an oscillation in the Central Thalamus using rare direct recordings of human thalamic electrophysiology.
The novel oscillation is tightly coupled to specific, natural states of consciousness.🧵
We are very excited to report the discovery of an oscillation in the Central Thalamus using rare direct recordings of human thalamic electrophysiology.
The novel oscillation is tightly coupled to specific, natural states of consciousness.🧵
Reposted by Valentin Riedl
David Lynch was an artist in all aspects of his life. I am a particular fan of his hair. He would have played Karl Friston in an fMRI biopic. RIP
January 16, 2025 at 7:41 PM
David Lynch was an artist in all aspects of his life. I am a particular fan of his hair. He would have played Karl Friston in an fMRI biopic. RIP
Reposted by Valentin Riedl
Honored that a piece I wrote made it to NYTimes. It’s about how my mom’s stroke changed my connection to time, science, and nature. What a privilege to honor my mom in Modern Love.
Below is a gift link. Let me know your thoughts 🙏🏼
www.nytimes.com/2024/12/20/s...
Below is a gift link. Let me know your thoughts 🙏🏼
www.nytimes.com/2024/12/20/s...
Grief Makes Us Time Travelers (Gift Article)
A neuroscientist studying memory, I used to believe time was linear. Then my mother had a stroke.
www.nytimes.com
December 20, 2024 at 3:04 PM
Honored that a piece I wrote made it to NYTimes. It’s about how my mom’s stroke changed my connection to time, science, and nature. What a privilege to honor my mom in Modern Love.
Below is a gift link. Let me know your thoughts 🙏🏼
www.nytimes.com/2024/12/20/s...
Below is a gift link. Let me know your thoughts 🙏🏼
www.nytimes.com/2024/12/20/s...
Reposted by Valentin Riedl
Mapping neuropeptide signaling in the human brain | doi.org/10.1101/2024...
Neuropeptides are among the functionally diverse signaling molecules in the brain and body.
@cebric.bsky.social curates an atlas of neuropeptide receptors and relates it brain function 🧩 🧠 ⤵️
Neuropeptides are among the functionally diverse signaling molecules in the brain and body.
@cebric.bsky.social curates an atlas of neuropeptide receptors and relates it brain function 🧩 🧠 ⤵️
December 19, 2024 at 2:16 PM
Mapping neuropeptide signaling in the human brain | doi.org/10.1101/2024...
Neuropeptides are among the functionally diverse signaling molecules in the brain and body.
@cebric.bsky.social curates an atlas of neuropeptide receptors and relates it brain function 🧩 🧠 ⤵️
Neuropeptides are among the functionally diverse signaling molecules in the brain and body.
@cebric.bsky.social curates an atlas of neuropeptide receptors and relates it brain function 🧩 🧠 ⤵️
Reposted by Valentin Riedl
Having a difficult day, but I'm glad to have microscopy to inspire me and hopefully inspire others as well. 💔
The brain keeps being amazing. These are neurons in the neocortex #FluorescenceFriday 🔬
The brain keeps being amazing. These are neurons in the neocortex #FluorescenceFriday 🔬
December 14, 2024 at 2:07 AM
Having a difficult day, but I'm glad to have microscopy to inspire me and hopefully inspire others as well. 💔
The brain keeps being amazing. These are neurons in the neocortex #FluorescenceFriday 🔬
The brain keeps being amazing. These are neurons in the neocortex #FluorescenceFriday 🔬
Reposted by Valentin Riedl
Quick reminder that Elsevier's share price has doubled in the past 5 years:
www.relx.com/investors/sh...
www.relx.com/investors/sh...
December 9, 2024 at 3:28 PM
Quick reminder that Elsevier's share price has doubled in the past 5 years:
www.relx.com/investors/sh...
www.relx.com/investors/sh...
beautiful and elegant 👏
Imagine seeing a disease's impact on every cell in the body. Now, you can! We introduce MouseMapper, an AI tool to reveal system-wide disease perturbations. It reveals obesity-induced changes in facial nerves & body-wide inflammation 👉🧵https://biorxiv.org/content/10.1101/2024.08.18.608300v1.full.pdf
December 5, 2024 at 6:34 PM
beautiful and elegant 👏
Reposted by Valentin Riedl
Here are some important populations of columnar neurons in the #Drosophila right optic lobe, from the #connectome released in April 2024 again. Note the subtle variations in morphologies. I made this video with Michael Reiser ( @michaelreiser.bsky.social), using neuVid driving #Blender.
December 3, 2024 at 10:12 AM
Here are some important populations of columnar neurons in the #Drosophila right optic lobe, from the #connectome released in April 2024 again. Note the subtle variations in morphologies. I made this video with Michael Reiser ( @michaelreiser.bsky.social), using neuVid driving #Blender.
Reposted by Valentin Riedl
Intracranial lymphatic vessels in a larval zebrafish. Credit to @zebrafish007.bsky.social. #ZebrafishZunday 🧪
December 1, 2024 at 9:49 AM
Intracranial lymphatic vessels in a larval zebrafish. Credit to @zebrafish007.bsky.social. #ZebrafishZunday 🧪
Reposted by Valentin Riedl
OK If we are moving to Bluesky I am rescuing my favourite ever twitter thread (Jan 2019).
The renamed:
Bluesky-sized history of neuroscience (biased by my interests)
The renamed:
Bluesky-sized history of neuroscience (biased by my interests)
December 1, 2024 at 8:29 PM
OK If we are moving to Bluesky I am rescuing my favourite ever twitter thread (Jan 2019).
The renamed:
Bluesky-sized history of neuroscience (biased by my interests)
The renamed:
Bluesky-sized history of neuroscience (biased by my interests)
Reposted by Valentin Riedl
Our new study shows that SARS-CoV-2 spike protein accumulates & persists in the body for years after infection, especially in the skull-meninges-brain axis, potentially driving long COVID. mRNA vaccines help but cannot stop it🔬🧠🦠🧵Your weekend read👇
@cellpress.bsky.social
cell.com/cell-host-mi...
@cellpress.bsky.social
cell.com/cell-host-mi...
November 29, 2024 at 4:01 PM
Our new study shows that SARS-CoV-2 spike protein accumulates & persists in the body for years after infection, especially in the skull-meninges-brain axis, potentially driving long COVID. mRNA vaccines help but cannot stop it🔬🧠🦠🧵Your weekend read👇
@cellpress.bsky.social
cell.com/cell-host-mi...
@cellpress.bsky.social
cell.com/cell-host-mi...