Brendan Manning
@bdmanning.bsky.social
Scientist working on signaling and metabolism in cancer, metabolic diseases, aging, and physiology. AKT-TSC-mTOR🧪
Just two of thousands of such stories. substack.com/home/post/p-...
I Was Just About To When My Grant Was Cut.
We ask researchers to send us their stories of what they were working on when their research grant was cut. Today, we share the stories of Tashara and Brendan.
substack.com
July 29, 2025 at 2:15 PM
Just two of thousands of such stories. substack.com/home/post/p-...
Reposted by Brendan Manning
I still can’t believe that all NIH grants to my colleagues at Harvard and Harvard Medical School have been nullified. And that, as a nation, we’re somehow okay with this illegal, arbitrary, and petty act. Just think of the consequences: scientists, students, and patients will all suffer.
July 18, 2025 at 3:30 AM
I still can’t believe that all NIH grants to my colleagues at Harvard and Harvard Medical School have been nullified. And that, as a nation, we’re somehow okay with this illegal, arbitrary, and petty act. Just think of the consequences: scientists, students, and patients will all suffer.
Inspired predominantly by insightful cryo-EM structures from Yanhui Xu’s lab and @drellisdon.bsky.social on the TSC protein complex, which we have been focused on the regulation of upstream of mTORC1 for 23 years and counting. Enjoy!
July 9, 2025 at 12:38 AM
Inspired predominantly by insightful cryo-EM structures from Yanhui Xu’s lab and @drellisdon.bsky.social on the TSC protein complex, which we have been focused on the regulation of upstream of mTORC1 for 23 years and counting. Enjoy!
Reposted by Brendan Manning
Congrats to Yann Cormerais and the entire lab for this publication on a new mouse model that disconnects the primary signal from PI3K to mTORC1, involving Akt-mediated phosphorylation of TSC2, which I discovered as a postdoc in Lew Cantley's lab 23 years ago. authors.elsevier.com/a/1lDFh5Sx5g...
authors.elsevier.com
June 5, 2025 at 3:33 PM
Congrats to Yann Cormerais and the entire lab for this publication on a new mouse model that disconnects the primary signal from PI3K to mTORC1, involving Akt-mediated phosphorylation of TSC2, which I discovered as a postdoc in Lew Cantley's lab 23 years ago. authors.elsevier.com/a/1lDFh5Sx5g...
Congrats to @harperlabhms.bsky.social and colleagues in @harvardcellbio.bsky.social for this tour de force dissection of endosomes
Nature research paper: EndoMAP.v1 charts the structural landscape of human early endosome complexes
https://go.nature.com/3Z6mJ1X
https://go.nature.com/3Z6mJ1X
EndoMAP.v1 charts the structural landscape of human early endosome complexes - Nature
A study presents EndoMAP.v1, a resource that combines information on protein interactions and crosslink-supported structural predictions to map the interaction landscape of early endosomes.
go.nature.com
June 4, 2025 at 11:46 AM
Congrats to @harperlabhms.bsky.social and colleagues in @harvardcellbio.bsky.social for this tour de force dissection of endosomes
Reposted by Brendan Manning
Nature research paper: EndoMAP.v1 charts the structural landscape of human early endosome complexes
https://go.nature.com/3Z6mJ1X
https://go.nature.com/3Z6mJ1X
EndoMAP.v1 charts the structural landscape of human early endosome complexes - Nature
A study presents EndoMAP.v1, a resource that combines information on protein interactions and crosslink-supported structural predictions to map the interaction landscape of early endosomes.
go.nature.com
June 4, 2025 at 7:59 AM
Nature research paper: EndoMAP.v1 charts the structural landscape of human early endosome complexes
https://go.nature.com/3Z6mJ1X
https://go.nature.com/3Z6mJ1X
Reposted by Brendan Manning
From @hsph.harvard.edu Hotamışlıgil Lab, @renata-goncalves.bsky.social identifies an important mechanism that leads to liver dysfunction in obesity—defective coenzyme Q metabolism. This finding paves the way for more targeted diabetes & metabolic disease treatments. Read more:
hsph.me/mitoT2D
hsph.me/mitoT2D
Newly discovered mechanism of mitochondrial dysfunction in obesity may drive insulin resistance and type 2 diabetes | Harvard T.H. Chan School of Public Health
A newly discovered mechanism that leads to liver dysfunction may be a key factor in type 2 diabetes and other metabolic disorders in individuals with obesity, according to a new study led by Harvard C...
hsph.harvard.edu
May 28, 2025 at 7:51 PM
From @hsph.harvard.edu Hotamışlıgil Lab, @renata-goncalves.bsky.social identifies an important mechanism that leads to liver dysfunction in obesity—defective coenzyme Q metabolism. This finding paves the way for more targeted diabetes & metabolic disease treatments. Read more:
hsph.me/mitoT2D
hsph.me/mitoT2D
Reposted by Brendan Manning
For 25 years, Dr. Manning & his lab have advanced TSC research, uncovering how the mTOR pathway shapes cell growth—and unlocking insights across cancer, diabetes & more. Research that until recently was supported by taxpayers through the NIH. #TSC #science #ResearchMatters
Brendan Manning: Unraveling the cell’s inner workings
For Brendan Manning, PhD, today’s advances in basic science are the stepping stones to the next breakthrough in treating tuberous sclerosis complex (TSC). Manning has spent the last 25 years researchi...
www.tscalliance.org
May 30, 2025 at 4:24 PM
For 25 years, Dr. Manning & his lab have advanced TSC research, uncovering how the mTOR pathway shapes cell growth—and unlocking insights across cancer, diabetes & more. Research that until recently was supported by taxpayers through the NIH. #TSC #science #ResearchMatters
Reposted by Brendan Manning
I urge everyone to read Unbreaking’s new page on everything the govt is doing to destroy & diminish medical research funding.
It’s the best thing I’ve read on this topic: @lizneeley.bsky.social & co have such done an incredible job.
unbreaking.org/issues/medic...
It’s the best thing I’ve read on this topic: @lizneeley.bsky.social & co have such done an incredible job.
unbreaking.org/issues/medic...
Medical Research Funding — Unbreaking
How the administration is breaking the government, and what that means for all of us.
unbreaking.org
May 30, 2025 at 9:38 PM
I urge everyone to read Unbreaking’s new page on everything the govt is doing to destroy & diminish medical research funding.
It’s the best thing I’ve read on this topic: @lizneeley.bsky.social & co have such done an incredible job.
unbreaking.org/issues/medic...
It’s the best thing I’ve read on this topic: @lizneeley.bsky.social & co have such done an incredible job.
unbreaking.org/issues/medic...
Reposted by Brendan Manning
28 of the most important drugs approved by the Food and Drug Administration (FDA) between 1985 and 2009. They found that 80 percent stemmed directly from basic discoveries made in the lab, often by scientists trying to understand a biological process or disease
bit.ly/4jLCfbC
bit.ly/4jLCfbC
Tracing the Path from Basic Research to Transformative Therapies
bit.ly
May 25, 2025 at 10:50 AM
28 of the most important drugs approved by the Food and Drug Administration (FDA) between 1985 and 2009. They found that 80 percent stemmed directly from basic discoveries made in the lab, often by scientists trying to understand a biological process or disease
bit.ly/4jLCfbC
bit.ly/4jLCfbC
I thank the taxpayers of the United States for supporting this research designed to better understand and treat the uncontrolled growth of cancer cells over the past 10 years.
Indeed, our Outstanding Investigator Award from the National Cancer Institute, which funded all research personnel and activities in my modest-sized lab of 5 has been unceremoniously terminated.
Harvard Chan scientists participate in a rigorous application process for federal grants to conduct their vital health research. The government has now terminated nearly every single one of those grants.
May 21, 2025 at 3:32 PM
I thank the taxpayers of the United States for supporting this research designed to better understand and treat the uncontrolled growth of cancer cells over the past 10 years.
Indeed, our Outstanding Investigator Award from the National Cancer Institute, which funded all research personnel and activities in my modest-sized lab of 5 has been unceremoniously terminated.
Harvard Chan scientists participate in a rigorous application process for federal grants to conduct their vital health research. The government has now terminated nearly every single one of those grants.
May 21, 2025 at 3:32 PM
Indeed, our Outstanding Investigator Award from the National Cancer Institute, which funded all research personnel and activities in my modest-sized lab of 5 has been unceremoniously terminated.
Reposted by Brendan Manning
With nearly all of Harvard Chan School’s direct federal grants terminated, we are relying on philanthropy to power our research and support our educational programs. Every gift, regardless of size, advances our vision of health, dignity, and justice for every human. Support our work: hsph.me/whygive
May 16, 2025 at 5:07 PM
With nearly all of Harvard Chan School’s direct federal grants terminated, we are relying on philanthropy to power our research and support our educational programs. Every gift, regardless of size, advances our vision of health, dignity, and justice for every human. Support our work: hsph.me/whygive
Reposted by Brendan Manning
A reminder that for next month’s BCDI in place of our regular discussion, we encourage you to attend the Cutter Distinguished Lecture @met-hsph.bsky.social by the great Scott Dixon!
See you there: Monday May 12, 2025, Kresge Building at HSPH, G1 auditorium, 12:00-1:00pm
See you there: Monday May 12, 2025, Kresge Building at HSPH, G1 auditorium, 12:00-1:00pm
April 18, 2025 at 3:13 PM
A reminder that for next month’s BCDI in place of our regular discussion, we encourage you to attend the Cutter Distinguished Lecture @met-hsph.bsky.social by the great Scott Dixon!
See you there: Monday May 12, 2025, Kresge Building at HSPH, G1 auditorium, 12:00-1:00pm
See you there: Monday May 12, 2025, Kresge Building at HSPH, G1 auditorium, 12:00-1:00pm
Reposted by Brendan Manning
From Nobel prize winning cancer researcher Bill Kaelin
Killing the Science Golden Goose - The American Journal of Medicine www.amjmed.com/article/S000...
Killing the Science Golden Goose - The American Journal of Medicine www.amjmed.com/article/S000...
Killing the Science Golden Goose
In the 1970’s I was probably one of the last American high school students who was
told that if you wanted to go to medical school, you should learn to speak German.
This was because in the late 19th ...
www.amjmed.com
April 18, 2025 at 10:54 AM
From Nobel prize winning cancer researcher Bill Kaelin
Killing the Science Golden Goose - The American Journal of Medicine www.amjmed.com/article/S000...
Killing the Science Golden Goose - The American Journal of Medicine www.amjmed.com/article/S000...
Reposted by Brendan Manning
Our partnership with the federal government has powered discoveries and solutions that have saved tens of millions of lives around the world. 🌎 The funding has enabled breakthrough research on deadly diseases from cancer to Alzheimer’s to stroke to HIV. 🦠 hsph.harvard.edu/news/trump-a...
Trump administration freezes $2.2 billion in grants to Harvard | Harvard T.H. Chan School of Public Health
The Trump administration announced late Monday that it was moving to freeze $2.2 billion in grants and $60 million in contracts to Harvard University. The federal freeze came hours after Harvard rejec...
hsph.harvard.edu
April 15, 2025 at 2:02 PM
Our partnership with the federal government has powered discoveries and solutions that have saved tens of millions of lives around the world. 🌎 The funding has enabled breakthrough research on deadly diseases from cancer to Alzheimer’s to stroke to HIV. 🦠 hsph.harvard.edu/news/trump-a...
Reposted by Brendan Manning
Check out the new homepage for Harvard!! Love it !!
www.harvard.edu
www.harvard.edu
Harvard University
Harvard University is devoted to excellence in teaching, learning, and research, and to developing leaders who make a difference globally.
www.harvard.edu
April 15, 2025 at 2:36 PM
Check out the new homepage for Harvard!! Love it !!
www.harvard.edu
www.harvard.edu
Reposted by Brendan Manning
With support from federal funding, @hsph.harvard.edu faculty have conducted groundbreaking research that has led directly to treatments, policies, and programs that have saved lives by the millions, in the US and around the world.
Here are just three examples: hsph.harvard.edu/news/federal...
Here are just three examples: hsph.harvard.edu/news/federal...
Federal funding drives groundbreaking research at Harvard Chan School | Harvard T.H. Chan School of Public Health
Harvard Chan faculty conduct groundbreaking research that has led directly to lifesaving vaccines, treatments, policies, and programs.
hsph.harvard.edu
March 21, 2025 at 1:51 PM
With support from federal funding, @hsph.harvard.edu faculty have conducted groundbreaking research that has led directly to treatments, policies, and programs that have saved lives by the millions, in the US and around the world.
Here are just three examples: hsph.harvard.edu/news/federal...
Here are just three examples: hsph.harvard.edu/news/federal...
Tough day on the slopes trying to keep up with these guys. But beats watching the news.
February 17, 2025 at 3:39 AM
Tough day on the slopes trying to keep up with these guys. But beats watching the news.
There it is! The end of academic science in the US. grants.nih.gov/grants/guide...
NOT-OD-25-068: Supplemental Guidance to the 2024 NIH Grants Policy Statement: Indirect Cost Rates
NIH Funding Opportunities and Notices in the NIH Guide for Grants and Contracts: Supplemental Guidance to the 2024 NIH Grants Policy Statement: Indirect Cost Rates NOT-OD-25-068. OD
grants.nih.gov
February 8, 2025 at 12:18 AM
There it is! The end of academic science in the US. grants.nih.gov/grants/guide...
Last day to apply to the hub of metabolism research at Harvard.
Join us in Boston! The Department of Molecular Metabolism (MET) at the Harvard T.H. Chan School of Public Health has just opened a Jr. Faculty search. Apply by January 15, 2025 at academicpositions.harvard.edu/postings/14371
Assistant Professor, Department of Molecular Metabolism
The Department of Molecular Metabolism (MET) at the Harvard T.H. Chan School of Public Health invites applications for the level of assistant professor. The shared interest of MET faculty is to explor...
academicpositions.harvard.edu
January 15, 2025 at 3:24 PM
Last day to apply to the hub of metabolism research at Harvard.
One week left to apply for a faculty position with us! We have a new website that still needs some love, but learn more about the department here: hsph.harvard.edu/department/m...
January 8, 2025 at 4:44 PM
One week left to apply for a faculty position with us! We have a new website that still needs some love, but learn more about the department here: hsph.harvard.edu/department/m...
Congrats to this incredible group!
Today we're thrilled to announce our 2024 #HannaGrayFellows! Please join us in welcoming and celebrating these outstanding early career scientists!
January 8, 2025 at 4:37 PM
Congrats to this incredible group!