Muir Lab
@muirlab.bsky.social
Reposted by Muir Lab
Melanoma cells that spread to lymph nodes depend on FSP1 to survive, revealing a new metabolic vulnerability. New study in Nature by @mariopalma.bsky.social @ubellackerlab.bsky.social and colleagues shows that blocking FSP1 triggers ferroptosis and suppresses tumor growth in lymph node metastases.
Lymph node environment drives FSP1 targetability in metastasizing melanoma - Nature
Targeting FSP1 in lymph nodes has considerable potential for blocking melanoma progression.
www.nature.com
November 5, 2025 at 5:28 PM
Melanoma cells that spread to lymph nodes depend on FSP1 to survive, revealing a new metabolic vulnerability. New study in Nature by @mariopalma.bsky.social @ubellackerlab.bsky.social and colleagues shows that blocking FSP1 triggers ferroptosis and suppresses tumor growth in lymph node metastases.
Reposted by Muir Lab
Excited to share our study out in @natcellbio.nature.com! Led by @mikelangelipid.bsky.social, we identify the first #LipidDroplet lipid quality control pathway: LD-localized FSP1 protects stored lipids from oxidative damage and prevents LD-initiated #ferroptosis.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
FSP1-mediated lipid droplet quality control prevents neutral lipid peroxidation and ferroptosis - Nature Cell Biology
Lange et al. identify a lipid droplet quality control pathway in which FSP1 safeguards stored neutral lipids from lipid peroxidation, thereby preventing the induction of ferroptosis.
www.nature.com
October 29, 2025 at 5:21 PM
Excited to share our study out in @natcellbio.nature.com! Led by @mikelangelipid.bsky.social, we identify the first #LipidDroplet lipid quality control pathway: LD-localized FSP1 protects stored lipids from oxidative damage and prevents LD-initiated #ferroptosis.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Muir Lab
Our work detailing the metabolic roles of serum for cancer cell proliferation is now out at JBC, @asbmbjournals.bsky.social!
Congrats to Oliver and Eric and many thanks to the editor and reviewers for a thoughtful and efficient review process.
See here:
www.sciencedirect.com/science/arti...
Congrats to Oliver and Eric and many thanks to the editor and reviewers for a thoughtful and efficient review process.
See here:
www.sciencedirect.com/science/arti...
October 13, 2025 at 8:47 PM
Our work detailing the metabolic roles of serum for cancer cell proliferation is now out at JBC, @asbmbjournals.bsky.social!
Congrats to Oliver and Eric and many thanks to the editor and reviewers for a thoughtful and efficient review process.
See here:
www.sciencedirect.com/science/arti...
Congrats to Oliver and Eric and many thanks to the editor and reviewers for a thoughtful and efficient review process.
See here:
www.sciencedirect.com/science/arti...
Reposted by Muir Lab
Repost! Please apply by October 15th for full consideration.
We have an Open Rank tenure-track faculty position in the Department of Nutrition & Integrative Physiology! Looking for a new colleague interested in making the University of Utah their new home to build a metabolic research program. Please share! @uofunuip.bsky.social
Open Rank, Tenure Track Position – Metabolic Physiology - Salt Lake City, Utah job with University of Utah | 674355
The Department of Nutrition and Integrated Physiology (NUIP) at the University of Utah seeks a Tenure Track faculty member at the rank of Assistant...
jobs.sciencecareers.org
October 12, 2025 at 11:50 PM
Repost! Please apply by October 15th for full consideration.
Reposted by Muir Lab
Just out in @science.org: Together with the lab of @wilhelmpalm.bsky.social, we used sequential in-vitro/in-vivo CRISPR screens to decipher metabolic adaptations in tumors. We find that acidosis is a dominant factor that shapes energy metabolism and stress resilience. www.science.org/doi/10.1126/...
October 9, 2025 at 7:37 PM
Just out in @science.org: Together with the lab of @wilhelmpalm.bsky.social, we used sequential in-vitro/in-vivo CRISPR screens to decipher metabolic adaptations in tumors. We find that acidosis is a dominant factor that shapes energy metabolism and stress resilience. www.science.org/doi/10.1126/...
Reposted by Muir Lab
A microneedle device for rapid dermal interstitial fluid sampling @stanforduniversity.bsky.social 🇺🇲 www.science.org/doi/10.1126/...
A microneedle device for rapid dermal interstitial fluid sampling
A device collects enough skin interstitial fluid for omics studies in just five minutes.
www.science.org
September 24, 2025 at 7:33 PM
A microneedle device for rapid dermal interstitial fluid sampling @stanforduniversity.bsky.social 🇺🇲 www.science.org/doi/10.1126/...
Super excited to share our new preprint from @cssheehan.bsky.social on how the tumor microenvironment causes drug resistance in pancreatic cancer: www.biorxiv.org/content/10.1...
Tumor nutrient stress gives rise to a drug tolerant cell state in pancreatic cancer
Cytotoxic chemotherapy remains the standard-of-care treatment for patients with pancreatic ductal adenocarcinoma (PDAC). However, chemotherapy only has modest effects at improving patient survival due...
www.biorxiv.org
September 9, 2025 at 9:38 PM
Super excited to share our new preprint from @cssheehan.bsky.social on how the tumor microenvironment causes drug resistance in pancreatic cancer: www.biorxiv.org/content/10.1...
Reposted by Muir Lab
An alternative route for β-hydroxybutyrate metabolism supports cytosolic acetyl-CoA synthesis in cancer cells www.nature.com/articles/s42...
An alternative route for β-hydroxybutyrate metabolism supports cytosolic acetyl-CoA synthesis in cancer cells - Nature Metabolism
Kaluba, Rogers et al. show that in cancer cells that can metabolize ketones, they may reroute them to produce cytosolic acetyl-CoA and support tumour growth.
www.nature.com
September 8, 2025 at 11:29 AM
An alternative route for β-hydroxybutyrate metabolism supports cytosolic acetyl-CoA synthesis in cancer cells www.nature.com/articles/s42...
Reposted by Muir Lab
I am thrilled to share that I have received an ERC Starting Grant for our project SpaceMet!
I am grateful for the ERC’s commitment to ambitious early-stage research and to KU Leuven for their support!
Stay tuned, new postdoc positions coming soon!I @erc.europa.eu @kuleuvenuniversity.bsky.social
I am grateful for the ERC’s commitment to ambitious early-stage research and to KU Leuven for their support!
Stay tuned, new postdoc positions coming soon!I @erc.europa.eu @kuleuvenuniversity.bsky.social
September 5, 2025 at 10:48 AM
I am thrilled to share that I have received an ERC Starting Grant for our project SpaceMet!
I am grateful for the ERC’s commitment to ambitious early-stage research and to KU Leuven for their support!
Stay tuned, new postdoc positions coming soon!I @erc.europa.eu @kuleuvenuniversity.bsky.social
I am grateful for the ERC’s commitment to ambitious early-stage research and to KU Leuven for their support!
Stay tuned, new postdoc positions coming soon!I @erc.europa.eu @kuleuvenuniversity.bsky.social
Reposted by Muir Lab
Hot off the presses! Was an honor to team up with Scott Dixon @stanforduniversity.bsky.social on this Nature Cancer review. We reflect on hurdles that have slowed translation of ferroptosis-directed therapies and share ideas on what it will take to bring these therapies to the clinic. rdcu.be/eBbqV
August 18, 2025 at 3:42 PM
Hot off the presses! Was an honor to team up with Scott Dixon @stanforduniversity.bsky.social on this Nature Cancer review. We reflect on hurdles that have slowed translation of ferroptosis-directed therapies and share ideas on what it will take to bring these therapies to the clinic. rdcu.be/eBbqV
Reposted by Muir Lab
🚨Preprint alert 🚨
We identify riboflavin (vitamin B₂) as a key modulator of ferroptosis sensitivity via stabilizing FSP1 & recycling lipid-soluble antioxidants.
www.biorxiv.org/content/10.1....
pls check @olzmannlab.bsky.social
www.biorxiv.org/content/10.1...
#ferroptosis #FSP1 #antioxidants
We identify riboflavin (vitamin B₂) as a key modulator of ferroptosis sensitivity via stabilizing FSP1 & recycling lipid-soluble antioxidants.
www.biorxiv.org/content/10.1....
pls check @olzmannlab.bsky.social
www.biorxiv.org/content/10.1...
#ferroptosis #FSP1 #antioxidants
Riboflavin metabolism shapes FSP1-driven ferroptosis resistance
Membrane protection against oxidative insults is achieved by the concerted action of glutathione peroxidase 4 (GPX4) and endogenous lipophilic antioxidants such as ubiquinone and vitamin E. Deficienci...
www.biorxiv.org
August 6, 2025 at 8:38 AM
🚨Preprint alert 🚨
We identify riboflavin (vitamin B₂) as a key modulator of ferroptosis sensitivity via stabilizing FSP1 & recycling lipid-soluble antioxidants.
www.biorxiv.org/content/10.1....
pls check @olzmannlab.bsky.social
www.biorxiv.org/content/10.1...
#ferroptosis #FSP1 #antioxidants
We identify riboflavin (vitamin B₂) as a key modulator of ferroptosis sensitivity via stabilizing FSP1 & recycling lipid-soluble antioxidants.
www.biorxiv.org/content/10.1....
pls check @olzmannlab.bsky.social
www.biorxiv.org/content/10.1...
#ferroptosis #FSP1 #antioxidants
Reposted by Muir Lab
Join me in Boston October 6th for a 1-day conference on #mappingbiology to transform #cancertherapeutics. Register by September 25th to benefit from the complimentary (free) admission! Topics, speakers, and talk opportunities here: abcam.me/mappingbiolo...
@abcamofficial.bsky.social
@abcamofficial.bsky.social
August 5, 2025 at 6:59 PM
Join me in Boston October 6th for a 1-day conference on #mappingbiology to transform #cancertherapeutics. Register by September 25th to benefit from the complimentary (free) admission! Topics, speakers, and talk opportunities here: abcam.me/mappingbiolo...
@abcamofficial.bsky.social
@abcamofficial.bsky.social
Reposted by Muir Lab
We have an Open Rank tenure-track faculty position in the Department of Nutrition & Integrative Physiology! Looking for a new colleague interested in making the University of Utah their new home to build a metabolic research program. Please share! @uofunuip.bsky.social
Open Rank, Tenure Track Position – Metabolic Physiology - Salt Lake City, Utah job with University of Utah | 674355
The Department of Nutrition and Integrated Physiology (NUIP) at the University of Utah seeks a Tenure Track faculty member at the rank of Assistant...
jobs.sciencecareers.org
July 21, 2025 at 7:25 PM
We have an Open Rank tenure-track faculty position in the Department of Nutrition & Integrative Physiology! Looking for a new colleague interested in making the University of Utah their new home to build a metabolic research program. Please share! @uofunuip.bsky.social
Reposted by Muir Lab
Fantastic meeting 🤩🤩
thank you @olzmannlab.bsky.social and Scott Dixon for the organisation and for all the colleagues and trainees that showed up and made ut such a great event!
#ferroptosis #faseb #Ros
thank you @olzmannlab.bsky.social and Scott Dixon for the organisation and for all the colleagues and trainees that showed up and made ut such a great event!
#ferroptosis #faseb #Ros
July 31, 2025 at 9:14 PM
Fantastic meeting 🤩🤩
thank you @olzmannlab.bsky.social and Scott Dixon for the organisation and for all the colleagues and trainees that showed up and made ut such a great event!
#ferroptosis #faseb #Ros
thank you @olzmannlab.bsky.social and Scott Dixon for the organisation and for all the colleagues and trainees that showed up and made ut such a great event!
#ferroptosis #faseb #Ros
Reposted by Muir Lab
The EAAT1 aspartate/glutamate transporter is dispensable for acute myeloid leukemia cell growth and response to therapy https://www.biorxiv.org/content/10.1101/2025.07.13.664609v1
July 18, 2025 at 11:48 AM
The EAAT1 aspartate/glutamate transporter is dispensable for acute myeloid leukemia cell growth and response to therapy https://www.biorxiv.org/content/10.1101/2025.07.13.664609v1
Reposted by Muir Lab
1/ If you are in the Midwest and ❤️ metabolism, take note!
This year’s Midwest Metabolism meeting will be held jointly with the Translational Research in Mitochondrial Metabolism in Aging and Disease (TRiMAD) conference.
www.vai.org/event/2025-m...
This year’s Midwest Metabolism meeting will be held jointly with the Translational Research in Mitochondrial Metabolism in Aging and Disease (TRiMAD) conference.
www.vai.org/event/2025-m...
2025 Midwest Metabolism Meeting
Join us for 2025 Midwest Metabolism Meeting at Van Andel Institute Stay informed about exciting upcoming events and activities.
www.vai.org
July 21, 2025 at 9:12 PM
1/ If you are in the Midwest and ❤️ metabolism, take note!
This year’s Midwest Metabolism meeting will be held jointly with the Translational Research in Mitochondrial Metabolism in Aging and Disease (TRiMAD) conference.
www.vai.org/event/2025-m...
This year’s Midwest Metabolism meeting will be held jointly with the Translational Research in Mitochondrial Metabolism in Aging and Disease (TRiMAD) conference.
www.vai.org/event/2025-m...
Super excited to share new review on metabolic stress and adaptations in pancreatic cancer to these stresses from @cssheehan.bsky.social
jci.org/articles/vie... 1/6
jci.org/articles/vie... 1/6
JCI -
What’s on the menu?: metabolic constraints in the pancreatic tumor microenvironment
jci.org
July 19, 2025 at 2:59 PM
Super excited to share new review on metabolic stress and adaptations in pancreatic cancer to these stresses from @cssheehan.bsky.social
jci.org/articles/vie... 1/6
jci.org/articles/vie... 1/6
Congrats to Dr. patrickjonker.bsky.social for successfully defending his thesis!
July 17, 2025 at 10:22 PM
Congrats to Dr. patrickjonker.bsky.social for successfully defending his thesis!
Reposted by Muir Lab
I'm excited to share the final version of some fun work from our lab. A few interesting phenotypes - depleting host glutathione causes intracellular Rickettsia to form long chains and get restricted by antibacterial autophagy. Congrats to the team!
urldefense.com/v3/__https:/...
urldefense.com/v3/__https:/...
Host glutathione is required for Rickettsia parkeri cell division and intracellular survival
Nature Communications - Rickettsia species are bacterial pathogens that obligately reside in the host cell cytosol. Here, Sun et al. report that Rickettsia use host glutathione as a nutrient source...
urldefense.com
July 1, 2025 at 5:03 PM
I'm excited to share the final version of some fun work from our lab. A few interesting phenotypes - depleting host glutathione causes intracellular Rickettsia to form long chains and get restricted by antibacterial autophagy. Congrats to the team!
urldefense.com/v3/__https:/...
urldefense.com/v3/__https:/...
Reposted by Muir Lab
It’s over 100°F in Boston, and though both the weather and funding climates are intense, we took a well-deserved ice cream break to celebrate the progress, and the incredible people past and present, behind it all. Happy 3rd birthday, ULab! 🎉
June 25, 2025 at 12:23 AM
It’s over 100°F in Boston, and though both the weather and funding climates are intense, we took a well-deserved ice cream break to celebrate the progress, and the incredible people past and present, behind it all. Happy 3rd birthday, ULab! 🎉
Last day! Please consider sending in a public comment about Schedule F!
It's currently at 19,430+ public comments, but the deadline is now extended to June 7.
The agency may be worried the large, well-reasoned opposition could tank the final rule in court—and is buying time to flood the docket with support.
Keep it coming!
The agency may be worried the large, well-reasoned opposition could tank the final rule in court—and is buying time to flood the docket with support.
Keep it coming!
June 6, 2025 at 10:33 AM
Last day! Please consider sending in a public comment about Schedule F!
Reposted by Muir Lab
Sign up for midwest metabolism & Trimad joint meeting! Abstracts are due 9/2/25. The vast majority of talks will come from the abstracts - great opportunity for trainees! www.vai.org/event/2025-m...
2025 Midwest Metabolism Meeting
Join us for 2025 Midwest Metabolism Meeting at Van Andel Institute Stay informed about exciting upcoming events and activities.
www.vai.org
June 4, 2025 at 6:21 PM
Sign up for midwest metabolism & Trimad joint meeting! Abstracts are due 9/2/25. The vast majority of talks will come from the abstracts - great opportunity for trainees! www.vai.org/event/2025-m...
Reposted by Muir Lab
HIRING! We're looking for an assistant professor/investigator to lead metabolism-focused research @morgridgemeta.bsky.social through a joint tenure track position with UW–Madison @bmolchem.bsky.social. Join our team! https://morgridge.org/job-posting/assistant-professor-in-metabolism-research/
May 27, 2025 at 5:10 PM
HIRING! We're looking for an assistant professor/investigator to lead metabolism-focused research @morgridgemeta.bsky.social through a joint tenure track position with UW–Madison @bmolchem.bsky.social. Join our team! https://morgridge.org/job-posting/assistant-professor-in-metabolism-research/
Reposted by Muir Lab
Check out this nice review article from my buds on cardiometabolism, including the emerging role of microproteins! We might have something to add to this conversation in a few years, stay tuned!
www.ahajournals.org/doi/full/10....
www.ahajournals.org/doi/full/10....
Emerging Technologies and Future Directions in Interorgan Crosstalk Cardiometabolic Research | Circulation Research
The heart does not work in isolation, with cardiac health and disease occurring through
complex interactions between the heart with multiple organs. Furthermore, the integration
of organ-specific lipi...
www.ahajournals.org
May 25, 2025 at 3:50 PM
Check out this nice review article from my buds on cardiometabolism, including the emerging role of microproteins! We might have something to add to this conversation in a few years, stay tuned!
www.ahajournals.org/doi/full/10....
www.ahajournals.org/doi/full/10....
Reposted by Muir Lab
Glad to report that this tour de force from our collaborator Caroline Alexander (with a bit of assistance from our lab in the form of Michaela Trautman) is now out: "Dietary lipids are largely deposited in skin and rapidly affect insulating properties" www.nature.com/articles/s41...
May 16, 2025 at 8:15 PM
Glad to report that this tour de force from our collaborator Caroline Alexander (with a bit of assistance from our lab in the form of Michaela Trautman) is now out: "Dietary lipids are largely deposited in skin and rapidly affect insulating properties" www.nature.com/articles/s41...