MetaStem
@metastem.bsky.social
Centre of Excellence in Stem Cell Metabolism at University of Helsinki. Funded by Research Council of Finland, Suomen Akatemia. www.helsinki.fi/metastem
@MetaStem_Center on X
@MetaStem_Center on X
Next MetaStem PhD defense in two days, go Hien! 🎩
Welcome to the PhD defense of @hienbui.bsky.social Age-selective segregation of organelles in asymmetric stem cell division, on Fri 7 Nov at 1 pm, Biocenter 2, 2041. Opponent Prof Carien Niessen, University of Cologne @helsinki.fi @hilife-helsinki.bsky.social #publicdefense #phddefense
November 5, 2025 at 8:07 AM
Next MetaStem PhD defense in two days, go Hien! 🎩
Still time today to sign up and submit an abstract for this excellent symposium
Excited to announce our Stem Cell Metabolism Symposium organized in Helsinki on November 12th. Fantastic invited speakers Marcia Haigis, Lydia Finley, Matthias Hebrok and Tom MacVicar. Sign up by Oct 22nd, free of charge, welcome! @hilife-helsinki.bsky.social @helsinki.fi @stemmprogram.bsky.social
October 22, 2025 at 10:32 AM
Still time today to sign up and submit an abstract for this excellent symposium
Next MetaStem PhD defense coming up on Tuesday, go Simon 👏@simonsterson.bsky.social
On Tue Oct 14th @simonsterson.bsky.social will defend his thesis Age-selective organellar metabolism in tissue stem cell function, at 1 pm in Biocenter 2 2041, Viikki. Excited to have Jared Rutter @rutterlab.bsky.social as the opponent 🎩⚔️ Welcome! @metastem.bsky.social @hilife-helsinki.bsky.social
October 9, 2025 at 12:16 PM
Next MetaStem PhD defense coming up on Tuesday, go Simon 👏@simonsterson.bsky.social
Tomorrow, welcome!
Welcome to the Stem Cell Seminar next week Friday Oct 3rd at 9-11, ☕️🍪 at 8:30. Exciting science on embryo development, ECM, cancer and stem cells by Juha Kere and @johannaienglund.bsky.social labs. See you there! @hilife-helsinki.bsky.social @helsinki-biotech.bsky.social @stemmprogram.bsky.social
October 2, 2025 at 5:55 AM
Tomorrow, welcome!
Excited to announce our Stem Cell Metabolism Symposium organized in Helsinki on November 12th. Fantastic invited speakers Marcia Haigis, Lydia Finley, Matthias Hebrok and Tom MacVicar. Sign up by Oct 22nd, free of charge, welcome! @hilife-helsinki.bsky.social @helsinki.fi @stemmprogram.bsky.social
October 1, 2025 at 10:33 AM
Excited to announce our Stem Cell Metabolism Symposium organized in Helsinki on November 12th. Fantastic invited speakers Marcia Haigis, Lydia Finley, Matthias Hebrok and Tom MacVicar. Sign up by Oct 22nd, free of charge, welcome! @hilife-helsinki.bsky.social @helsinki.fi @stemmprogram.bsky.social
Welcome to the Stem Cell Seminar next week Friday Oct 3rd at 9-11, ☕️🍪 at 8:30. Exciting science on embryo development, ECM, cancer and stem cells by Juha Kere and @johannaienglund.bsky.social labs. See you there! @hilife-helsinki.bsky.social @helsinki-biotech.bsky.social @stemmprogram.bsky.social
September 24, 2025 at 6:21 AM
Welcome to the Stem Cell Seminar next week Friday Oct 3rd at 9-11, ☕️🍪 at 8:30. Exciting science on embryo development, ECM, cancer and stem cells by Juha Kere and @johannaienglund.bsky.social labs. See you there! @hilife-helsinki.bsky.social @helsinki-biotech.bsky.social @stemmprogram.bsky.social
Reposted by MetaStem
#CFM_MolCellAging: The third session will deal with the regulation of aging processes, with talks by
@pekka-katajisto.bsky.social @metastem.bsky.social @helsinki.fi and Salvador Aznar @irbbarcelona.org
Registration: http://bit.ly/4kOyYch
🤝With support of @caixaresearch.bsky.social
@pekka-katajisto.bsky.social @metastem.bsky.social @helsinki.fi and Salvador Aznar @irbbarcelona.org
Registration: http://bit.ly/4kOyYch
🤝With support of @caixaresearch.bsky.social
September 11, 2025 at 12:02 PM
#CFM_MolCellAging: The third session will deal with the regulation of aging processes, with talks by
@pekka-katajisto.bsky.social @metastem.bsky.social @helsinki.fi and Salvador Aznar @irbbarcelona.org
Registration: http://bit.ly/4kOyYch
🤝With support of @caixaresearch.bsky.social
@pekka-katajisto.bsky.social @metastem.bsky.social @helsinki.fi and Salvador Aznar @irbbarcelona.org
Registration: http://bit.ly/4kOyYch
🤝With support of @caixaresearch.bsky.social
Welcome to the Metabolism seminar tomorrow in Viikki. Excited to have @nunuping.bsky.social and @sirakarvinen.bsky.social groups present their research
September 8, 2025 at 5:22 PM
Welcome to the Metabolism seminar tomorrow in Viikki. Excited to have @nunuping.bsky.social and @sirakarvinen.bsky.social groups present their research
News from our CoE by @katajistolab.bsky.social @simonsterson.bsky.social found that intestinal stem cells with old mitochondria make Paneth cells faster due to higher aKG levels and aKG improves regeneration in old animals by renewal of Paneth cells. www.nature.com/articles/s42... @helsinki.fi
Old mitochondria regulate niche renewal via α-ketoglutarate metabolism in stem cells - Nature Metabolism
Andersson et al. show that intestinal stem cells enriched for old mitochondria are metabolically distinct and have enhanced ability to regenerate the epithelial niche.
www.nature.com
July 28, 2025 at 8:01 AM
News from our CoE by @katajistolab.bsky.social @simonsterson.bsky.social found that intestinal stem cells with old mitochondria make Paneth cells faster due to higher aKG levels and aKG improves regeneration in old animals by renewal of Paneth cells. www.nature.com/articles/s42... @helsinki.fi
News from our CoE by @otonkoskit.bsky.social lab, Eliisa Vähäkangas et al show that upon engraftment into mice stem cell derived pancreatic islets become insensitive to pyruvate, correlating with down regulation of the pyruvate/lactate transporter MCT1. link.springer.com/article/10.1... @helsinki.fi
Stem-cell-derived beta cells mature metabolically upon murine engraftment - Diabetologia
Aims/hypothesis The use of stem-cell-derived islets (SC-islets) as a source for cell-based therapy of type 1 diabetes shows great potential. However, SC-islets have a metabolically immature phenotype ...
link.springer.com
July 28, 2025 at 7:46 AM
News from our CoE by @otonkoskit.bsky.social lab, Eliisa Vähäkangas et al show that upon engraftment into mice stem cell derived pancreatic islets become insensitive to pyruvate, correlating with down regulation of the pyruvate/lactate transporter MCT1. link.springer.com/article/10.1... @helsinki.fi
Reposted by MetaStem
Proudly presenting Simon’s @simonsterson.bsky.social paper on asymmetric apportioning of old mitochondria biasing intestinal stem cells for the Paneth cell linage through aKG-dependent metabolism
@naturemetabolism.bsky.social www.nature.com/articles/s42... @helsinki.fi @metastem.bsky.social 🧵1/8
@naturemetabolism.bsky.social www.nature.com/articles/s42... @helsinki.fi @metastem.bsky.social 🧵1/8
Old mitochondria regulate niche renewal via α-ketoglutarate metabolism in stem cells - Nature Metabolism
Andersson et al. show that intestinal stem cells enriched for old mitochondria are metabolically distinct and have enhanced ability to regenerate the epithelial niche.
www.nature.com
July 14, 2025 at 10:21 AM
Proudly presenting Simon’s @simonsterson.bsky.social paper on asymmetric apportioning of old mitochondria biasing intestinal stem cells for the Paneth cell linage through aKG-dependent metabolism
@naturemetabolism.bsky.social www.nature.com/articles/s42... @helsinki.fi @metastem.bsky.social 🧵1/8
@naturemetabolism.bsky.social www.nature.com/articles/s42... @helsinki.fi @metastem.bsky.social 🧵1/8
News from our CoE by @htyynismaa.bsky.social group characterize the role of mitochondrial intermembrane space protein CHCHD10 in metabolism and spinal muscular atrophy Jokela type (SMAJ) actaneurocomms.biomedcentral.com/articles/10.... Congratulations Sandra! @helsinki.fi @stemmprogram.bsky.social
Dose-dependent CHCHD10 dysregulation dictates motor neuron disease severity and alters creatine metabolism - Acta Neuropathologica Communications
Dominant defects in CHCHD10, a mitochondrial intermembrane space protein, lead to a range of neurological and muscle disease phenotypes including amyotrophic lateral sclerosis. Many patients present w...
actaneurocomms.biomedcentral.com
May 22, 2025 at 6:00 AM
News from our CoE by @htyynismaa.bsky.social group characterize the role of mitochondrial intermembrane space protein CHCHD10 in metabolism and spinal muscular atrophy Jokela type (SMAJ) actaneurocomms.biomedcentral.com/articles/10.... Congratulations Sandra! @helsinki.fi @stemmprogram.bsky.social
Reposted by MetaStem
Hien’s peroxisome story is out! Amazing effort starting from description of a new phenomenon, building in vivo tools, and describing how sub-cellular localization of metabolic activities can guide stem cell fate. Congrats Hien and thank you to the great collaborators!
Happy to present Hien’s paper on age-selective apportioning of peroxisomes as a fate determinant in adult stem cells www.nature.com/articles/s41... @metastem.bsky.social @helsinki.fi @ki.se @helsinki-biotech.bsky.social out now in @natcomms.nature.com
A thread 🧵 1/9
A thread 🧵 1/9
Glucose-6-phosphate-dehydrogenase on old peroxisomes maintains self-renewal of epithelial stem cells after asymmetric cell division - Nature Communications
Peroxisomes are essential but their role in cell fate regulation remains understudied. Here, the authors reveal that young and old peroxisomes are not equally distributed in asymmetrically dividing st...
www.nature.com
April 28, 2025 at 8:24 PM
Hien’s peroxisome story is out! Amazing effort starting from description of a new phenomenon, building in vivo tools, and describing how sub-cellular localization of metabolic activities can guide stem cell fate. Congrats Hien and thank you to the great collaborators!
Last Friday Pooja Manjunath successfully defended her thesis on Mitochondrial proteostasis and structure. Well done Dr Pooja 🎩👏 @htyynismaa.bsky.social @stemmprogram.bsky.social
April 28, 2025 at 12:58 PM
Last Friday Pooja Manjunath successfully defended her thesis on Mitochondrial proteostasis and structure. Well done Dr Pooja 🎩👏 @htyynismaa.bsky.social @stemmprogram.bsky.social
A new study from our CoE finds that stem cells can control whether they self-renew or differentiate by localizing certain metabolic reactions differently www.helsinki.fi/en/faculty-b... @helsinki.fi @helsinki-biotech.bsky.social #stemcell #metabolism #peroxisome
Organelle age guides tissue renewal through subcellular compartmentalization of metabolism | Faculty of Biological and Environmental Sciences | University of Helsinki
A new study sheds light on the mechanisms that regulate how our tissues develop and are constantly renewed to keep up their function. In the future, these results might contribute to the understanding...
www.helsinki.fi
April 28, 2025 at 11:35 AM
A new study from our CoE finds that stem cells can control whether they self-renew or differentiate by localizing certain metabolic reactions differently www.helsinki.fi/en/faculty-b... @helsinki.fi @helsinki-biotech.bsky.social #stemcell #metabolism #peroxisome
News for our CoE by @katajistolab.bsky.social show how tissue stem cells can metabolically regulate tissue renewal and differentiation by providing daughter cells with peroxisomes of different age and metabolic properties nature.com/articles/s41... @helsinki.fi @helsinki-biotech.bsky.social
Glucose-6-phosphate-dehydrogenase on old peroxisomes maintains self-renewal of epithelial stem cells after asymmetric cell division - Nature Communications
Peroxisomes are essential but their role in cell fate regulation remains understudied. Here, the authors reveal that young and old peroxisomes are not equally distributed in asymmetrically dividing st...
nature.com
April 28, 2025 at 11:32 AM
News for our CoE by @katajistolab.bsky.social show how tissue stem cells can metabolically regulate tissue renewal and differentiation by providing daughter cells with peroxisomes of different age and metabolic properties nature.com/articles/s41... @helsinki.fi @helsinki-biotech.bsky.social
Reposted by MetaStem
Happy to present Hien’s paper on age-selective apportioning of peroxisomes as a fate determinant in adult stem cells www.nature.com/articles/s41... @metastem.bsky.social @helsinki.fi @ki.se @helsinki-biotech.bsky.social out now in @natcomms.nature.com
A thread 🧵 1/9
A thread 🧵 1/9
Glucose-6-phosphate-dehydrogenase on old peroxisomes maintains self-renewal of epithelial stem cells after asymmetric cell division - Nature Communications
Peroxisomes are essential but their role in cell fate regulation remains understudied. Here, the authors reveal that young and old peroxisomes are not equally distributed in asymmetrically dividing st...
www.nature.com
April 28, 2025 at 10:49 AM
Happy to present Hien’s paper on age-selective apportioning of peroxisomes as a fate determinant in adult stem cells www.nature.com/articles/s41... @metastem.bsky.social @helsinki.fi @ki.se @helsinki-biotech.bsky.social out now in @natcomms.nature.com
A thread 🧵 1/9
A thread 🧵 1/9
Reposted by MetaStem
Glad to be highlighted as FutureLeaders in Cancer research by Cancer Grand Challenges @cancergrand.bsky.social. Thank you! @fimm-uh.bsky.social, @helsinki-biotech.bsky.social, @metastem.bsky.social, @cruk-si.bsky.social.
features.cancerresearchuk.org/cancergrandc...
features.cancerresearchuk.org/cancergrandc...
April 28, 2025 at 5:22 AM
Glad to be highlighted as FutureLeaders in Cancer research by Cancer Grand Challenges @cancergrand.bsky.social. Thank you! @fimm-uh.bsky.social, @helsinki-biotech.bsky.social, @metastem.bsky.social, @cruk-si.bsky.social.
features.cancerresearchuk.org/cancergrandc...
features.cancerresearchuk.org/cancergrandc...
Tomorrow, welcome!
Welcome to the Stem Cell Seminar April 23rd. Stem cell metabolism of both tissue and pluripotent stem cells on the menu with exiting presentations from @rafabolism.bsky.social and @rutorregrosa.bsky.social @stemmprogram.bsky.social @helsinki.fi @helsinki-biotech.bsky.social @fimm-uh.bsky.social
April 22, 2025 at 10:02 AM
Tomorrow, welcome!
MetaStem PhD defence 🎩 April 25th at 12 Pooja Manjunath from @htyynismaa.bsky.social lab will defend her thesis Preserving Mitochondrial Proteostasis and Structure-The Roles of Mitochondrial Co-Chaperones GRPEL1, GRPEL2, and Small Protein NERCLIN in Porthania PIII. Opponent Prof Kostas Tokatlidis 👏
April 17, 2025 at 12:32 PM
MetaStem PhD defence 🎩 April 25th at 12 Pooja Manjunath from @htyynismaa.bsky.social lab will defend her thesis Preserving Mitochondrial Proteostasis and Structure-The Roles of Mitochondrial Co-Chaperones GRPEL1, GRPEL2, and Small Protein NERCLIN in Porthania PIII. Opponent Prof Kostas Tokatlidis 👏
Reposted by MetaStem
Welcome to the Stem Cell Seminar April 23rd. Stem cell metabolism of both tissue and pluripotent stem cells on the menu with exiting presentations from @rafabolism.bsky.social and @rutorregrosa.bsky.social @stemmprogram.bsky.social @helsinki.fi @helsinki-biotech.bsky.social @fimm-uh.bsky.social
April 8, 2025 at 12:22 PM
Welcome to the Stem Cell Seminar April 23rd. Stem cell metabolism of both tissue and pluripotent stem cells on the menu with exiting presentations from @rafabolism.bsky.social and @rutorregrosa.bsky.social @stemmprogram.bsky.social @helsinki.fi @helsinki-biotech.bsky.social @fimm-uh.bsky.social
Welcome to the Stem Cell Seminar April 23rd. Stem cell metabolism of both tissue and pluripotent stem cells on the menu with exiting presentations from @rafabolism.bsky.social and @rutorregrosa.bsky.social @stemmprogram.bsky.social @helsinki.fi @helsinki-biotech.bsky.social @fimm-uh.bsky.social
April 8, 2025 at 12:22 PM
Welcome to the Stem Cell Seminar April 23rd. Stem cell metabolism of both tissue and pluripotent stem cells on the menu with exiting presentations from @rafabolism.bsky.social and @rutorregrosa.bsky.social @stemmprogram.bsky.social @helsinki.fi @helsinki-biotech.bsky.social @fimm-uh.bsky.social
Reposted by MetaStem
The @katajistolab.bsky.social modeled #epithelial regeneration using small intestinal scaffolds and identified #asporin is a mediator of fetal-like reprogramming.
Read the @cp-cellstemcell.bsky.social article: bit.ly/41LJbhn
Listen to the conversation: bit.ly/4kTt36a
Read the @cp-cellstemcell.bsky.social article: bit.ly/41LJbhn
Listen to the conversation: bit.ly/4kTt36a
March 26, 2025 at 5:19 PM
The @katajistolab.bsky.social modeled #epithelial regeneration using small intestinal scaffolds and identified #asporin is a mediator of fetal-like reprogramming.
Read the @cp-cellstemcell.bsky.social article: bit.ly/41LJbhn
Listen to the conversation: bit.ly/4kTt36a
Read the @cp-cellstemcell.bsky.social article: bit.ly/41LJbhn
Listen to the conversation: bit.ly/4kTt36a
Tomorrow, welcome! 👇
Welcome to the next Metabolism seminar, March 18th at 9-11 am in Meilahti. Excellent speaker lineup with Kirsi Pietiläinen and Robin Cristofari groups presenting about #obesity #adiposetissue #diet #aging in humans and penguins @helsinki.fi @stemmprogram.bsky.social @helsinki-biotech.bsky.social
March 17, 2025 at 7:28 AM
Tomorrow, welcome! 👇
Welcome to the next Metabolism seminar, March 18th at 9-11 am in Meilahti. Excellent speaker lineup with Kirsi Pietiläinen and Robin Cristofari groups presenting about #obesity #adiposetissue #diet #aging in humans and penguins @helsinki.fi @stemmprogram.bsky.social @helsinki-biotech.bsky.social
March 10, 2025 at 11:37 AM
Welcome to the next Metabolism seminar, March 18th at 9-11 am in Meilahti. Excellent speaker lineup with Kirsi Pietiläinen and Robin Cristofari groups presenting about #obesity #adiposetissue #diet #aging in humans and penguins @helsinki.fi @stemmprogram.bsky.social @helsinki-biotech.bsky.social