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The Lancet
@thelancet.com
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Welcome to The Lancet, one of the world’s leading medical journals, published weekly since 1823.

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thelancet.com
The 2025 @lancetcountdown.bsky.social report reveals climate change inaction is costing lives and livelihoods, and harming the economy.

During #COP30, explore recommendations for action: spkl.io/63324AbjGM #LancetClimate25
Cover of the 2025 report of the Lancet Countdown on health and climate change: Climate change action offers a lifeline.
November 10, 2025 at 3:34 PM
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"Belém offers a chance to place health at the centre of climate governance and confront the increasingly ominous consequences of delay."

Ahead of #COP30, a new World Report: spkl.io/63326AbDDC
The COP30 logo is seen in front of the central building ahead of the COP30 Brazil Amazonia 2025 on November 3, 2025 in Belem, Brazil. Copyright: Wagner Meier/Getty Images.
November 8, 2025 at 6:03 PM
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The use of drones as a weapon of war has transformed conflict, with grave implications for the health & safety of both military personnel & civilians.

Our Editorial calls for greater scrutiny about the neglected physical & psychological effects of drone warfare: spkl.io/63326AbBUq
A drone operator launches a quadrocopter to search for the wounded fighters on the battlefield. Copyright: Mykhaylo Palinchak/SOPA Images/LightRocket via Getty Images
November 7, 2025 at 2:33 PM
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On the cover, a new analysis of the SELECT trial confirms semaglutide lowers the risk of major heart problems in people who are overweight or obese and already have heart disease, even if they don’t have diabetes. 🫀

Read this & more in our new issue: tinyurl.com/58p97aud
Cover of The Lancet's Nov 8, 2025 issue. Quote on cover reads "The cardioprotective effects of semaglutide were independent of baseline adiposity and weight loss and had only a small association with waist circumference, suggesting some mechanisms for benefit beyond adiposity reduction."
November 7, 2025 at 11:31 AM
thelancet.com
What if we could find new ways to approach liver cancer prevention and treatment?

Join Helena Wang on Nov 27 to explore how we can work together to reverse the rise of this global health challenge.

👉 Register now: hubs.li/Q03GK-q50

#oncology #hepatology #lgcw2025
Blue graphic with hexagon pattern. Text says: "The Lancet Webinars. Join Helena Wang, Asia Senior Executive Editor at The Lancet, for our global webinar on global strategies to reverse the rise of liver cancer on Thursday, November 27, 2025 at 9am GMT/10am CET". A photograph of Helena Wang appears on the right-hand side. Copyright: Elsevier Ltd.
November 7, 2025 at 11:10 AM
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Endometriosis affects around 190 million women and girls globally. Despite progress, the exact causes remain unknown.

The latest issue of @lancetobgyn-wh.bsky.social features articles on advancements & the research still needed.

🔗 : tinyurl.com/4by2evfs
Alt-text: The cover of The Lancet Obstetrics, Gynaecology, & Women’s Health which features artwork of a woman curled around, holding her abdomen due to pain from endometriosis. The world map is visible in the background. Copyright: Cover image by Elizabeth Sanduvete Chaves.
November 6, 2025 at 1:02 PM
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"We must reflect on current prevention strategies in the context of the changing contribution of different cardiovascular conditions."

@nath-conrad.bsky.social & colleagues explore the evolving spectrum of cardiovascular disease: tinyurl.com/5c9pe8mj
The proportion of newly diagnosed cardiovascular disease in the UK, by individual condition, from 2000 to 2002 and 2017 to 2019. Proportions were calculated by dividing the age–sex-standardised incidence rate for the condition of interest by the sum of the age–sex-standardised incidence rates across all ten conditions. Copyright: 2025 Elsevier Ltd. All rights are reserved.
November 5, 2025 at 11:26 AM
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👉 Register now: hubs.li/Q03NdTNP0
📆 Nov 20, 2025 | 2pm GMT / 9am EST / 10pm CST

Join our expert panel as they explore innate immunity’s role in neurological diseases, and therapies to prevent inflammation-driven neurodegeneration.

#neurology #brainhealth #lancetwebinar
Blue graphic with text saying: "Webinar: Innate immunity regulation of brain health on Thursday, November 20, 2025 at 2pm GMT/9am EST/10pm CST. Join Elena Becker-Barroso, Editor-in-Chief of The Lancet Neurology, Sam Rose, Scientific Editor of Neuron, David Hunt, Professor of Medicine at University of Edinburgh, Andrea Ablasser, Professor at École Polytechnique Fédérale de Lausanne, and Manuel Friese, Professor of Neurology at University Medical Center Hamburg-Eppendorf". The Cell Press and The Lancet logos appear in the top left and right corners respectively. Copyright: Elsevier Ltd.
November 5, 2025 at 7:50 AM
thelancet.com
Time is an under-recognised social determinant of brain health.

In The Lancet Healthy Longevity, authors call for temporal justice through research and policies that recognise time as both a resource and a site of inequity in ageing and dementia: tinyurl.com/bdhfy93p
Figure Integrative illustration of micro (individual)-level, meso (relational and organisational)-level, and macro (systemic)-level factors that shape people’s experience, use, and availability of time relevant to brain health. Copyright: 2025 The Author(s). Published by Elsevier Ltd. CC BY 4.0.
November 4, 2025 at 4:05 PM
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📈 There has been significant progress in sexual and reproductive health globally over the past two decades. However, significant financial gaps remain.

A new Series explores cost-effective solutions to bridge these gaps and address unmet needs: tinyurl.com/y87d3sjf
Indicative annual funding levels for HIV care, STI care, contraception, and abortion care. For STI care, contraception, and abortion, the bars represent estimated current expenditure based on assumed current coverage multiplied by assumed costs. For abortion, the funding needed category includes the cost-saving impact of providing abortions safely. Copyright: 2025 Elsevier Ltd. All rights are reserved.
November 4, 2025 at 2:38 PM
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What if we could work together to change the future of liver cancer?

Join our webinar exploring how we can tackle the rising trend of liver cancer and differences in disease management across regions, hosted as part of London Global Cancer Week.

📆 Nov 27, 9am GMT
👉 Register: hubs.li/Q03GK-q50
Blue graphic with text saying: "The Lancet Webinars. Join our global webinar on the global strategies to reverse the rise of liver cancer on Thursday, November 27, 2025 at 9am GMT/10am CET. An image of a red liver in a blue body appears on the right of the graphic in a hexagonal frame. Copyright: Elsevier Ltd.
November 3, 2025 at 3:23 PM
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🆕 Peripartum cardiomyopathy is now the leading cause of maternal death in many parts of the world.

A Seminar summarises current knowledge of peripartum cardiomyopathy genetics, pathophysiology, diagnostic approaches, medical management, and outcome: tinyurl.com/4pf365hh
Figure showing risk factors and pathological mechanisms linked to peripartum cardiomyopathy. Copyright: 2025 Elsevier Ltd. All rights are reserved.
November 3, 2025 at 12:02 PM
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🚨 A new @thelancetoncol.bsky.social Commission warns of a growing “human crisis” in cancer.

Despite scientific advances, many patients are not getting the compassionate, holistic support they need.

Authors call for a shift towards more human-centered care: tinyurl.com/5x3rmnsv
Cover of The Lancet Oncology Commission on the human crisis in cancer. The image shows a female doctor holding hands with a stressed patient while consoling at a clinic. The cover quote reads, “The human crisis of cancer is not defined by pathology, mortality, or cause, but by the erosion of meaning, connection, and compassion in the experience of cancer.” Credit: Maskot/Getty Images
November 3, 2025 at 8:26 AM
thelancet.com
The US Federal Government is gridlocked, causing the second longest funding lapse in US history.

Our latest Editorial discusses the ongoing federal government shutdown and its impact on health-care services and coverage:
tinyurl.com/4bwkzvyj
Quote from The Lancet's Nov 1, 2025 Editorial. Quote reads: "How the disagreement over key federal programmes is eventually resolved will shape health in the USA for decades, but the shutdown is already having immediate adverse effects, including on health-care services."
October 31, 2025 at 3:10 PM
thelancet.com
Antidepressants can affect the normal or proper functioning of the body's organs. However, the degree to which these physiological effects occur in treatment is unclear.

A new study compared and ranked antidepressants based on physiological side-effects.

Read this & more 👉 tinyurl.com/8j4upevz
Cover of The Lancet's Nov 1, 2025 issue. Quote on cover reads: "We found strong evidence that antidepressants differ markedly in their physiological effects, particularly for cardiometabolic parameters. Treatment guidelines should be updated[...]."
October 31, 2025 at 12:36 PM
thelancet.com
📢 Missed our recent webinar on reporting race and ethnicity data in research?

Catch up at your convenience and gain practical tips and clear guidance from our expert editors to help you apply our reporting guidelines to your work.

▶️ Watch now: hubs.li/Q03GrSjy0
Blue graphic with text saying: "Watch on-demand our Lancet Webinar on reporting race and ethnicity data in Lancet journals: a pathways to improving health outcomes and equity in research and clinical practice". The Lancet Webinars logo features in the bottom left corner. Copyright: Elsevier Ltd.
October 31, 2025 at 10:28 AM
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The 2025 Lancet Countdown report shows health systems are preparing for the dangers of climate change whilst reducing their greenhouse gas emissions.

Find out more: tinyurl.com/y3hcjhv8 #LancetClimate25
Promotional card for the 2025 Lancet Countdown Report. Image depicts an ambulance moving at pace in Tokyo. Text reads "Health Systems are stepping up and preparing for the dangers of climate change." Promotional card for the 2025 Lancet Countdown Report. Text reads: "As the health impacts of climate change grow, the health sector is stepping up. 58% of WHO member states have completed a Vulnerability and Adaptation assessment, while 60% have completed a Health National Adaptation Plan. Almost two-thirds of medical students around the world received climate and health education in 2024." Promotional card for the 2025 Lancet Countdown Report. Text reads: "Health systems are also taking action to reduce their contributions to climate change. While delivering improvements in healthcare, healthcare-related greenhouse gas emissions fell by 16% between 2021 and 2022 - mainly driven by reduced waste and increased efficiency." Promotional card for the 2025 Lancet Countdown Report. Text reads: "The 2025 Global Report of the Lancet Countdown informs opportunities for a healthier future. From individuals and communities to corporations, funders, and governments at every level - securing a health future requires all hands on deck."
October 30, 2025 at 4:34 PM
thelancet.com
Heterozygous familial hypercholesterolemia is a common genetic condition characterised by high LDL cholesterol levels from a young age.

A new Review discusses the contemporary knowledge of familial hypercholesterolaemia and its unmet clinical needs: tinyurl.com/2sef5ktt
Implementation recommendations for familial hypercholesterolaemia models of care. Copyright: 2025 Elsevier Ltd. All rights are reserved.
October 29, 2025 at 4:22 PM
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The 2025 @lancetcountdown.bsky.social report launches today!

📊 Most comprehensive assessment yet of climate/health connections
❤️‍🩹 Outlines priority actions for the protection of health amidst global turmoil

Get the details: tinyurl.com/y3hcjhv8 #LancetClimate25
Cover of the 2025 report of the Lancet Countdown on health and climate change: Climate change action offers a lifeline.
October 29, 2025 at 12:06 PM
thelancet.com
📢 Missed our recent webinar on sex and gender reporting in research?

Catch up at your convenience and gain practical tips and clear guidance from our expert editors to help you apply sex- and gender-based analyses in your own work.

▶️ Watch now: hubs.li/Q03FQ_pC0
Blue graphic with text saying: "Watch on-demand our Lancet Webinar on the importance of analysing, reporting, and interpreting data according to sex and gender". Also includes The Lancet Webinars in the bottom left corner. Copyright: Elsevier Ltd.
October 29, 2025 at 10:17 AM
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A new study provides the first truly global picture of how breast, cervical, and ovarian cancer are diagnosed and treated, offering the clearest evidence yet of global inequalities in care.

Read the paper ➡️ tinyurl.com/mrue2tby
Median time between diagnosis and breast-conserving surgery (A) or mastectomy (B) for early-stage breast cancer. Median time between diagnosis and surgery for early-stage cervical (C) and early-stage ovarian (D) cancer. Copyright: 2025 The Author(s). Published by Elsevier Ltd. CC BY-NC-ND 4.0.
October 28, 2025 at 9:20 AM
thelancet.com
📅 Save the date!

What can the world learn from Africa’s fight against HIV? Find out at this year’s @acmedsci.bsky.social & The Lancet International Health Lecture, delivered by Professor Quarraisha Abdool Karim.

🔗 Register now to attend in person or online on Nov 4: hubs.li/Q03H1YKY0
The International Health Lecture 2025. Copyright: The Academy of Medical Sciences.
October 28, 2025 at 8:45 AM
thelancet.com
Osteoporotic fractures are one of the most common diseases of advanced ageing.

A Seminar presents new evidence on osteoporosis screening recommendations, nutrition-based therapies and fracture-risk assessments: tinyurl.com/3mr6x3dz
Panel 1: Osteoporosis in men. Copyright: 2025 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.
October 27, 2025 at 4:13 PM
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How does research drive real change?

Our new Lancet- @elsfoundation.bsky.social Evidence to Impact Award is open for proposals!

If your project champions implementation science, health equity, and community engagement, apply now: tinyurl.com/j5dty567
Promotional card for the Lancet-Elsevier Foundation Evidence to Impact Award. Images depict two healthcare workers looking at a clipboard and a person facing into the sun with their eyes closed and holding their hand on their chest.
October 27, 2025 at 2:54 PM
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The UK is facing a pharma exodus, driven by claims that insufficient NHS investment threatens pharmaceutical innovation.

Yet, evidence suggests that the current pharma business model prioritises shareholder profits over innovation.

Find out more in an Editorial: tinyurl.com/n4pczpzx
Quote from the Lancet's Oct 25, 2025 Editorial. Quote reads: "The dysfunctionalities of the pharma business model will not be solved by ramping up drug prices."
October 24, 2025 at 1:56 PM