Anupam Patgiri
@apatgiri.bsky.social
Assistant Professor @EmoryMedicine passionate about #mitochondria #metabolism and #chemicalbiology | PhD @aroralabnyu, Postdoc @VamsiMootha | Amateur Photographer | Lab website: patgirilab.org | 🇮🇳🇺🇸
Reposted by Anupam Patgiri
Good morning everyone, below is last issue of #mitophagy news 🪫 🔋 🗑️
biomed.news/bims-tofagi/...
This week you'll find insights on the role of mitophagy in germline cells and in inheritance of mtDNA, in mice and in the male arabidopsis germline
Thanks to @biomednews.bsky.social for pre-sorting
biomed.news/bims-tofagi/...
This week you'll find insights on the role of mitophagy in germline cells and in inheritance of mtDNA, in mice and in the male arabidopsis germline
Thanks to @biomednews.bsky.social for pre-sorting
January 26, 2026 at 9:00 AM
Good morning everyone, below is last issue of #mitophagy news 🪫 🔋 🗑️
biomed.news/bims-tofagi/...
This week you'll find insights on the role of mitophagy in germline cells and in inheritance of mtDNA, in mice and in the male arabidopsis germline
Thanks to @biomednews.bsky.social for pre-sorting
biomed.news/bims-tofagi/...
This week you'll find insights on the role of mitophagy in germline cells and in inheritance of mtDNA, in mice and in the male arabidopsis germline
Thanks to @biomednews.bsky.social for pre-sorting
Reposted by Anupam Patgiri
5 years of MITOtalks!
Feels like it was yesterday when @wanrooij20.bsky.social
and @nunoraimundo.bsky.social
opened the first MITOtalk to introduce
@frezzalab.bsky.social.
But it turns out FIVE YEARS have passed. That's 57 MITOtalks, 44 MITOchats, 6000+ followers.
Onwards and upwards!
Feels like it was yesterday when @wanrooij20.bsky.social
and @nunoraimundo.bsky.social
opened the first MITOtalk to introduce
@frezzalab.bsky.social.
But it turns out FIVE YEARS have passed. That's 57 MITOtalks, 44 MITOchats, 6000+ followers.
Onwards and upwards!
January 21, 2026 at 4:50 PM
5 years of MITOtalks!
Feels like it was yesterday when @wanrooij20.bsky.social
and @nunoraimundo.bsky.social
opened the first MITOtalk to introduce
@frezzalab.bsky.social.
But it turns out FIVE YEARS have passed. That's 57 MITOtalks, 44 MITOchats, 6000+ followers.
Onwards and upwards!
Feels like it was yesterday when @wanrooij20.bsky.social
and @nunoraimundo.bsky.social
opened the first MITOtalk to introduce
@frezzalab.bsky.social.
But it turns out FIVE YEARS have passed. That's 57 MITOtalks, 44 MITOchats, 6000+ followers.
Onwards and upwards!
Reposted by Anupam Patgiri
House Appropriations minibus bill funding NIH is out now.
- $400M increase
- Multiyear funding of new awards capped at 2025 levels.
- No line item for BRAIN Initiative
text here: docs.house.gov/billsthiswee...
Screenshots from Dem summary and Sec 240 (multiyear funding text).
- $400M increase
- Multiyear funding of new awards capped at 2025 levels.
- No line item for BRAIN Initiative
text here: docs.house.gov/billsthiswee...
Screenshots from Dem summary and Sec 240 (multiyear funding text).
January 20, 2026 at 2:29 PM
House Appropriations minibus bill funding NIH is out now.
- $400M increase
- Multiyear funding of new awards capped at 2025 levels.
- No line item for BRAIN Initiative
text here: docs.house.gov/billsthiswee...
Screenshots from Dem summary and Sec 240 (multiyear funding text).
- $400M increase
- Multiyear funding of new awards capped at 2025 levels.
- No line item for BRAIN Initiative
text here: docs.house.gov/billsthiswee...
Screenshots from Dem summary and Sec 240 (multiyear funding text).
Reposted by Anupam Patgiri
Why is obesity often associated with dysregulated, low-grade chronic inflammation?
In our new paper in @science.org we show that obesity rewires nucleotide metabolism in immune cells, making inflammatory responses much easier to trigger. www.science.org/doi/10.1126/...
In our new paper in @science.org we show that obesity rewires nucleotide metabolism in immune cells, making inflammatory responses much easier to trigger. www.science.org/doi/10.1126/...
Nucleotide metabolic rewiring enables NLRP3 inflammasome hyperactivation in obesity
Obesity is a major disease risk factor due to obesity-associated hyperinflammation. We found that obesity induced Nod-like receptor pyrin domain–containing 3 (NLRP3) inflammasome hyperactivation and e...
www.science.org
January 16, 2026 at 6:14 PM
Why is obesity often associated with dysregulated, low-grade chronic inflammation?
In our new paper in @science.org we show that obesity rewires nucleotide metabolism in immune cells, making inflammatory responses much easier to trigger. www.science.org/doi/10.1126/...
In our new paper in @science.org we show that obesity rewires nucleotide metabolism in immune cells, making inflammatory responses much easier to trigger. www.science.org/doi/10.1126/...
Reposted by Anupam Patgiri
📢Last weeks #immunometabolism discoveries
@biomednews.bsky.social ⬇️⬇️⬇️
biomed.news/bims-imicid/...
Interesting paper:
Metabolic adaptations rewire CD4+ T cells in a subset-specific manner in human critical illness with and without sepsis
@biomednews.bsky.social ⬇️⬇️⬇️
biomed.news/bims-imicid/...
Interesting paper:
Metabolic adaptations rewire CD4+ T cells in a subset-specific manner in human critical illness with and without sepsis
January 18, 2026 at 12:13 PM
📢Last weeks #immunometabolism discoveries
@biomednews.bsky.social ⬇️⬇️⬇️
biomed.news/bims-imicid/...
Interesting paper:
Metabolic adaptations rewire CD4+ T cells in a subset-specific manner in human critical illness with and without sepsis
@biomednews.bsky.social ⬇️⬇️⬇️
biomed.news/bims-imicid/...
Interesting paper:
Metabolic adaptations rewire CD4+ T cells in a subset-specific manner in human critical illness with and without sepsis
Reposted by Anupam Patgiri
Excited to announce that registration is officially open for #METPHYS2026!
All meeting details can be found here:
www.sablesys.com/metphys-the-...
All meeting details can be found here:
www.sablesys.com/metphys-the-...
January 13, 2026 at 4:12 PM
Excited to announce that registration is officially open for #METPHYS2026!
All meeting details can be found here:
www.sablesys.com/metphys-the-...
All meeting details can be found here:
www.sablesys.com/metphys-the-...
Lactate-Driven Heterogeneity of Immune Checkpoint Expression in Breast and Lung Cancer Cell Lines www.biorxiv.org/content/10.6...
Lactate-Driven Heterogeneity of Immune Checkpoint Expression in Breast and Lung Cancer Cell Lines
Tumor-derived lactate is increasingly recognized as an immunosuppressive metabolite within the tumor microenvironment (TME), with emerging evidence highlighting its role beyond metabolism to include e...
www.biorxiv.org
January 13, 2026 at 3:20 AM
Lactate-Driven Heterogeneity of Immune Checkpoint Expression in Breast and Lung Cancer Cell Lines www.biorxiv.org/content/10.6...
Reposted by Anupam Patgiri
Welcome to another week of mitophagy papers! 🪫🗑️
biomed.news/bims-tofagi/...
highlights:
-A rab1 A Rab1 interactome illuminates a dual role in autophagy and membrane trafficking
-a review on the role of superoxide in mitophagy
-USP15 inhibition ameliorates PD phenotype in mouse models of disease
biomed.news/bims-tofagi/...
highlights:
-A rab1 A Rab1 interactome illuminates a dual role in autophagy and membrane trafficking
-a review on the role of superoxide in mitophagy
-USP15 inhibition ameliorates PD phenotype in mouse models of disease
January 11, 2026 at 10:50 AM
Welcome to another week of mitophagy papers! 🪫🗑️
biomed.news/bims-tofagi/...
highlights:
-A rab1 A Rab1 interactome illuminates a dual role in autophagy and membrane trafficking
-a review on the role of superoxide in mitophagy
-USP15 inhibition ameliorates PD phenotype in mouse models of disease
biomed.news/bims-tofagi/...
highlights:
-A rab1 A Rab1 interactome illuminates a dual role in autophagy and membrane trafficking
-a review on the role of superoxide in mitophagy
-USP15 inhibition ameliorates PD phenotype in mouse models of disease
Reposted by Anupam Patgiri
Good Sunday, all. Here is a great summary of last week's papers in #cancermetabolism and #mitochondrialbiology. Don't miss it! Find it here: biomed.news/bims-camemi/... Biomed News #keepreading
"Life isn't a dress rehearsal; this is it. It's your job to show up for this moment" Oliver Burkeman
"Life isn't a dress rehearsal; this is it. It's your job to show up for this moment" Oliver Burkeman
January 11, 2026 at 6:37 AM
Good Sunday, all. Here is a great summary of last week's papers in #cancermetabolism and #mitochondrialbiology. Don't miss it! Find it here: biomed.news/bims-camemi/... Biomed News #keepreading
"Life isn't a dress rehearsal; this is it. It's your job to show up for this moment" Oliver Burkeman
"Life isn't a dress rehearsal; this is it. It's your job to show up for this moment" Oliver Burkeman
Reposted by Anupam Patgiri
The first two issues of #autophagy and #mTOR papers of the year pre-selected by @biomednews.bsky.social engine. Enjoy and Happy New Year to all!
biomed.news/bims-auttor/...
biomed.news/bims-auttor/...
biomed.news/bims-auttor/...
biomed.news/bims-auttor/...
kermit the frog is dancing in front of a red curtain with the words its week # 2 !!!
ALT: kermit the frog is dancing in front of a red curtain with the words its week # 2 !!!
media.tenor.com
January 11, 2026 at 12:05 PM
The first two issues of #autophagy and #mTOR papers of the year pre-selected by @biomednews.bsky.social engine. Enjoy and Happy New Year to all!
biomed.news/bims-auttor/...
biomed.news/bims-auttor/...
biomed.news/bims-auttor/...
biomed.news/bims-auttor/...
Reposted by Anupam Patgiri
Last 2 weeks of research papers relevant to #MitochondrialDisease!
biomed.news/bims-mitdis/...
biomed.news/bims-mitdis/...
@biomednews.bsky.social @gavinmcstay.bsky.social @mitoscientist.bsky.social
Mitochondrial control of fuel switching via carnitine biosynthesis
www.science.org/doi/10.1126/...
biomed.news/bims-mitdis/...
biomed.news/bims-mitdis/...
@biomednews.bsky.social @gavinmcstay.bsky.social @mitoscientist.bsky.social
Mitochondrial control of fuel switching via carnitine biosynthesis
www.science.org/doi/10.1126/...
Mitochondrial control of fuel switching via carnitine biosynthesis
Environmental adaptation often involves a shift in energy utilization toward mitochondrial fatty acid oxidation, which requires carnitine. Besides dietary sources of animal origin, carnitine biosynthe...
www.science.org
January 11, 2026 at 12:53 PM
Last 2 weeks of research papers relevant to #MitochondrialDisease!
biomed.news/bims-mitdis/...
biomed.news/bims-mitdis/...
@biomednews.bsky.social @gavinmcstay.bsky.social @mitoscientist.bsky.social
Mitochondrial control of fuel switching via carnitine biosynthesis
www.science.org/doi/10.1126/...
biomed.news/bims-mitdis/...
biomed.news/bims-mitdis/...
@biomednews.bsky.social @gavinmcstay.bsky.social @mitoscientist.bsky.social
Mitochondrial control of fuel switching via carnitine biosynthesis
www.science.org/doi/10.1126/...
Reposted by Anupam Patgiri
What genetic change to Indian wheat led to superior baking in a tandoor?
A naan sense mutation
A naan sense mutation
January 10, 2026 at 12:07 AM
What genetic change to Indian wheat led to superior baking in a tandoor?
A naan sense mutation
A naan sense mutation
Reposted by Anupam Patgiri
If you are submitting an NIH grant in February, you will be required to use SciENcv to prepare you biosketch.
IT IS MUCH WORSE THAN YOU CAN POSSIBLY IMAGINE.
Set aside *at least* 4 hours just to transfer an existing an biosketch into SciENcv.
IT IS MUCH WORSE THAN YOU CAN POSSIBLY IMAGINE.
Set aside *at least* 4 hours just to transfer an existing an biosketch into SciENcv.
January 6, 2026 at 11:29 PM
If you are submitting an NIH grant in February, you will be required to use SciENcv to prepare you biosketch.
IT IS MUCH WORSE THAN YOU CAN POSSIBLY IMAGINE.
Set aside *at least* 4 hours just to transfer an existing an biosketch into SciENcv.
IT IS MUCH WORSE THAN YOU CAN POSSIBLY IMAGINE.
Set aside *at least* 4 hours just to transfer an existing an biosketch into SciENcv.
Reposted by Anupam Patgiri
Reposted by Anupam Patgiri
New post!
There was a lot of innovation in medicine and biomedical research this year, and I've tried to summarize the biggest ones in this blogpost.
Medical breakthroughs in 2025. Plus a serious note at the end.
www.scientificdiscovery.dev/p/medical-br...
There was a lot of innovation in medicine and biomedical research this year, and I've tried to summarize the biggest ones in this blogpost.
Medical breakthroughs in 2025. Plus a serious note at the end.
www.scientificdiscovery.dev/p/medical-br...
Medical breakthroughs in 2025
... and a happy new year.
www.scientificdiscovery.dev
December 28, 2025 at 6:37 PM
New post!
There was a lot of innovation in medicine and biomedical research this year, and I've tried to summarize the biggest ones in this blogpost.
Medical breakthroughs in 2025. Plus a serious note at the end.
www.scientificdiscovery.dev/p/medical-br...
There was a lot of innovation in medicine and biomedical research this year, and I've tried to summarize the biggest ones in this blogpost.
Medical breakthroughs in 2025. Plus a serious note at the end.
www.scientificdiscovery.dev/p/medical-br...
Reposted by Anupam Patgiri
Good morning all! Here is the last weekly issue of the year in #cancermetabolism and #mitochondrialbiology to accompany your readings! biomed.news/bims-camemi/... @biomednews.bsky.social #keepreading
"It is a serious thing, just to be alive on this fresh morning, in the broken world."-Mary Oliver
"It is a serious thing, just to be alive on this fresh morning, in the broken world."-Mary Oliver
bims-camemi 2025-12-28 papers
biomed.news
December 28, 2025 at 6:56 AM
Good morning all! Here is the last weekly issue of the year in #cancermetabolism and #mitochondrialbiology to accompany your readings! biomed.news/bims-camemi/... @biomednews.bsky.social #keepreading
"It is a serious thing, just to be alive on this fresh morning, in the broken world."-Mary Oliver
"It is a serious thing, just to be alive on this fresh morning, in the broken world."-Mary Oliver
Reposted by Anupam Patgiri
Mitochondria-derived PEP licenses glycerolipid synthesis via SLC25A35
pubmed.ncbi.nlm.nih.gov/41446167/
pubmed.ncbi.nlm.nih.gov/41446167/
December 28, 2025 at 12:21 AM
Mitochondria-derived PEP licenses glycerolipid synthesis via SLC25A35
pubmed.ncbi.nlm.nih.gov/41446167/
pubmed.ncbi.nlm.nih.gov/41446167/
Reposted by Anupam Patgiri
Christmas edition🎄of #MitochondrialDisease collection of papers! 🎁 📚
biomed.news/bims-mitdis/...
@biomednews.bsky.social @gavinmcstay.bsky.social @mitoscientist.bsky.social @mitoscientists.bsky.social
Fuel your mitos well and happy holidays!
biomed.news/bims-mitdis/...
@biomednews.bsky.social @gavinmcstay.bsky.social @mitoscientist.bsky.social @mitoscientists.bsky.social
Fuel your mitos well and happy holidays!
December 21, 2025 at 2:53 PM
Christmas edition🎄of #MitochondrialDisease collection of papers! 🎁 📚
biomed.news/bims-mitdis/...
@biomednews.bsky.social @gavinmcstay.bsky.social @mitoscientist.bsky.social @mitoscientists.bsky.social
Fuel your mitos well and happy holidays!
biomed.news/bims-mitdis/...
@biomednews.bsky.social @gavinmcstay.bsky.social @mitoscientist.bsky.social @mitoscientists.bsky.social
Fuel your mitos well and happy holidays!
Reposted by Anupam Patgiri
Mitochondrial Dynamics and Their Role in the Pathogenesis of Age-Related Macular Degeneration: A Comprehensive Review
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
December 21, 2025 at 6:03 PM
Mitochondrial Dynamics and Their Role in the Pathogenesis of Age-Related Macular Degeneration: A Comprehensive Review
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Reposted by Anupam Patgiri
🧪 The main page for peerai is now the preprint curation platform. We now only review and curate preprints.
Anyone can add any preprint, up to five per account per month.
See where your favorite preprint lands!
Cite your peer ai score on your cv and in job applications! Peerai.app
Anyone can add any preprint, up to five per account per month.
See where your favorite preprint lands!
Cite your peer ai score on your cv and in job applications! Peerai.app
peerAI - AI-Powered Scientific Peer Review
Get comprehensive AI peer reviews for your scientific manuscripts. Fast, thorough feedback from multiple AI reviewers with detailed analysis.
Peerai.app
December 16, 2025 at 3:16 AM
🧪 The main page for peerai is now the preprint curation platform. We now only review and curate preprints.
Anyone can add any preprint, up to five per account per month.
See where your favorite preprint lands!
Cite your peer ai score on your cv and in job applications! Peerai.app
Anyone can add any preprint, up to five per account per month.
See where your favorite preprint lands!
Cite your peer ai score on your cv and in job applications! Peerai.app
Reposted by Anupam Patgiri
#week50 of #mitochondrialdisease literature! 📚
biomed.news/bims-mitdis/...
@biomednews.bsky.social @gavinmcstay.bsky.social @mitoscientist.bsky.social @mitoscientists.bsky.social
Mutations in mitochondrial ferredoxin FDX2 suppress frataxin deficiency
Meisel et al
biomed.news/bims-mitdis/...
@biomednews.bsky.social @gavinmcstay.bsky.social @mitoscientist.bsky.social @mitoscientists.bsky.social
Mutations in mitochondrial ferredoxin FDX2 suppress frataxin deficiency
Meisel et al
December 14, 2025 at 1:32 PM
#week50 of #mitochondrialdisease literature! 📚
biomed.news/bims-mitdis/...
@biomednews.bsky.social @gavinmcstay.bsky.social @mitoscientist.bsky.social @mitoscientists.bsky.social
Mutations in mitochondrial ferredoxin FDX2 suppress frataxin deficiency
Meisel et al
biomed.news/bims-mitdis/...
@biomednews.bsky.social @gavinmcstay.bsky.social @mitoscientist.bsky.social @mitoscientists.bsky.social
Mutations in mitochondrial ferredoxin FDX2 suppress frataxin deficiency
Meisel et al
Reposted by Anupam Patgiri
Happy to see our News & Views is out! We highlight two landmark papers demonstrating the potential for therapeutic targeting of FSP1 and #ferroptosis in in vivo cancer models. Beautiful work from @ubellackerlab.bsky.social, Thales Papagiannakopoulos, and colleagues. 🥳
www.nature.com/articles/s41...
www.nature.com/articles/s41...
In vivo models bring FSP1 inhibitors to life - Nature Cell Biology
FSP1 is a key suppressor of lipid peroxidation and ferroptosis, yet it is largely dispensable in standard cell culture models. Two new studies now show that FSP1 becomes essential for tumour growth in...
www.nature.com
December 12, 2025 at 4:15 PM
Happy to see our News & Views is out! We highlight two landmark papers demonstrating the potential for therapeutic targeting of FSP1 and #ferroptosis in in vivo cancer models. Beautiful work from @ubellackerlab.bsky.social, Thales Papagiannakopoulos, and colleagues. 🥳
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Anupam Patgiri
Nature research paper: Mutations in mitochondrial ferredoxin FDX2 suppress frataxin deficiency
go.nature.com/4pqQwNK
go.nature.com/4pqQwNK
Mutations in mitochondrial ferredoxin FDX2 suppress frataxin deficiency - Nature
A forward genetic screen in Caenorhabditis elegans reveals that decreased levels of the ferredoxin FDX2 suppress the loss of frataxin in worms and in mice by relief of FDX2 inhibition of frataxin-stimulated NFS1 activity.
go.nature.com
December 11, 2025 at 3:36 PM
Nature research paper: Mutations in mitochondrial ferredoxin FDX2 suppress frataxin deficiency
go.nature.com/4pqQwNK
go.nature.com/4pqQwNK
Reposted by Anupam Patgiri
Why do we age? A detailed look at the data shows only one theory that matches observation: onlinelibrary.wiley.com/doi/epdf/10....
Why we age
You have to enable JavaScript in your browser's settings in order to use the eReader.
onlinelibrary.wiley.com
December 11, 2025 at 3:42 AM
Why do we age? A detailed look at the data shows only one theory that matches observation: onlinelibrary.wiley.com/doi/epdf/10....
Mutations in mitochondrial ferredoxin FDX2 suppress frataxin deficiency www.nature.com/articles/s41...
Mutations in mitochondrial ferredoxin FDX2 suppress frataxin deficiency - Nature
A forward genetic screen in Caenorhabditis elegans reveals that decreased levels of the ferredoxin FDX2 suppress the loss of frataxin in worms and in mice by relief of FDX2 inhibition of fra...
www.nature.com
December 10, 2025 at 5:58 PM
Mutations in mitochondrial ferredoxin FDX2 suppress frataxin deficiency www.nature.com/articles/s41...