The Lancet Diabetes Endocrinology

Realigning diabetes regimens in older adults: a 4S Pathway to guide simplification and deprescribing strategies

The Lancet Diabetes & Endocrinology @thelancetendo.bsky.social · 12h

Most #diabetes guidelines focus on improving glycaemia through addition of medications, but few address strategies to reduce medication burden for older adults—a concept known as deprescribing www.thelancet.com/journals/lan... #T1D #T2D #olderadults
#WorldDiabetesDay

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Treating older people with diabetes is challenging due to multiple medical comorbidities that might interfere with patients' ability to perform self-care. Most diabetes guidelines focus on improving g...

Re-evaluating the concept of remission in type 2 diabetes: a call for patient-centric approaches

The Lancet Diabetes & Endocrinology @thelancetendo.bsky.social · 12h

Re-evaluating the concept of #remission in type 2 #diabetes: a call for patient-centric approaches www.thelancet.com/journals/lan... #T2D
#WorldDiabetesDay

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Controlling weight and cardiovascular risk factors is paramount in type 2 diabetes management; however, the definition and feasibility of remission warrant closer examination. Type 2 diabetes remissio...

Diabetes support at work: an unmet need

The Lancet @thelancet.com · 18h

People with diabetes can face many challenges in the workplace.

On #WorldDiabetesDay, an Editorial in @thelancetendo.bsky.social explores how employers and employees can foster supportive, health-promoting workplaces that empower people with diabetes: spkl.io/63322Aj3Xj

Quote from The Lancet Diabetes & Endocrinology December 2025 Editorial. Quote reads: "This year’s World Diabetes Day is a wakeup call to both employers and employees to create workplaces that empower people with diabetes to thrive and promote health as a key part of work and life."

The Lancet Diabetes & Endocrinology @thelancetendo.bsky.social · 23h

Today, World Diabetes Day 2025, is a wake-up call to both employers and employees to create workplaces that empower people with #diabetes to thrive and promote health as a key part of work and life www.thelancet.com/journals/lan...
#FREE to read
#WorldDiabetesDay #DiabetesAtWork

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According to the latest edition of the IDF Diabetes Atlas, 589 million people around the world were living with diabetes in 2024, with 70% being of working age. People with diabetes face many challeng...

The Lancet @thelancet.com · 1d

Preventing disease through early intervention is a compelling alternative to chronic disease management.

A recent study investigated the safety & efficacy of oral insulin immunotherapy in children genetically at risk for type 1 diabetes: spkl.io/63326AjJ6O

Figure 3 Kaplan–Meier curves for the effects of treatment with oral insulin on the development of the primary outcome (two or more islet autoantibodies). The red line shows the estimate of the proportions of participants who received oral insulin who developed the primary outcome after randomisation; the blue line shows participants who received placebo and developed the primary outcome. Copyright: 2025 The Author(s). Published by Elsevier Ltd. CC BY 4.0.

Primary aldosteronism and plasma renin targets

The Lancet @thelancet.com · 1d

Despite major strides in the treatment and management of type 1 diabetes, the disease burden remains high.

A Seminar reviews the field of type 1 diabetes, and highlights progress, challenges to clinical care, & future directions in research: spkl.io/63324Ab7f4 #WorldDiabetesDay

Lancet infographic illustrating how type 1 diabetes develops.

The Lancet Diabetes & Endocrinology @thelancetendo.bsky.social · 2d

Linked Comment by Kevin S Fay & Debbie L Cohen:
Primary #aldosteronism and plasma #renin targets www.thelancet.com/journals/lan...

#MedSky #EndoSky #CardioSky

Over the past two decades there have been tremendous advancements in the understanding of both the prevalence and the clinical significance of primary aldosteronism. Where previously only the most ext...

Empagliflozin in chronic kidney disease: evidence for early, inclusive, and confident use

The Lancet Diabetes & Endocrinology @thelancetendo.bsky.social · 2d

The association between unsuppressed #renin following medical therapy for primary #aldosteronism and reduced risk of cardiovascular events and all-cause mortality suggests that renin normalisation might serve as a therapeutic target www.thelancet.com/journals/lan...
#primary #aldosteronism

#EndoSky

The Lancet Diabetes & Endocrinology @thelancetendo.bsky.social · 2d

Also read the Linked Comment;
#Empagliflozin in chronic #kidney disease: evidence for early, inclusive, and confident use www.thelancet.com/journals/lan...
#CKD #T2D
#FREE to read with registration (also FREE)

#MedSky #endoSky #RenalSky

The scenario of chronic kidney disease (CKD) management has been transformed by the advent of sodium glucose co-transporter-2 (SGLT2) inhibitors, a class of drugs with benefits extending well beyond g...

Effects of empagliflozin on conventional and exploratory acute and chronic kidney outcomes: an individual participant-level meta-analysis

The Lancet Diabetes & Endocrinology @thelancetendo.bsky.social · 2d

#SGLT2 inhibition reduces risk of acute and chronic kidney outcomes irrespective of the size of the acute dip in eGFR www.thelancet.com/journals/lan...
#CKD #T2D
#OpenAccess

#MedSky #EndoSky #RenalSky

SGLT2 inhibition reduces risk of acute and chronic kidney outcomes irrespective of the size of the acute dip in eGFR. Kidney benefits are evident irrespective of diabetes status, heart failure status,...

Life stage transitions for people with type 1 diabetes

The Lancet @thelancet.com · 2d

📣 Big news! We’re excited to announce the Advisory Board for The #LancetSummit: shaping the future of #diabetes prevention. Welcome Amanda Adler, Kamlesh Khunti, Dianna Magliano, Chantal Mathieu and Didac Mauricio Puente. Find out more and submit your abstract to join the Summit: hubs.li/Q03MV20T0

The Lancet Summit: shaping the future of diabetes prevention. Image credit: Ixefra / Getty Images.

The Lancet Diabetes & Endocrinology @thelancetendo.bsky.social · 2d

New in the December issue:
Life stage transitions for people with type 1 #diabetes www.thelancet.com/journals/lan...
#T1D

#MedSky #EndoSky

Type 1 diabetes affects individuals of all ages, with different clinical priorities and support needs at different stages of life. In this Personal View, we define the two major transitions that occur...

Diabetes support at work: an unmet need

The Lancet Diabetes & Endocrinology @thelancetendo.bsky.social · 2d

Ahead of World Diabetes Day, read our new December issue Editorial:
Diabetes support at work: an unmet need thelancet.com/journals/lan...
#FREE to read
#WorldDiabetesDay #DiabetesAtWork

#MedSky #EndoSky

The road towards standardisation in cyclic Cushing's syndrome

The Lancet Diabetes & Endocrinology @thelancetendo.bsky.social · 3d

Hyperprolactinaemia can result from dopamine antagonist drug effects and reduced prolactin clearance with liver or kidney disease with loss of feedback regulation www.thelancet.com/journals/lan...
#hyperprolactinaemia #prolactinomas #pituitary

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The Lancet Diabetes & Endocrinology @thelancetendo.bsky.social · 4d

Dan Alexandru Niculescu comments on:
The road towards standardisation in cyclic Cushing's syndrome thelancet.com/journals/lan...
cyclic #Cushing's syndrome (#cCS)

#MedSky #EndoSky

Endogenous Cushing's syndrome is a severe, potentially lethal, endocrine condition. It is well known for its pleomorphic clinical manifestations that often overlap with those of frequent endocrine and...

Cycle characterisation and clinical complications in patients with cyclic Cushing's syndrome: insights from an international retrospective cohort study

The Lancet Diabetes & Endocrinology @thelancetendo.bsky.social · 4d

Cycle characterisation and clinical complications in patients with cyclic Cushing's syndrome: insights from an international retrospective cohort study thelancet.com/journals/lan...
cyclic #Cushing's syndrome (#cCS)

#MedSky #EndoSky

Even in specialised centres, cCS diagnosis and management remain challenging with high rates of spontaneous adrenal insufficiency, inappropriate surgeries, and poor outcomes. Ectopic cCS showed the mo...

Glucocorticoid-induced osteoporosis: novel concepts and clinical implications

The Lancet Diabetes & Endocrinology @thelancetendo.bsky.social · 4d

Fragility #fractures remain a common & serious complication of long-term oral #glucocorticoid therapy that might affect all skeletal sites, although the spine is particularly prone to fractures owing to its high proportion of trabecular bone thelancet.com/journals/lan...
#OpenAccess
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Despite advances in targeted therapies, treatment with glucocorticoids remains a mainstay in the management of various immune-mediated diseases. High cumulative doses of exogenous glucocorticoids lead...

Recent advances in research and care of familial hypercholesterolaemia

The Lancet Diabetes & Endocrinology @thelancetendo.bsky.social · 5d

Current efforts to manage #diabetes appear to have narrowed the gap between people with and without diabetes in terms of
#atherosclerotic #cardiovascular disease mortality, but not in terms of heart failure mortality www.thelancet.com/journals/lan...
#T2D #heartfailure #ASCVD

#EndoSky #CardioSky

The Lancet Diabetes & Endocrinology @thelancetendo.bsky.social · 5d

Heterozygous familial #hypercholesterolaemia is a common, autosomal semi-dominant condition characterised by elevation of #LDL #cholesterol from birth and early onset of #atherosclerotic #cardiovascular disease www.thelancet.com/journals/lan...
#HeFH #ASCVD

#MedSky #EndoSky #CardioSky

Heterozygous familial hypercholesterolaemia is a common, autosomal semi-dominant condition characterised by elevation of LDL cholesterol from birth and early onset of atherosclerotic cardiovascular di...

From reproduction to metabolism: FSH as a key modulator in menopause

The Lancet Diabetes & Endocrinology @thelancetendo.bsky.social · 5d

Interventions targeting #FSH signalling could offer an integrated strategy to counteract #female #age-related metabolic changes, harmonising bone, adipose, and systemic energy regulation www.thelancet.com/journals/lan...
#follicle-stimulating hormone #menopause

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Follicle-stimulating hormone (FSH), a glycoprotein secreted by gonadotroph cells of the anterior pituitary, is classically known as a key regulator of reproduction in both sexes, acting mainly on the ...

Redifferentiation therapy in unresectable or metastatic radioactive iodine refractory thyroid cancer: an International Thyroid Oncology Group statement

The Lancet Diabetes & Endocrinology @thelancetendo.bsky.social · 5d

In patients with follicular cell-derived #thyroid #cancer that have distant metastases and no iodine uptake, #redifferentiation—ie, the restoration of tumoural 131I uptake with systemic therapy—is now possible www.thelancet.com/journals/lan...
#thyroidcancer
#OpenAccess

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In patients with follicular cell-derived thyroid cancer that have distant metastases and no iodine uptake, redifferentiation—ie, the restoration of tumoural 131I uptake with systemic therapy—is now po...

The unique signature of tyrosine kinase inhibitor-induced hypothyroidism

The Lancet Diabetes & Endocrinology @thelancetendo.bsky.social · 5d

The combined action of tyrosine kinase inhibitors (TKIs) on #thyroid gland function & peripheral deiodinases generates a unique phenotype of primary #hypothyroidism characterised by increased TSH concentrations & a reduced T3 to T4 ratio www.thelancet.com/journals/lan...
#TKIs

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Tyrosine kinase inhibitors (TKIs) are anti-cancer agents that inhibit the activity of oncogenic protein kinases. Thyroid hormone abnormalities are common during treatment with TKIs, typically manifest...

Cardiovascular mortality trends among people with and without diabetes

The Lancet Diabetes & Endocrinology @thelancetendo.bsky.social · 5d

The hypothalamic–pituitary–thyroid axis plays a crucial role in the pathogenesis, diagnosis, risk stratification, effectiveness of radioiodine therapy, & treatment response evaluation in epithelial #thyroid #cancer www.thelancet.com/journals/lan...
#thyroidcancer #HPT axis
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The Lancet Diabetes & Endocrinology @thelancetendo.bsky.social · 6d

Ranjit Mohan Anjana comments on:
#Cardiovascular mortality trends among people with and without #diabetes thelancet.com/journals/lan...
#HeartFailure #ASCVD #T2D

#MedSky #EndoSky #CardioSky

Cardiovascular disease (CVD), a composite of coronary heart disease (CHD), cerebrovascular disease, and heart failure, remains the leading cause of morbidity and mortality worldwide. Although mortalit...

Time trends in mortality from heart failure and atherosclerotic cardiovascular disease in people with and without diabetes: a multi-national population-based study

The Lancet Diabetes & Endocrinology @thelancetendo.bsky.social · 6d

New—Time trends in mortality from heart failure and #atherosclerotic #cardiovascular disease in people with and without #diabetes: a multi-national population-based study thelancet.com/journals/lan...
#HeartFailure #ASCVD #T2D

#MedSky #EndoSky #CardioSky

Declines in heart failure mortality in both people with and without diabetes were less marked than were declines in CHD and cerebrovascular disease mortality in most jurisdictions. Heart failure morta...

Bone health in adults with obesity before and after interventions to promote weight loss

The Lancet Gastroenterology & Hepatology @lancetgastrohep.bsky.social · 8d

Our December issue is out now at www.thelancet.com/journals/lan...

Content includes diet in GI disorders; IBS; IBD; oesophageal cancer; alcohol-related liver disease; MASLD + more!

#GastroSky #LiverSky #MedSky

The Lancet Diabetes & Endocrinology @thelancetendo.bsky.social · 9d

#Fractures affect a substantial proportion of people with #obesity and result from reduced #bone strength relative to increased mechanical loading, together with an increased risk of #falls www.thelancet.com/journals/lan...
#osteoporosis #BoneHealth #weightloss #obesity

#MedSky #EndoSky #RheumSky

Obesity and its associated comorbidities constitute a serious and growing public health burden. Fractures affect a substantial proportion of people with obesity and result from reduced bone strength r...