Ubellacker Lab
@ubellackerlab.bsky.social
Targeting metabolic mechanisms of metastasis. Ferroptosis, lymph & lipid enthusiasts.
Reposted by Ubellacker Lab
new out in Nature, targeting FSP1 to trigger ferroptosis
www.nature.com/articles/s41...
www.nature.com/articles/s41...
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Targeting FSP1 triggers ferroptosis in lung cancer - Nature
The ferroptosis suppressor protein FSP1 has a critical role in ferroptosis protection of tumours across multiple in vivo models and is linked to worse prognosis in human lung adenocarcinoma, suggestin...
www.nature.com
November 6, 2025 at 7:39 AM
new out in Nature, targeting FSP1 to trigger ferroptosis
www.nature.com/articles/s41...
www.nature.com/articles/s41...
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Ubellacker Lab
Please read more about this publication in this article in the Harvard Newsletter: Triggering cell death in metastatic melanoma may pave the way for new cancer treatments
Triggering cell death in metastatic melanoma may pave the way for new cancer treatments | Harvard T.H. Chan School of Public Health
A Harvard Chan School study offers new ways to understand cancer and its vulnerabilities, and suggests that certain protein inhibitors could potentially be effective treatments for the disease.
hsph.harvard.edu
November 5, 2025 at 5:28 PM
Please read more about this publication in this article in the Harvard Newsletter: Triggering cell death in metastatic melanoma may pave the way for new cancer treatments
Reposted by Ubellacker Lab
Melanoma cells that spread to lymph nodes depend on FSP1 to survive, revealing a new metabolic vulnerability. New study in Nature by @mariopalma.bsky.social @ubellackerlab.bsky.social and colleagues shows that blocking FSP1 triggers ferroptosis and suppresses tumor growth in lymph node metastases.
Lymph node environment drives FSP1 targetability in metastasizing melanoma - Nature
Targeting FSP1 in lymph nodes has considerable potential for blocking melanoma progression.
www.nature.com
November 5, 2025 at 5:28 PM
Melanoma cells that spread to lymph nodes depend on FSP1 to survive, revealing a new metabolic vulnerability. New study in Nature by @mariopalma.bsky.social @ubellackerlab.bsky.social and colleagues shows that blocking FSP1 triggers ferroptosis and suppresses tumor growth in lymph node metastases.
Reposted by Ubellacker Lab
Excited to share my postdoctoral work, out today in Nature! www.nature.com/articles/s41...
We discovered that melanoma cells in lymph nodes gain a targetable FSP1 dependency that limits melanoma progression.
We discovered that melanoma cells in lymph nodes gain a targetable FSP1 dependency that limits melanoma progression.
Lymph node environment drives FSP1 targetability in metastasizing melanoma - Nature
Targeting FSP1 in lymph nodes has considerable potential for blocking melanoma progression.
www.nature.com
November 5, 2025 at 4:35 PM
Excited to share my postdoctoral work, out today in Nature! www.nature.com/articles/s41...
We discovered that melanoma cells in lymph nodes gain a targetable FSP1 dependency that limits melanoma progression.
We discovered that melanoma cells in lymph nodes gain a targetable FSP1 dependency that limits melanoma progression.
Excited to share our work @nature.com! Postdoc @mariopalma.bsky.social, with major contributions from @retickerflynn.bsky.social and collaborators, discovered melanoma cells in lymph nodes gain a targetable FSP1 dependency that limits progression. #TeamFSP1
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Lymph node environment drives FSP1 targetability in metastasizing melanoma | Nature
www.nature.com
November 5, 2025 at 4:11 PM
Excited to share our work @nature.com! Postdoc @mariopalma.bsky.social, with major contributions from @retickerflynn.bsky.social and collaborators, discovered melanoma cells in lymph nodes gain a targetable FSP1 dependency that limits progression. #TeamFSP1
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Ubellacker Lab
Excited to share our study out in @natcellbio.nature.com! Led by @mikelangelipid.bsky.social, we identify the first #LipidDroplet lipid quality control pathway: LD-localized FSP1 protects stored lipids from oxidative damage and prevents LD-initiated #ferroptosis.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
FSP1-mediated lipid droplet quality control prevents neutral lipid peroxidation and ferroptosis - Nature Cell Biology
Lange et al. identify a lipid droplet quality control pathway in which FSP1 safeguards stored neutral lipids from lipid peroxidation, thereby preventing the induction of ferroptosis.
www.nature.com
October 29, 2025 at 5:21 PM
Excited to share our study out in @natcellbio.nature.com! Led by @mikelangelipid.bsky.social, we identify the first #LipidDroplet lipid quality control pathway: LD-localized FSP1 protects stored lipids from oxidative damage and prevents LD-initiated #ferroptosis.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Ubellacker Lab
Excited to share my postdoc work @olzmannlab.bsky.social! We found lipid droplets, the cell’s lipid storage depots, are subject to oxidative damage and are protected by FSP1. Loss of FSP1 triggers droplet peroxidation and cell death, revealing a new layer of lipid quality control!
shorturl.at/B5XYD
shorturl.at/B5XYD
FSP1-mediated lipid droplet quality control prevents neutral lipid peroxidation and ferroptosis - Nature Cell Biology
Lange et al. identify a lipid droplet quality control pathway in which FSP1 safeguards stored neutral lipids from lipid peroxidation, thereby preventing the induction of ferroptosis.
www.nature.com
October 29, 2025 at 8:45 PM
Excited to share my postdoc work @olzmannlab.bsky.social! We found lipid droplets, the cell’s lipid storage depots, are subject to oxidative damage and are protected by FSP1. Loss of FSP1 triggers droplet peroxidation and cell death, revealing a new layer of lipid quality control!
shorturl.at/B5XYD
shorturl.at/B5XYD
Hot off the presses! Was an honor to team up with Scott Dixon @stanforduniversity.bsky.social on this Nature Cancer review. We reflect on hurdles that have slowed translation of ferroptosis-directed therapies and share ideas on what it will take to bring these therapies to the clinic. rdcu.be/eBbqV
August 18, 2025 at 3:42 PM
Hot off the presses! Was an honor to team up with Scott Dixon @stanforduniversity.bsky.social on this Nature Cancer review. We reflect on hurdles that have slowed translation of ferroptosis-directed therapies and share ideas on what it will take to bring these therapies to the clinic. rdcu.be/eBbqV
Fantastic lymph node protocols from @retickerflynn.bsky.social Lab, Cort Breuer, and team. Check it out!
Interested in studying lymph node metastasis? Check out our protocol by Cort Breuer out today in @natprot.nature.com
bsky.app/profile/nat...
bsky.app/profile/nat...
Nature Protocols (@natprot.nature.com)
New Article! Spontaneous and experimental models of lymph node metastasis
https://bit.ly/4fzWoAj
bsky.app
August 13, 2025 at 4:17 PM
Fantastic lymph node protocols from @retickerflynn.bsky.social Lab, Cort Breuer, and team. Check it out!
Reposted by Ubellacker Lab
Interested in studying lymph node metastasis? Check out our protocol by Cort Breuer out today in @natprot.nature.com
bsky.app/profile/nat...
bsky.app/profile/nat...
Nature Protocols (@natprot.nature.com)
New Article! Spontaneous and experimental models of lymph node metastasis
https://bit.ly/4fzWoAj
bsky.app
August 13, 2025 at 3:20 PM
Interested in studying lymph node metastasis? Check out our protocol by Cort Breuer out today in @natprot.nature.com
bsky.app/profile/nat...
bsky.app/profile/nat...
Reposted by Ubellacker Lab
New Article! Spontaneous and experimental models of lymph node metastasis
Spontaneous and experimental models of lymph node metastasis
Nature Protocols, Published online: 13 August 2025; doi:10.1038/s41596-025-01200-5We provide two procedures to cover distinct approaches for the initiation of lymph node metastases in mice: one for studying the metastatic cascade in tumorigenic cells and the other for studying the effect of metastatic formations in the host.
bit.ly
August 13, 2025 at 9:05 AM
New Article! Spontaneous and experimental models of lymph node metastasis
Reposted by Ubellacker Lab
Riboflavin metabolism shapes FSP1-driven ferroptosis resistance https://www.biorxiv.org/content/10.1101/2025.08.05.668651v1
August 6, 2025 at 8:30 AM
Riboflavin metabolism shapes FSP1-driven ferroptosis resistance https://www.biorxiv.org/content/10.1101/2025.08.05.668651v1
Reposted by Ubellacker Lab
Vitamin B2 metabolism promotes FSP1 stability to prevent ferroptosis https://www.biorxiv.org/content/10.1101/2025.08.05.668752v1
August 6, 2025 at 8:30 AM
Vitamin B2 metabolism promotes FSP1 stability to prevent ferroptosis https://www.biorxiv.org/content/10.1101/2025.08.05.668752v1
Join me in Boston October 6th for a 1-day conference on #mappingbiology to transform #cancertherapeutics. Register by September 25th to benefit from the complimentary (free) admission! Topics, speakers, and talk opportunities here: abcam.me/mappingbiolo...
@abcamofficial.bsky.social
@abcamofficial.bsky.social
August 5, 2025 at 6:59 PM
Join me in Boston October 6th for a 1-day conference on #mappingbiology to transform #cancertherapeutics. Register by September 25th to benefit from the complimentary (free) admission! Topics, speakers, and talk opportunities here: abcam.me/mappingbiolo...
@abcamofficial.bsky.social
@abcamofficial.bsky.social
Reposted by Ubellacker Lab
1/Patient-derived xenografts (PDXs) are used in preclinical testing of cancer therapies, including metabolic therapies. We determined which metabolic properties are retained, and which are lost, when melanomas from patients are implanted and passaged as PDXs in mice.
www.nature.com/articles/s42...
www.nature.com/articles/s42...
Conservation and divergence of metabolic phenotypes between patient tumours and matched xenografts - Nature Metabolism
Rao and Cai et al. perform a detailed metabolic comparison between primary tumours from patients and their matching xenografts, which identify conserved as well as divergent metabolic patterns.
www.nature.com
July 29, 2025 at 2:56 PM
1/Patient-derived xenografts (PDXs) are used in preclinical testing of cancer therapies, including metabolic therapies. We determined which metabolic properties are retained, and which are lost, when melanomas from patients are implanted and passaged as PDXs in mice.
www.nature.com/articles/s42...
www.nature.com/articles/s42...
Huge thank you to @olzmannlab.bsky.social and Scott Dixon for a phenomenal 1st FASEB Ferroptosis conference! I’m grateful to be part of such a collaborative community and it was especially great to meet all the brilliant trainees whose insights are clearly shaping the exciting future of the field! 🎉
The first FASEB Ferroptosis conference! ✔️ Thank you to my co-organizer Scott Dixon, our sponsors, and the whole #Ferroptosis community for showing up and making this such a wonderful meeting! 🤩 ❤️
August 1, 2025 at 8:50 PM
Huge thank you to @olzmannlab.bsky.social and Scott Dixon for a phenomenal 1st FASEB Ferroptosis conference! I’m grateful to be part of such a collaborative community and it was especially great to meet all the brilliant trainees whose insights are clearly shaping the exciting future of the field! 🎉
Reposted by Ubellacker Lab
New preprint w/ the Dupage lab led by @jgcastillo.bsky.social! FSP1 KO in Tregs / Tcells promotes tumor suppression, highlighting the therapeutic value potential of FSP1 inhibition. New paradigm for targeting ferroptosis in immune system (not just in cancer cells). 🤩
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Selective disruption of lipid peroxide homeostasis in intratumoral regulatory T cells by targeting FSP1 enhances cancer immunity
A burgeoning approach to treat cancer is the pharmacological induction of ferroptotic cell death of tumor cells. However, the impact of disrupting anti-ferroptotic pathways in the broader tumor microe...
www.biorxiv.org
July 11, 2025 at 1:23 AM
New preprint w/ the Dupage lab led by @jgcastillo.bsky.social! FSP1 KO in Tregs / Tcells promotes tumor suppression, highlighting the therapeutic value potential of FSP1 inhibition. New paradigm for targeting ferroptosis in immune system (not just in cancer cells). 🤩
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
It’s over 100°F in Boston, and though both the weather and funding climates are intense, we took a well-deserved ice cream break to celebrate the progress, and the incredible people past and present, behind it all. Happy 3rd birthday, ULab! 🎉
June 25, 2025 at 12:23 AM
It’s over 100°F in Boston, and though both the weather and funding climates are intense, we took a well-deserved ice cream break to celebrate the progress, and the incredible people past and present, behind it all. Happy 3rd birthday, ULab! 🎉
Reposted by Ubellacker Lab
Thrilled this paper is out! We solved the first cocrystal structure of FSP1 with an inhibitor (FSEN1), providing mechanistic insight & a foundation for medchem. Led by Amalia Megarioti & Sitao Zhang. A terrific collaboration with Da Jia.
Brief Skytorial!
1/9
Brief Skytorial!
1/9
Cocrystal structure reveals the mechanism of FSP1 inhibition by FSEN1 | PNAS
FSP1 is an FAD-dependent oxidoreductase that uses NAD(P)H to regenerate the reduced
forms of lipophilic quinone antioxidants, such as coenzyme Q10 ...
www.pnas.org
May 29, 2025 at 6:02 PM
Thrilled this paper is out! We solved the first cocrystal structure of FSP1 with an inhibitor (FSEN1), providing mechanistic insight & a foundation for medchem. Led by Amalia Megarioti & Sitao Zhang. A terrific collaboration with Da Jia.
Brief Skytorial!
1/9
Brief Skytorial!
1/9
Join us next Monday: June 2, 3-4PM off the Harvard Longwood Quad for two great cell death discussions on ferroptosis in breast cancer metastasis from
@mariesabatier.bsky.social
(Ubellacker Lab) and on thiol-reductive stress from Maolin Ge (Bar-Peled Lab)!
@mariesabatier.bsky.social
(Ubellacker Lab) and on thiol-reductive stress from Maolin Ge (Bar-Peled Lab)!
Join us June 2, 3-4PM off the Harvard Longwood Quad for two great cell death discussions on ferroptosis in breast cancer metastasis from @mariesabatier.bsky.social (Ubellacker Lab) and on thiol-reductive stress from Maolin Ge (Bar-Peled Lab)
May 27, 2025 at 11:40 AM
Join us next Monday: June 2, 3-4PM off the Harvard Longwood Quad for two great cell death discussions on ferroptosis in breast cancer metastasis from
@mariesabatier.bsky.social
(Ubellacker Lab) and on thiol-reductive stress from Maolin Ge (Bar-Peled Lab)!
@mariesabatier.bsky.social
(Ubellacker Lab) and on thiol-reductive stress from Maolin Ge (Bar-Peled Lab)!
Reposted by Ubellacker Lab
Harvard Chan scientists participate in a rigorous application process for federal grants to conduct their vital health research. The government has now terminated nearly every single one of those grants.
May 20, 2025 at 2:23 PM
Harvard Chan scientists participate in a rigorous application process for federal grants to conduct their vital health research. The government has now terminated nearly every single one of those grants.
Reposted by Ubellacker Lab
Indeed, our Outstanding Investigator Award from the National Cancer Institute, which funded all research personnel and activities in my modest-sized lab of 5 has been unceremoniously terminated.
Harvard Chan scientists participate in a rigorous application process for federal grants to conduct their vital health research. The government has now terminated nearly every single one of those grants.
May 21, 2025 at 3:32 PM
Indeed, our Outstanding Investigator Award from the National Cancer Institute, which funded all research personnel and activities in my modest-sized lab of 5 has been unceremoniously terminated.
Way-to-go Alanis Carmona and Lewis Hendrianto for your incredible posters today at the Landry Cancer Biology Consortium, and shout-out to Alanis on your Karin Grunebaum Cancer Research Foundation Rising Young Scientist Award!
May 22, 2025 at 1:42 AM
Way-to-go Alanis Carmona and Lewis Hendrianto for your incredible posters today at the Landry Cancer Biology Consortium, and shout-out to Alanis on your Karin Grunebaum Cancer Research Foundation Rising Young Scientist Award!
Join us June 2, 3-4PM off the Harvard Longwood Quad for two great cell death discussions on ferroptosis in breast cancer metastasis from @mariesabatier.bsky.social (Ubellacker Lab) and on thiol-reductive stress from Maolin Ge (Bar-Peled Lab)
May 14, 2025 at 2:48 PM
Join us June 2, 3-4PM off the Harvard Longwood Quad for two great cell death discussions on ferroptosis in breast cancer metastasis from @mariesabatier.bsky.social (Ubellacker Lab) and on thiol-reductive stress from Maolin Ge (Bar-Peled Lab)
Fantastic visit yesterday from the great Scott Dixon as part of our Cutter Distinguished Lecture on Molecular Metabolism series. An honor to host such an outstanding scientist and mentor to so many in the cell death field!
May 13, 2025 at 12:12 PM
Fantastic visit yesterday from the great Scott Dixon as part of our Cutter Distinguished Lecture on Molecular Metabolism series. An honor to host such an outstanding scientist and mentor to so many in the cell death field!