Craig Anderson
@craigandersn.bsky.social
Interested in DNA damage, mutations, adaptation and evolution.
Reposted by Craig Anderson
📣 Paper alert!
I am delighted that our paper exploring the impact of Neanderthal-derived variants on the activity of a disease-associated craniofacial enhancer has been published in Development today!
journals.biologists.com/dev/article/...
I am delighted that our paper exploring the impact of Neanderthal-derived variants on the activity of a disease-associated craniofacial enhancer has been published in Development today!
journals.biologists.com/dev/article/...
November 10, 2025 at 11:11 AM
📣 Paper alert!
I am delighted that our paper exploring the impact of Neanderthal-derived variants on the activity of a disease-associated craniofacial enhancer has been published in Development today!
journals.biologists.com/dev/article/...
I am delighted that our paper exploring the impact of Neanderthal-derived variants on the activity of a disease-associated craniofacial enhancer has been published in Development today!
journals.biologists.com/dev/article/...
Reposted by Craig Anderson
Single cell whole genome and transcriptome sequencing links somatic mutations to cell identity and ancestry https://www.biorxiv.org/content/10.1101/2025.10.28.685157v1
October 29, 2025 at 11:33 AM
Single cell whole genome and transcriptome sequencing links somatic mutations to cell identity and ancestry https://www.biorxiv.org/content/10.1101/2025.10.28.685157v1
Reposted by Craig Anderson
Our latest collaboration with the talented Susi @sbantele.bsky.social and Jiri Lukas is out now @science.org 🤩. We reveal the hidden price for DNA repair, with potential implications for genome function, gene therapy and ageing👇
𝗖𝗮𝗻 𝗰𝗲𝗹𝗹𝘀 𝗲𝘃𝗲𝗿 𝘁𝗿𝘂𝗹𝘆 𝗿𝗲𝗰𝗼𝘃𝗲𝗿 𝗳𝗿𝗼𝗺 𝗗𝗡𝗔 𝗱𝗮𝗺𝗮𝗴𝗲?Excited to share our new study “Repair of DNA double-strand breaks leaves heritable impairment to genome function”, revealing DNA repair’s hidden cost, out now @science.org tinyurl.com/5n6zw3ye. Led by @sbantele.bsky.social and Jiri Lukas.🧵👇1/n
Repair of DNA double-strand breaks leaves heritable impairment to genome function
Upon DNA breakage, a genomic locus undergoes alterations in three-dimensional chromatin architecture to facilitate signaling and repair. Although cells possess mechanisms to repair damaged DNA, it is ...
tinyurl.com
November 7, 2025 at 8:34 AM
Our latest collaboration with the talented Susi @sbantele.bsky.social and Jiri Lukas is out now @science.org 🤩. We reveal the hidden price for DNA repair, with potential implications for genome function, gene therapy and ageing👇
Reposted by Craig Anderson
Explore the origins, patterns and consequences of mutations across biological systems! #MITS26
🗓️ Conference dates: 13-15 April 2026
Participate in expert-led knowledge exchange on how genome evolution shapes human health and ageing 🧬
Check out our exciting speakers ➡️ bit.ly/4hmbnyr
#Genomics
🗓️ Conference dates: 13-15 April 2026
Participate in expert-led knowledge exchange on how genome evolution shapes human health and ageing 🧬
Check out our exciting speakers ➡️ bit.ly/4hmbnyr
#Genomics
October 27, 2025 at 8:00 AM
Explore the origins, patterns and consequences of mutations across biological systems! #MITS26
🗓️ Conference dates: 13-15 April 2026
Participate in expert-led knowledge exchange on how genome evolution shapes human health and ageing 🧬
Check out our exciting speakers ➡️ bit.ly/4hmbnyr
#Genomics
🗓️ Conference dates: 13-15 April 2026
Participate in expert-led knowledge exchange on how genome evolution shapes human health and ageing 🧬
Check out our exciting speakers ➡️ bit.ly/4hmbnyr
#Genomics
Reposted by Craig Anderson
New preprint from another part of my PhD! 📝👇
Some mutations arise after fertilisation 🧬, so early they can appear in both a parent’s body and their germ cells.
By analysing family trio genomes 👪, we built one of the largest catalogues of these “hidden” inherited variants yet.
tinyurl.com/mvns2ytv
Some mutations arise after fertilisation 🧬, so early they can appear in both a parent’s body and their germ cells.
By analysing family trio genomes 👪, we built one of the largest catalogues of these “hidden” inherited variants yet.
tinyurl.com/mvns2ytv
Landscape of parental postzygotic mutations in >11,000 rare disease trios
Postzygotic mutations (PZMs) arising post-fertilisation, prior to primordial germ cell specification, may be subsequently inherited by both somatic and germ cells, causing somatic mosaicism in the par...
tinyurl.com
October 28, 2025 at 11:04 AM
New preprint from another part of my PhD! 📝👇
Some mutations arise after fertilisation 🧬, so early they can appear in both a parent’s body and their germ cells.
By analysing family trio genomes 👪, we built one of the largest catalogues of these “hidden” inherited variants yet.
tinyurl.com/mvns2ytv
Some mutations arise after fertilisation 🧬, so early they can appear in both a parent’s body and their germ cells.
By analysing family trio genomes 👪, we built one of the largest catalogues of these “hidden” inherited variants yet.
tinyurl.com/mvns2ytv
Mutations in Time and Space is headed to Cambridge, UK for 2026!
You can check out the exciting list of invited speakers here: coursesandconferences.wellcomeconnectingscience.org/event/mutati...
See you at the Wellcome Genome Campus, on 13–15 April?
Nice one! ;-) #MITS26
You can check out the exciting list of invited speakers here: coursesandconferences.wellcomeconnectingscience.org/event/mutati...
See you at the Wellcome Genome Campus, on 13–15 April?
Nice one! ;-) #MITS26
Mutations in Time and Space — 20260413
Mutations in Time and Space
coursesandconferences.wellcomeconnectingscience.org
October 13, 2025 at 10:07 AM
Mutations in Time and Space is headed to Cambridge, UK for 2026!
You can check out the exciting list of invited speakers here: coursesandconferences.wellcomeconnectingscience.org/event/mutati...
See you at the Wellcome Genome Campus, on 13–15 April?
Nice one! ;-) #MITS26
You can check out the exciting list of invited speakers here: coursesandconferences.wellcomeconnectingscience.org/event/mutati...
See you at the Wellcome Genome Campus, on 13–15 April?
Nice one! ;-) #MITS26
Age distinguishes selection from causation in cancer genomes https://www.biorxiv.org/content/10.1101/2025.10.06.680730v1
October 10, 2025 at 8:25 AM
Reposted by Craig Anderson
Now published! Our paper on:
(1) Accurate sequencing of sperm at scale
(2) Positive selection of spermatogenesis driver mutations across the exome
(3) Offspring disease risks from male reproductive aging
[1/n]
www.nature.com/articles/s41...
(1) Accurate sequencing of sperm at scale
(2) Positive selection of spermatogenesis driver mutations across the exome
(3) Offspring disease risks from male reproductive aging
[1/n]
www.nature.com/articles/s41...
Sperm sequencing reveals extensive positive selection in the male germline - Nature
A combination of whole-genome NanoSeq with deep whole-exome and targeted NanoSeq is used to accurately characterize mutation rates and genes under positive selection in sperm cells.
www.nature.com
October 8, 2025 at 3:51 PM
Now published! Our paper on:
(1) Accurate sequencing of sperm at scale
(2) Positive selection of spermatogenesis driver mutations across the exome
(3) Offspring disease risks from male reproductive aging
[1/n]
www.nature.com/articles/s41...
(1) Accurate sequencing of sperm at scale
(2) Positive selection of spermatogenesis driver mutations across the exome
(3) Offspring disease risks from male reproductive aging
[1/n]
www.nature.com/articles/s41...
Reposted by Craig Anderson
Our paper on clonal expansions in Sperm is out in Nature www.nature.com/articles/s41...
If you are interested in working at an intersection of Mendelian genomics/Population genetics/Clonal expansions +Cancer genetics/ and of course mutagenesis, please rich out about postdoc in my lab
If you are interested in working at an intersection of Mendelian genomics/Population genetics/Clonal expansions +Cancer genetics/ and of course mutagenesis, please rich out about postdoc in my lab
October 8, 2025 at 4:52 PM
Our paper on clonal expansions in Sperm is out in Nature www.nature.com/articles/s41...
If you are interested in working at an intersection of Mendelian genomics/Population genetics/Clonal expansions +Cancer genetics/ and of course mutagenesis, please rich out about postdoc in my lab
If you are interested in working at an intersection of Mendelian genomics/Population genetics/Clonal expansions +Cancer genetics/ and of course mutagenesis, please rich out about postdoc in my lab
Reposted by Craig Anderson
Our latest work is out in Nature today. In this paper, we introduce an improved version of NanoSeq, a duplex sequencing protocol with <5 errors per billion bp in single DNA molecules, and use it to study the somatic mutation landscape of oral epithelium in >1000 people www.nature.com/articles/s41...
Somatic mutation and selection at population scale - Nature
A new version of nanorate DNA sequencing, with an error rate lower than five errors per billion base pairs and compatible with whole-exome and targeted capture, enables epidemiological-scale studies of somatic mutation and selection and the generation of high-resolution selection maps across coding and non-coding sites for many genes.
www.nature.com
October 8, 2025 at 4:31 PM
Our latest work is out in Nature today. In this paper, we introduce an improved version of NanoSeq, a duplex sequencing protocol with <5 errors per billion bp in single DNA molecules, and use it to study the somatic mutation landscape of oral epithelium in >1000 people www.nature.com/articles/s41...
Reposted by Craig Anderson
🚨 New paper alert!
Sex and smoking bias in the selection of somatic mutations in human bladder
www.nature.com/articles/s41...
by @raquelbmi.bsky.social, @ferriol.bsky.social et al (in collaboration with Rosana Risques lab in @uwmedicine.bsky.social)
Sex and smoking bias in the selection of somatic mutations in human bladder
www.nature.com/articles/s41...
by @raquelbmi.bsky.social, @ferriol.bsky.social et al (in collaboration with Rosana Risques lab in @uwmedicine.bsky.social)
Sex and smoking bias in the selection of somatic mutations in human bladder - Nature
Sex bias and association with smoking history identified in the landscape of driver mutations and clonal expansions in normal human bladder tissue may explain the higher bladder cancer risk in men and smokers.
www.nature.com
October 8, 2025 at 4:44 PM
🚨 New paper alert!
Sex and smoking bias in the selection of somatic mutations in human bladder
www.nature.com/articles/s41...
by @raquelbmi.bsky.social, @ferriol.bsky.social et al (in collaboration with Rosana Risques lab in @uwmedicine.bsky.social)
Sex and smoking bias in the selection of somatic mutations in human bladder
www.nature.com/articles/s41...
by @raquelbmi.bsky.social, @ferriol.bsky.social et al (in collaboration with Rosana Risques lab in @uwmedicine.bsky.social)
Reposted by Craig Anderson
Congratulations to Martin Taylor for being shortlisted in this year’s #CancerGrandChallenges! The CAUSE team will now compete for the chance to receive up to £20m to make radical progress against cancer’s toughest challenges: bit.ly/41KM1DS
@cancergrand.bsky.social @cmvm-edinburghuni.bsky.social
@cancergrand.bsky.social @cmvm-edinburghuni.bsky.social
September 24, 2025 at 1:18 PM
Congratulations to Martin Taylor for being shortlisted in this year’s #CancerGrandChallenges! The CAUSE team will now compete for the chance to receive up to £20m to make radical progress against cancer’s toughest challenges: bit.ly/41KM1DS
@cancergrand.bsky.social @cmvm-edinburghuni.bsky.social
@cancergrand.bsky.social @cmvm-edinburghuni.bsky.social
Reposted by Craig Anderson
📢OUT @natgenet.nature.com
📰DNA methylation cooperates with genomic alterations during non-small cell lung cancer evolution.
By Francisco Gimeno-Valiente, Nnennaya Kanu and colleagues.
⬇️
www.nature.com/articles/s41...
📰DNA methylation cooperates with genomic alterations during non-small cell lung cancer evolution.
By Francisco Gimeno-Valiente, Nnennaya Kanu and colleagues.
⬇️
www.nature.com/articles/s41...
DNA methylation cooperates with genomic alterations during non-small cell lung cancer evolution - Nature Genetics
Integrated multi-omic analyses using samples from the TRACERx study highlight cross-talk between DNA hypermethylation and genomic lesions in non-small cell lung cancer.
www.nature.com
September 15, 2025 at 11:53 AM
📢OUT @natgenet.nature.com
📰DNA methylation cooperates with genomic alterations during non-small cell lung cancer evolution.
By Francisco Gimeno-Valiente, Nnennaya Kanu and colleagues.
⬇️
www.nature.com/articles/s41...
📰DNA methylation cooperates with genomic alterations during non-small cell lung cancer evolution.
By Francisco Gimeno-Valiente, Nnennaya Kanu and colleagues.
⬇️
www.nature.com/articles/s41...
Reposted by Craig Anderson
In these dark times, it comes as a rare pleasure to highlight @natanaels.bsky.social & @marcdemanuel.bsky.social's work on germline and somatic mutations in humans. 1/n
www.biorxiv.org/cgi/content/...
www.biorxiv.org/cgi/content/...
Collateral mutagenesis funnels multiple sources of DNA damage into a ubiquitous mutational signature
Mutations reflect the net effects of myriad types of damage, replication errors, and repair mechanisms, and thus are expected to differ across cell types with distinct exposures to mutagens, division ...
www.biorxiv.org
September 2, 2025 at 11:44 AM
In these dark times, it comes as a rare pleasure to highlight @natanaels.bsky.social & @marcdemanuel.bsky.social's work on germline and somatic mutations in humans. 1/n
www.biorxiv.org/cgi/content/...
www.biorxiv.org/cgi/content/...
Reposted by Craig Anderson
This preprint from Helen Sakharova is one of the coolest things to come out of my lab: “Protein language models reveal evolutionary constraints on synonymous codon choice.” Codon choice is a big puzzle in how information is encoded in genomes, and we have a new angle. www.biorxiv.org/content/10.1...
Protein language models reveal evolutionary constraints on synonymous codon choice
Evolution has shaped the genetic code, with subtle pressures leading to preferences for some synonymous codons over others. Codons are translated at different speeds by the ribosome, imposing constrai...
www.biorxiv.org
August 7, 2025 at 8:29 AM
This preprint from Helen Sakharova is one of the coolest things to come out of my lab: “Protein language models reveal evolutionary constraints on synonymous codon choice.” Codon choice is a big puzzle in how information is encoded in genomes, and we have a new angle. www.biorxiv.org/content/10.1...
Reposted by Craig Anderson
An innovative and fascinating sequencing tech detects DNA changes before they lock in as mutations... offering fresh insight into cancer, aging, & genetic disease.
Explore the science behind it:
www.biorxiv.org/content/10.1...
Explore the science behind it:
www.biorxiv.org/content/10.1...
Single-strand mismatch and damage patterns revealed by single-molecule DNA sequencing
Mutations accumulate in the genome of every cell of the body throughout life, causing cancer and other genetic diseases[1][1]-[4][2]. Almost all of these mosaic mutations begin as nucleotide mismatche...
www.biorxiv.org
August 29, 2025 at 4:41 PM
An innovative and fascinating sequencing tech detects DNA changes before they lock in as mutations... offering fresh insight into cancer, aging, & genetic disease.
Explore the science behind it:
www.biorxiv.org/content/10.1...
Explore the science behind it:
www.biorxiv.org/content/10.1...
Reposted by Craig Anderson
It is not always safe to repair DNA Damage. Sometimes, cells "just bypass it".
During DNA replication, repair of lesions on DNA can be dangerous. Cells instead "tolerate" DNA damage and focus on finishing replication.
Read our review and find out why and how: doi.org/10.1016/j.ti...
During DNA replication, repair of lesions on DNA can be dangerous. Cells instead "tolerate" DNA damage and focus on finishing replication.
Read our review and find out why and how: doi.org/10.1016/j.ti...
August 22, 2025 at 11:48 AM
It is not always safe to repair DNA Damage. Sometimes, cells "just bypass it".
During DNA replication, repair of lesions on DNA can be dangerous. Cells instead "tolerate" DNA damage and focus on finishing replication.
Read our review and find out why and how: doi.org/10.1016/j.ti...
During DNA replication, repair of lesions on DNA can be dangerous. Cells instead "tolerate" DNA damage and focus on finishing replication.
Read our review and find out why and how: doi.org/10.1016/j.ti...
Reposted by Craig Anderson
New paper out today in @science.org! Very proud that my team was able to contribute to this fantastic work from @bethpsaila.bsky.social's group. In short: platelets contain a fair amount of cfDNA taken up from the surrounding! Read the summary by lead author @l-cmurphy.bsky.social:
🚨 New paper alert! 🚨 I’m thrilled and proud to share that our latest work has just been published in @science.org! 🎉 🧽
📖 Read our paper here: doi.org/10.1126/sci...
🎬 Watch a summary: youtu.be/MttCA3GGWEM
🧵 Or keep reading for the key points! 🔑 1/19
📖 Read our paper here: doi.org/10.1126/sci...
🎬 Watch a summary: youtu.be/MttCA3GGWEM
🧵 Or keep reading for the key points! 🔑 1/19
August 15, 2025 at 8:16 AM
New paper out today in @science.org! Very proud that my team was able to contribute to this fantastic work from @bethpsaila.bsky.social's group. In short: platelets contain a fair amount of cfDNA taken up from the surrounding! Read the summary by lead author @l-cmurphy.bsky.social:
Would you like to do some unique experiments in cancer genomics and mutagenesis, in beautiful Munich? Well then apply for this PhD position: jobs.dkfz.de/en/jobs/1679...
You'll learn a lot and it'll be fun and interesting!
#DKTK @dkfz.bsky.social @lmumuenchen.bsky.social
You'll learn a lot and it'll be fun and interesting!
#DKTK @dkfz.bsky.social @lmumuenchen.bsky.social
PhD Student in Mutational Processes Driving Somatic Evolution
jobs.dkfz.de
August 19, 2025 at 2:54 PM
Would you like to do some unique experiments in cancer genomics and mutagenesis, in beautiful Munich? Well then apply for this PhD position: jobs.dkfz.de/en/jobs/1679...
You'll learn a lot and it'll be fun and interesting!
#DKTK @dkfz.bsky.social @lmumuenchen.bsky.social
You'll learn a lot and it'll be fun and interesting!
#DKTK @dkfz.bsky.social @lmumuenchen.bsky.social
Reposted by Craig Anderson
New paper from our lab - @bbglab.bsky.social.
Oncodrive3D: fast and accurate detection of structural clusters of somatic mutations under positive selection
academic.oup.com/nar/article/...
Kudos to Stefano, Olivia, @fmuinos.bsky.social and Abel
Oncodrive3D: fast and accurate detection of structural clusters of somatic mutations under positive selection
academic.oup.com/nar/article/...
Kudos to Stefano, Olivia, @fmuinos.bsky.social and Abel
Oncodrive3D: fast and accurate detection of structural clusters of somatic mutations under positive selection
Abstract. Identifying the genes capable of driving tumorigenesis in different tissues is one of the central goals of cancer genomics. Computational methods
academic.oup.com
August 14, 2025 at 1:10 PM
New paper from our lab - @bbglab.bsky.social.
Oncodrive3D: fast and accurate detection of structural clusters of somatic mutations under positive selection
academic.oup.com/nar/article/...
Kudos to Stefano, Olivia, @fmuinos.bsky.social and Abel
Oncodrive3D: fast and accurate detection of structural clusters of somatic mutations under positive selection
academic.oup.com/nar/article/...
Kudos to Stefano, Olivia, @fmuinos.bsky.social and Abel
Reposted by Craig Anderson
new out in Nature yesterday www.nature.com/articles/s41...
Clone copy number diversity is linked to survival in lung cancer - Nature
A study presents ALPACA, a computational method for inferring clone- and allele-specific copy numbers of individual clones from multi-sample bulk DNA-sequencing data, and demonstrates its use to study...
www.nature.com
August 14, 2025 at 8:13 AM
new out in Nature yesterday www.nature.com/articles/s41...
Reposted by Craig Anderson
Dive into the step-by-step choreography of transcription-coupled DNA repair.
In our new review published in Nature Cell Biology, we explore what we know and what’s next in this exciting field of research!
www.nature.com/articles/s41...
In our new review published in Nature Cell Biology, we explore what we know and what’s next in this exciting field of research!
www.nature.com/articles/s41...
The molecular basis of human transcription-coupled DNA repair - Nature Cell Biology
This Review discusses transcription-coupled DNA repair in response to the stalling of RNA polymerase II on different types of DNA lesions and highlights the molecular details for the different steps i...
www.nature.com
August 5, 2025 at 9:49 AM
Dive into the step-by-step choreography of transcription-coupled DNA repair.
In our new review published in Nature Cell Biology, we explore what we know and what’s next in this exciting field of research!
www.nature.com/articles/s41...
In our new review published in Nature Cell Biology, we explore what we know and what’s next in this exciting field of research!
www.nature.com/articles/s41...
Reposted by Craig Anderson
🚨 Looking for postdocs!
I'm starting my lab at UT Southwestern this September.
If you're interested in:
🧬 Somatic & germline mutagenesis
🐭 Evolution of mutation processes
🧠 Adjacent areas like Mendelian genomics & population genetics—please consider joining.
Formal ad coming soon. DM me!
I'm starting my lab at UT Southwestern this September.
If you're interested in:
🧬 Somatic & germline mutagenesis
🐭 Evolution of mutation processes
🧠 Adjacent areas like Mendelian genomics & population genetics—please consider joining.
Formal ad coming soon. DM me!
June 4, 2025 at 4:09 AM
🚨 Looking for postdocs!
I'm starting my lab at UT Southwestern this September.
If you're interested in:
🧬 Somatic & germline mutagenesis
🐭 Evolution of mutation processes
🧠 Adjacent areas like Mendelian genomics & population genetics—please consider joining.
Formal ad coming soon. DM me!
I'm starting my lab at UT Southwestern this September.
If you're interested in:
🧬 Somatic & germline mutagenesis
🐭 Evolution of mutation processes
🧠 Adjacent areas like Mendelian genomics & population genetics—please consider joining.
Formal ad coming soon. DM me!
Today is my last day at the @uoe-igc.bsky.social in Edinburgh, as I'm starting my own lab in Munich as part of the German Cancer Consortium (DKTK), DKFZ and the LMU. I'll continue to focus on DNA damage and mutagenesis to determine their role in somatic evolution and disease.
July 18, 2025 at 8:44 AM
Today is my last day at the @uoe-igc.bsky.social in Edinburgh, as I'm starting my own lab in Munich as part of the German Cancer Consortium (DKTK), DKFZ and the LMU. I'll continue to focus on DNA damage and mutagenesis to determine their role in somatic evolution and disease.
Reposted by Craig Anderson
We found a new asymmetry in the large-scale chromosome structure: sister chromatids are systematically shifted by hundreds of kb in the 5′→3′ direction of their inherited strands! The work was led by Flavia Corsi, in close collaboration with the Daniel Gerlich lab.
www.biorxiv.org/content/10.1...
1/
www.biorxiv.org/content/10.1...
1/
July 15, 2025 at 8:11 AM
We found a new asymmetry in the large-scale chromosome structure: sister chromatids are systematically shifted by hundreds of kb in the 5′→3′ direction of their inherited strands! The work was led by Flavia Corsi, in close collaboration with the Daniel Gerlich lab.
www.biorxiv.org/content/10.1...
1/
www.biorxiv.org/content/10.1...
1/