KatajistoLab
@katajistolab.bsky.social
Lab of Pekka Katajisto @pekka-katajisto.bsky.social at University of Helsinki and Karolinska Institutet. We study stem cells, aging, metabolism, organelle age and niche interactions https://www.katajisto-lab.com
Pinned
KatajistoLab
@katajistolab.bsky.social
· Jul 14
Old mitochondria regulate niche renewal via α-ketoglutarate metabolism in stem cells - Nature Metabolism
Andersson et al. show that intestinal stem cells enriched for old mitochondria are metabolically distinct and have enhanced ability to regenerate the epithelial niche.
www.nature.com
Proudly presenting Simon’s @simonsterson.bsky.social paper on asymmetric apportioning of old mitochondria biasing intestinal stem cells for the Paneth cell linage through aKG-dependent metabolism
@naturemetabolism.bsky.social www.nature.com/articles/s42... @helsinki.fi @metastem.bsky.social 🧵1/8
@naturemetabolism.bsky.social www.nature.com/articles/s42... @helsinki.fi @metastem.bsky.social 🧵1/8
Welcome to the PhD defense of @hienbui.bsky.social Age-selective segregation of organelles in asymmetric stem cell division, on Fri 7 Nov at 1 pm, Biocenter 2, 2041. Opponent Prof Carien Niessen, University of Cologne @helsinki.fi @hilife-helsinki.bsky.social #publicdefense #phddefense
November 5, 2025 at 7:59 AM
Welcome to the PhD defense of @hienbui.bsky.social Age-selective segregation of organelles in asymmetric stem cell division, on Fri 7 Nov at 1 pm, Biocenter 2, 2041. Opponent Prof Carien Niessen, University of Cologne @helsinki.fi @hilife-helsinki.bsky.social #publicdefense #phddefense
Reposted by KatajistoLab
Suomen Akatemia on valinnut 11 uutta tutkimuksen huippuyksikköä ohjelmakaudelle 2026–2033. Niistä viittä johdetaan Helsingin yliopistosta.
Yhteensä yliopiston tutkijat ovat mukana kahdeksassa uudessa huippuyksikössä.
www.helsinki.fi/fi/uutiset/y...
Yhteensä yliopiston tutkijat ovat mukana kahdeksassa uudessa huippuyksikössä.
www.helsinki.fi/fi/uutiset/y...
Helsingin yliopisto johtaa viittä uutta tutkimuksen huippuyksikköä | Helsingin yliopisto
Suomen Akatemia on valinnut 11 uutta tutkimuksen huippuyksikköä ohjelmakaudelle 2026–2033. Niistä viittä johdetaan Helsingin yliopistosta, ja yhteensä yliopiston tutkijat ovat mukana kahdeksassa uudes...
www.helsinki.fi
October 30, 2025 at 12:17 PM
Suomen Akatemia on valinnut 11 uutta tutkimuksen huippuyksikköä ohjelmakaudelle 2026–2033. Niistä viittä johdetaan Helsingin yliopistosta.
Yhteensä yliopiston tutkijat ovat mukana kahdeksassa uudessa huippuyksikössä.
www.helsinki.fi/fi/uutiset/y...
Yhteensä yliopiston tutkijat ovat mukana kahdeksassa uudessa huippuyksikössä.
www.helsinki.fi/fi/uutiset/y...
Reposted by KatajistoLab
Still time today to sign up and submit an abstract for this excellent symposium
Excited to announce our Stem Cell Metabolism Symposium organized in Helsinki on November 12th. Fantastic invited speakers Marcia Haigis, Lydia Finley, Matthias Hebrok and Tom MacVicar. Sign up by Oct 22nd, free of charge, welcome! @hilife-helsinki.bsky.social @helsinki.fi @stemmprogram.bsky.social
October 22, 2025 at 10:32 AM
Still time today to sign up and submit an abstract for this excellent symposium
On Tue Oct 14th @simonsterson.bsky.social will defend his thesis Age-selective organellar metabolism in tissue stem cell function, at 1 pm in Biocenter 2 2041, Viikki. Excited to have Jared Rutter @rutterlab.bsky.social as the opponent 🎩⚔️ Welcome! @metastem.bsky.social @hilife-helsinki.bsky.social
October 9, 2025 at 12:11 PM
On Tue Oct 14th @simonsterson.bsky.social will defend his thesis Age-selective organellar metabolism in tissue stem cell function, at 1 pm in Biocenter 2 2041, Viikki. Excited to have Jared Rutter @rutterlab.bsky.social as the opponent 🎩⚔️ Welcome! @metastem.bsky.social @hilife-helsinki.bsky.social
Check out the symposium organized by our CoE, excited to have Marcia Haigis, @lydiafinley.bsky.social, Matthias Hebrok and Tom MacVicar over in Helsinki in November. Sign up by October 22nd 👇
Excited to announce our Stem Cell Metabolism Symposium organized in Helsinki on November 12th. Fantastic invited speakers Marcia Haigis, Lydia Finley, Matthias Hebrok and Tom MacVicar. Sign up by Oct 22nd, free of charge, welcome! @hilife-helsinki.bsky.social @helsinki.fi @stemmprogram.bsky.social
October 1, 2025 at 10:40 AM
Check out the symposium organized by our CoE, excited to have Marcia Haigis, @lydiafinley.bsky.social, Matthias Hebrok and Tom MacVicar over in Helsinki in November. Sign up by October 22nd 👇
Reposted by KatajistoLab
Welcome to the Stem Cell Seminar next week Friday Oct 3rd at 9-11, ☕️🍪 at 8:30. Exciting science on embryo development, ECM, cancer and stem cells by Juha Kere and @johannaienglund.bsky.social labs. See you there! @hilife-helsinki.bsky.social @helsinki-biotech.bsky.social @stemmprogram.bsky.social
September 24, 2025 at 6:21 AM
Welcome to the Stem Cell Seminar next week Friday Oct 3rd at 9-11, ☕️🍪 at 8:30. Exciting science on embryo development, ECM, cancer and stem cells by Juha Kere and @johannaienglund.bsky.social labs. See you there! @hilife-helsinki.bsky.social @helsinki-biotech.bsky.social @stemmprogram.bsky.social
Reposted by KatajistoLab
#CFM_MolCellAging: The third session will deal with the regulation of aging processes, with talks by
@pekka-katajisto.bsky.social @metastem.bsky.social @helsinki.fi and Salvador Aznar @irbbarcelona.org
Registration: http://bit.ly/4kOyYch
🤝With support of @caixaresearch.bsky.social
@pekka-katajisto.bsky.social @metastem.bsky.social @helsinki.fi and Salvador Aznar @irbbarcelona.org
Registration: http://bit.ly/4kOyYch
🤝With support of @caixaresearch.bsky.social
September 11, 2025 at 12:02 PM
#CFM_MolCellAging: The third session will deal with the regulation of aging processes, with talks by
@pekka-katajisto.bsky.social @metastem.bsky.social @helsinki.fi and Salvador Aznar @irbbarcelona.org
Registration: http://bit.ly/4kOyYch
🤝With support of @caixaresearch.bsky.social
@pekka-katajisto.bsky.social @metastem.bsky.social @helsinki.fi and Salvador Aznar @irbbarcelona.org
Registration: http://bit.ly/4kOyYch
🤝With support of @caixaresearch.bsky.social
Reposted by KatajistoLab
Pekka Katajisto @katajistolab.bsky.social introducing Nobel laureate Shinya Yamanaka who will talk about 2 of my favorite topics: sciences and marathons
September 5, 2025 at 10:06 AM
Pekka Katajisto @katajistolab.bsky.social introducing Nobel laureate Shinya Yamanaka who will talk about 2 of my favorite topics: sciences and marathons
Also read the research briefing on our latest paper in @natmetabolism.nature.com
July 15, 2025 at 1:28 PM
Also read the research briefing on our latest paper in @natmetabolism.nature.com
Reposted by KatajistoLab
Proudly presenting Simon’s @simonsterson.bsky.social paper on asymmetric apportioning of old mitochondria biasing intestinal stem cells for the Paneth cell linage through aKG-dependent metabolism
@naturemetabolism.bsky.social www.nature.com/articles/s42... @helsinki.fi @metastem.bsky.social 🧵1/8
@naturemetabolism.bsky.social www.nature.com/articles/s42... @helsinki.fi @metastem.bsky.social 🧵1/8
Old mitochondria regulate niche renewal via α-ketoglutarate metabolism in stem cells - Nature Metabolism
Andersson et al. show that intestinal stem cells enriched for old mitochondria are metabolically distinct and have enhanced ability to regenerate the epithelial niche.
www.nature.com
July 14, 2025 at 10:21 AM
Proudly presenting Simon’s @simonsterson.bsky.social paper on asymmetric apportioning of old mitochondria biasing intestinal stem cells for the Paneth cell linage through aKG-dependent metabolism
@naturemetabolism.bsky.social www.nature.com/articles/s42... @helsinki.fi @metastem.bsky.social 🧵1/8
@naturemetabolism.bsky.social www.nature.com/articles/s42... @helsinki.fi @metastem.bsky.social 🧵1/8
Thank you to the organizers of the fantastic meeting #CSMetabolites2025 Kivanc Birsoy @robzonculab.bsky.social and @cellpress.bsky.social editors Allyson Evans @kristabledsoe.bsky.social We had a fantastic time in Sitges, looking forward to this meeting happening again! @cellpressevents.bsky.social
May 15, 2025 at 8:26 AM
Thank you to the organizers of the fantastic meeting #CSMetabolites2025 Kivanc Birsoy @robzonculab.bsky.social and @cellpress.bsky.social editors Allyson Evans @kristabledsoe.bsky.social We had a fantastic time in Sitges, looking forward to this meeting happening again! @cellpressevents.bsky.social
Happy to present Hien’s paper on age-selective apportioning of peroxisomes as a fate determinant in adult stem cells www.nature.com/articles/s41... @metastem.bsky.social @helsinki.fi @ki.se @helsinki-biotech.bsky.social out now in @natcomms.nature.com
A thread 🧵 1/9
A thread 🧵 1/9
Glucose-6-phosphate-dehydrogenase on old peroxisomes maintains self-renewal of epithelial stem cells after asymmetric cell division - Nature Communications
Peroxisomes are essential but their role in cell fate regulation remains understudied. Here, the authors reveal that young and old peroxisomes are not equally distributed in asymmetrically dividing st...
www.nature.com
April 28, 2025 at 10:49 AM
Happy to present Hien’s paper on age-selective apportioning of peroxisomes as a fate determinant in adult stem cells www.nature.com/articles/s41... @metastem.bsky.social @helsinki.fi @ki.se @helsinki-biotech.bsky.social out now in @natcomms.nature.com
A thread 🧵 1/9
A thread 🧵 1/9
Reposted by KatajistoLab
Tomorrow, welcome!
Welcome to the Stem Cell Seminar April 23rd. Stem cell metabolism of both tissue and pluripotent stem cells on the menu with exiting presentations from @rafabolism.bsky.social and @rutorregrosa.bsky.social @stemmprogram.bsky.social @helsinki.fi @helsinki-biotech.bsky.social @fimm-uh.bsky.social
April 22, 2025 at 10:02 AM
Tomorrow, welcome!
Reposted by KatajistoLab
Welcome to the Stem Cell Seminar April 23rd. Stem cell metabolism of both tissue and pluripotent stem cells on the menu with exiting presentations from @rafabolism.bsky.social and @rutorregrosa.bsky.social @stemmprogram.bsky.social @helsinki.fi @helsinki-biotech.bsky.social @fimm-uh.bsky.social
April 8, 2025 at 12:22 PM
Welcome to the Stem Cell Seminar April 23rd. Stem cell metabolism of both tissue and pluripotent stem cells on the menu with exiting presentations from @rafabolism.bsky.social and @rutorregrosa.bsky.social @stemmprogram.bsky.social @helsinki.fi @helsinki-biotech.bsky.social @fimm-uh.bsky.social
Reposted by KatajistoLab
The @katajistolab.bsky.social modeled #epithelial regeneration using small intestinal scaffolds and identified #asporin is a mediator of fetal-like reprogramming.
Read the @cp-cellstemcell.bsky.social article: bit.ly/41LJbhn
Listen to the conversation: bit.ly/4kTt36a
Read the @cp-cellstemcell.bsky.social article: bit.ly/41LJbhn
Listen to the conversation: bit.ly/4kTt36a
March 26, 2025 at 5:19 PM
The @katajistolab.bsky.social modeled #epithelial regeneration using small intestinal scaffolds and identified #asporin is a mediator of fetal-like reprogramming.
Read the @cp-cellstemcell.bsky.social article: bit.ly/41LJbhn
Listen to the conversation: bit.ly/4kTt36a
Read the @cp-cellstemcell.bsky.social article: bit.ly/41LJbhn
Listen to the conversation: bit.ly/4kTt36a
Reposted by KatajistoLab
1/6 Proudly presenting Sharif’s @sharifiqbal.bsky.social paper on the role of Asporin in intestinal regeneration through TGF-B-dependent fetal-like reversion www.sciencedirect.com/science/arti... out in @cp-cellstemcell.bsky.social @pekka-katajisto.bsky.social @helsinki.fi @metastem.bsky.social 🧵
Fetal-like reversion in the regenerating intestine is regulated by mesenchymal asporin
Mesenchymal cells and the extracellular matrix (ECM) support epithelium during homeostasis and regeneration. However, the role of the mesenchyme in ep…
www.sciencedirect.com
March 7, 2025 at 12:30 PM
1/6 Proudly presenting Sharif’s @sharifiqbal.bsky.social paper on the role of Asporin in intestinal regeneration through TGF-B-dependent fetal-like reversion www.sciencedirect.com/science/arti... out in @cp-cellstemcell.bsky.social @pekka-katajisto.bsky.social @helsinki.fi @metastem.bsky.social 🧵
1/6 Proudly presenting Sharif’s @sharifiqbal.bsky.social paper on the role of Asporin in intestinal regeneration through TGF-B-dependent fetal-like reversion www.sciencedirect.com/science/arti... out in @cp-cellstemcell.bsky.social @pekka-katajisto.bsky.social @helsinki.fi @metastem.bsky.social 🧵
Fetal-like reversion in the regenerating intestine is regulated by mesenchymal asporin
Mesenchymal cells and the extracellular matrix (ECM) support epithelium during homeostasis and regeneration. However, the role of the mesenchyme in ep…
www.sciencedirect.com
March 7, 2025 at 12:30 PM
1/6 Proudly presenting Sharif’s @sharifiqbal.bsky.social paper on the role of Asporin in intestinal regeneration through TGF-B-dependent fetal-like reversion www.sciencedirect.com/science/arti... out in @cp-cellstemcell.bsky.social @pekka-katajisto.bsky.social @helsinki.fi @metastem.bsky.social 🧵
Excited that Pekka is presenting at @CellSymposia Metabolites: Organellar Communication in Health and Disease this May 11–13, 2025, in Sitges, Spain!
The abstract submission deadline has been extended until Feb 14th. Hope to see you at #CSMetabolites2025
cell-symposia.com/metabolites-...
The abstract submission deadline has been extended until Feb 14th. Hope to see you at #CSMetabolites2025
cell-symposia.com/metabolites-...
Home – Cell Symposia: Metabolites: organellar communication in health and disease
Cell Symposia: Metabolites: organellar communication in health and disease
cell-symposia.com
January 30, 2025 at 7:12 AM
Excited that Pekka is presenting at @CellSymposia Metabolites: Organellar Communication in Health and Disease this May 11–13, 2025, in Sitges, Spain!
The abstract submission deadline has been extended until Feb 14th. Hope to see you at #CSMetabolites2025
cell-symposia.com/metabolites-...
The abstract submission deadline has been extended until Feb 14th. Hope to see you at #CSMetabolites2025
cell-symposia.com/metabolites-...
Reposted by KatajistoLab
Finishing the year with 1st preprint from the lab! Together with @katajistolab.bsky.social and @valerioizzi.bsky.social we investigated the role of basement membrane protein Lama5 and found it is critical for luminal breast cancer initiation and growth
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Tumour-derived LAMA5 is critical for tumour initiation and controls progression and phenotype in luminal breast cancer
Basement membrane (BM) supports and regulates the structural integrity, function and differentiation of epithelial tissues and protects against stromal invasion of breast cancer cells. Here we show th...
www.biorxiv.org
December 28, 2024 at 9:28 AM
Finishing the year with 1st preprint from the lab! Together with @katajistolab.bsky.social and @valerioizzi.bsky.social we investigated the role of basement membrane protein Lama5 and found it is critical for luminal breast cancer initiation and growth
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...