The Lancet Diabetes & Endocrinology
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Your leading source of international, cutting-edge research, review, and opinion in clinical #diabetes and #endocrinology. IF=41·8.
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The Lancet is a weekly peer-reviewed general medical journal, founded in England in 1823. It is one of the world's highest-impact academic journals and also one of the oldest medical journals still in publication. .. more
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Read our February Issue, featuring global diabetes prevalence estimates, thyroid cancer, familial hypercholesterolaemia, prediabetes remission, diabetes technology use during pregnancy, obesity, sleep medicine, & much more tinyurl.com/mwfu4c6m
#MedSky #EndoSky #CardioSky #OncSky #GastroSky
#MedSky #EndoSky #CardioSky #OncSky #GastroSky
Clinical features, investigation, and management of Addison's disease thelancet.com/journals/lan...
#Addison's disease
#adrenal insufficiency
#adrenal crisis
#MedSky #EndoSky
#Addison's disease
#adrenal insufficiency
#adrenal crisis
#MedSky #EndoSky
Evaluating baseline risk of #breast #cancer before prescription of #MHT should be considered a minimum standard alongside education on risk factors that can help decrease the risk of breast cancer with or without using MHT www.thelancet.com/journals/lan...
#menopausal #hormone #treatment #menopause
#menopausal #hormone #treatment #menopause
3 months of romosozumab: a pragmatic clinical solution
A longstanding goal in the treatment of osteoporosis has been rejuvenating the ageing
skeleton to essentially reverse or cure osteoporosis. Although antiresorptive drugs
such as bisphosphonates or den...
thelancet.com
Sundeep Khosla comments on:
3 months of #romosozumab: a pragmatic clinical solution thelancet.com/journals/lan...
#postmenopausal #osteoporosis #BoneHealth #WomensHealth
#FREE to read with registration (also FREE)
#MedSky #EndoSky #RheumSky
3 months of #romosozumab: a pragmatic clinical solution thelancet.com/journals/lan...
#postmenopausal #osteoporosis #BoneHealth #WomensHealth
#FREE to read with registration (also FREE)
#MedSky #EndoSky #RheumSky
3 months vs 12 months of romosozumab for postmenopausal osteoporosis (LIDA): an open-label, non-inferiority, randomised controlled trial
In postmenopausal women at high risk of fracture, 3 months of romosozumab followed
by 9 months of denosumab was non-inferior to 12 months of romosozumab in increasing
total hip BMD. Given the expense,...
thelancet.com
New—3 months vs 12 months of #romosozumab for #postmenopausal #osteoporosis (LIDA): an open-label, non-inferiority, randomised controlled trial thelancet.com/journals/lan...
#BoneHealth #WomensHealth
#OpenAccess
#MedSky #EndoSky #RheumSky
#BoneHealth #WomensHealth
#OpenAccess
#MedSky #EndoSky #RheumSky
Country-level implementation of Europe's Safe Hearts Plan for cardiovascular health
The European Diabetes Forum (EUDF) welcomes the Safe Hearts Plan1 for cardiovascular
health in the EU, released on Dec 16, 2025. We strongly support the Safe Hearts Plan's
integrated approach to diabe...
www.thelancet.com
Investing in strengthened care pathways for #diabetes, including early detection and empowering people to understand & manage their diabetes, will support sustainable health-care systems and improve patient outcomes and quality of life www.thelancet.com/journals/lan...
#MedSky #EndoSky #CardioSky
#MedSky #EndoSky #CardioSky
The siRNA therapeutic inclisiran, on top of standard-of-care treatment, results in sustained lowering of LDL cholesterol in this paediatric patient population, with a favourable safety & tolerability profile that is consistent with studies in adult populations www.thelancet.com/journals/lan...
#HeFH
#HeFH
Reposted by The Lancet Diabetes Endocrinology
The Lancet
@thelancet.com
· 2d
Globally, metabolic dysfunction-associated steatotic liver disease (MASLD) is the most common chronic liver disease.
In @lancetgastrohep.bsky.social, a Review summarises recent breakthroughs and potential future developments: spkl.io/63323Aq7BR
In @lancetgastrohep.bsky.social, a Review summarises recent breakthroughs and potential future developments: spkl.io/63323Aq7BR
Menopausal hormone treatment and breast cancer
Breast cancer risk is a central concern in shared decision-making when considering
menopausal hormone treatment (MHT). Women spend approximately 40% of their lives in
menopause, and climacteric sympto...
www.thelancet.com
New—Menopausal hormone treatment and breast cancer www.thelancet.com/journals/lan...
#MHT #HRT #menopause #breastcancer #WomensHealth
#MedSky #EndoSky #WomensHealthSky
#MHT #HRT #menopause #breastcancer #WomensHealth
#MedSky #EndoSky #WomensHealthSky
Gene-environment interactions underlying temporal trends in type 2 diabetes prevalence
The global prevalence of type 2 diabetes has risen dramatically over recent decades,
fuelled primarily by the growing burden of obesity and characterised by an earlier
onset and a multifaceted spectru...
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Tiange Wang comment on:
Gene-environment interactions underlying temporal trends in type 2 #diabetes prevalence www.thelancet.com/journals/lan... #T2D
#MedSky #EndoSky
Gene-environment interactions underlying temporal trends in type 2 #diabetes prevalence www.thelancet.com/journals/lan... #T2D
#MedSky #EndoSky
Feasibility of general population screening for type 1 diabetes in the UK: the ELSA study
Type 1 diabetes is a chronic autoimmune inflammatory disease resulting in loss of insulin-secreting β cells and the subsequent need for lifelong insulin therapy.1 Presymptomatic type 1 diabetes is marked by the presence of two or more islet autoantibodies. Detection at this early stage offers substantial benefits, including improved long-term glucose control, preparation time for insulin therapy, and a reduced risk of diabetic emergencies, such as diabetic ketoacidosis.2 Furthermore, the advent of disease-modifying therapies to delay the need for insulin makes it crucial to identify type 1 diabetes at the presymptomatic stage.
www.thelancet.com
The ELSA study is the first to explore the feasibility of implementation and psychosocial effect of general population #screening for #paediatric type 1 #diabetes in the UK www.thelancet.com/journals/lan... #T1D
#FREE to read
#MedSky #EndoSky
#FREE to read
#MedSky #EndoSky
Inclisiran for children: is it worth it?
Familial hypercholesterolaemia is one of the most common inherited metabolic disorders,
with heterozygous familial hypercholesterolaemia (HeFH) affecting more than 30 million
individuals worldwide, a ...
thelancet.com
Lluís Masana & Daiana Ibarretxe comment on:
Inclisiran for children: is it worth it? thelancet.com/journals/lan...
#heterozygous #familial #hypercholesterolaemia #HeFH #ASCVD
#MedSky #EndoSky #CardioSky
Inclisiran for children: is it worth it? thelancet.com/journals/lan...
#heterozygous #familial #hypercholesterolaemia #HeFH #ASCVD
#MedSky #EndoSky #CardioSky
Efficacy and safety of inclisiran in adolescents with heterozygous familial hypercholesterolaemia (ORION-16): a two-part, randomised, multicentre clinical trial
In adolescents with HeFH, inclisiran was effective in lowering LDL cholesterol, with
sustained efficacy over 2 years, and was well tolerated. These results support inclisiran
as a potentially useful a...
www.thelancet.com
In this adolescent patient population with #HeFH and elevated #LDL #cholesterol despite standard of care, inclisiran was effective in lowering LDL cholesterol, showing sustained efficacy over 2 years of treatment, with a reduction of −33·7% from baseline at day 720 www.thelancet.com/journals/lan....
Clinical features, investigation, and management of Addison's disease
Addison's disease is the manifestation of adrenal glucocorticoid and mineralocorticoid
deficiency from T-cell mediated destruction of the adrenal cortex, and is the commonest
cause of primary adrenal ...
thelancet.com
Health-care providers should consider #Addison's disease as a differential in a wide variety of presentations, and understand the correct interpretation and limitations of widely available cortisol assays thelancet.com/journals/lan...
#adrenal insufficiency
#adrenal crisis
#MedSky #EndoSky
#adrenal insufficiency
#adrenal crisis
#MedSky #EndoSky
Despite oral corticosteroid replacement therapy, people with #Addison's disease have increased mortality in addition to reduced HRQoL and working ability thelancet.com/journals/lan...
#adrenal insufficiency
#adrenal crisis
#adrenal insufficiency
#adrenal crisis
Fragility #fractures remain a common & serious
complication of long-term oral #glucocorticoid therapy
that might affect all skeletal sites, although the spine is
particularly prone to fractures owing to its high proportion
of trabecular bone www.thelancet.com/journals/lan...
#osteoporosis
#EndoSky
complication of long-term oral #glucocorticoid therapy
that might affect all skeletal sites, although the spine is
particularly prone to fractures owing to its high proportion
of trabecular bone www.thelancet.com/journals/lan...
#osteoporosis
#EndoSky
All patients with #Addison’s disease should be given a steroid emergency card and provided with and trained to use a glucocorticoid injection kit www.thelancet.com/journals/lan...
#adrenal insufficiency
#adrenal crisis
#adrenal insufficiency
#adrenal crisis
Addison's disease is the manifestation of adrenal glucocorticoid and mineralocorticoid deficiency from T-cell mediated destruction of the adrenal cortex, and is the commonest cause of primary adrenal insufficiency in adults www.thelancet.com/journals/lan...
#adrenal insufficiency
#MedSky #EndoSky
#adrenal insufficiency
#MedSky #EndoSky
Reaching #prediabetes #remission is linked to a decades-long benefit, halving the risk of #cardiovascular death or hospitalisation for #heartfailure in diverse populations. Targeting remission might represent a new approach to cardiovascular prevention www.thelancet.com/journals/lan...
#OpenAccess
#OpenAccess
More liberal use of bilateral adrenalectomy for bilateral adrenal tumours with cortisol excess
Bilateral adrenal tumours with cortisol hypersecretion represent a common clinical
challenge. Adrenal incidentalomas are detected in approximately 4% of abdominal imaging
studies, with prevalence incr...
thelancet.com
Quan-Yang Duh & Michelle B Mulder comment on:
More liberal use of bilateral #adrenalectomy for bilateral #adrenal #tumours with #cortisol excess thelancet.com/journals/lan...
#cardiometabolic #morbidity #mortality
#adrenal crises
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More liberal use of bilateral #adrenalectomy for bilateral #adrenal #tumours with #cortisol excess thelancet.com/journals/lan...
#cardiometabolic #morbidity #mortality
#adrenal crises
#MedSky #EndoSky #OncSky
Effect of surgical versus conservative management on cardiovascular outcomes in patients with bilateral adrenal tumours and cortisol excess: an international, retrospective cohort study
Although mortality and cardiovascular event rates were similar across treatments,
surgery led to better biochemical control and more favourable comorbidity outcomes.
thelancet.com
New—Effect of surgical versus conservative management on #cardiovascular outcomes in patients with #bilateral #adrenal #tumours and #cortisol excess: an international, retrospective cohort study thelancet.com/journals/lan...
#cardiometabolic #morbidity #mortality
#adrenal crises
#MedSky #EndoSky
#cardiometabolic #morbidity #mortality
#adrenal crises
#MedSky #EndoSky
Reposted by The Lancet Diabetes Endocrinology
The Lancet
@thelancet.com
· 10d
🆕 Glucagon-like receptor agonists and next-generation incretin-based medications: metabolic, cardiovascular, and renal benefits spkl.io/63323AUMb5
New—Feasibility of general population screening for type 1 #diabetes in the UK: the ELSA study www.thelancet.com/journals/lan...
#T1D #screening
#MedSky #EndoSky
#T1D #screening
#MedSky #EndoSky
Reposted by The Lancet Diabetes Endocrinology
The Lancet
@thelancet.com
· 11d
📢 Call for Abstracts!
Submit by June 12, 2026 to present a talk or poster at The #LancetSummit. Join a stellar faculty and explore strategies to prevent type 1, type 2, and gestational #diabetes.
View topics & submit: hubs.li/Q03MV1LQ0
📅 Nov 30–Dec 2, 2026
📍 Sitges, Spain
Submit by June 12, 2026 to present a talk or poster at The #LancetSummit. Join a stellar faculty and explore strategies to prevent type 1, type 2, and gestational #diabetes.
View topics & submit: hubs.li/Q03MV1LQ0
📅 Nov 30–Dec 2, 2026
📍 Sitges, Spain
#Incretin hormones—glucagon-like peptide-1 (#GLP-1) & glucose-dependent insulinotropic peptide (#GIP)—act as a critical link connecting digestion, metabolism & cardiovascular function, supporting physiological adaptations to nutrient intake tinyurl.com/yc5st685
#MedSky #EndoSky #GastroSky #CardioSky
#MedSky #EndoSky #GastroSky #CardioSky
The application of implementation science to expanding knowledge of #familial #hypercholesterolaemia has enabled the development and design of potentially more effective models of care thelancet.com/journals/lan...
#HoFH #HeFH #ASCVD
#MedSky #EndoSky #CardioSky
#HoFH #HeFH #ASCVD
#MedSky #EndoSky #CardioSky