Anupam Patgiri
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apatgiri.bsky.social
Anupam Patgiri
@apatgiri.bsky.social
1.8K followers 1.7K following 230 posts
Assistant Professor @EmoryMedicine passionate about #mitochondria #metabolism and #chemicalbiology | PhD @aroralabnyu, Postdoc @VamsiMootha | Amateur Photographer | Lab website: patgirilab.org | 🇮🇳🇺🇸
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Reposted by Anupam Patgiri
pride-ebi.bsky.social
PXD062734 🚨

Proteomic analysis of binding partners of the OMM anchored ubiquitin-fusion degradation substrate

🚨 New dataset alert! 🚨
November 24, 2025 at 11:00 AM
Reposted by Anupam Patgiri
shoshana.bsky.social
Boston's Mayor Wu playing with Yo-Yo Ma at Symphony Hall
November 23, 2025 at 5:11 AM
Reposted by Anupam Patgiri
ryanlab.bsky.social
📢Last 2 weeks of #immunometabolism discoveries @biomednews.bsky.social ⬇️⬇️

biomed.news/bims-imicid/...
biomed.news/bims-imicid/...

Exciting to have a paper in the collection!

An inherited mitochondrial DNA mutation remodels inflammatory cytokine responses in macrophages and in vivo in mice
November 23, 2025 at 1:05 PM
Reposted by Anupam Patgiri
frezzalab.bsky.social
Good Sunday, all. What a great week for #cancermetabolism and #mitochondrialbiology. Find here a selection of groundbreaking discoveries: biomed.news/bims-camemi/... @biomednews.bsky.social #keepreading

"Trying to define yourself is like trying to bite your own teeth."-Alan Watts
November 23, 2025 at 6:51 AM
Reposted by Anupam Patgiri
sculpturatus.bsky.social
The chemotypes within FDA approvals so far this year are quite diverse. Most of the 2025 small molecule approvals are chiral with four covalent electrophiles.
November 23, 2025 at 12:58 AM
Reposted by Anupam Patgiri
pride-ebi.bsky.social
PXD068737 🚨

LC-MS/MS analysis of lactylated proteins in C2C12 cells

🚨 New dataset alert! 🚨
November 22, 2025 at 11:00 PM
apatgiri.bsky.social
Bacterial CipB is an exogenous receptor to drive the mitophagy-TFEB axis and promote pathogenesis rupress.org/jcb/article-...
Bacterial CipB is an exogenous receptor to drive the mitophagy-TFEB axis and promote pathogenesis
Liu et al. discover that pathogenic bacteria use a shared strategy to exploit the host’s cellular recycling process, mitophagy. Through an effector protein
rupress.org
November 22, 2025 at 6:08 PM
Reposted by Anupam Patgiri
dplamartin.bsky.social
link.springer.com/epdf/10.1007...
Mitochondria quality control: preserving the cells’ command center
link.springer.com
November 22, 2025 at 12:27 PM
apatgiri.bsky.social
The metabolic engine of cognition: microglia–neuron interactions in health, ageing and disease www.nature.com/articles/s42...
The metabolic engine of cognition: microglia–neuron interactions in health, ageing and disease - Nature Metabolism
This Review highlights how metabolic interactions between microglia and neurons shape brain health, and how their disruption in ageing and disease contributes to cognitive decline.
www.nature.com
November 22, 2025 at 12:07 AM
Reposted by Anupam Patgiri
ryanlab.bsky.social
Very excited to announce that the first paper from the lab is now live @natcomms.nature.com #mitochondria #immunometabolism

This work was led by postdoc Eloise marques with many important contributions from all of our co-authors.

Please check it out!

www.nature.com/articles/s41...
An inherited mitochondrial DNA mutation remodels inflammatory cytokine responses in macrophages and in vivo in mice - Nature Communications
Inherited mitochondrial DNA mutations can result in diverse clinical phenotypes. Here, the authors characterise a heteroplasmic tRNAAla mutation (m.5019A>G) in mice and demonstrate that macrophages...
www.nature.com
November 20, 2025 at 4:09 PM
Reposted by Anupam Patgiri
elife.bsky.social
Toxoplasma gondii carefully balances calcium between its organelles. This study shows the ER, via the SERCA pump, is central to controlling Ca²⁺ in the cytosol and mitochondria.

🔗 buff.ly/RFgcZgE
November 20, 2025 at 11:28 PM
Reposted by Anupam Patgiri
willoremus.com
every company in 2025
comic strip with call and response text. who are we? CEOs what do we want? AI! AI to do what? We don't know! When do we want it? Right now!
November 12, 2025 at 5:59 PM
apatgiri.bsky.social
An inherited mitochondrial DNA mutation remodels inflammatory cytokine responses in macrophages and in vivo in mice
www.nature.com/articles/s41...
An inherited mitochondrial DNA mutation remodels inflammatory cytokine responses in macrophages and in vivo in mice - Nature Communications
Inherited mitochondrial DNA mutations can result in diverse clinical phenotypes. Here, the authors characterise a heteroplasmic tRNAAla mutation (m.5019A>G) in mice and demonstrate that macrophages...
www.nature.com
November 20, 2025 at 3:42 PM
apatgiri.bsky.social
Missing the magic of New England’s fall colors! I captured this shot of Sleepy Hollow Farm in Vermont back in 2019.
#FallVibes #AutumnColors #FallFoliage #FallMagic #PeakFoliage #NaturePhotography #LandscapePhotography #NewEngland #Vermont
November 20, 2025 at 12:13 PM
Reposted by Anupam Patgiri
ryanlab.bsky.social
Last week's #immunometabolism discoveries @biomednews.bsky.social ⬇️⬇️⬇️

biomed.news/bims-imicid/...

Interesting finding:

Intracellular Salmonella hijacks the mitochondrial citrate carrier to evade host oxidative defenses
November 10, 2025 at 9:23 AM
Reposted by Anupam Patgiri
frezzalab.bsky.social
www.nature.com/articles/s42...
Glycerol-3-phosphate activates ChREBP, FGF21 transcription and lipogenesis in citrin deficiency

@charlesmbrenner.bsky.social congratulations!
Glycerol-3-phosphate activates ChREBP, FGF21 transcription and lipogenesis in citrin deficiency - Nature Metabolism
In a mouse model of the rare disease citrin deficiency, the authors discovered that the accumulation of glycerol-3-phosphate leads to ChREBP activation and FGF21 induction. The study identifies glycer...
www.nature.com
November 16, 2025 at 7:21 AM
Reposted by Anupam Patgiri
frezzalab.bsky.social
Good Sunday!. A wonderful selection of papers in #cancermetabolism and #mitochondrialbiology is waiting for you here: biomed.news/bims-camemi/... @biomednews.bsky.social #keepreading

"99.9 per cent of everything you think, and of everything you do, is for yourself—and there isn't one."
-Wei Wu Wei
November 16, 2025 at 7:04 AM
Reposted by Anupam Patgiri
frisophagy.bsky.social
Only good papers on mitophagy this week!

biomed.news/bims-tofagi/...

Highlights:
-The bottleneck for maternal transmission of mtDNA is linked to purifying selection by autophagy
-Piecemeal Mitochondrial degradation in plants
-Allophagy?!

Thanks to @biomednews.bsky.social
Altered bottleneck and mitochondrial turnover affect mtDNA mutation load and selection efficiency. (A) Mutational burden was quantified as the total number of mtDNA variants detected per animal. (B) For each animal, the mtDNA N/S ratio was calculated by dividing the number of nonsynonymous variants, normalized to the number of possible nonsynonymous variants in the mitochondrial genome, by the number of synonymous variants, normalized to the number of possible synonymous sites. For (A) and (B): dashed line, median value of the Polg+/+ control group; dotted line, modal value of the Polg+/+ control group; gray, Polg+/+ control group; orange, Polg+/+ Tfam+/− group; blue, Polg+/+ Tfam+/OE group; green, Polg+/+ Bcl2l13−/− group; and pink, Polg+/+ Ulk2−/− group.
November 16, 2025 at 10:53 AM
apatgiri.bsky.social
Metabolic Messengers: itaconate www.nature.com/articles/s42...
Metabolic Messengers: itaconate - Nature Metabolism
McGettrick et al. provide a succinct yet broad overview of the immunometabolite itaconate as an immunomodulatory molecule.
www.nature.com
November 15, 2025 at 7:13 PM
Reposted by Anupam Patgiri
josephwgordon.bsky.social
www.nature.com/articles/s41...
Leucine inhibits degradation of outer mitochondrial membrane proteins to adapt mitochondrial respiration - Nature Cell Biology
Li et al. uncover a connection between metabolic cues and mitochondrial protein degradation, showing that specifically leucine stabilizes outer mitochondrial membrane proteins by inhibiting ubiquityla...
www.nature.com
November 13, 2025 at 1:03 PM
Reposted by Anupam Patgiri
jourdainlab.bsky.social
Very excited to share the published version of our #uridine #CRISPR screen in naturemetabolism.bsky.social! 🎉

Led by Abigail Strefeler with @pagliarini-lab.bsky.social @zakbaker.bsky.social and team!

#NUDT5 #DMQ @dib-unil.bsky.social @fbm-unil.bsky.social

🔗 www.nature.com/articles/s42...
🧵1/17
Uridine-sensitized screening identifies demethoxy-coenzyme Q and NUDT5 as regulators of nucleotide synthesis - Nature Metabolism
A uridine-sensitized CRISPR-Cas9 screening identifies demethoxy-CoQ as an alternative electron acceptor in the absence of CoQ, and NUDT5 as a regulator of de novo pyrimidine synthesis via its interact...
www.nature.com
November 13, 2025 at 10:19 AM
Reposted by Anupam Patgiri
frezzalab.bsky.social
www.nature.com/articles/s41...
Cytosolic acetyl-coenzyme A is a signalling metabolite to control mitophagy
Cytosolic acetyl-coenzyme A is a signalling metabolite to control mitophagy - Nature
Acetyl-coenzyme A functions as a non-canonical signal to trigger mitophagy, and the acetyl-coenzyme A–NLRX1 axis underlies the KRAS-inhibitor-induced mitophagy response and promotes drug resistan...
www.nature.com
November 12, 2025 at 6:02 PM
Reposted by Anupam Patgiri
cvasilescu.bsky.social
A new collection of papers on #mitochondrialdisease from #week45! 📚 💚
biomed.news/bims-mitdis/...

@biomednews.bsky.social @gavinmcstay.bsky.social @mitoscientist.bsky.social

Mito complex III-derived ROS amplify immunometab changes in astrocytes and promote dementia
www.nature.com/articles/s42...
Mitochondrial complex III-derived ROS amplify immunometabolic changes in astrocytes and promote dementia pathology - Nature Metabolism
Barnett et al. disentangle the differential contribution of mitochondrial complex I- and complex III-derived ROS to astrocytic function, with CIII-derived ROS being a major driver of neuroinflammatory...
www.nature.com
November 9, 2025 at 12:53 PM
Reposted by Anupam Patgiri
frezzalab.bsky.social
Good Sunday, all. The weekly curated issue of papers in #cancermetabolism and #mitochondrialbiology is out, a concentrate of groundbreaking discoveries:

biomed.news/bims-camemi/...
@biomednews.bsky.social #keepreading

"There are years that ask questions and years that answer."-Zora Neale Hurston
November 9, 2025 at 6:28 AM
Reposted by Anupam Patgiri
rjdlab.bsky.social
1/New paper from Zheng Wu, Phong Nguyen et al. @cri-utsw.bsky.social shows how cells balance the two pathways that produce purine nucleotides: de novo purine biosynthesis (DNPB) and purine salvage. The surprising mechanism involves NUDT5, a Nudix hydrolase

www.science.org/doi/10.1126/...
NUDT5 regulates purine metabolism and thiopurine sensitivity by interacting with PPAT
Cells generate purine nucleotides through de novo purine biosynthesis (DNPB) and purine salvage. Purine salvage represses DNPB to prevent excessive purine nucleotide synthesis through mechanisms that ...
www.science.org
November 6, 2025 at 7:01 PM