Lydia Finley
@lydiafinley.bsky.social
cell biologist with an interest in pretty much everything
ski.edu/finley
ski.edu/finley
Reposted by Lydia Finley
Lab’s 1st preprint!
Menstruation is understudied due to societal taboos + a biological challenge: mice (a key system for research + drug discovery) don’t menstruate.
@cagricevrim.bsky.social made menstruating mice + used them to discover early events in menstruation.
He is on the job market!
Menstruation is understudied due to societal taboos + a biological challenge: mice (a key system for research + drug discovery) don’t menstruate.
@cagricevrim.bsky.social made menstruating mice + used them to discover early events in menstruation.
He is on the job market!
I’m thrilled to share my postdoc work and the first paper from the McKinley Lab! 🎉
@karalmckinley.bsky.social
We built the first transgenic model of menstruation in mice.
We used it to uncover how the endometrium organizes and sheds during menstruation. 🧪
www.biorxiv.org/content/10.1...
🧵
@karalmckinley.bsky.social
We built the first transgenic model of menstruation in mice.
We used it to uncover how the endometrium organizes and sheds during menstruation. 🧪
www.biorxiv.org/content/10.1...
🧵
Induction of menstruation in mice reveals the regulation of menstrual shedding
During menstruation, an inner layer of the endometrium is selectively shed, while an outer, progenitor-containing layer is preserved to support repeated regeneration. Progress in understanding this co...
www.biorxiv.org
October 10, 2025 at 1:26 PM
Lab’s 1st preprint!
Menstruation is understudied due to societal taboos + a biological challenge: mice (a key system for research + drug discovery) don’t menstruate.
@cagricevrim.bsky.social made menstruating mice + used them to discover early events in menstruation.
He is on the job market!
Menstruation is understudied due to societal taboos + a biological challenge: mice (a key system for research + drug discovery) don’t menstruate.
@cagricevrim.bsky.social made menstruating mice + used them to discover early events in menstruation.
He is on the job market!
Reposted by Lydia Finley
Just out in @science.org: Together with the lab of @wilhelmpalm.bsky.social, we used sequential in-vitro/in-vivo CRISPR screens to decipher metabolic adaptations in tumors. We find that acidosis is a dominant factor that shapes energy metabolism and stress resilience. www.science.org/doi/10.1126/...
October 9, 2025 at 7:37 PM
Just out in @science.org: Together with the lab of @wilhelmpalm.bsky.social, we used sequential in-vitro/in-vivo CRISPR screens to decipher metabolic adaptations in tumors. We find that acidosis is a dominant factor that shapes energy metabolism and stress resilience. www.science.org/doi/10.1126/...
Reposted by Lydia Finley
Just out in @science.org: Together with the lab of @johanneszuber.bsky.social, we used sequential in-vitro/in-vivo screens to decipher metabolic adaptations in tumors. We find that acidosis is a dominant factor that shapes energy metabolism and stress resilience. www.science.org/doi/10.1126/...
October 9, 2025 at 8:12 PM
Just out in @science.org: Together with the lab of @johanneszuber.bsky.social, we used sequential in-vitro/in-vivo screens to decipher metabolic adaptations in tumors. We find that acidosis is a dominant factor that shapes energy metabolism and stress resilience. www.science.org/doi/10.1126/...
Reposted by Lydia Finley
Check out the symposium organized by our CoE, excited to have Marcia Haigis, @lydiafinley.bsky.social, Matthias Hebrok and Tom MacVicar over in Helsinki in November. Sign up by October 22nd 👇
Excited to announce our Stem Cell Metabolism Symposium organized in Helsinki on November 12th. Fantastic invited speakers Marcia Haigis, Lydia Finley, Matthias Hebrok and Tom MacVicar. Sign up by Oct 22nd, free of charge, welcome! @hilife-helsinki.bsky.social @helsinki.fi @stemmprogram.bsky.social
October 1, 2025 at 10:40 AM
Check out the symposium organized by our CoE, excited to have Marcia Haigis, @lydiafinley.bsky.social, Matthias Hebrok and Tom MacVicar over in Helsinki in November. Sign up by October 22nd 👇
Reposted by Lydia Finley
Happy to share the most recent preprint from the lab, the thesis work of Dr. Adam Krebs and a collaboration with many, including the Geissmann lab @mskcancercenter.bsky.social
Here is a short paper thread. #tuberculosis #macrophages 🦠
www.biorxiv.org/content/10.1...
Here is a short paper thread. #tuberculosis #macrophages 🦠
www.biorxiv.org/content/10.1...
Human iPSC derived alveolar macrophages reveal macrophage subtype specific functions of itaconate in M. tuberculosis host defense
M. tuberculosis must survive within multiple macrophage populations during infection, including alveolar macrophages (AM) and recruited inflammatory macrophages. In mice, itaconate, produced in macrop...
www.biorxiv.org
July 28, 2025 at 9:43 PM
Happy to share the most recent preprint from the lab, the thesis work of Dr. Adam Krebs and a collaboration with many, including the Geissmann lab @mskcancercenter.bsky.social
Here is a short paper thread. #tuberculosis #macrophages 🦠
www.biorxiv.org/content/10.1...
Here is a short paper thread. #tuberculosis #macrophages 🦠
www.biorxiv.org/content/10.1...
Reposted by Lydia Finley
Super excited to share new review on metabolic stress and adaptations in pancreatic cancer to these stresses from @cssheehan.bsky.social
jci.org/articles/vie... 1/6
jci.org/articles/vie... 1/6
JCI -
What’s on the menu?: metabolic constraints in the pancreatic tumor microenvironment
jci.org
July 19, 2025 at 2:59 PM
Super excited to share new review on metabolic stress and adaptations in pancreatic cancer to these stresses from @cssheehan.bsky.social
jci.org/articles/vie... 1/6
jci.org/articles/vie... 1/6
Reposted by Lydia Finley
Proudly presenting Simon’s @simonsterson.bsky.social paper on asymmetric apportioning of old mitochondria biasing intestinal stem cells for the Paneth cell linage through aKG-dependent metabolism
@naturemetabolism.bsky.social www.nature.com/articles/s42... @helsinki.fi @metastem.bsky.social 🧵1/8
@naturemetabolism.bsky.social www.nature.com/articles/s42... @helsinki.fi @metastem.bsky.social 🧵1/8
Old mitochondria regulate niche renewal via α-ketoglutarate metabolism in stem cells - Nature Metabolism
Andersson et al. show that intestinal stem cells enriched for old mitochondria are metabolically distinct and have enhanced ability to regenerate the epithelial niche.
www.nature.com
July 14, 2025 at 10:21 AM
Proudly presenting Simon’s @simonsterson.bsky.social paper on asymmetric apportioning of old mitochondria biasing intestinal stem cells for the Paneth cell linage through aKG-dependent metabolism
@naturemetabolism.bsky.social www.nature.com/articles/s42... @helsinki.fi @metastem.bsky.social 🧵1/8
@naturemetabolism.bsky.social www.nature.com/articles/s42... @helsinki.fi @metastem.bsky.social 🧵1/8
Reposted by Lydia Finley
Our paper on regulation of BCAA catabolism by mitochondrial calcium signaling is out!
Mitochondrial calcium signaling regulates branched-chain amino acid catabolism in fibrolamellar carcinoma | Science Advances www.science.org/doi/10.1126/...
Mitochondrial calcium signaling regulates branched-chain amino acid catabolism in fibrolamellar carcinoma | Science Advances www.science.org/doi/10.1126/...
Mitochondrial calcium signaling regulates branched-chain amino acid catabolism in fibrolamellar carcinoma
Mitochondrial Ca2+ signaling regulates branched-chain amino acid catabolism in an adolescent liver cancer.
www.science.org
May 31, 2025 at 6:24 AM
Our paper on regulation of BCAA catabolism by mitochondrial calcium signaling is out!
Mitochondrial calcium signaling regulates branched-chain amino acid catabolism in fibrolamellar carcinoma | Science Advances www.science.org/doi/10.1126/...
Mitochondrial calcium signaling regulates branched-chain amino acid catabolism in fibrolamellar carcinoma | Science Advances www.science.org/doi/10.1126/...
Reposted by Lydia Finley
Reposted by Lydia Finley
I'm excited to share our latest story from the
@lydiafinley.bsky.social lab, where we show that it's not just whether cells take up nutrients that matters, but how and where those metabolites are used. Out now in @naturemetabolism.bsky.social: rdcu.be/ejFTs 1/
@lydiafinley.bsky.social lab, where we show that it's not just whether cells take up nutrients that matters, but how and where those metabolites are used. Out now in @naturemetabolism.bsky.social: rdcu.be/ejFTs 1/
Intracellular metabolic gradients dictate dependence on exogenous pyruvate
Nature Metabolism - Jackson et al. provide insight into how metabolic adaptations that accompany cell state transitions drive reliance on exogenous nutrient availability, focusing on pyruvate as a...
rdcu.be
April 28, 2025 at 2:28 PM
I'm excited to share our latest story from the
@lydiafinley.bsky.social lab, where we show that it's not just whether cells take up nutrients that matters, but how and where those metabolites are used. Out now in @naturemetabolism.bsky.social: rdcu.be/ejFTs 1/
@lydiafinley.bsky.social lab, where we show that it's not just whether cells take up nutrients that matters, but how and where those metabolites are used. Out now in @naturemetabolism.bsky.social: rdcu.be/ejFTs 1/
Reposted by Lydia Finley
Happy to present Hien’s paper on age-selective apportioning of peroxisomes as a fate determinant in adult stem cells www.nature.com/articles/s41... @metastem.bsky.social @helsinki.fi @ki.se @helsinki-biotech.bsky.social out now in @natcomms.nature.com
A thread 🧵 1/9
A thread 🧵 1/9
Glucose-6-phosphate-dehydrogenase on old peroxisomes maintains self-renewal of epithelial stem cells after asymmetric cell division - Nature Communications
Peroxisomes are essential but their role in cell fate regulation remains understudied. Here, the authors reveal that young and old peroxisomes are not equally distributed in asymmetrically dividing st...
www.nature.com
April 28, 2025 at 10:49 AM
Happy to present Hien’s paper on age-selective apportioning of peroxisomes as a fate determinant in adult stem cells www.nature.com/articles/s41... @metastem.bsky.social @helsinki.fi @ki.se @helsinki-biotech.bsky.social out now in @natcomms.nature.com
A thread 🧵 1/9
A thread 🧵 1/9
Reposted by Lydia Finley
Showcase your research! Submit your poster abstract by April 16 (11:59pm MST) to join speakers @lydiafinley.bsky.social, Ralph J. DeBeradinis, & Keynote Navdeep Chandel. Apply now: keysym.us/KSMetabDev25. Can't attend? Access insights On Demand for 6 months post-conference!
#KSMetabDev25 #cellfate
#KSMetabDev25 #cellfate
April 10, 2025 at 9:27 PM
Showcase your research! Submit your poster abstract by April 16 (11:59pm MST) to join speakers @lydiafinley.bsky.social, Ralph J. DeBeradinis, & Keynote Navdeep Chandel. Apply now: keysym.us/KSMetabDev25. Can't attend? Access insights On Demand for 6 months post-conference!
#KSMetabDev25 #cellfate
#KSMetabDev25 #cellfate
2 weeks to go to the annual NYAS cancer metabolism symposium, April 8 at NYU Langone!
www.nyas.org/shaping-scie...
Register now using code CancerMetabolism10 for a 10% discount. And hurry! Last year we sold out!
cc: @lyssiotislab.bsky.social @marcusgon.bsky.social
www.nyas.org/shaping-scie...
Register now using code CancerMetabolism10 for a 10% discount. And hurry! Last year we sold out!
cc: @lyssiotislab.bsky.social @marcusgon.bsky.social
Cancer Metabolism and Signaling in the Tumor Microenvironment - NYAS
April 8, 2025 | 9:00 AM – 5:00 PM ET Join leading experts at the forefront of cancer metabolism research for a one-day event on April 8, 2025, in New York City. The New York Academy of Sciences invite...
www.nyas.org
March 25, 2025 at 4:31 PM
2 weeks to go to the annual NYAS cancer metabolism symposium, April 8 at NYU Langone!
www.nyas.org/shaping-scie...
Register now using code CancerMetabolism10 for a 10% discount. And hurry! Last year we sold out!
cc: @lyssiotislab.bsky.social @marcusgon.bsky.social
www.nyas.org/shaping-scie...
Register now using code CancerMetabolism10 for a 10% discount. And hurry! Last year we sold out!
cc: @lyssiotislab.bsky.social @marcusgon.bsky.social
Reposted by Lydia Finley
www.quantamagazine.org/how-metaboli...
Seems like a good time to remind you of an upcoming meeting on this exact topic:
www.keystonesymposia.org/conferences/...
Seems like a good time to remind you of an upcoming meeting on this exact topic:
www.keystonesymposia.org/conferences/...
How Metabolism Can Shape Cells’ Destinies | Quanta Magazine
A growing body of work suggests that cell metabolism — the chemical reactions that provide energy and building materials — plays a vital, overlooked role in the first steps of life.
www.quantamagazine.org
March 21, 2025 at 4:57 PM
www.quantamagazine.org/how-metaboli...
Seems like a good time to remind you of an upcoming meeting on this exact topic:
www.keystonesymposia.org/conferences/...
Seems like a good time to remind you of an upcoming meeting on this exact topic:
www.keystonesymposia.org/conferences/...
Reposted by Lydia Finley
We are 2 weeks out from the @NYASciences Cancer Metabolism meeting - still time to register! Join us for:
Exciting science ✅
Awesome speakers ✅
Great camaraderie ✅
Science jokes⚠️
Celebrity appearances‼️ (probably not)
Please circulate 🔁
events.nyas.org/event/16a78a...
Exciting science ✅
Awesome speakers ✅
Great camaraderie ✅
Science jokes⚠️
Celebrity appearances‼️ (probably not)
Please circulate 🔁
events.nyas.org/event/16a78a...
March 20, 2025 at 3:23 AM
We are 2 weeks out from the @NYASciences Cancer Metabolism meeting - still time to register! Join us for:
Exciting science ✅
Awesome speakers ✅
Great camaraderie ✅
Science jokes⚠️
Celebrity appearances‼️ (probably not)
Please circulate 🔁
events.nyas.org/event/16a78a...
Exciting science ✅
Awesome speakers ✅
Great camaraderie ✅
Science jokes⚠️
Celebrity appearances‼️ (probably not)
Please circulate 🔁
events.nyas.org/event/16a78a...
Reposted by Lydia Finley
Unlock $200 in savings on Metabolic and Nutritional Control by registering before 11:59 PM MST on March 20! Don't miss the chance to hear from @lydiafinley.bsky.social this May in Beverly, MA, USA. Secure your spot now: keysym.us/KSMetabDev25.
#KSMetabDev25 #metabolism youtu.be/le7D7qpo4sM
#KSMetabDev25 #metabolism youtu.be/le7D7qpo4sM
KSQA: Dr. Lydia Finley (Metabolic and Nutritional Control)
YouTube video by KeystoneSymposia
youtu.be
March 19, 2025 at 2:21 PM
Unlock $200 in savings on Metabolic and Nutritional Control by registering before 11:59 PM MST on March 20! Don't miss the chance to hear from @lydiafinley.bsky.social this May in Beverly, MA, USA. Secure your spot now: keysym.us/KSMetabDev25.
#KSMetabDev25 #metabolism youtu.be/le7D7qpo4sM
#KSMetabDev25 #metabolism youtu.be/le7D7qpo4sM
Reposted by Lydia Finley
1/Happy to share a new paper reporting a metabolic approach to radiosensitization in lung cancer, from Rachel Chiang, Faith Zhang and colleagues at UT Southwestern Radiation Oncology and @cri-utsw.bsky.social
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Lipoylation inhibition enhances radiation control of lung cancer by suppressing homologous recombination DNA damage repair
Genetic screen finds lipoylation as a target to improve radiation success in lung cancer by blocking DNA damage repair.
www.science.org
March 15, 2025 at 5:27 PM
1/Happy to share a new paper reporting a metabolic approach to radiosensitization in lung cancer, from Rachel Chiang, Faith Zhang and colleagues at UT Southwestern Radiation Oncology and @cri-utsw.bsky.social
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Reposted by Lydia Finley
New preprint time!!
This one has been brewing in the lab for ~8 years describes a strategy for tumor selective WNT suppression. It was led by an amazing (then) grad student, Jill Zimmerman, with help from a host of lab members and collaborators along the way.
www.biorxiv.org/content/10.1...
This one has been brewing in the lab for ~8 years describes a strategy for tumor selective WNT suppression. It was led by an amazing (then) grad student, Jill Zimmerman, with help from a host of lab members and collaborators along the way.
www.biorxiv.org/content/10.1...
A potent and selective TNKS2 inhibitor for tumor-selective WNT suppression
Hyperactive WNT signaling is a potent cancer driver, but clinical translation of WNT inhibitors has been hampered on-target toxicities. WNT signaling can be constrained through inhibition of the PARP ...
www.biorxiv.org
March 12, 2025 at 4:08 PM
New preprint time!!
This one has been brewing in the lab for ~8 years describes a strategy for tumor selective WNT suppression. It was led by an amazing (then) grad student, Jill Zimmerman, with help from a host of lab members and collaborators along the way.
www.biorxiv.org/content/10.1...
This one has been brewing in the lab for ~8 years describes a strategy for tumor selective WNT suppression. It was led by an amazing (then) grad student, Jill Zimmerman, with help from a host of lab members and collaborators along the way.
www.biorxiv.org/content/10.1...
Reposted by Lydia Finley
Metabolic & Nutritional Control of Development and Cell Fate is just around the corner. Register by March 20 (11:59pm MST) and snag a $200 discount! Don't miss our incredible speaker lineup! 👉 keysym.us/KSMetabDev25.
#KSMetabDev25 youtu.be/CSto4rJv40I
@lydiafinley.bsky.social @rjdlab.bsky.social
#KSMetabDev25 youtu.be/CSto4rJv40I
@lydiafinley.bsky.social @rjdlab.bsky.social
Metabolic and Nutritional Control Meeting Promo
YouTube video by KeystoneSymposia
youtu.be
March 12, 2025 at 4:26 PM
Metabolic & Nutritional Control of Development and Cell Fate is just around the corner. Register by March 20 (11:59pm MST) and snag a $200 discount! Don't miss our incredible speaker lineup! 👉 keysym.us/KSMetabDev25.
#KSMetabDev25 youtu.be/CSto4rJv40I
@lydiafinley.bsky.social @rjdlab.bsky.social
#KSMetabDev25 youtu.be/CSto4rJv40I
@lydiafinley.bsky.social @rjdlab.bsky.social
Reposted by Lydia Finley
📢3 weeks left to submit your abstract for the Cancer Metabolism Showcase and Workshop!📢
We already have over 150 registrants!
Sign up for free today at www.cancermetabolismshowcase.org
We already have over 150 registrants!
Sign up for free today at www.cancermetabolismshowcase.org
9:30 AM - 3 PM EST, May 5th and 6th, 2025
www.cancermetabolismshowcase.org
February 28, 2025 at 3:25 PM
📢3 weeks left to submit your abstract for the Cancer Metabolism Showcase and Workshop!📢
We already have over 150 registrants!
Sign up for free today at www.cancermetabolismshowcase.org
We already have over 150 registrants!
Sign up for free today at www.cancermetabolismshowcase.org
Reposted by Lydia Finley
Excited to share a recent preprint by Oliver Newsom, where we evaluate the functional contributions of serum for cancer cell proliferation. Inside:
A broadly applicable serum-free media,
Quantitative lipid uptake characterization,
Evidence lipid scavenging > synthesis for cancer cell proliferation.
A broadly applicable serum-free media,
Quantitative lipid uptake characterization,
Evidence lipid scavenging > synthesis for cancer cell proliferation.
Defined media reveals the essential role of lipid scavenging to support cancer cell proliferation https://www.biorxiv.org/content/10.1101/2025.02.12.637975v1
February 20, 2025 at 2:43 AM
Excited to share a recent preprint by Oliver Newsom, where we evaluate the functional contributions of serum for cancer cell proliferation. Inside:
A broadly applicable serum-free media,
Quantitative lipid uptake characterization,
Evidence lipid scavenging > synthesis for cancer cell proliferation.
A broadly applicable serum-free media,
Quantitative lipid uptake characterization,
Evidence lipid scavenging > synthesis for cancer cell proliferation.
Reposted by Lydia Finley
Happy to share our new #NIHfunded study! Led by Kath Oñate + crew of #WomenInSTEM 💪🏽💪🏻💪, we ID potential of normal mesenchyme to restrain #inflammation, epithelial identity, & #pancreaticcancer via KITL, a cue lost in transition to a CAF state. Now at Cancer Discovery aacrjournals.org/cancerdiscov...
Stromal KITL/SCF maintains pancreas tissue homeostasis and restrains tumor progression
Abstract. Components of normal tissue architecture serve as barriers to tumor progression. Inflammatory and wound-healing programs are requisite features of solid tumorigenesis, wherein alterations to...
aacrjournals.org
February 7, 2025 at 2:14 PM
Happy to share our new #NIHfunded study! Led by Kath Oñate + crew of #WomenInSTEM 💪🏽💪🏻💪, we ID potential of normal mesenchyme to restrain #inflammation, epithelial identity, & #pancreaticcancer via KITL, a cue lost in transition to a CAF state. Now at Cancer Discovery aacrjournals.org/cancerdiscov...
Reposted by Lydia Finley
We are soliciting poster and short talk abstracts for the NYASciences Cancer Metabolism meeting. Just around the corner - join us for awesome metabolism in the Big Apple 🍎
Speakers: Kivanc Birsoy, Christine Chio, Marcia Haigis, Andy Intlekofer, Thales PapaG, Jared Rutter, Dan Wahl, Eileen White
Speakers: Kivanc Birsoy, Christine Chio, Marcia Haigis, Andy Intlekofer, Thales PapaG, Jared Rutter, Dan Wahl, Eileen White
February 5, 2025 at 3:35 PM
We are soliciting poster and short talk abstracts for the NYASciences Cancer Metabolism meeting. Just around the corner - join us for awesome metabolism in the Big Apple 🍎
Speakers: Kivanc Birsoy, Christine Chio, Marcia Haigis, Andy Intlekofer, Thales PapaG, Jared Rutter, Dan Wahl, Eileen White
Speakers: Kivanc Birsoy, Christine Chio, Marcia Haigis, Andy Intlekofer, Thales PapaG, Jared Rutter, Dan Wahl, Eileen White
Massive work from Jess Spinelli's lab at UMASS demonstrating a SECOND electron carrier in the mammalian ETC:
www.cell.com/cell/fulltex...
www.cell.com/cell/fulltex...
Rhodoquinone carries electrons in the mammalian electron transport chain
Valeros et al. identify rhodoquinone (RQ), an electron carrier present in mammalian
mitochondria, that can deliver electrons to fumarate instead of O2 as the terminal
electron acceptor. The authors de...
www.cell.com
February 4, 2025 at 9:40 PM
Massive work from Jess Spinelli's lab at UMASS demonstrating a SECOND electron carrier in the mammalian ETC:
www.cell.com/cell/fulltex...
www.cell.com/cell/fulltex...
Reposted by Lydia Finley
The Cancer Metabolism and Signaling in the Tumor Microenvironment *Abstract Deadline* is rapidly approaching 2/4/25. Don't miss this star-studded event!
@nyasciences.bsky.social @nyulangonepccsm.bsky.social events.nyas.org/event/16a78a...
@nyasciences.bsky.social @nyulangonepccsm.bsky.social events.nyas.org/event/16a78a...
Cancer Metabolism and Signaling 2025
events.nyas.org
January 8, 2025 at 9:35 PM
The Cancer Metabolism and Signaling in the Tumor Microenvironment *Abstract Deadline* is rapidly approaching 2/4/25. Don't miss this star-studded event!
@nyasciences.bsky.social @nyulangonepccsm.bsky.social events.nyas.org/event/16a78a...
@nyasciences.bsky.social @nyulangonepccsm.bsky.social events.nyas.org/event/16a78a...