Corey Griffith
@coreymgriffith.bsky.social
Metabolic Biochemist. Interested in problems that intersect analytical chemistry, metabolism, toxicology, and the environment.
Pinned
CLYBL averts vitamin B12 depletion by repairing malyl-CoA - Nature Chemical Biology
CLYBL has a role beyond itaconate catabolism to degrade malyl-CoA, a noncanonical metabolite and methylmalonyl-CoA mutase inhibitor that depletes coenzyme B12, implying that malyl-CoA contributes to t...
doi.org
Non-canonical metabolites are continuously formed in primary metabolism & #MetaboliteRepair enzymes have evolved to eliminate these often toxic byproducts. Out today in @nchembio.bsky.social, we found that CLYBL repairs malyl-CoA, a TCA cycle side-product, to avert vitamin B12 depletion 🧪
Reposted by Corey Griffith
Measuring mitochondrial membrane potential
@marcliesa.bsky.social , Guillermo Martínez-Corrales et al @ibmb-csic.bsky.social comment on common misinterpretation of mitochondrial membrane potential measurements & suggest guidelines for accurate determination in cells
www.embopress.org/doi/full/10....
@marcliesa.bsky.social , Guillermo Martínez-Corrales et al @ibmb-csic.bsky.social comment on common misinterpretation of mitochondrial membrane potential measurements & suggest guidelines for accurate determination in cells
www.embopress.org/doi/full/10....
November 17, 2025 at 2:28 PM
Measuring mitochondrial membrane potential
@marcliesa.bsky.social , Guillermo Martínez-Corrales et al @ibmb-csic.bsky.social comment on common misinterpretation of mitochondrial membrane potential measurements & suggest guidelines for accurate determination in cells
www.embopress.org/doi/full/10....
@marcliesa.bsky.social , Guillermo Martínez-Corrales et al @ibmb-csic.bsky.social comment on common misinterpretation of mitochondrial membrane potential measurements & suggest guidelines for accurate determination in cells
www.embopress.org/doi/full/10....
Reposted by Corey Griffith
Nature research paper: A missing enzyme-rescue metabolite as cause of a rare skeletal dysplasia
go.nature.com/45Eb8te
go.nature.com/45Eb8te
A missing enzyme-rescue metabolite as cause of a rare skeletal dysplasia - Nature
In mammals, the enzyme TGDS produces UDP-4-keto-6-deoxyglucose, which binds to the catalytic pocket of UDP-xylose synthase, thereby regenerating the essential NAD+ cofactor of UDP-xylose synthase in conditions of low NAD+.
go.nature.com
August 21, 2025 at 4:56 PM
Nature research paper: A missing enzyme-rescue metabolite as cause of a rare skeletal dysplasia
go.nature.com/45Eb8te
go.nature.com/45Eb8te
Reposted by Corey Griffith
Accumulation of succinate suppresses de novo purine synthesis through succinylation-mediated control of the mitochondrial folate cyclehttps://
www.sciencedirect.com/science/article/abs/pii/S1097276525008196
Congratulations @bensahralab.bsky.social !!
www.sciencedirect.com/science/article/abs/pii/S1097276525008196
Congratulations @bensahralab.bsky.social !!
Accumulation of succinate suppresses de novo purine synthesis through succinylation-mediated control of the mitochondrial folate cycle
The de novo purine synthesis pathway is fundamental for nucleotide production, yet the role of mitochondrial metabolism in modulating this process rem…
www.sciencedirect.com
October 29, 2025 at 5:23 AM
Accumulation of succinate suppresses de novo purine synthesis through succinylation-mediated control of the mitochondrial folate cyclehttps://
www.sciencedirect.com/science/article/abs/pii/S1097276525008196
Congratulations @bensahralab.bsky.social !!
www.sciencedirect.com/science/article/abs/pii/S1097276525008196
Congratulations @bensahralab.bsky.social !!
Great resource: doi.org/10.1038/s41467-025-63751-1
Best practices and tools in R and Python for statistical processing and visualization of lipidomics and metabolomics data - Nature Communications
Mass spectrometry-based lipidomics and metabolomics generate large, complex datasets requiring effective analysis. Here, authors review key statistical and visualization methods alongside widely used ...
doi.org
October 17, 2025 at 9:46 AM
Great resource: doi.org/10.1038/s41467-025-63751-1
Reposted by Corey Griffith
Exciting to see IC-MS getting more attention. It really does have excellent separation and coverage for central carbon metabolites, including those pesky sugar phosphates.
New Article! Metabolomics using anion-exchange chromatography mass spectrometry for the analysis of cells, tissues and biofluids
Metabolomics using anion-exchange chromatography mass spectrometry for the analysis of cells, tissues and biofluids
Nature Protocols, Published online: 22 August 2025; doi:10.1038/s41596-025-01222-zWe present a protocol for the analysis of polar and ionic metabolites by using anion-exchange chromatography–tandem mass spectrometry (AEC-MS/MS) with an untargeted or semi-targeted workflow for the identification of metabolites in biological samples.
bit.ly
August 26, 2025 at 8:20 AM
Exciting to see IC-MS getting more attention. It really does have excellent separation and coverage for central carbon metabolites, including those pesky sugar phosphates.
Check out our article in this issue on the metabolite repair role of CLYBL!
Our June issue is live with a mini-focus on metabolism, featuring an Editorial, Research Highlights, Reviews, and Perspectives on the interplay between chemical biology and metabolism.
www.nature.com/nchembio/vol...
The spotlights in the cover highlight beta cell regeneration in the pancreas
www.nature.com/nchembio/vol...
The spotlights in the cover highlight beta cell regeneration in the pancreas
June 5, 2025 at 6:52 AM
Check out our article in this issue on the metabolite repair role of CLYBL!
Some really nice points outlining the misuse of metabolomics in pathway analysis.
To add, unless you have proof of gene/protein/pathway regulation, metabolomics data can only tell us that metabolite levels increase or decrease. This is not the same as up/down regulation.
doi.org/10.1038/s422...
To add, unless you have proof of gene/protein/pathway regulation, metabolomics data can only tell us that metabolite levels increase or decrease. This is not the same as up/down regulation.
doi.org/10.1038/s422...
Metabolites are not genes — avoiding the misuse of pathway analysis in metabolomics - Nature Metabolism
Pathway analysis, originally developed for gene expression data, has been adapted for metabolomics. However, owing to the unique characteristics and constraints of metabolites compared with genes, pat...
doi.org
April 11, 2025 at 6:46 AM
Some really nice points outlining the misuse of metabolomics in pathway analysis.
To add, unless you have proof of gene/protein/pathway regulation, metabolomics data can only tell us that metabolite levels increase or decrease. This is not the same as up/down regulation.
doi.org/10.1038/s422...
To add, unless you have proof of gene/protein/pathway regulation, metabolomics data can only tell us that metabolite levels increase or decrease. This is not the same as up/down regulation.
doi.org/10.1038/s422...
Non-canonical metabolites are continuously formed in primary metabolism & #MetaboliteRepair enzymes have evolved to eliminate these often toxic byproducts. Out today in @nchembio.bsky.social, we found that CLYBL repairs malyl-CoA, a TCA cycle side-product, to avert vitamin B12 depletion 🧪
CLYBL averts vitamin B12 depletion by repairing malyl-CoA - Nature Chemical Biology
CLYBL has a role beyond itaconate catabolism to degrade malyl-CoA, a noncanonical metabolite and methylmalonyl-CoA mutase inhibitor that depletes coenzyme B12, implying that malyl-CoA contributes to t...
doi.org
March 19, 2025 at 12:50 PM
Non-canonical metabolites are continuously formed in primary metabolism & #MetaboliteRepair enzymes have evolved to eliminate these often toxic byproducts. Out today in @nchembio.bsky.social, we found that CLYBL repairs malyl-CoA, a TCA cycle side-product, to avert vitamin B12 depletion 🧪
Reposted by Corey Griffith
I had the opportunity to give my perspective to The Analytical Scientist about recent events. With this article, I hope to give a voice to others who may not have the ability to speak out. #StandUpForScience
theanalyticalscientist.com/business-edu...
theanalyticalscientist.com/business-edu...
A Bleak Future?
Recent layoffs and funding cuts have not only crippled morale among scientists, they’ve also set an alarming precedent for the future of science
theanalyticalscientist.com
March 7, 2025 at 1:01 PM
I had the opportunity to give my perspective to The Analytical Scientist about recent events. With this article, I hope to give a voice to others who may not have the ability to speak out. #StandUpForScience
theanalyticalscientist.com/business-edu...
theanalyticalscientist.com/business-edu...
Reposted by Corey Griffith
Free access to 2,656 metabolites from 9 platforms measured at 56 time points and covering 6 challenges "suffered" by 15 healthy volunteers:
The HuMet Repository - Watching human metabolism at work
www.sciencedirect.com/science/arti...
All data provided in an interactive repository:
humet.org
The HuMet Repository - Watching human metabolism at work
www.sciencedirect.com/science/arti...
All data provided in an interactive repository:
humet.org
March 5, 2025 at 12:58 PM
Free access to 2,656 metabolites from 9 platforms measured at 56 time points and covering 6 challenges "suffered" by 15 healthy volunteers:
The HuMet Repository - Watching human metabolism at work
www.sciencedirect.com/science/arti...
All data provided in an interactive repository:
humet.org
The HuMet Repository - Watching human metabolism at work
www.sciencedirect.com/science/arti...
All data provided in an interactive repository:
humet.org
The T32 training grant supported the interdisciplinary and multi-department design of the UC Riverside Environmental Toxicology Graduate Program. Funding from it gave me valuable time to focus on research and I am eternally grateful for the impact it has had on my career.
Many graduates of the program are now academic faculty, biotech researchers, startup founders, and more - boosting knowledge and creating jobs. T32s are a magnificent investment for public benefit. /n
March 6, 2025 at 8:29 AM
The T32 training grant supported the interdisciplinary and multi-department design of the UC Riverside Environmental Toxicology Graduate Program. Funding from it gave me valuable time to focus on research and I am eternally grateful for the impact it has had on my career.
Reposted by Corey Griffith
Thank you @jeremymberg.bsky.social for highlighting the special importance of T32s. This allowed me to launch an interdisciplinary chemistry/biology interface (CBI) graduate program at UCB in early 2000s. For the first time, due to this funding, chem PhD students were able to do rotations. 1/n
One class of NIH grants that are crucial to developing future generations of biomedical workers are
NIH training grants using the T32 mechanism.
These awards provide direct support for graduate students and/or fellows during at least part of their training periods.
1/n
NIH training grants using the T32 mechanism.
These awards provide direct support for graduate students and/or fellows during at least part of their training periods.
1/n
March 6, 2025 at 4:07 AM
Thank you @jeremymberg.bsky.social for highlighting the special importance of T32s. This allowed me to launch an interdisciplinary chemistry/biology interface (CBI) graduate program at UCB in early 2000s. For the first time, due to this funding, chem PhD students were able to do rotations. 1/n
Reposted by Corey Griffith
the rich and powerful want to destroy biomedical science, like they wanted to destroy climate science, and before that tobacco science and before that asbestos science -- because science and universities are an independent source of truth that can reduce the power and money of oligarchs.
February 27, 2025 at 4:54 AM
the rich and powerful want to destroy biomedical science, like they wanted to destroy climate science, and before that tobacco science and before that asbestos science -- because science and universities are an independent source of truth that can reduce the power and money of oligarchs.
Neat perspective on the connection between metabolism & PTMs.
Cells spend a lot of effort combating reactive chemistry, but they also take advantage of it. The line between utility and toxicity must depend, at least partially, on metabolite/protein repair enzymes.
www.nature.com/articles/s41...
Cells spend a lot of effort combating reactive chemistry, but they also take advantage of it. The line between utility and toxicity must depend, at least partially, on metabolite/protein repair enzymes.
www.nature.com/articles/s41...
Mechanisms of metabolism-coupled protein modifications - Nature Chemical Biology
This Perspective highlights how metabolic states regulate diverse protein modifications that affect physiology. In addition, the roles of subcellular localization of metabolic enzymes and the importan...
www.nature.com
February 26, 2025 at 12:05 PM
Neat perspective on the connection between metabolism & PTMs.
Cells spend a lot of effort combating reactive chemistry, but they also take advantage of it. The line between utility and toxicity must depend, at least partially, on metabolite/protein repair enzymes.
www.nature.com/articles/s41...
Cells spend a lot of effort combating reactive chemistry, but they also take advantage of it. The line between utility and toxicity must depend, at least partially, on metabolite/protein repair enzymes.
www.nature.com/articles/s41...
Reposted by Corey Griffith
I've noted some of the procedural things Democrats could be doing in Congress, but this point from @edgeofsports.bsky.social's great piece in the Nation deserves emphasis.
This is basic politics, and it's baffling that every Democrat isn't doing it every day.
www.thenation.com/article/poli...
This is basic politics, and it's baffling that every Democrat isn't doing it every day.
www.thenation.com/article/poli...
February 19, 2025 at 1:32 PM
I've noted some of the procedural things Democrats could be doing in Congress, but this point from @edgeofsports.bsky.social's great piece in the Nation deserves emphasis.
This is basic politics, and it's baffling that every Democrat isn't doing it every day.
www.thenation.com/article/poli...
This is basic politics, and it's baffling that every Democrat isn't doing it every day.
www.thenation.com/article/poli...
Reposted by Corey Griffith
Join us! Science Homecoming helps scientists reconnect with communities by writing about the importance of science funding in their hometown newspapers. We’ve mapped every small newspaper in the U.S. and provide resources to get you started. Help science get back home 🧪🔬🧬 🏠
sciencehomecoming.com
sciencehomecoming.com
Science Homecoming
sciencehomecoming.com
February 18, 2025 at 5:12 PM
Join us! Science Homecoming helps scientists reconnect with communities by writing about the importance of science funding in their hometown newspapers. We’ve mapped every small newspaper in the U.S. and provide resources to get you started. Help science get back home 🧪🔬🧬 🏠
sciencehomecoming.com
sciencehomecoming.com
Reposted by Corey Griffith
Yes, and this is super-important.
People don’t know what’s happening. Most of the country has no idea that American science — cancer cures — are being shredded. They really don’t know!
The job of all scientists 🧪 in this moment should be to get the word out.
People don’t know what’s happening. Most of the country has no idea that American science — cancer cures — are being shredded. They really don’t know!
The job of all scientists 🧪 in this moment should be to get the word out.
And traditional Republican citizens, who are genuinely interested in reducing the debt, do not understand the recklessness with which this alleged “cost cutting” is being carried out. Just had a long talk with a family member who was frankly incredulous when I described ongoing attack on NIH/VA.
February 16, 2025 at 12:32 AM
Yes, and this is super-important.
People don’t know what’s happening. Most of the country has no idea that American science — cancer cures — are being shredded. They really don’t know!
The job of all scientists 🧪 in this moment should be to get the word out.
People don’t know what’s happening. Most of the country has no idea that American science — cancer cures — are being shredded. They really don’t know!
The job of all scientists 🧪 in this moment should be to get the word out.
Reposted by Corey Griffith
Massive work from Jess Spinelli's lab at UMASS demonstrating a SECOND electron carrier in the mammalian ETC:
www.cell.com/cell/fulltex...
www.cell.com/cell/fulltex...
Rhodoquinone carries electrons in the mammalian electron transport chain
Valeros et al. identify rhodoquinone (RQ), an electron carrier present in mammalian
mitochondria, that can deliver electrons to fumarate instead of O2 as the terminal
electron acceptor. The authors de...
www.cell.com
February 4, 2025 at 9:40 PM
Massive work from Jess Spinelli's lab at UMASS demonstrating a SECOND electron carrier in the mammalian ETC:
www.cell.com/cell/fulltex...
www.cell.com/cell/fulltex...
Reposted by Corey Griffith
Darby makes this point but I just want to reinforce it: These words are entirely legitimate to discuss science, accurately and correctly. This attack on "DEI" (🙄) is not only an attempt to resegregate science but also an attack on expertise, itself.
Resisting it is a defense of science
Resisting it is a defense of science
🚨BREAKING. From a program officer at the National Science Foundation, a list of keywords that can cause a grant to be pulled. I will be sharing screenshots of these keywords along with a decision tree. Please share widely. This is a crisis for academic freedom & science.
February 4, 2025 at 4:30 AM
Darby makes this point but I just want to reinforce it: These words are entirely legitimate to discuss science, accurately and correctly. This attack on "DEI" (🙄) is not only an attempt to resegregate science but also an attack on expertise, itself.
Resisting it is a defense of science
Resisting it is a defense of science
Reposted by Corey Griffith
A human metabolic map of pharmacological perturbations reveals drug modes of action - @zampierilab.bsky.social @depbiomedicine.bsky.social go.nature.com/3CreANg
A human metabolic map of pharmacological perturbations reveals drug modes of action - Nature Biotechnology
Mapping the metabolic effects of drugs helps define their mode of action.
go.nature.com
January 28, 2025 at 3:42 PM
A human metabolic map of pharmacological perturbations reveals drug modes of action - @zampierilab.bsky.social @depbiomedicine.bsky.social go.nature.com/3CreANg
Reposted by Corey Griffith
CLYBL averts methylmalonyl-CoA mutase inhibition and loss of vitamin B12 by eliminating malyl-CoA https://www.biorxiv.org/content/10.1101/2024.09.25.614871v1
CLYBL averts methylmalonyl-CoA mutase inhibition and loss of vitamin B12 by eliminating malyl-CoA https://www.biorxiv.org/content/10.1101/2024.09.25.614871v1
Citrate lyase beta-like protein (CLYBL) is a ubiquitously expressed mammalian enzyme known for its r
www.biorxiv.org
September 27, 2024 at 7:45 PM
CLYBL averts methylmalonyl-CoA mutase inhibition and loss of vitamin B12 by eliminating malyl-CoA https://www.biorxiv.org/content/10.1101/2024.09.25.614871v1