Cancer cachexia contender enters first pivotal trial www.nature.com/articles/d41...
Can Pfizer’s appetite-boosting antibody ponsegromab address a cancer-induced wasting syndrome — and help patients live longer in the process? Find out more in this news article #CancerGrandChallenges
Can Pfizer’s appetite-boosting antibody ponsegromab address a cancer-induced wasting syndrome — and help patients live longer in the process? Find out more in this news article #CancerGrandChallenges
October 10, 2025 at 2:22 PM
Cancer cachexia contender enters first pivotal trial www.nature.com/articles/d41...
Can Pfizer’s appetite-boosting antibody ponsegromab address a cancer-induced wasting syndrome — and help patients live longer in the process? Find out more in this news article #CancerGrandChallenges
Can Pfizer’s appetite-boosting antibody ponsegromab address a cancer-induced wasting syndrome — and help patients live longer in the process? Find out more in this news article #CancerGrandChallenges
Congratulations to Martin Taylor for being shortlisted in this year’s #CancerGrandChallenges! The CAUSE team will now compete for the chance to receive up to £20m to make radical progress against cancer’s toughest challenges: bit.ly/41KM1DS
@cancergrand.bsky.social @cmvm-edinburghuni.bsky.social
@cancergrand.bsky.social @cmvm-edinburghuni.bsky.social
September 24, 2025 at 1:18 PM
Congratulations to Martin Taylor for being shortlisted in this year’s #CancerGrandChallenges! The CAUSE team will now compete for the chance to receive up to £20m to make radical progress against cancer’s toughest challenges: bit.ly/41KM1DS
@cancergrand.bsky.social @cmvm-edinburghuni.bsky.social
@cancergrand.bsky.social @cmvm-edinburghuni.bsky.social
Team ILLUMINE, which includes our Director Prof Greg Hannon, has been shortlisted for the final stages of #CancerGrandChallenges for a project to map the cancer dark proteome - a mysterious group of largely unknown proteins in our cells. @cancergrand.bsky.social
www.cruk.cam.ac.uk/news/prof-gr...
www.cruk.cam.ac.uk/news/prof-gr...
Prof Greg Hannon shortlisted for prestigious Cancer Grand Challenge - Cancer Research UK Cambridge Institute
www.cruk.cam.ac.uk
September 24, 2025 at 12:04 PM
Team ILLUMINE, which includes our Director Prof Greg Hannon, has been shortlisted for the final stages of #CancerGrandChallenges for a project to map the cancer dark proteome - a mysterious group of largely unknown proteins in our cells. @cancergrand.bsky.social
www.cruk.cam.ac.uk/news/prof-gr...
www.cruk.cam.ac.uk/news/prof-gr...
Seven New Cancer Grand Challenges Announced
www.cancergrandchallenges.org/new-challenges
With awards of up to £20m ($25m). Expressions of Interest are now open.
@cancergrand.bsky.social #CancerGrandChallenges
www.cancergrandchallenges.org/new-challenges
With awards of up to £20m ($25m). Expressions of Interest are now open.
@cancergrand.bsky.social #CancerGrandChallenges
March 5, 2025 at 3:16 PM
Seven New Cancer Grand Challenges Announced
www.cancergrandchallenges.org/new-challenges
With awards of up to £20m ($25m). Expressions of Interest are now open.
@cancergrand.bsky.social #CancerGrandChallenges
www.cancergrandchallenges.org/new-challenges
With awards of up to £20m ($25m). Expressions of Interest are now open.
@cancergrand.bsky.social #CancerGrandChallenges
September 26 is the first-ever Cancer Cachexia Awareness Day – a debilitating weakness and wasting of the body that affects 80% of people with advanced cancer.
At Crossroads4Hope, we are proud to be part of CANCAN #CancerGrandChallenges
At Crossroads4Hope, we are proud to be part of CANCAN #CancerGrandChallenges
September 26, 2025 at 5:15 PM
September 26 is the first-ever Cancer Cachexia Awareness Day – a debilitating weakness and wasting of the body that affects 80% of people with advanced cancer.
At Crossroads4Hope, we are proud to be part of CANCAN #CancerGrandChallenges
At Crossroads4Hope, we are proud to be part of CANCAN #CancerGrandChallenges
We are finalizing the programme of our #CancerGrandChallenges Conference on #ecDNAs, and I couldn't be more proud and excited! Watch this space for updates! Also, register soon as we're nearly sold out! 👇
www.cancergrandchallenges.org/ecDNA-2025
www.cancergrandchallenges.org/ecDNA-2025
Cancer Grand Challenges Conference: extrachromosomal DNA
Taking place on 11 - 13 June 2025 in London, UK. Registration is now open.
www.cancergrandchallenges.org
April 15, 2025 at 10:14 PM
We are finalizing the programme of our #CancerGrandChallenges Conference on #ecDNAs, and I couldn't be more proud and excited! Watch this space for updates! Also, register soon as we're nearly sold out! 👇
www.cancergrandchallenges.org/ecDNA-2025
www.cancergrandchallenges.org/ecDNA-2025
Congratulations to #CancerGrandChallenges MATCHMAKERS team member Regina Barzilay for making the 2025 #TIME100 list of global #AI leaders!
At @aihealthmit.bsky.social, Regina has advanced cancer prediction and antibiotic discovery—and is now tackling our TCR challenge to transform #immunotherapy
At @aihealthmit.bsky.social, Regina has advanced cancer prediction and antibiotic discovery—and is now tackling our TCR challenge to transform #immunotherapy
We're thrilled to share that @aihealthmit.bsky.social faculty lead Regina Barzilay has been included in TIME's list of #TIME100AI for 2025! 👏
📢Full Announcement: jclinic.mit.edu/regina-barzi...
📰More from TIME: time.com/collections/... #AISky
📢Full Announcement: jclinic.mit.edu/regina-barzi...
📰More from TIME: time.com/collections/... #AISky
August 29, 2025 at 2:06 PM
Congratulations to #CancerGrandChallenges MATCHMAKERS team member Regina Barzilay for making the 2025 #TIME100 list of global #AI leaders!
At @aihealthmit.bsky.social, Regina has advanced cancer prediction and antibiotic discovery—and is now tackling our TCR challenge to transform #immunotherapy
At @aihealthmit.bsky.social, Regina has advanced cancer prediction and antibiotic discovery—and is now tackling our TCR challenge to transform #immunotherapy
@charlesswanton.bsky.social kicks off the @cancergrand.bsky.social Summit and mentions the commentaries on the impact of the original #CancerGrandChallenges teams published in the January issue of Cancer Discovery - you can read them here: aacrjournals.org/cancerdiscov...
March 5, 2025 at 2:42 PM
@charlesswanton.bsky.social kicks off the @cancergrand.bsky.social Summit and mentions the commentaries on the impact of the original #CancerGrandChallenges teams published in the January issue of Cancer Discovery - you can read them here: aacrjournals.org/cancerdiscov...
💡 New research from the #CancerGrandChallenges NexTGen team offers a way to make CAR T-cell therapy more effective — even against cancers that try to hide.
📖 Read the open-access paper in Nature Cancer: doi.org/10.1038/s43018-025-01056-4
#Immunotherapy #CART #PaediatricOncology #CancerResearch
📖 Read the open-access paper in Nature Cancer: doi.org/10.1038/s43018-025-01056-4
#Immunotherapy #CART #PaediatricOncology #CancerResearch
Engineering T cells with a membrane-tethered version of SLP-76 overcomes antigen-low resistance to CAR T cell therapy - Nature Cancer
Majzner and colleagues show that engineering T cells with a membrane-tethered version of the signaling adaptor molecule SLP-76 alongside a chimeric antigen receptor (CAR) enhances CAR T cell activity ...
doi.org
November 7, 2025 at 2:12 PM
💡 New research from the #CancerGrandChallenges NexTGen team offers a way to make CAR T-cell therapy more effective — even against cancers that try to hide.
📖 Read the open-access paper in Nature Cancer: doi.org/10.1038/s43018-025-01056-4
#Immunotherapy #CART #PaediatricOncology #CancerResearch
📖 Read the open-access paper in Nature Cancer: doi.org/10.1038/s43018-025-01056-4
#Immunotherapy #CART #PaediatricOncology #CancerResearch
Fascinating interview! Howard Chang shares insights on ecDNAs and his long-standing collaboration with Paul Mischel, both of which were central to his time as a co-investigator on #CancerGrandChallenges team eDyNAmiC whilst at Stanford University.
From gene hunter to drug hunter
www.nature.com/articles/d41...
Howard Chang, Amgen’s new CSO, discusses genetic target discovery, extrachromosomal DNA and technology development
www.nature.com/articles/d41...
Howard Chang, Amgen’s new CSO, discusses genetic target discovery, extrachromosomal DNA and technology development
August 22, 2025 at 10:01 AM
Fascinating interview! Howard Chang shares insights on ecDNAs and his long-standing collaboration with Paul Mischel, both of which were central to his time as a co-investigator on #CancerGrandChallenges team eDyNAmiC whilst at Stanford University.
Seven new #CancerGrandChallenges with up to £20m (€24m) @cancergrand.bsky.social
www.cancergrandchallenges.org/new-challenges
www.cancergrandchallenges.org/new-challenges
New challenges
Explore the challenges currently open for Expressions of Interest.
www.cancergrandchallenges.org
March 5, 2025 at 4:37 PM
Seven new #CancerGrandChallenges with up to £20m (€24m) @cancergrand.bsky.social
www.cancergrandchallenges.org/new-challenges
www.cancergrandchallenges.org/new-challenges
Excited to be here for the inaugural #CancerGrandChallenges ecDNA conference! #CGecDNA @CancerGrandChallenges
June 11, 2025 at 8:07 AM
Excited to be here for the inaugural #CancerGrandChallenges ecDNA conference! #CGecDNA @CancerGrandChallenges
In this
#CRCTrialsChat #VideoShorts, Dr. Yin Cao tells us what PROSPECT aims to accomplish.
"Advance correlation to causation for actionable prevention"
To hear more, watch this:
youtu.be/0p91S8-ZrZU
#CRCSM
#earlyonsetCRC
#colorectalcancer
#CancerGrandChallenges
#CRCTrialsChat #VideoShorts, Dr. Yin Cao tells us what PROSPECT aims to accomplish.
"Advance correlation to causation for actionable prevention"
To hear more, watch this:
youtu.be/0p91S8-ZrZU
#CRCSM
#earlyonsetCRC
#colorectalcancer
#CancerGrandChallenges
PROSPECT Project: what it aims to accomplish
YouTube video by PALTOWN Development Foundation
youtu.be
December 26, 2024 at 10:44 PM
In this
#CRCTrialsChat #VideoShorts, Dr. Yin Cao tells us what PROSPECT aims to accomplish.
"Advance correlation to causation for actionable prevention"
To hear more, watch this:
youtu.be/0p91S8-ZrZU
#CRCSM
#earlyonsetCRC
#colorectalcancer
#CancerGrandChallenges
#CRCTrialsChat #VideoShorts, Dr. Yin Cao tells us what PROSPECT aims to accomplish.
"Advance correlation to causation for actionable prevention"
To hear more, watch this:
youtu.be/0p91S8-ZrZU
#CRCSM
#earlyonsetCRC
#colorectalcancer
#CancerGrandChallenges
Congratulations to Juan Garaycoechea, @puckknipscheer.bsky.social and team CAUSE for being shortlisted in this year’s @cancergrand.bsky.social! They compete with 11 teams for £20M to study how DNA damage leads to mutation signatures in our DNA that can cause cancer. #CancerGrandChallenges
September 24, 2025 at 1:18 PM
Congratulations to Juan Garaycoechea, @puckknipscheer.bsky.social and team CAUSE for being shortlisted in this year’s @cancergrand.bsky.social! They compete with 11 teams for £20M to study how DNA damage leads to mutation signatures in our DNA that can cause cancer. #CancerGrandChallenges
In today's #CRCTrialsChat #VideoShorts, let's hear about the #CancerGrandChallenges #PROSPECT project.
Let's 1st get to know the PIs, Dr. Andy Chan from MGH and Dr. Yin Cao from WashU.
Watch this video to learn more:
youtu.be/PTsnFvtTqdc
#CRCSM #EarlyOnsetCRC
Let's 1st get to know the PIs, Dr. Andy Chan from MGH and Dr. Yin Cao from WashU.
Watch this video to learn more:
youtu.be/PTsnFvtTqdc
#CRCSM #EarlyOnsetCRC
PROSPECT 1 Intros, DR. Andy Chan & Dr. Yin Cao
YouTube video by PALTOWN Development Foundation
youtu.be
December 26, 2024 at 10:29 PM
In today's #CRCTrialsChat #VideoShorts, let's hear about the #CancerGrandChallenges #PROSPECT project.
Let's 1st get to know the PIs, Dr. Andy Chan from MGH and Dr. Yin Cao from WashU.
Watch this video to learn more:
youtu.be/PTsnFvtTqdc
#CRCSM #EarlyOnsetCRC
Let's 1st get to know the PIs, Dr. Andy Chan from MGH and Dr. Yin Cao from WashU.
Watch this video to learn more:
youtu.be/PTsnFvtTqdc
#CRCSM #EarlyOnsetCRC
The #CancerGrandChallenges Mutographs team reveals how tobacco smoke damages DNA to drive different types of head and neck cancer 🧬
They also show that smoking combined with drinking alcohol can more than double the damaging effect on DNA ⤵️
www.sanger.ac.uk/news_item/sc...
They also show that smoking combined with drinking alcohol can more than double the damaging effect on DNA ⤵️
www.sanger.ac.uk/news_item/sc...
Scientists unlock secret behind how smoking and drinking alcohol causes cancer
Scientists have revealed exactly how tobacco smoke damages DNA to drive the development of different types of head and neck cancer, a finding that could unlock new treatments and prevention strategies...
www.sanger.ac.uk
April 1, 2025 at 3:26 PM
The #CancerGrandChallenges Mutographs team reveals how tobacco smoke damages DNA to drive different types of head and neck cancer 🧬
They also show that smoking combined with drinking alcohol can more than double the damaging effect on DNA ⤵️
www.sanger.ac.uk/news_item/sc...
They also show that smoking combined with drinking alcohol can more than double the damaging effect on DNA ⤵️
www.sanger.ac.uk/news_item/sc...
Congrats to @MEBirnbaum, @BarzilayRegina, Brandon DeKosky, @seyvos and @ohyilmaz on taking on #CancerGrandChallenges.
Joining 3 teams, they will tackle challenges in personalized immunotherapies, solid tumors in children & early-onset colorectal cancers.
news.mit.edu/2024/mit-facul…
Joining 3 teams, they will tackle challenges in personalized immunotherapies, solid tumors in children & early-onset colorectal cancers.
news.mit.edu/2024/mit-facul…
Five MIT faculty members take on Cancer Grand Challenges
MIT faculty members Michael Birnbaum, Regina Barzilay, Brandon DeKosky, Seychelle Vos, and Omer Yilmaz join three winning Cancer Grand Challenges teams to take on projects in personalized cancer immunotherapies, early-onset colorectal cancers, and developing new treatments for children's cancers.
news.mit.edu
February 10, 2025 at 2:39 PM
Congrats to @MEBirnbaum, @BarzilayRegina, Brandon DeKosky, @seyvos and @ohyilmaz on taking on #CancerGrandChallenges.
Joining 3 teams, they will tackle challenges in personalized immunotherapies, solid tumors in children & early-onset colorectal cancers.
news.mit.edu/2024/mit-facul…
Joining 3 teams, they will tackle challenges in personalized immunotherapies, solid tumors in children & early-onset colorectal cancers.
news.mit.edu/2024/mit-facul…
We are proud to be involved in picking the finalists for the @cancergrand.bsky.social #CancerGrandChallenges. The submission deadline is 18 June www.cancergrandchallenges.org/new-challenges
New challenges
Explore the challenges currently open for Expressions of Interest.
www.cancergrandchallenges.org
March 6, 2025 at 4:09 PM
We are proud to be involved in picking the finalists for the @cancergrand.bsky.social #CancerGrandChallenges. The submission deadline is 18 June www.cancergrandchallenges.org/new-challenges
📰 BREAKING
We are very proud and privileged to be a member of the CancerGrandChallenges community.
Looking forward to doing team science PROSPECT, w/ challenge on early-onset cancers, led by Yin Cao and Andy Chan!
Details here: cancergrandchallenges.org/teams/prospect
We are very proud and privileged to be a member of the CancerGrandChallenges community.
Looking forward to doing team science PROSPECT, w/ challenge on early-onset cancers, led by Yin Cao and Andy Chan!
Details here: cancergrandchallenges.org/teams/prospect
March 6, 2024 at 5:13 PM
📰 BREAKING
We are very proud and privileged to be a member of the CancerGrandChallenges community.
Looking forward to doing team science PROSPECT, w/ challenge on early-onset cancers, led by Yin Cao and Andy Chan!
Details here: cancergrandchallenges.org/teams/prospect
We are very proud and privileged to be a member of the CancerGrandChallenges community.
Looking forward to doing team science PROSPECT, w/ challenge on early-onset cancers, led by Yin Cao and Andy Chan!
Details here: cancergrandchallenges.org/teams/prospect
Targeted protein degraders could change how we treat childhood cancers.
John Buell of team KOODAC explains how our global team is working to develop safer, more effective therapies through #CancerGrandChallenges.
Find out more: koodac.com/scientific-e...
John Buell of team KOODAC explains how our global team is working to develop safer, more effective therapies through #CancerGrandChallenges.
Find out more: koodac.com/scientific-e...
October 1, 2025 at 12:42 PM
Targeted protein degraders could change how we treat childhood cancers.
John Buell of team KOODAC explains how our global team is working to develop safer, more effective therapies through #CancerGrandChallenges.
Find out more: koodac.com/scientific-e...
John Buell of team KOODAC explains how our global team is working to develop safer, more effective therapies through #CancerGrandChallenges.
Find out more: koodac.com/scientific-e...
Interesting @economist.com piece on #CancerGrandChallenges team Mutographs, Phil Jones (@sangerinstitute.bsky.social) & Sci Committee Chair Charles Swanton. Their work reshapes how we think about cancer’s origins - A great read if you have access.
👉 www.economist.com/science-and-...
👉 www.economist.com/science-and-...
September 5, 2025 at 3:39 PM
Interesting @economist.com piece on #CancerGrandChallenges team Mutographs, Phil Jones (@sangerinstitute.bsky.social) & Sci Committee Chair Charles Swanton. Their work reshapes how we think about cancer’s origins - A great read if you have access.
👉 www.economist.com/science-and-...
👉 www.economist.com/science-and-...
An interesting perspective in Molecular Cell from Cristina Mayor-Ruiz (team PROTECT), Georg E. Winter (team KOODAC), Alessio Ciulli (team KOODAC and co-authors - Opportunities in proximity modulation: Bridging academia and industry #CancerGrandChallenges
🤝 #IRBBarcelona Group Leader Cristina Mayor-Ruiz has co-authored a Perspective in #MolecularCell proposing the creation of a #EuropeanAlliance to accelerate the development of proximity-induced therapies.
More information here 🔗 www.irbbarcelona.org/en/news/scie...
🧪 #TargetedProteinDegradation
More information here 🔗 www.irbbarcelona.org/en/news/scie...
🧪 #TargetedProteinDegradation
August 22, 2025 at 4:07 PM
An interesting perspective in Molecular Cell from Cristina Mayor-Ruiz (team PROTECT), Georg E. Winter (team KOODAC), Alessio Ciulli (team KOODAC and co-authors - Opportunities in proximity modulation: Bridging academia and industry #CancerGrandChallenges
Tackling Cancer through Global Team Science #cancergrandchallenges @theaacr.bsky.social aacrjournals.org/cancerdiscov...
Tackling Cancer through Global Team Science
Summary:. Here, we discuss the seven new challenges set by Cancer Grand Challenges that are currently open for creative applications. We invite the research community to assemble global, interdiscipli...
aacrjournals.org
March 9, 2025 at 2:23 PM
Tackling Cancer through Global Team Science #cancergrandchallenges @theaacr.bsky.social aacrjournals.org/cancerdiscov...
After nearly a decade of leadership, Margaret Grayson MBE reflects on her time as Chair of the #CancerGrandChallenges Advocacy Panel. Thank you Margaret for embedding the voices of those affected by cancer into discovery research.
features.cancerresearchuk.org/cancergrandc...
features.cancerresearchuk.org/cancergrandc...
DFS 0161 CGC Discover mag 2024 — Patient advocacy
A year of scientific creativity
features.cancerresearchuk.org
August 20, 2025 at 2:58 PM
After nearly a decade of leadership, Margaret Grayson MBE reflects on her time as Chair of the #CancerGrandChallenges Advocacy Panel. Thank you Margaret for embedding the voices of those affected by cancer into discovery research.
features.cancerresearchuk.org/cancergrandc...
features.cancerresearchuk.org/cancergrandc...