Nuria Lopez-Bigas
@nlbigas.bsky.social
ICREA Research Professor at IRB Barcelona. Working on computational cancer genomics. Leading @bbglab.bsky.social
http://bbglab.irbbarcelona.org
http://bbglab.irbbarcelona.org
Reposted by Nuria Lopez-Bigas
Today, Nuria López-Bigas @nlbigas.bsky.social and Mònica Sánchez-Guixé @guixe-m.bsky.social are at the #BarcelonaBiomed Conference, organised by #IRBBarcelona.
A great occasion to share our projects related to childhood cancers.
A great occasion to share our projects related to childhood cancers.
November 11, 2025 at 1:54 PM
Today, Nuria López-Bigas @nlbigas.bsky.social and Mònica Sánchez-Guixé @guixe-m.bsky.social are at the #BarcelonaBiomed Conference, organised by #IRBBarcelona.
A great occasion to share our projects related to childhood cancers.
A great occasion to share our projects related to childhood cancers.
Reposted by Nuria Lopez-Bigas
Delighted and honored to have hosted the 3rd PROMINENT Retreat in Barcelona.
The @cancergrand.bsky.social project led by Allan Balmain, Paul Brennan and Nuria Lopez-Bigas, is progressing thanks to the excellent science being performed by all the teams. Great meeting and best participants!
The @cancergrand.bsky.social project led by Allan Balmain, Paul Brennan and Nuria Lopez-Bigas, is progressing thanks to the excellent science being performed by all the teams. Great meeting and best participants!
November 7, 2025 at 2:04 PM
Delighted and honored to have hosted the 3rd PROMINENT Retreat in Barcelona.
The @cancergrand.bsky.social project led by Allan Balmain, Paul Brennan and Nuria Lopez-Bigas, is progressing thanks to the excellent science being performed by all the teams. Great meeting and best participants!
The @cancergrand.bsky.social project led by Allan Balmain, Paul Brennan and Nuria Lopez-Bigas, is progressing thanks to the excellent science being performed by all the teams. Great meeting and best participants!
Reposted by Nuria Lopez-Bigas
Don't miss our extraordinary #seminar to be held next week, with @jdegregori.bsky.social, from the University of Colorado Anschutz (@cuanschutz.bsky.social).
Host: Dr. @nlbigas.bsky.social (@bbglab.bsky.social, #IRBBarcelona)
Register here 👉 https://shorturl.at/n74Th
#CancerResearch
🧪
Host: Dr. @nlbigas.bsky.social (@bbglab.bsky.social, #IRBBarcelona)
Register here 👉 https://shorturl.at/n74Th
#CancerResearch
🧪
October 24, 2025 at 9:01 AM
Don't miss our extraordinary #seminar to be held next week, with @jdegregori.bsky.social, from the University of Colorado Anschutz (@cuanschutz.bsky.social).
Host: Dr. @nlbigas.bsky.social (@bbglab.bsky.social, #IRBBarcelona)
Register here 👉 https://shorturl.at/n74Th
#CancerResearch
🧪
Host: Dr. @nlbigas.bsky.social (@bbglab.bsky.social, #IRBBarcelona)
Register here 👉 https://shorturl.at/n74Th
#CancerResearch
🧪
Reposted by Nuria Lopez-Bigas
Excited to see this thought provoking piece of work now published. So much more to learn about mutagenesis in healthy tissue.
🚨 New paper alert!
Sex and smoking bias in the selection of somatic mutations in human bladder
www.nature.com/articles/s41...
by @raquelbmi.bsky.social, @ferriol.bsky.social et al (in collaboration with Rosana Risques lab in @uwmedicine.bsky.social)
Sex and smoking bias in the selection of somatic mutations in human bladder
www.nature.com/articles/s41...
by @raquelbmi.bsky.social, @ferriol.bsky.social et al (in collaboration with Rosana Risques lab in @uwmedicine.bsky.social)
Sex and smoking bias in the selection of somatic mutations in human bladder - Nature
Sex bias and association with smoking history identified in the landscape of driver mutations and clonal expansions in normal human bladder tissue may explain the higher bladder cancer risk in men and smokers.
www.nature.com
October 9, 2025 at 11:51 PM
Excited to see this thought provoking piece of work now published. So much more to learn about mutagenesis in healthy tissue.
Reposted by Nuria Lopez-Bigas
Very excited to share our new paper on the influence of biological sex and smoking in the clonal landscape of normal human bladder, just published in Nature.
A big thank you and congrats to all the authors, specially to @raquelbmi.bsky.social for all the shared efforts in this journey!
⬇️More info⬇️
A big thank you and congrats to all the authors, specially to @raquelbmi.bsky.social for all the shared efforts in this journey!
⬇️More info⬇️
🚨 New paper alert!
Sex and smoking bias in the selection of somatic mutations in human bladder
www.nature.com/articles/s41...
by @raquelbmi.bsky.social, @ferriol.bsky.social et al (in collaboration with Rosana Risques lab in @uwmedicine.bsky.social)
Sex and smoking bias in the selection of somatic mutations in human bladder
www.nature.com/articles/s41...
by @raquelbmi.bsky.social, @ferriol.bsky.social et al (in collaboration with Rosana Risques lab in @uwmedicine.bsky.social)
Sex and smoking bias in the selection of somatic mutations in human bladder - Nature
Sex bias and association with smoking history identified in the landscape of driver mutations and clonal expansions in normal human bladder tissue may explain the higher bladder cancer risk in men and smokers.
www.nature.com
October 8, 2025 at 6:04 PM
Very excited to share our new paper on the influence of biological sex and smoking in the clonal landscape of normal human bladder, just published in Nature.
A big thank you and congrats to all the authors, specially to @raquelbmi.bsky.social for all the shared efforts in this journey!
⬇️More info⬇️
A big thank you and congrats to all the authors, specially to @raquelbmi.bsky.social for all the shared efforts in this journey!
⬇️More info⬇️
Reposted by Nuria Lopez-Bigas
Very happy to share that our paper on the influence of biological sex and smoking in the clonal landscape of the normal human bladder is out today in Nature. Kudos to all the authors and especially to @ferriol.bsky.social for coming along with me during this project's journey!
🧵Summary following ⬇️
🧵Summary following ⬇️
🚨 New paper alert!
Sex and smoking bias in the selection of somatic mutations in human bladder
www.nature.com/articles/s41...
by @raquelbmi.bsky.social, @ferriol.bsky.social et al (in collaboration with Rosana Risques lab in @uwmedicine.bsky.social)
Sex and smoking bias in the selection of somatic mutations in human bladder
www.nature.com/articles/s41...
by @raquelbmi.bsky.social, @ferriol.bsky.social et al (in collaboration with Rosana Risques lab in @uwmedicine.bsky.social)
Sex and smoking bias in the selection of somatic mutations in human bladder - Nature
Sex bias and association with smoking history identified in the landscape of driver mutations and clonal expansions in normal human bladder tissue may explain the higher bladder cancer risk in men and smokers.
www.nature.com
October 8, 2025 at 5:10 PM
Very happy to share that our paper on the influence of biological sex and smoking in the clonal landscape of the normal human bladder is out today in Nature. Kudos to all the authors and especially to @ferriol.bsky.social for coming along with me during this project's journey!
🧵Summary following ⬇️
🧵Summary following ⬇️
🚨 New paper alert!
Sex and smoking bias in the selection of somatic mutations in human bladder
www.nature.com/articles/s41...
by @raquelbmi.bsky.social, @ferriol.bsky.social et al (in collaboration with Rosana Risques lab in @uwmedicine.bsky.social)
Sex and smoking bias in the selection of somatic mutations in human bladder
www.nature.com/articles/s41...
by @raquelbmi.bsky.social, @ferriol.bsky.social et al (in collaboration with Rosana Risques lab in @uwmedicine.bsky.social)
Sex and smoking bias in the selection of somatic mutations in human bladder - Nature
Sex bias and association with smoking history identified in the landscape of driver mutations and clonal expansions in normal human bladder tissue may explain the higher bladder cancer risk in men and smokers.
www.nature.com
October 8, 2025 at 4:44 PM
🚨 New paper alert!
Sex and smoking bias in the selection of somatic mutations in human bladder
www.nature.com/articles/s41...
by @raquelbmi.bsky.social, @ferriol.bsky.social et al (in collaboration with Rosana Risques lab in @uwmedicine.bsky.social)
Sex and smoking bias in the selection of somatic mutations in human bladder
www.nature.com/articles/s41...
by @raquelbmi.bsky.social, @ferriol.bsky.social et al (in collaboration with Rosana Risques lab in @uwmedicine.bsky.social)
New paper from our lab - @bbglab.bsky.social.
Oncodrive3D: fast and accurate detection of structural clusters of somatic mutations under positive selection
academic.oup.com/nar/article/...
Kudos to Stefano, Olivia, @fmuinos.bsky.social and Abel
Oncodrive3D: fast and accurate detection of structural clusters of somatic mutations under positive selection
academic.oup.com/nar/article/...
Kudos to Stefano, Olivia, @fmuinos.bsky.social and Abel
Oncodrive3D: fast and accurate detection of structural clusters of somatic mutations under positive selection
Abstract. Identifying the genes capable of driving tumorigenesis in different tissues is one of the central goals of cancer genomics. Computational methods
academic.oup.com
August 14, 2025 at 1:10 PM
New paper from our lab - @bbglab.bsky.social.
Oncodrive3D: fast and accurate detection of structural clusters of somatic mutations under positive selection
academic.oup.com/nar/article/...
Kudos to Stefano, Olivia, @fmuinos.bsky.social and Abel
Oncodrive3D: fast and accurate detection of structural clusters of somatic mutations under positive selection
academic.oup.com/nar/article/...
Kudos to Stefano, Olivia, @fmuinos.bsky.social and Abel
Reposted by Nuria Lopez-Bigas
Back after a few days in Lisbon for the annual #EACR2025 conference! Inspiring and great science. Glad for the opportunity to present our work, coming home with a bunch of new ideas! @bbglab.bsky.social @ferriol.bsky.social
June 20, 2025 at 3:11 PM
Back after a few days in Lisbon for the annual #EACR2025 conference! Inspiring and great science. Glad for the opportunity to present our work, coming home with a bunch of new ideas! @bbglab.bsky.social @ferriol.bsky.social
Reposted by Nuria Lopez-Bigas
@ewaszczurek.bsky.social explains how evolution is the generative process of cancer at #AACR25.
April 25, 2025 at 10:52 PM
@ewaszczurek.bsky.social explains how evolution is the generative process of cancer at #AACR25.
Reposted by Nuria Lopez-Bigas
Jeffrey Townsend (that's me!) presents on dismantling the coarse approximation of drivers and passengers in cancer at #AACR25.
Thank you @nlbigas.bsky.social for the photo!
Thank you @nlbigas.bsky.social for the photo!
April 25, 2025 at 11:06 PM
Jeffrey Townsend (that's me!) presents on dismantling the coarse approximation of drivers and passengers in cancer at #AACR25.
Thank you @nlbigas.bsky.social for the photo!
Thank you @nlbigas.bsky.social for the photo!
Reposted by Nuria Lopez-Bigas
@nlbigas.bsky.social explains how they assemble a compenduim of driver genes 🧬 in cancer at #AACR25.
April 25, 2025 at 9:56 PM
@nlbigas.bsky.social explains how they assemble a compenduim of driver genes 🧬 in cancer at #AACR25.
Reposted by Nuria Lopez-Bigas
We're at #CCG2025 in Amsterdam! Project Coordinator @nlbigas.bsky.social is delivering a keynote lecture on the CGI-Clinics project today, 'Data-driven cancer genome interpretation for clinical decision making': www.ccg2025.eu/speaker/nuri...
March 21, 2025 at 11:22 AM
We're at #CCG2025 in Amsterdam! Project Coordinator @nlbigas.bsky.social is delivering a keynote lecture on the CGI-Clinics project today, 'Data-driven cancer genome interpretation for clinical decision making': www.ccg2025.eu/speaker/nuri...
European Association of Cancer Reasearch statement on threats to cancer reasearch
@helloeacr.bsky.social
eacr.org/statement-on...
@helloeacr.bsky.social
eacr.org/statement-on...
March 10, 2025 at 1:08 PM
European Association of Cancer Reasearch statement on threats to cancer reasearch
@helloeacr.bsky.social
eacr.org/statement-on...
@helloeacr.bsky.social
eacr.org/statement-on...
March 5, 2025 at 8:09 PM
Seven New Cancer Grand Challenges Announced
www.cancergrandchallenges.org/new-challenges
With awards of up to £20m ($25m). Expressions of Interest are now open.
@cancergrand.bsky.social #CancerGrandChallenges
www.cancergrandchallenges.org/new-challenges
With awards of up to £20m ($25m). Expressions of Interest are now open.
@cancergrand.bsky.social #CancerGrandChallenges
March 5, 2025 at 3:16 PM
Seven New Cancer Grand Challenges Announced
www.cancergrandchallenges.org/new-challenges
With awards of up to £20m ($25m). Expressions of Interest are now open.
@cancergrand.bsky.social #CancerGrandChallenges
www.cancergrandchallenges.org/new-challenges
With awards of up to £20m ($25m). Expressions of Interest are now open.
@cancergrand.bsky.social #CancerGrandChallenges
Reposted by Nuria Lopez-Bigas
🌟NEW PREPRINT ALERT!🌟
We are very pleased to introduce #StrainDifferences: “Genetic background sets the trajectory of cancer evolution”
www.biorxiv.org/content/10.1...
🧵[1/12]
We are very pleased to introduce #StrainDifferences: “Genetic background sets the trajectory of cancer evolution”
www.biorxiv.org/content/10.1...
🧵[1/12]
Genetic background sets the trajectory of cancer evolution
Human cancers are heterogeneous. Their genomes evolve from genetically diverse germlines in complex and dynamic environments, including exposure to potential carcinogens. This heterogeneity of humans,...
www.biorxiv.org
January 15, 2025 at 7:19 PM
🌟NEW PREPRINT ALERT!🌟
We are very pleased to introduce #StrainDifferences: “Genetic background sets the trajectory of cancer evolution”
www.biorxiv.org/content/10.1...
🧵[1/12]
We are very pleased to introduce #StrainDifferences: “Genetic background sets the trajectory of cancer evolution”
www.biorxiv.org/content/10.1...
🧵[1/12]
Reposted by Nuria Lopez-Bigas
Less than a week for registration. Check out the program: www.ccg2025.eu. With keynotes by @nlbigas.bsky.social and @charlesswanton.bsky.social and exciting sessions on clinical implementation and impact, research insights and future developments around cancer whole genome sequencing
#ccg2025
#ccg2025
January 10, 2025 at 1:30 PM
Less than a week for registration. Check out the program: www.ccg2025.eu. With keynotes by @nlbigas.bsky.social and @charlesswanton.bsky.social and exciting sessions on clinical implementation and impact, research insights and future developments around cancer whole genome sequencing
#ccg2025
#ccg2025
Molt trista per aquesta notícia. Gran professor, comunicador i científic. Una persona propera que ha deixat empremta a tots els que hem tingut la sort d'interaccionar amb ell. Deixa un llegat immens a l'IRB i a la ciència al nostre país.
With great sadness, we announce the passing of Dr. Joan Guinovart, founder, former scientist, director, and Emeritus Professor of IRB Barcelona.
Our deepest condolences to his loved ones and the IRB Barcelona community.
You will always be remembered, Captain.
Our deepest condolences to his loved ones and the IRB Barcelona community.
You will always be remembered, Captain.
January 1, 2025 at 4:55 PM
Molt trista per aquesta notícia. Gran professor, comunicador i científic. Una persona propera que ha deixat empremta a tots els que hem tingut la sort d'interaccionar amb ell. Deixa un llegat immens a l'IRB i a la ciència al nostre país.
Reposted by Nuria Lopez-Bigas
🎉 I'm thrilled to announce that OpenVariant is finally published! A comprehensive toolkit to facilitate reading, parsing and refinement of diverse input file formats in a customizable structure, all within a single process. @bbglab.bsky.social at @irbbarcelona.bsky.social
doi.org/10.1093/bioi...
doi.org/10.1093/bioi...
OpenVariant: a toolkit to parse and operate multiple input file formats
AbstractSummary. Advances in high-throughput DNA sequencing technologies and decreasing costs have fueled the identification of small genetic variants (suc
academic.oup.com
December 12, 2024 at 10:11 AM
🎉 I'm thrilled to announce that OpenVariant is finally published! A comprehensive toolkit to facilitate reading, parsing and refinement of diverse input file formats in a customizable structure, all within a single process. @bbglab.bsky.social at @irbbarcelona.bsky.social
doi.org/10.1093/bioi...
doi.org/10.1093/bioi...
**Clinical Cancer Genomics Conference**
First of an annual recurring series. It will be a very important meeting for the advance of clinical implementation of cancer genomics.
Proud to be part of it.
March 20th-21st 2025 in Amsterdam.
Registration open: www.ccg2025.eu
#CCG2025
First of an annual recurring series. It will be a very important meeting for the advance of clinical implementation of cancer genomics.
Proud to be part of it.
March 20th-21st 2025 in Amsterdam.
Registration open: www.ccg2025.eu
#CCG2025
December 9, 2024 at 3:33 PM
**Clinical Cancer Genomics Conference**
First of an annual recurring series. It will be a very important meeting for the advance of clinical implementation of cancer genomics.
Proud to be part of it.
March 20th-21st 2025 in Amsterdam.
Registration open: www.ccg2025.eu
#CCG2025
First of an annual recurring series. It will be a very important meeting for the advance of clinical implementation of cancer genomics.
Proud to be part of it.
March 20th-21st 2025 in Amsterdam.
Registration open: www.ccg2025.eu
#CCG2025
**Mutations in Time and Space**
Looking forward to it.
Abstract submission is now open
broadinstitute.swoogo.com/mits2025/
Looking forward to it.
Abstract submission is now open
broadinstitute.swoogo.com/mits2025/
December 6, 2024 at 6:44 PM
**Mutations in Time and Space**
Looking forward to it.
Abstract submission is now open
broadinstitute.swoogo.com/mits2025/
Looking forward to it.
Abstract submission is now open
broadinstitute.swoogo.com/mits2025/
Reposted by Nuria Lopez-Bigas
This Friday 12/6 at 4pm, Núria López-Bigas, PhD @nlbigas.bsky.social @irbbarcelona.bsky.social presents "Somatic mutations in tumors and normal tissues" at our Friday Seminar Series in Basic and Translational Research cancer.ucsf.edu/seminars
December 3, 2024 at 5:56 PM
This Friday 12/6 at 4pm, Núria López-Bigas, PhD @nlbigas.bsky.social @irbbarcelona.bsky.social presents "Somatic mutations in tumors and normal tissues" at our Friday Seminar Series in Basic and Translational Research cancer.ucsf.edu/seminars
Reposted by Nuria Lopez-Bigas
Today at IRB Barcelona (@irbbarcelona.bsky.social) #NodeSeminar Stefano Pellegrini presented:
"Detection of cancer driver genes with clusters of somatic mutations in protein three-dimensional structure"
Very good presentation and nice discussion within the IRB Barcelona community
"Detection of cancer driver genes with clusters of somatic mutations in protein three-dimensional structure"
Very good presentation and nice discussion within the IRB Barcelona community
November 27, 2024 at 2:43 PM
Today at IRB Barcelona (@irbbarcelona.bsky.social) #NodeSeminar Stefano Pellegrini presented:
"Detection of cancer driver genes with clusters of somatic mutations in protein three-dimensional structure"
Very good presentation and nice discussion within the IRB Barcelona community
"Detection of cancer driver genes with clusters of somatic mutations in protein three-dimensional structure"
Very good presentation and nice discussion within the IRB Barcelona community