Lyssiotis Lab
@lyssiotislab.bsky.social
Cancer and Immune Metabolism Research Laboratory, University of Michigan
9/ Human cell relevance
In primary human blood progenitors, knocking out GOT1/2 also blocked RBC formation & increased cell death, mirroring mouse results.
In primary human blood progenitors, knocking out GOT1/2 also blocked RBC formation & increased cell death, mirroring mouse results.
September 25, 2025 at 1:14 PM
9/ Human cell relevance
In primary human blood progenitors, knocking out GOT1/2 also blocked RBC formation & increased cell death, mirroring mouse results.
In primary human blood progenitors, knocking out GOT1/2 also blocked RBC formation & increased cell death, mirroring mouse results.
7/ Bringing in a tissue-specific, LbNOX mouse model, we then demonstrated that correcting NADH reductive stress didn’t rescue the anemia. So MAS/redox was not the mechanism!
September 25, 2025 at 1:14 PM
7/ Bringing in a tissue-specific, LbNOX mouse model, we then demonstrated that correcting NADH reductive stress didn’t rescue the anemia. So MAS/redox was not the mechanism!
5/ Got1 vs. Got2
Surprisingly, Got1 or Got2 loss both caused anemia, but altered aspartate in opposite directions:
GOT2 loss: ↓ aspartate
GOT1 loss: ↑ aspartate
Both led to a block in red blood cell maturation—so, not just about aspartate levels!
Surprisingly, Got1 or Got2 loss both caused anemia, but altered aspartate in opposite directions:
GOT2 loss: ↓ aspartate
GOT1 loss: ↑ aspartate
Both led to a block in red blood cell maturation—so, not just about aspartate levels!
September 25, 2025 at 1:14 PM
5/ Got1 vs. Got2
Surprisingly, Got1 or Got2 loss both caused anemia, but altered aspartate in opposite directions:
GOT2 loss: ↓ aspartate
GOT1 loss: ↑ aspartate
Both led to a block in red blood cell maturation—so, not just about aspartate levels!
Surprisingly, Got1 or Got2 loss both caused anemia, but altered aspartate in opposite directions:
GOT2 loss: ↓ aspartate
GOT1 loss: ↑ aspartate
Both led to a block in red blood cell maturation—so, not just about aspartate levels!
3/ Background
RBCs are constantly replenished (~200B/day), but the metabolic needs of this process are unclear. Profiling shows: Aspartate rises during erythropoiesis. Does aspartate metabolism drive red cell formation? 🤔
RBCs are constantly replenished (~200B/day), but the metabolic needs of this process are unclear. Profiling shows: Aspartate rises during erythropoiesis. Does aspartate metabolism drive red cell formation? 🤔
September 25, 2025 at 1:14 PM
3/ Background
RBCs are constantly replenished (~200B/day), but the metabolic needs of this process are unclear. Profiling shows: Aspartate rises during erythropoiesis. Does aspartate metabolism drive red cell formation? 🤔
RBCs are constantly replenished (~200B/day), but the metabolic needs of this process are unclear. Profiling shows: Aspartate rises during erythropoiesis. Does aspartate metabolism drive red cell formation? 🤔
2/ Working with the @YatrikShahLab and Khoriaty labs, Narges discovered a previously unrecognized, critical role for aspartate aminotransferases (GOT1 & GOT2) in red blood cell (RBC) production, with implications for anemia therapy.
September 25, 2025 at 1:14 PM
2/ Working with the @YatrikShahLab and Khoriaty labs, Narges discovered a previously unrecognized, critical role for aspartate aminotransferases (GOT1 & GOT2) in red blood cell (RBC) production, with implications for anemia therapy.
We are 2 weeks out from the @NYASciences Cancer Metabolism meeting - still time to register! Join us for:
Exciting science ✅
Awesome speakers ✅
Great camaraderie ✅
Science jokes⚠️
Celebrity appearances‼️ (probably not)
Please circulate 🔁
events.nyas.org/event/16a78a...
Exciting science ✅
Awesome speakers ✅
Great camaraderie ✅
Science jokes⚠️
Celebrity appearances‼️ (probably not)
Please circulate 🔁
events.nyas.org/event/16a78a...
March 20, 2025 at 3:23 AM
We are 2 weeks out from the @NYASciences Cancer Metabolism meeting - still time to register! Join us for:
Exciting science ✅
Awesome speakers ✅
Great camaraderie ✅
Science jokes⚠️
Celebrity appearances‼️ (probably not)
Please circulate 🔁
events.nyas.org/event/16a78a...
Exciting science ✅
Awesome speakers ✅
Great camaraderie ✅
Science jokes⚠️
Celebrity appearances‼️ (probably not)
Please circulate 🔁
events.nyas.org/event/16a78a...
A beautiful thesis defense from Narges Pourmandi for CMB, Michigan Medicine. Back to the hospital next week to complete her medical training ❤️🙌🏼🩺
We are so proud of her many accomplishments! @YatrikShahLab
We are so proud of her many accomplishments! @YatrikShahLab
March 12, 2025 at 4:07 PM
A beautiful thesis defense from Narges Pourmandi for CMB, Michigan Medicine. Back to the hospital next week to complete her medical training ❤️🙌🏼🩺
We are so proud of her many accomplishments! @YatrikShahLab
We are so proud of her many accomplishments! @YatrikShahLab
We are soliciting poster and short talk abstracts for the NYASciences Cancer Metabolism meeting. Just around the corner - join us for awesome metabolism in the Big Apple 🍎
Speakers: Kivanc Birsoy, Christine Chio, Marcia Haigis, Andy Intlekofer, Thales PapaG, Jared Rutter, Dan Wahl, Eileen White
Speakers: Kivanc Birsoy, Christine Chio, Marcia Haigis, Andy Intlekofer, Thales PapaG, Jared Rutter, Dan Wahl, Eileen White
February 5, 2025 at 3:35 PM
We are soliciting poster and short talk abstracts for the NYASciences Cancer Metabolism meeting. Just around the corner - join us for awesome metabolism in the Big Apple 🍎
Speakers: Kivanc Birsoy, Christine Chio, Marcia Haigis, Andy Intlekofer, Thales PapaG, Jared Rutter, Dan Wahl, Eileen White
Speakers: Kivanc Birsoy, Christine Chio, Marcia Haigis, Andy Intlekofer, Thales PapaG, Jared Rutter, Dan Wahl, Eileen White
Recruiting the next generation of Cancer Biology graduate students in matching Shah Lab swag 🔥
February 1, 2025 at 8:51 PM
Recruiting the next generation of Cancer Biology graduate students in matching Shah Lab swag 🔥
Metabolic pathways were a dominant feature in this analysis (to our enjoyment) 💪🏼 And the @NwosuLab has launched several projects based on these observations! Reach out to them for collaborations or to discuss!
January 8, 2025 at 2:00 PM
Metabolic pathways were a dominant feature in this analysis (to our enjoyment) 💪🏼 And the @NwosuLab has launched several projects based on these observations! Reach out to them for collaborations or to discuss!
Zeribe compiled all the existing publicly available datasets to narrow down a list of consistently, differentially, expressed genes… the majority of which have not been studied in PDAC! (Get to searching for your faves)
January 8, 2025 at 2:00 PM
Zeribe compiled all the existing publicly available datasets to narrow down a list of consistently, differentially, expressed genes… the majority of which have not been studied in PDAC! (Get to searching for your faves)
🚨New paper dropped from Zeribe (now @NwosuLab) @PascaLab, @LyssiotisLb in @JCI_insight
insight.jci.org/articles/vie...
insight.jci.org/articles/vie...
January 8, 2025 at 2:00 PM
🚨New paper dropped from Zeribe (now @NwosuLab) @PascaLab, @LyssiotisLb in @JCI_insight
insight.jci.org/articles/vie...
insight.jci.org/articles/vie...
The end of an era. @brandontwchen.bsky.social brought us kicking & screaming into cell biology, and what an exciting journey it’s been. We are so very proud of everything he’s accomplished! Join us 1/17 for his defense. Thereafter… watch out NYC, here he comes!!
January 3, 2025 at 6:34 PM
The end of an era. @brandontwchen.bsky.social brought us kicking & screaming into cell biology, and what an exciting journey it’s been. We are so very proud of everything he’s accomplished! Join us 1/17 for his defense. Thereafter… watch out NYC, here he comes!!
New TrendsinBiotech w/ Shea Lab, led by Kate & Michael. We cover concepts bridging nano/materials and immunity; e.g., nanoparticles can be designed with immune-modulatory metabolites (poly-lactate) 😎
t.co/3FQRYgsMvv
t.co/3FQRYgsMvv
December 30, 2024 at 12:00 PM
New TrendsinBiotech w/ Shea Lab, led by Kate & Michael. We cover concepts bridging nano/materials and immunity; e.g., nanoparticles can be designed with immune-modulatory metabolites (poly-lactate) 😎
t.co/3FQRYgsMvv
t.co/3FQRYgsMvv
Helpful infographic from the NCI on the new K32 mechanism
December 29, 2024 at 9:15 PM
Helpful infographic from the NCI on the new K32 mechanism
The NCI is discontinuing the F32 postdoctoral fellowship. Is there a backstory here?
December 11, 2024 at 3:29 PM
The NCI is discontinuing the F32 postdoctoral fellowship. Is there a backstory here?
If you are attending #ASCB2024, check out this suite of Shah/Lyssiotis Lab presentations!
@brandontwchen.bsky.social
@brandontwchen.bsky.social
December 9, 2024 at 5:12 PM
If you are attending #ASCB2024, check out this suite of Shah/Lyssiotis Lab presentations!
@brandontwchen.bsky.social
@brandontwchen.bsky.social
>4 years? Remarkable fortitude 💪🏼
December 6, 2024 at 2:08 PM
>4 years? Remarkable fortitude 💪🏼
Friends in Ann Arbor: join us today at 3PM for Heather Giza’s PhD defense and to celebrate her many accomplishments!
December 6, 2024 at 2:06 PM
Friends in Ann Arbor: join us today at 3PM for Heather Giza’s PhD defense and to celebrate her many accomplishments!
Is BluSky ready for this much Mo?
This group of Dudes is serious about Mo’s and about raising awareness for men’s mental health and cancer research 👨🏻💪🏼 #Movember
@ja-nietocarrion.bsky.social
This group of Dudes is serious about Mo’s and about raising awareness for men’s mental health and cancer research 👨🏻💪🏼 #Movember
@ja-nietocarrion.bsky.social
December 2, 2024 at 8:23 PM
Is BluSky ready for this much Mo?
This group of Dudes is serious about Mo’s and about raising awareness for men’s mental health and cancer research 👨🏻💪🏼 #Movember
@ja-nietocarrion.bsky.social
This group of Dudes is serious about Mo’s and about raising awareness for men’s mental health and cancer research 👨🏻💪🏼 #Movember
@ja-nietocarrion.bsky.social
Undergrads, looking for a summer research opportunity in cancer biology? Consider applying for a CARSIP position! Details below 👇🏼
Please [re] circulate widely 🔁!
Please [re] circulate widely 🔁!
November 25, 2024 at 10:33 PM
Undergrads, looking for a summer research opportunity in cancer biology? Consider applying for a CARSIP position! Details below 👇🏼
Please [re] circulate widely 🔁!
Please [re] circulate widely 🔁!
1/ Mary, Muneesh, & Pavan are not on this platform, so let me blow this up💥
In short, 🥔 dietary approach 🥔 to address graft vs host disease in patients post stem cell transplant.
t.co/oisx7wOkFO
In short, 🥔 dietary approach 🥔 to address graft vs host disease in patients post stem cell transplant.
t.co/oisx7wOkFO
October 21, 2023 at 11:46 PM
1/ Mary, Muneesh, & Pavan are not on this platform, so let me blow this up💥
In short, 🥔 dietary approach 🥔 to address graft vs host disease in patients post stem cell transplant.
t.co/oisx7wOkFO
In short, 🥔 dietary approach 🥔 to address graft vs host disease in patients post stem cell transplant.
t.co/oisx7wOkFO
📢Peer reviewers with expertise in all things cancer and metabolism wanted.
Junior faculty and senior postdocs interested in peer review, in my new role at the journal Cancer & Metabolism, I am looking for you 🫵🏼! Reply or DM.
Please RT and share widely 🙏🏼
Junior faculty and senior postdocs interested in peer review, in my new role at the journal Cancer & Metabolism, I am looking for you 🫵🏼! Reply or DM.
Please RT and share widely 🙏🏼
October 21, 2023 at 11:37 PM
📢Peer reviewers with expertise in all things cancer and metabolism wanted.
Junior faculty and senior postdocs interested in peer review, in my new role at the journal Cancer & Metabolism, I am looking for you 🫵🏼! Reply or DM.
Please RT and share widely 🙏🏼
Junior faculty and senior postdocs interested in peer review, in my new role at the journal Cancer & Metabolism, I am looking for you 🫵🏼! Reply or DM.
Please RT and share widely 🙏🏼
Applications to apply to the Cancer Biology PhD graduate program through the Michigan Medicine Program in Biomedical Sciences (PIBS) are open through December 1st, 2023! Come join our amazing group of researchers!
Link to apply: medicine.umich.edu/medschool/ed...
Link to apply: medicine.umich.edu/medschool/ed...
October 21, 2023 at 1:41 AM
Applications to apply to the Cancer Biology PhD graduate program through the Michigan Medicine Program in Biomedical Sciences (PIBS) are open through December 1st, 2023! Come join our amazing group of researchers!
Link to apply: medicine.umich.edu/medschool/ed...
Link to apply: medicine.umich.edu/medschool/ed...
Collectively inspired Lyssiotis Lab Mission Statement.
October 20, 2023 at 1:08 AM
Collectively inspired Lyssiotis Lab Mission Statement.