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The Lancet
@thelancet.com
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Welcome to The Lancet, one of the world’s leading medical journals, published weekly since 1823.

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The Lancet is a weekly peer-reviewed general medical journal, founded in England in 1823. It is one of the world's highest-impact academic journals and also one of the oldest medical journals still in publication. .. more

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The Lancet @thelancet.com Β· 7d
A picture is worth a thousand words πŸ“·

In our final issue of 2025, explore the winning photos of The Lancet's 2025 Highlights competition, representing a year of pursuing health and hope in challenging conditions.

Access the full issue: spkl.io/63327Aci33
The Lancet December 20/27, 2025-January 2, 2026 issue. On the cover, a black and white portrait of a mother and sleeping child, relating to the Smile China mission. Credit: Wayne F Larrabee Jr.

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The Lancet @thelancet.com Β· 2d
πŸ‘€ Among our most-read in 2025:

A major meta-analysis investigating the effects of antidepressants on cardiometabolic and other physiological parameters.

Find out more: spkl.io/63325AYEFX
Research in context panel for Lancet paper "The effects of antidepressants on cardiometabolic and other physiological parameters: a systematic review and network meta-analysis". Copyright: 2025 The Author(s). Published by Elsevier Ltd. CC BY 4.0.

Reposted by The Lancet Diabetes Endocrinology

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The Lancet @thelancet.com Β· 3d
New Hypothesisβ€”Amylin and the renin-angiotensin system: risk or opportunity in amylin-based therapy? spkl.io/63329AYEvx
Figure showing the rationale for the potential benefit of combining amylin-based therapies with renin-angiotensin system inhibitors. Copyright: 2025 Elsevier Ltd. All rights are reserved.

Reposted by The Lancet

Reposted by The Lancet Diabetes Endocrinology

thelancet.com
The Lancet @thelancet.com Β· 4d
Among our most-read in 2025 ‡️

Ultra-processed foods – what’s the impact?

In a Lancet Series, experts warn a global rise in #UPFs presents a growing public health threat.

Read the evidence & policy recommendations ⬇️
spkl.io/63323AYDz7
Part of a Lancet Infographic summarising the findings from the Lancet Series on Ultra-Processed Foods and Human Health. Part of a Lancet Infographic summarising the findings from the Lancet Series on Ultra-Processed Foods and Human Health. Part of a Lancet Infographic summarising the findings from the Lancet Series on Ultra-Processed Foods and Human Health.

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The Lancet @thelancet.com Β· 5d
The therapeutic landscape for prostate cancer has evolved substantially in the past 5 years, resulting in improved patient outcomes.

A new Seminar provides an up-to-date overview of the management of prostate cancer at different stages of the disease: spkl.io/63322AcVaC
Figure showing localised and locally advanced non-metastatic prostate cancer: different treatment options per risk group. Copyright: 2025 Elsevier Ltd. All rights are reserved.

thelancet.com
The Lancet @thelancet.com Β· 6d
In the 2025 Lancet #WakleyPrize winning essay, @donnawakefield.bsky.social explores how personal experiences and understanding of the social determinants of health can transform patient care and foster a more inclusive healthcare system.

Read now πŸ‘‰ spkl.io/63329AcBBV
Quote from the 2025 Lancet Wakley Prize winning essay by Donna Wakefield. Quote reads: "Medicine must be practised with openness and without prejudice towards people's social circumstances. This outlook is essential to deliver holistic care."

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The Lancet @thelancet.com Β· 7d
"the most disastrous year for US public health policy"

The US faces a critical public health crossroads as recent policy shifts threaten decades of progress.

What are the implications for future health security and scientific integrity?

Our Editorial: spkl.io/63326AcVQy
Workers demolish the facade of the East Wing of the White House on October 20, 2025 in Washington, DC. Copyright: Kevin Dietsch/Getty Images.

thelancet.com
The Lancet @thelancet.com Β· 8d
Randomised controlled trials have commonly excluded women who are pregnant, lactating, or of reproductive potential.

A new Viewpoint discusses the factors contributing to the exclusion of these women and provides recommendations to increase their inclusion: spkl.io/63328AiCtk
Figure listing proposed multilevel solutions to increase the inclusion of women who are pregnant, lactating, or of reproductive potential in clinical trials. Copyright: 2025 Elsevier Ltd. All rights are reserved.

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The Lancet @thelancet.com Β· 9d
The Russian military's invasion of Ukraine has revived the threat of large-scale conflict in Europe.

A new letter discusses the UK's need to prepare its healthcare system for potential large-scale military conflicts, providing key research priorities: spkl.io/63328AiAj4
Panel listing urgent research priorities for NHS resilience in large-scale conflict. Copyright: 2025 Elsevier Ltd. All rights are reserved.

thelancet.com
The Lancet @thelancet.com Β· 9d
Use of nicotine pouches has increased from 0.1% to 1% in the UK from 2020 to 2025, primarily driven by their use in young people, study suggests in @thelancetph.bsky.social

Explore the research ➑️ spkl.io/63320AiU6g
Figure showing trends in current nicotine pouch use in Great Britain overall among adults aged β‰₯18 years (A) and by age group among people aged β‰₯16 years (B) Lines represent the modelled weighted prevalence by monthly survey wave (estimated using logistic regression, with time modelled with restricted cubic splines); shaded bands represent 95% CIs; and crosses represent the unmodelled weighted prevalence in each month. Copyright: 2025 The Author(s). Published by Elsevier Ltd. CC BY 4.0.

Reposted by The Lancet Diabetes Endocrinology

thelancet.com
The Lancet @thelancet.com Β· 10d
Acute kidney injury (AKI) is a common and important complication of major surgery, yet recommended preventive care is rarely administered.

A new study investigated the effectiveness of a preventive care strategy to reduce moderate or severe AKI after major surgery: spkl.io/63321Ai4Fl
Figure showing rates of moderate or severe acute kidney injury. The figure shows that within 72 h of surgery, moderate or severe AKI occurred in 84 patients (14Β·4%) in the intervention group and in 131 (22Β·3%) patients in the control group 2025 The Author(s). Published by Elsevier Ltd. CC BY 4.0.