Lyssiotis Lab
@lyssiotislab.bsky.social
Cancer and Immune Metabolism Research Laboratory, University of Michigan
Pinned
Lyssiotis Lab
@lyssiotislab.bsky.social
· Apr 24
Beyond grateful to share that my main PhD thesis project, Targeting PIKfyve-driven lipid metabolism in pancreatic cancer (@lyssiotislab.bsky.social + Arul Chinnaiyan lab), has just been published in @nature.com!
🔥Smoking hot new paper and tweetorial from @djcalebc.bsky.social (collab with Chinnaiyan Lab)! 🔥
We are over the moon about this new work and its therapeutic implications for pancreatic cancer. Please have a read and share your thoughts/feedback! 🙏🏼
We are over the moon about this new work and its therapeutic implications for pancreatic cancer. Please have a read and share your thoughts/feedback! 🙏🏼
Reposted by Lyssiotis Lab
q.e.d Science
Critical Thinking AI for constructive criticism and science evaluation
qedscience.com
October 15, 2025 at 12:22 PM
Reposted by Lyssiotis Lab
#NatMetabPicks | In @nature.com led by @danwahlmd.bsky.social @lyssiotislab.bsky.social @dnagrathlab.bsky.social WN Al-Holou ( @umich.edu )
Gliomas take up serine from the tumor microenvironment, and can be targeted with dietary serine restriction.
🧪
www.nature.com/articles/s41...
Gliomas take up serine from the tumor microenvironment, and can be targeted with dietary serine restriction.
🧪
www.nature.com/articles/s41...
Rewiring of cortical glucose metabolism fuels human brain cancer growth - Nature
The cortex fuels essential physiological processes with glucose-derived carbon, while gliomas fuel their aggressiveness by rerouting glucose carbon pathways and scavenging alternative carbon sources such as environmental amino acids, providing a potential therapeutic target.
www.nature.com
September 29, 2025 at 3:47 PM
#NatMetabPicks | In @nature.com led by @danwahlmd.bsky.social @lyssiotislab.bsky.social @dnagrathlab.bsky.social WN Al-Holou ( @umich.edu )
Gliomas take up serine from the tumor microenvironment, and can be targeted with dietary serine restriction.
🧪
www.nature.com/articles/s41...
Gliomas take up serine from the tumor microenvironment, and can be targeted with dietary serine restriction.
🧪
www.nature.com/articles/s41...
Excited to share a new story from the Lab! 🚨🩸
🧵 1/ Aspartate transaminases control blood development, by Narges Pourmandi, et al
www.biorxiv.org/content/10.1...
🧵 1/ Aspartate transaminases control blood development, by Narges Pourmandi, et al
www.biorxiv.org/content/10.1...
Aspartate transaminases are required for blood development
Red blood cells (RBCs) have a limited lifespan of approximately 120 days. This necessitates continuous RBC production, resulting in ∼200 billion new RBCs made per day to maintain oxygen delivery. Desp...
www.biorxiv.org
September 25, 2025 at 1:14 PM
Excited to share a new story from the Lab! 🚨🩸
🧵 1/ Aspartate transaminases control blood development, by Narges Pourmandi, et al
www.biorxiv.org/content/10.1...
🧵 1/ Aspartate transaminases control blood development, by Narges Pourmandi, et al
www.biorxiv.org/content/10.1...
Reposted by Lyssiotis Lab
In @nytopinion.nytimes.com
The Trump administration’s autism project “is built on the premise that an autism diagnosis is a terrible tragedy and that scientists and doctors have failed,” Roy Grinker, a cultural anthropologist and the father of an autistic child, says. “But science has not failed.”
The Trump administration’s autism project “is built on the premise that an autism diagnosis is a terrible tragedy and that scientists and doctors have failed,” Roy Grinker, a cultural anthropologist and the father of an autistic child, says. “But science has not failed.”
Opinion | Autism Has Never Been One Thing
We’ve come too far to go back to a time when autism was defined solely in terms of deficits and mothers were made to feel guilty.
nyti.ms
September 25, 2025 at 1:00 PM
In @nytopinion.nytimes.com
The Trump administration’s autism project “is built on the premise that an autism diagnosis is a terrible tragedy and that scientists and doctors have failed,” Roy Grinker, a cultural anthropologist and the father of an autistic child, says. “But science has not failed.”
The Trump administration’s autism project “is built on the premise that an autism diagnosis is a terrible tragedy and that scientists and doctors have failed,” Roy Grinker, a cultural anthropologist and the father of an autistic child, says. “But science has not failed.”
Reposted by Lyssiotis Lab
New discovery from our team defining how human brain cancers rewire the metabolism of the normal brain published this week @nature.com and led by stellar postdoc Drew Scott (comentored by @lyssiotislab.bsky.social and currently on job market with a K99/R00). www.nature.com/articles/s41...
Rewiring of cortical glucose metabolism fuels human brain cancer growth - Nature
The cortex fuels essential physiological processes with glucose-derived carbon, while gliomas fuel their aggressiveness by rerouting glucose carbon pathways and scavenging alternative carbon sources s...
www.nature.com
September 6, 2025 at 12:41 PM
New discovery from our team defining how human brain cancers rewire the metabolism of the normal brain published this week @nature.com and led by stellar postdoc Drew Scott (comentored by @lyssiotislab.bsky.social and currently on job market with a K99/R00). www.nature.com/articles/s41...
Reposted by Lyssiotis Lab
Glioblastoma depends on the amino acid serine as a fuel source & serine-deficient diet slows tumor growth in mice @nature.com @dnagrathlab.bsky.social @lyssiotislab.bsky.social
www.nature.com/articles/s41...
www.nature.com/articles/d41...
www.nature.com/articles/d41...
www.nature.com/articles/s41...
www.nature.com/articles/d41...
www.nature.com/articles/d41...
September 3, 2025 at 6:03 PM
Glioblastoma depends on the amino acid serine as a fuel source & serine-deficient diet slows tumor growth in mice @nature.com @dnagrathlab.bsky.social @lyssiotislab.bsky.social
www.nature.com/articles/s41...
www.nature.com/articles/d41...
www.nature.com/articles/d41...
www.nature.com/articles/s41...
www.nature.com/articles/d41...
www.nature.com/articles/d41...
Reposted by Lyssiotis Lab
Rewiring of cortical glucose metabolism fuels human brain cancer growth
www.nature.com/articles/s41...
Congrats to the many involved, including @lyssiotislab.bsky.social and @dnagrathlab.bsky.social
www.nature.com/articles/s41...
Congrats to the many involved, including @lyssiotislab.bsky.social and @dnagrathlab.bsky.social
Rewiring of cortical glucose metabolism fuels human brain cancer growth - Nature
The cortex fuels essential physiological processes with glucose-derived carbon, while gliomas fuel their aggressiveness by rerouting glucose carbon pathways and scavenging alternative carbon sources s...
www.nature.com
September 4, 2025 at 8:20 AM
Rewiring of cortical glucose metabolism fuels human brain cancer growth
www.nature.com/articles/s41...
Congrats to the many involved, including @lyssiotislab.bsky.social and @dnagrathlab.bsky.social
www.nature.com/articles/s41...
Congrats to the many involved, including @lyssiotislab.bsky.social and @dnagrathlab.bsky.social
Reposted by Lyssiotis Lab
A massive team effort by U-M researchers have found that glioblastoma cells rewire how they use sugar, which can be targeted in mice to slow tumor growth and improve treatment responses. @lyssiotislab.bsky.social @dnagrathlab.bsky.social
Learn more: michmed.org/MD2X2.
Learn more: michmed.org/MD2X2.
Dietary changes could provide a therapeutic avenue for brain cancer
A team of researchers from Michigan Medicine tracked how glucose is used in glioblastoma tumor cells. They showed that dietary interventions can slow brain cancer growth in mice.
michmed.org
September 4, 2025 at 3:39 PM
A massive team effort by U-M researchers have found that glioblastoma cells rewire how they use sugar, which can be targeted in mice to slow tumor growth and improve treatment responses. @lyssiotislab.bsky.social @dnagrathlab.bsky.social
Learn more: michmed.org/MD2X2.
Learn more: michmed.org/MD2X2.
Reposted by Lyssiotis Lab
Three senior leaders who resigned in protest told The Post they were asked to participate in an unscientific vaccine recommendation process that they believe could harm the health of Americans.
More from @lenasun.bsky.social @laurenweberhp.bsky.social @davidovalle.bsky.social
🎁: wapo.st/46aNJB0
More from @lenasun.bsky.social @laurenweberhp.bsky.social @davidovalle.bsky.social
🎁: wapo.st/46aNJB0
CDC leaders who resigned said RFK Jr. undermined vaccine science, risking lives
As the CDC reels from departures, White House appoints Jim O’Neill as acting director.
wapo.st
August 28, 2025 at 10:49 PM
Three senior leaders who resigned in protest told The Post they were asked to participate in an unscientific vaccine recommendation process that they believe could harm the health of Americans.
More from @lenasun.bsky.social @laurenweberhp.bsky.social @davidovalle.bsky.social
🎁: wapo.st/46aNJB0
More from @lenasun.bsky.social @laurenweberhp.bsky.social @davidovalle.bsky.social
🎁: wapo.st/46aNJB0
Reposted by Lyssiotis Lab
Ok so does anyone know anything about the NSF GRFP? Has anyone made any statement?
Grad students keep telling me they’re writing it and I’m like discouraging them from spending time on this…. But do we have any actual information?
Grad students keep telling me they’re writing it and I’m like discouraging them from spending time on this…. But do we have any actual information?
August 29, 2025 at 4:06 PM
Ok so does anyone know anything about the NSF GRFP? Has anyone made any statement?
Grad students keep telling me they’re writing it and I’m like discouraging them from spending time on this…. But do we have any actual information?
Grad students keep telling me they’re writing it and I’m like discouraging them from spending time on this…. But do we have any actual information?
Our department is recruiting a new tenure track Assistant/Associate Professor. Come join the #1 physiology department in the country and some awesome colleagues doing high impact science and training the next generation of scientists
jobs.sciencecareers.org/job/674815/a...
jobs.sciencecareers.org/job/674815/a...
Assistant/Associate Professor - Tenure Track - Physiology - University of Michigan, Ann Arbor job with University of Michigan Department of Molecular & Integrative Physiology | 674815
Tenure track assistant/associate professor in the Department of Molecular & Integrative Physiology at the University of Michigan Medical School.
jobs.sciencecareers.org
August 28, 2025 at 3:35 PM
Our department is recruiting a new tenure track Assistant/Associate Professor. Come join the #1 physiology department in the country and some awesome colleagues doing high impact science and training the next generation of scientists
jobs.sciencecareers.org/job/674815/a...
jobs.sciencecareers.org/job/674815/a...
Reposted by Lyssiotis Lab
Congratulations 2025 Gilliam Fellows and Advisors! 🎉
The Gilliam Fellows Program launches promising PhD students into impactful scientific research careers while fostering inclusive training environments.
Through this program, HHMI supports both graduate students and their faculty thesis advisors.
The Gilliam Fellows Program launches promising PhD students into impactful scientific research careers while fostering inclusive training environments.
Through this program, HHMI supports both graduate students and their faculty thesis advisors.
August 7, 2025 at 1:05 PM
Congratulations 2025 Gilliam Fellows and Advisors! 🎉
The Gilliam Fellows Program launches promising PhD students into impactful scientific research careers while fostering inclusive training environments.
Through this program, HHMI supports both graduate students and their faculty thesis advisors.
The Gilliam Fellows Program launches promising PhD students into impactful scientific research careers while fostering inclusive training environments.
Through this program, HHMI supports both graduate students and their faculty thesis advisors.
Reposted by Lyssiotis Lab
I am so happy to join the HHMI Gilliam community, keep working in cancer metabolism, and continuing my passions in scientific outreach and communication!
Huge thanks to all of my current and past mentors!
@lyssiotislab.bsky.social, @ajdiazphd.bsky.social, Dr. Yatrik Shah
Huge thanks to all of my current and past mentors!
@lyssiotislab.bsky.social, @ajdiazphd.bsky.social, Dr. Yatrik Shah
Congratulations 2025 Gilliam Fellows and Advisors! 🎉
The Gilliam Fellows Program launches promising PhD students into impactful scientific research careers while fostering inclusive training environments.
Through this program, HHMI supports both graduate students and their faculty thesis advisors.
The Gilliam Fellows Program launches promising PhD students into impactful scientific research careers while fostering inclusive training environments.
Through this program, HHMI supports both graduate students and their faculty thesis advisors.
August 8, 2025 at 1:11 PM
I am so happy to join the HHMI Gilliam community, keep working in cancer metabolism, and continuing my passions in scientific outreach and communication!
Huge thanks to all of my current and past mentors!
@lyssiotislab.bsky.social, @ajdiazphd.bsky.social, Dr. Yatrik Shah
Huge thanks to all of my current and past mentors!
@lyssiotislab.bsky.social, @ajdiazphd.bsky.social, Dr. Yatrik Shah
Reposted by Lyssiotis Lab
Buffy is so old there were only 103 named elements, we’re at 118 now.
(Yes I pause every show that has a periodic table to see if its period accurate)
(Yes I pause every show that has a periodic table to see if its period accurate)
July 27, 2025 at 9:36 AM
Buffy is so old there were only 103 named elements, we’re at 118 now.
(Yes I pause every show that has a periodic table to see if its period accurate)
(Yes I pause every show that has a periodic table to see if its period accurate)
Reposted by Lyssiotis Lab
Reposted by Lyssiotis Lab
PO just confirmed that our 5th percentile R01 is not getting funded. Past NCI Payline at 4 percent. Cant believe it.
July 23, 2025 at 7:35 PM
PO just confirmed that our 5th percentile R01 is not getting funded. Past NCI Payline at 4 percent. Cant believe it.
Reposted by Lyssiotis Lab
Science finally retracts the Arsenic life paper www.science.org/content/arti...
Fifteen years later, Science retracts ‘arsenic life’ paper despite study authors’ protests
Belated decision on widely disputed 2010 study pleases some critics but puzzles and dismays others
www.science.org
July 24, 2025 at 6:51 PM
Science finally retracts the Arsenic life paper www.science.org/content/arti...
Reposted by Lyssiotis Lab
Delighted to share that our work “Uridine Phosphorylase-1 supports metastasis by altering immune and extracellular matrix landscapes” was published today in @emboreports.org, describing how neutrophil metabolism influences niche priming to support metastasis (1/14) www.embopress.org/doi/full/10....
Uridine phosphorylase-1 supports metastasis by altering immune and extracellular matrix landscapes | EMBO reports
imageimageMetastatic primary tumours upregulate Upp1 in neutrophils, which elevates circulating uracil. UPP1-expressing neutrophils accumulate
in the lung where they inhibit CD8+ T cells, promote fibr...
www.embopress.org
July 23, 2025 at 8:48 PM
Delighted to share that our work “Uridine Phosphorylase-1 supports metastasis by altering immune and extracellular matrix landscapes” was published today in @emboreports.org, describing how neutrophil metabolism influences niche priming to support metastasis (1/14) www.embopress.org/doi/full/10....
1/ If you are in the Midwest and ❤️ metabolism, take note!
This year’s Midwest Metabolism meeting will be held jointly with the Translational Research in Mitochondrial Metabolism in Aging and Disease (TRiMAD) conference.
www.vai.org/event/2025-m...
This year’s Midwest Metabolism meeting will be held jointly with the Translational Research in Mitochondrial Metabolism in Aging and Disease (TRiMAD) conference.
www.vai.org/event/2025-m...
2025 Midwest Metabolism Meeting
Join us for 2025 Midwest Metabolism Meeting at Van Andel Institute Stay informed about exciting upcoming events and activities.
www.vai.org
July 21, 2025 at 9:12 PM
1/ If you are in the Midwest and ❤️ metabolism, take note!
This year’s Midwest Metabolism meeting will be held jointly with the Translational Research in Mitochondrial Metabolism in Aging and Disease (TRiMAD) conference.
www.vai.org/event/2025-m...
This year’s Midwest Metabolism meeting will be held jointly with the Translational Research in Mitochondrial Metabolism in Aging and Disease (TRiMAD) conference.
www.vai.org/event/2025-m...
So grateful and excited to partner with the Stephenson Global Pancreatic Cancer Research Institute to advance our collaborative program targeting lysosome and Kras metabolism in pancreatic cancer!
michmed.org/rwVDK
michmed.org/rwVDK
Lyssiotis awarded Stephenson Global Scholar Grant for pancreatic cancer research
Costas Lyssiotis, Ph.D., co-director of the Rogel and Blondy Center for Pancreatic Cancer at the Rogel Cancer Center, was one of six researchers to receive inaugural grants from the Stephenson Global ...
michmed.org
July 18, 2025 at 1:43 PM
So grateful and excited to partner with the Stephenson Global Pancreatic Cancer Research Institute to advance our collaborative program targeting lysosome and Kras metabolism in pancreatic cancer!
michmed.org/rwVDK
michmed.org/rwVDK
Reposted by Lyssiotis Lab
Model organism communities are fantastic. Good work, "Drosophilists"! www.nature.com/articles/d41...
Giant study finds a research field that’s mostly reproducible
Researchers assessed more than 1,000 results from fruit-fly immunity research published between 1959 and 2011. The majority of findings look verifiable.
www.nature.com
July 16, 2025 at 5:55 PM
Model organism communities are fantastic. Good work, "Drosophilists"! www.nature.com/articles/d41...
Reposted by Lyssiotis Lab
Hey @nature.com What's up with your share buttons? Can we please also get 🦋 and 🦣 options to not exclusively promote the network of the guy who has done more than most to harm US science?
July 16, 2025 at 5:46 PM
Hey @nature.com What's up with your share buttons? Can we please also get 🦋 and 🦣 options to not exclusively promote the network of the guy who has done more than most to harm US science?
Reposted by Lyssiotis Lab
Reposted by Lyssiotis Lab
Today, 1,152 NAS members/Nobel Laureates (as private individuals) sent a letter to Congress regarding the cuts to science being proposed by the Administration, and currently going through the House and Senate Appropriations Committees.
tinyurl.com/5n7y7853
@standupforscience.bsky.social
tinyurl.com/5n7y7853
@standupforscience.bsky.social
Letter to Congress Requesting Protection of Science Funding in the FY26 Budget
tinyurl.com
July 16, 2025 at 9:20 PM
Today, 1,152 NAS members/Nobel Laureates (as private individuals) sent a letter to Congress regarding the cuts to science being proposed by the Administration, and currently going through the House and Senate Appropriations Committees.
tinyurl.com/5n7y7853
@standupforscience.bsky.social
tinyurl.com/5n7y7853
@standupforscience.bsky.social
Reposted by Lyssiotis Lab
If anyone claims vaccines haven’t been properly studied, show them this:
Our living dataset now includes 502 controlled vaccine trials with ~7.2 million trial participants, and it is still growing.
The vast majority of trials reported safety outcomes.
bit.ly/4le8z7D
Our living dataset now includes 502 controlled vaccine trials with ~7.2 million trial participants, and it is still growing.
The vast majority of trials reported safety outcomes.
bit.ly/4le8z7D
Controlled Vaccine RCTs (Living List)
bit.ly
July 8, 2025 at 4:13 AM
If anyone claims vaccines haven’t been properly studied, show them this:
Our living dataset now includes 502 controlled vaccine trials with ~7.2 million trial participants, and it is still growing.
The vast majority of trials reported safety outcomes.
bit.ly/4le8z7D
Our living dataset now includes 502 controlled vaccine trials with ~7.2 million trial participants, and it is still growing.
The vast majority of trials reported safety outcomes.
bit.ly/4le8z7D