Mike Lange
@mikelangelipid.bsky.social
Postdoc at University of California at Berkeley. Excited about lipid metabolism and lipid quality control #massspec #lipidomics #ferroptosis
Excited to share my postdoc work @olzmannlab.bsky.social! We found lipid droplets, the cell’s lipid storage depots, are subject to oxidative damage and are protected by FSP1. Loss of FSP1 triggers droplet peroxidation and cell death, revealing a new layer of lipid quality control!
shorturl.at/B5XYD
shorturl.at/B5XYD
FSP1-mediated lipid droplet quality control prevents neutral lipid peroxidation and ferroptosis - Nature Cell Biology
Lange et al. identify a lipid droplet quality control pathway in which FSP1 safeguards stored neutral lipids from lipid peroxidation, thereby preventing the induction of ferroptosis.
www.nature.com
October 29, 2025 at 8:45 PM
Excited to share my postdoc work @olzmannlab.bsky.social! We found lipid droplets, the cell’s lipid storage depots, are subject to oxidative damage and are protected by FSP1. Loss of FSP1 triggers droplet peroxidation and cell death, revealing a new layer of lipid quality control!
shorturl.at/B5XYD
shorturl.at/B5XYD
Reposted by Mike Lange
We're growing! Our newest Investigator @henrydebelly.bsky.social will join the CRI Tissue #Regeneration Program in January 2026. Learn more about Henry ➡️ cri.utsw.edu/faculty/henr... and 📌apply to research in his lab cri.utsw.edu/careers
October 16, 2025 at 7:24 PM
We're growing! Our newest Investigator @henrydebelly.bsky.social will join the CRI Tissue #Regeneration Program in January 2026. Learn more about Henry ➡️ cri.utsw.edu/faculty/henr... and 📌apply to research in his lab cri.utsw.edu/careers
Reposted by Mike Lange
Excited to share our new preprint, led by Kirandeep Deol! 🤩 Genetic screens uncover mechanisms regulating FSP1 abundance in cancer. Vitamin B2 metabolism promotes FSP1 stability via FAD synth / binding, further linking nutrient metabolism to ferroptosis.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Vitamin B2 metabolism promotes FSP1 stability to prevent ferroptosis
Ferroptosis, a regulated form of cell death driven by excessive lipid peroxidation, has emerged as a promising therapeutic target in cancer. Ferroptosis suppressor protein 1 (FSP1) is a critical regul...
www.biorxiv.org
August 6, 2025 at 3:21 PM
Excited to share our new preprint, led by Kirandeep Deol! 🤩 Genetic screens uncover mechanisms regulating FSP1 abundance in cancer. Vitamin B2 metabolism promotes FSP1 stability via FAD synth / binding, further linking nutrient metabolism to ferroptosis.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Mike Lange
The count down has begun! 1-week until the 1st FASEB Ferroptosis conference! Looking forward to seeing everyone at the meeting. Get excited!! 🤩
events.faseb.org/event/11797f...
events.faseb.org/event/11797f...
July 20, 2025 at 8:06 AM
The count down has begun! 1-week until the 1st FASEB Ferroptosis conference! Looking forward to seeing everyone at the meeting. Get excited!! 🤩
events.faseb.org/event/11797f...
events.faseb.org/event/11797f...
Reposted by Mike Lange
My third paper from grad school is out on Biorxiv! This was a fun collaboration with @olzmannlab.bsky.social where we show that Ferroptosis Suppressor Protein-1 is a better target than GPX4 because it disrupts Treg function while leaving effector T cell function intact.
Selective disruption of lipid peroxide homeostasis in intratumoral regulatory T cells by targeting FSP1 enhances cancer immunity https://www.biorxiv.org/content/10.1101/2025.07.06.663397v1
July 10, 2025 at 11:19 PM
My third paper from grad school is out on Biorxiv! This was a fun collaboration with @olzmannlab.bsky.social where we show that Ferroptosis Suppressor Protein-1 is a better target than GPX4 because it disrupts Treg function while leaving effector T cell function intact.
Reposted by Mike Lange
New preprint w/ the Dupage lab led by @jgcastillo.bsky.social! FSP1 KO in Tregs / Tcells promotes tumor suppression, highlighting the therapeutic value potential of FSP1 inhibition. New paradigm for targeting ferroptosis in immune system (not just in cancer cells). 🤩
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Selective disruption of lipid peroxide homeostasis in intratumoral regulatory T cells by targeting FSP1 enhances cancer immunity
A burgeoning approach to treat cancer is the pharmacological induction of ferroptotic cell death of tumor cells. However, the impact of disrupting anti-ferroptotic pathways in the broader tumor microe...
www.biorxiv.org
July 11, 2025 at 1:23 AM
New preprint w/ the Dupage lab led by @jgcastillo.bsky.social! FSP1 KO in Tregs / Tcells promotes tumor suppression, highlighting the therapeutic value potential of FSP1 inhibition. New paradigm for targeting ferroptosis in immune system (not just in cancer cells). 🤩
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Mike Lange
FYI - We've extended abstract submission deadline to June 8. Submit soon to be considered for a short talk. Come join us at the first FASEB #Ferroptosis meeting! It's going to be awwwwesome! 🤩
events.faseb.org/event/11797f...
events.faseb.org/event/11797f...
Home - Ferroptosis, Oxidative Stress, and Lipid Metabolism
events.faseb.org
June 3, 2025 at 4:24 PM
FYI - We've extended abstract submission deadline to June 8. Submit soon to be considered for a short talk. Come join us at the first FASEB #Ferroptosis meeting! It's going to be awwwwesome! 🤩
events.faseb.org/event/11797f...
events.faseb.org/event/11797f...
Reposted by Mike Lange
The world is small... Randomly found out that @mikelangelipid.bsky.social and I are both in Osaka, so we met up for some drinks and #lipidtime talk.
May 29, 2025 at 1:19 PM
The world is small... Randomly found out that @mikelangelipid.bsky.social and I are both in Osaka, so we met up for some drinks and #lipidtime talk.
Reposted by Mike Lange
Our team (hsph.harvard.edu/research/ube...) is excited to have contributed to the intranodal in vivo testing of the remarkable new compound, Fentomycin-1. Congrats to team Rodriguez et al. for the implications of this work in targeting ferroptosis in cancer. Check it out here!
new out in Nature, very cool story www.nature.com/articles/s41...
Activation of lysosomal iron triggers ferroptosis in cancer - Nature
Some cancer cells exhibit high loads of reactive iron in lysosomes, and this feature is exploited by using fentomycin-1, a newly developed small molecule, to induce ferroptosis.
www.nature.com
May 7, 2025 at 3:57 PM
Our team (hsph.harvard.edu/research/ube...) is excited to have contributed to the intranodal in vivo testing of the remarkable new compound, Fentomycin-1. Congrats to team Rodriguez et al. for the implications of this work in targeting ferroptosis in cancer. Check it out here!
Reposted by Mike Lange
Excited to see our N&V w/ @mikelangelipid.bsky.social published in Nature, highlighting new work from Raphael Rodriguez and team. A heterofunctional molecule that activates lysosomal iron triggers lipid peroxidation and ferroptosis in therapy-resistant cancer cells. www.nature.com/articles/d41...
Lipid-degrading small molecule kills cancer cells by ferroptosis
A molecule designed to activate iron locked up in organelles called lysosomes and thereby induce cell death might offer a way to tackle treatment-resistant cancer.
www.nature.com
May 7, 2025 at 10:17 PM
Excited to see our N&V w/ @mikelangelipid.bsky.social published in Nature, highlighting new work from Raphael Rodriguez and team. A heterofunctional molecule that activates lysosomal iron triggers lipid peroxidation and ferroptosis in therapy-resistant cancer cells. www.nature.com/articles/d41...
Fantastic new study from Raphael Rodriguez' lab shows that induced proximity concepts can be used to induce Ferroptosis! Inducing proximity of lysosomal iron and lipids induces lipid peroxidation! What a cool concept! Have a look at our News/Views with @olzmannlab.bsky.social shorturl.at/cbc8D
Lipid-degrading small molecule kills cancer cells by ferroptosis
A molecule designed to activate iron locked up in organelles called lysosomes and thereby induce cell death might offer a way to tackle treatment-resistant cancer.
shorturl.at
May 8, 2025 at 1:17 AM
Fantastic new study from Raphael Rodriguez' lab shows that induced proximity concepts can be used to induce Ferroptosis! Inducing proximity of lysosomal iron and lipids induces lipid peroxidation! What a cool concept! Have a look at our News/Views with @olzmannlab.bsky.social shorturl.at/cbc8D
Reposted by Mike Lange
**Rapid Response Bridge Funding Program** -- $25,000 grants earmarked for early-career researchers whose NSF-funded research on STEM and education has just been terminated.
www.spencer.org/grant_types/...
hub.jhu.edu/2025/04/28/j...
Thanks @lizneeley.bsky.social !
www.spencer.org/grant_types/...
hub.jhu.edu/2025/04/28/j...
Thanks @lizneeley.bsky.social !
Rapid Response Bridge Funding Program
In the face of recent abrupt shifts in federal funding for education research, including large-scale terminations of National Science Foundation (NSF) research grant awards, we have developed a rap...
www.spencer.org
May 3, 2025 at 3:22 PM
**Rapid Response Bridge Funding Program** -- $25,000 grants earmarked for early-career researchers whose NSF-funded research on STEM and education has just been terminated.
www.spencer.org/grant_types/...
hub.jhu.edu/2025/04/28/j...
Thanks @lizneeley.bsky.social !
www.spencer.org/grant_types/...
hub.jhu.edu/2025/04/28/j...
Thanks @lizneeley.bsky.social !
Join for the first FASEB Ferroptosis conference in the US this July! This stellar speaker line up brings together almost all leaders in the field!
Reminder: The 1st FASEB #Ferroptosis Meeting is this summer! Spectacular speaker lineup + short talks selected from submitted abstracts. It is going to be awesome! Trainees, newcomers & all interested are welcome!
📅 Abstract deadline: June 1, 2025.
shorturl.at/QA6T1
📅 Abstract deadline: June 1, 2025.
shorturl.at/QA6T1
May 4, 2025 at 1:44 AM
Join for the first FASEB Ferroptosis conference in the US this July! This stellar speaker line up brings together almost all leaders in the field!
Reposted by Mike Lange
Join us next week: Bits and Bites on May 8, from 9-1pm, on Zoom. Registration and payment here: na.eventscloud.com/ereg/index.p... We will present and discuss the best practice for #Quality Control and Quality Assurance. #metabolomics #NMR #GC-MS #LC-MS @mikelangelipid.bsky.social @crick.ac.uk
April 30, 2025 at 10:33 PM
Join us next week: Bits and Bites on May 8, from 9-1pm, on Zoom. Registration and payment here: na.eventscloud.com/ereg/index.p... We will present and discuss the best practice for #Quality Control and Quality Assurance. #metabolomics #NMR #GC-MS #LC-MS @mikelangelipid.bsky.social @crick.ac.uk
Fantastic study out today by superstar postdoc @aakritijain.bsky.social! It identifies the unresolved function of LyLAP, a protein associated with poor prognosis in PDAC. It is not a phospholipase but a membrane protein protease! Happy that I could help through our untargeted lipidomics platform
SO excited to share that a major part of the postdoctoral work in @robzonculab.bsky.social lab is now published: “Leucine aminopeptidase LyLAP enables lysosomal degradation of membrane proteins” www.science.org/doi/10.1126/...
Leucine aminopeptidase LyLAP enables lysosomal degradation of membrane proteins
Breakdown of every transmembrane protein trafficked to lysosomes requires proteolysis of their hydrophobic helical transmembrane domains. Combining lysosomal proteomics with functional genomic dataset...
www.science.org
March 28, 2025 at 12:57 AM
Fantastic study out today by superstar postdoc @aakritijain.bsky.social! It identifies the unresolved function of LyLAP, a protein associated with poor prognosis in PDAC. It is not a phospholipase but a membrane protein protease! Happy that I could help through our untargeted lipidomics platform
Reposted by Mike Lange
February 7, 2025 at 9:54 AM
Reposted by Mike Lange
RIP any human subjects methods section: women, gender, female, excluded
RIP math/stats: biases, marginalise, equality, inequality, group, inclusive
RIP social sciences: status, systemic, political, group, socioeconomic, institutional, cultural
This is not just evil it is also SO VERY DUMB
RIP math/stats: biases, marginalise, equality, inequality, group, inclusive
RIP social sciences: status, systemic, political, group, socioeconomic, institutional, cultural
This is not just evil it is also SO VERY DUMB
🚨BREAKING. From a program officer at the National Science Foundation, a list of keywords that can cause a grant to be pulled. I will be sharing screenshots of these keywords along with a decision tree. Please share widely. This is a crisis for academic freedom & science.
February 4, 2025 at 2:49 AM
RIP any human subjects methods section: women, gender, female, excluded
RIP math/stats: biases, marginalise, equality, inequality, group, inclusive
RIP social sciences: status, systemic, political, group, socioeconomic, institutional, cultural
This is not just evil it is also SO VERY DUMB
RIP math/stats: biases, marginalise, equality, inequality, group, inclusive
RIP social sciences: status, systemic, political, group, socioeconomic, institutional, cultural
This is not just evil it is also SO VERY DUMB
Reposted by Mike Lange
🚨BREAKING. From a program officer at the National Science Foundation, a list of keywords that can cause a grant to be pulled. I will be sharing screenshots of these keywords along with a decision tree. Please share widely. This is a crisis for academic freedom & science.
February 4, 2025 at 1:26 AM
🚨BREAKING. From a program officer at the National Science Foundation, a list of keywords that can cause a grant to be pulled. I will be sharing screenshots of these keywords along with a decision tree. Please share widely. This is a crisis for academic freedom & science.
Reposted by Mike Lange
If you’re a federal govt employee targeted for leave or termination on the basis of your DEI work, please file an EEO (Equal Employment Opportunity) complaint & retain legal counsel.
I’m a former NIH PI. Happy to refer you to a law firm that has successfully sued the govt many times!
Pls repost 🙏❤️
I’m a former NIH PI. Happy to refer you to a law firm that has successfully sued the govt many times!
Pls repost 🙏❤️
January 24, 2025 at 10:02 AM
If you’re a federal govt employee targeted for leave or termination on the basis of your DEI work, please file an EEO (Equal Employment Opportunity) complaint & retain legal counsel.
I’m a former NIH PI. Happy to refer you to a law firm that has successfully sued the govt many times!
Pls repost 🙏❤️
I’m a former NIH PI. Happy to refer you to a law firm that has successfully sued the govt many times!
Pls repost 🙏❤️
Reposted by Mike Lange
Excited to share our new preprint! Exceptional work by @mikelangelipid.bsky.social identifies the first #LipidDroplet lipid quality control pathway! LD-localized FSP1 safeguards neutral lipids from peroxidation and prevents #ferroptosis. 🤩https://www.biorxiv.org/content/10.1101/2025.01.06.631537v1
FSP1-mediated lipid droplet quality control prevents neutral lipid peroxidation and ferroptosis
Lipid droplets (LDs) are organelles that store and supply lipids based on cellular needs. While mechanisms preventing oxidative damage to membrane phospholipids are established, the vulnerability of L...
www.biorxiv.org
January 8, 2025 at 4:23 PM
Excited to share our new preprint! Exceptional work by @mikelangelipid.bsky.social identifies the first #LipidDroplet lipid quality control pathway! LD-localized FSP1 safeguards neutral lipids from peroxidation and prevents #ferroptosis. 🤩https://www.biorxiv.org/content/10.1101/2025.01.06.631537v1
I am excited to report the preprint of my postdoc work in the @olzmannlab.bsky.social! We have discovered the first lipid droplet quality control pathway with broad implications for lipid physiology and diseases associated with LD accumulation and oxidative stress! #lipidtime
shorturl.at/2HqFd
shorturl.at/2HqFd
January 8, 2025 at 1:46 PM
I am excited to report the preprint of my postdoc work in the @olzmannlab.bsky.social! We have discovered the first lipid droplet quality control pathway with broad implications for lipid physiology and diseases associated with LD accumulation and oxidative stress! #lipidtime
shorturl.at/2HqFd
shorturl.at/2HqFd
Reposted by Mike Lange
Interested in #organelle biogenesis, subcellular #membrane #protein targeting or #LipidMetabolism? We are hiring! #PhD student or #postdoc.
We combine #Biochemistry & #CellBiology with Computational Modeling & Experimental Physics / Physical Chemistry approaches.
#research #academicsky #AcademicJob
We combine #Biochemistry & #CellBiology with Computational Modeling & Experimental Physics / Physical Chemistry approaches.
#research #academicsky #AcademicJob
November 26, 2024 at 2:51 PM
Interested in #organelle biogenesis, subcellular #membrane #protein targeting or #LipidMetabolism? We are hiring! #PhD student or #postdoc.
We combine #Biochemistry & #CellBiology with Computational Modeling & Experimental Physics / Physical Chemistry approaches.
#research #academicsky #AcademicJob
We combine #Biochemistry & #CellBiology with Computational Modeling & Experimental Physics / Physical Chemistry approaches.
#research #academicsky #AcademicJob
Happy to see the scientific community thriving at Bluesky!
I am a postdoc at UC Berkeley in the @olzmannlab.bsky.social and I combine lipidomics, redox and cell biology and in vitro biochemistry to understand pathways of cellular lipid quality control.
Excited to see some cool #LipidTime on here!
I am a postdoc at UC Berkeley in the @olzmannlab.bsky.social and I combine lipidomics, redox and cell biology and in vitro biochemistry to understand pathways of cellular lipid quality control.
Excited to see some cool #LipidTime on here!
November 25, 2024 at 3:12 PM
Happy to see the scientific community thriving at Bluesky!
I am a postdoc at UC Berkeley in the @olzmannlab.bsky.social and I combine lipidomics, redox and cell biology and in vitro biochemistry to understand pathways of cellular lipid quality control.
Excited to see some cool #LipidTime on here!
I am a postdoc at UC Berkeley in the @olzmannlab.bsky.social and I combine lipidomics, redox and cell biology and in vitro biochemistry to understand pathways of cellular lipid quality control.
Excited to see some cool #LipidTime on here!