Joseph Gordon
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josephwgordon.bsky.social
Joseph Gordon
@josephwgordon.bsky.social
1.2K followers 460 following 280 posts
Associate Professor, University of Prince Edward Island
Heart and Stroke Foundation Canada Provincial Advisory Board for PEI
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Reposted by Joseph Gordon
frezzalab.bsky.social
I am very happy to share this paper from a great scientist and surgeon, Cissy Yong, on how warm ischaemia can affect the metabolic profile of a tumour: www.nature.com/articles/s41... 💥 👏
full text access here rdcu.be/ePcEK
Tumour sampling conditions perturb the metabolic landscape of clear cell renal cell carcinoma - Nature Communications
Yong et al. highlight how sampling conditions affect metabolic profile in renal cancer, showing that prolonged ischemic exposure disrupts tissue metabolome stability and masks important phenotypes, su...
www.nature.com
November 10, 2025 at 5:09 PM
josephwgordon.bsky.social
www.nature.com/articles/s41...
Medical nutrition therapy for the management of type 2 diabetes mellitus - Nature Reviews Endocrinology
Medical nutrition therapy (MNT) is a key component of the management of type 2 diabetes mellitus (T2DM), and there is increasing evidence that specific dietary interventions can improve metabolic heal...
www.nature.com
November 11, 2025 at 2:22 PM
josephwgordon.bsky.social
www.nature.com/articles/s41...
Cardiometabolic and renal benefits of sodium–glucose cotransporter 2 inhibitors - Nature Reviews Endocrinology
In the past decade, the therapeutic scope of sodium–glucose cotransporter 2 (SGLT2) inhibitors has expanded beyond glycaemic regulation in the management of type 2 diabetes mellitus. In this Review, L...
www.nature.com
November 11, 2025 at 2:21 PM
josephwgordon.bsky.social
www.embopress.org/doi/full/10....
Metabolic cardiomyopathies: untangling clinical heterogeneity with human stem-cell derived models | EMBO Molecular Medicine
EMBO Press is an editorially independent publishing platform for the development of EMBO scientific publications.
www.embopress.org
November 11, 2025 at 2:21 PM
josephwgordon.bsky.social
www.nature.com/articles/s41...
A high-throughput screening approach to discover potential colorectal cancer chemotherapeutics: repurposing drugs to identify novel disruptors of 14-3-3 proteins - Cell Death & Disease
Cell Death & Disease - A high-throughput screening approach to discover potential colorectal cancer chemotherapeutics: repurposing drugs to identify novel disruptors of 14-3-3 proteins
www.nature.com
November 10, 2025 at 10:53 PM
josephwgordon.bsky.social
www.nature.com/articles/s41...
Alterations in peroxisome-mitochondria interplay in skeletal muscle accelerate muscle dysfunction - Nature Communications
The role of peroxisomes in skeletal muscle remains largely unexplored. Here, the authors show that peroxisomal dysfunction and disrupted crosstalk with mitochondria drive age-related muscle decline, u...
www.nature.com
November 10, 2025 at 10:51 PM
josephwgordon.bsky.social
apple.news/AQMNOT4LQSEG...
Opinion: How much are MPs entitled to know about research grants? Not as much as they think — The Globe and Mail
A parliamentary committee is asking for academics’ private information on a strange anti-DEI crusade
apple.news
November 4, 2025 at 7:23 PM
Reposted by Joseph Gordon
addgene.bsky.social
Need a big toolkit for your next cloning project, a whole palette of biosensors or fluorescent proteins, or expression constructs spanning your favorite pathway? Addgene kits may be just what you need!
Addgene: Plasmid Kits
Addgene plasmid kits for cloning, genome engineering, fluorescent proteins & more.
twp.ai
November 4, 2025 at 2:01 PM
josephwgordon.bsky.social
rupress.org/jcb/article/...
PEX14 acts as a molecular link between optineurin and the autophagic machinery to induce pexophagy | Journal of Cell Biology | Rockefeller University Press
This study uncovers and defines the peroxisomal membrane protein PEX14 as a key player in optineurin-driven pexophagy, advancing our mechanistic understand
rupress.org
November 4, 2025 at 5:02 PM
josephwgordon.bsky.social
In case you missed the ILCOR release, highlights of the new resuscitation guidelines can be found here: cpr.heartandstroke.ca/s/article/20...
Heart & Stroke Training Portal
cpr.heartandstroke.ca
October 26, 2025 at 12:46 AM
josephwgordon.bsky.social
openreview.net/forum?id=lrZ...
Decoding Type 2 Diabetes Progression via Metabolic Hormone Time-Series
Unraveling the dynamics of diabetes hormones and peptides, including insulin, glucagon, and C-peptide, is important for understanding diabetes progression and for personalized treatment. The...
openreview.net
October 25, 2025 at 3:56 PM
josephwgordon.bsky.social
www.nature.com/articles/s41...
Myocardial reprogramming by HMGN1 underlies heart defects in trisomy 21
Nature - Studies using human pluripotent stem cells and a mouse model of Down syndrome identify HMGN1 as a key contributor to congenital heart defects in individuals with Down syndrome.
www.nature.com
October 24, 2025 at 3:23 PM
Reposted by Joseph Gordon
erictopol.bsky.social
The benefit of Ozempic (semaglutide) for protection from major adverse cardiovascular events (MACE) is independent of weight loss magnitude and baseline adiposity, likely related to the GLP-1 anti-inflammatory effect
thelancet.com/journals/lan...
Semaglutide and cardiovascular outcomes by baseline and changes in adiposity measurements: a prespecified analysis of the SELECT trial
The cardioprotective effects of semaglutide were independent of baseline adiposity and weight loss and had only a small association with waist circumference, suggesting some mechanisms for benefit bey...
thelancet.com
October 22, 2025 at 10:43 PM
Reposted by Joseph Gordon
kristalamb.bsky.social
I recently had the opportunity to chat with Dr. Shazhan Amed about how she is using data in innovative ways to improve outcomes for children and youth living with type 1 diabetes. Thanks to the T2D Network (part of IHSTS) for hosting this conversation. www.youtube.com/watch?v=Eazx...
Empowering Diabetes Care Integrating Health Information
YouTube video by T2D Network
www.youtube.com
October 20, 2025 at 9:47 PM
josephwgordon.bsky.social
www.pnas.org/doi/abs/10.1...
Precise gene editing of pathogenic Lamin A mutations corrects cardiac disease | PNAS
Mutations in the Lamin A (LMNA) gene, which encodes the Lamin A and C proteins, cause severe human diseases collectively known as laminopathies. Th...
www.pnas.org
October 18, 2025 at 3:51 PM
Reposted by Joseph Gordon
frezzalab.bsky.social
Aged mice exhibit widespread metabolic changes but preserved major fluxes: Cell Metabolism www.cell.com/cell-metabol...
Aged mice exhibit widespread metabolic changes but preserved major fluxes
Metabolic dysregulation is a hallmark of aging, but how metabolic pathway activity (flux) changes with age has yet to be broadly assessed. Here, Jankowski et al. measure metabolite concentrations and ...
www.cell.com
October 16, 2025 at 6:15 PM
josephwgordon.bsky.social
www.upei.ca/communicatio...
UPEI researchers awarded over $1.7 million in federal funding
Researchers at the University of Prince Edward Island have been awarded over $1.7 million in federal funding from the Natural Sciences and Engineering Research Council of Canada (NSERC) and the Social...
www.upei.ca
October 17, 2025 at 1:44 AM
josephwgordon.bsky.social
The Heart and Stroke Foundation of Canada (@heartandstroke.bsky.social) has released 2 very important initiatives. The first is #BeatHeartDisease (www.heartandstroke.ca/research-sav...) an important engagement tool highlighting the importance of research in cardiovascular care.
Research saves lives
Donate now to beat heart disease and stroke and keep families together, longer.
www.heartandstroke.ca
October 17, 2025 at 12:31 AM
josephwgordon.bsky.social
www.embopress.org/doi/full/10....
Mammalian mitohormesis: from mitochondrial stressors to organismal benefits | The EMBO Journal
EMBO Press is an editorially independent publishing platform for the development of EMBO scientific publications.
www.embopress.org
October 16, 2025 at 12:09 PM
josephwgordon.bsky.social
www.cell.com/molecular-ce...
Tuning insulin receptor signaling using de novo-designed agonists
Wang, Cardoso, and Cai et al. design synthetic insulin receptor agonists that impose distinct receptor conformations, leading to modulated signaling. These agonists outperform insulin in metabolic con...
www.cell.com
October 16, 2025 at 2:00 AM
josephwgordon.bsky.social
www.cell.com/cell-metabol...
Machine-learning-guided discovery of SLC25A45 as a mediator of mitochondrial methylated amino acid import and carnitine synthesis
Khan et al. apply machine learning to identify substrates of UNC93A, SLC45A4, and SLC25A45. Biochemical assays and in vivo metabolite tracing establish SLC25A45 as a key mediator of mitochondrial impo...
www.cell.com
October 11, 2025 at 1:38 PM
josephwgordon.bsky.social
www.cell.com/molecular-ce...
SLC25A45 is required for mitochondrial uptake of methylated amino acids and de novo carnitine biosynthesis
Dias et al. discover that the orphan solute carrier protein, SLC25A45, enables mitochondrial import of methylated amino acids. SLC25A45-dependent mitochondrial uptake of trimethyllysine drives carniti...
www.cell.com
October 11, 2025 at 1:37 PM
josephwgordon.bsky.social
www.nature.com/articles/s41...
Twenty years of progress in human exercise metabolism research - Nature Reviews Endocrinology
Molecular biology and omics-based approaches over the past 20 years have rapidly advanced the discipline of exercise metabolism. Here, we examine three innovative human metabolic studies that have increased our understanding of exercise’s complex molecular landscape in skeletal muscle and beyond, and highlight key future directions.
www.nature.com
October 11, 2025 at 1:35 PM
josephwgordon.bsky.social
www.nature.com/articles/s41...
The past and future of obesity research - Nature Reviews Endocrinology
Over the past 20 years, obesity research has resulted in a better understanding of the complex disease mechanisms underlying the condition, including biological, behavioural, societal and environmental factors. Although obesity research in the past 10 years has resulted in very effective and safe obesity treatments, more research is needed to improve the lives of people with obesity.
www.nature.com
October 11, 2025 at 1:34 PM
josephwgordon.bsky.social
www.nature.com/articles/s41...
The role of ultra-processed food in obesity - Nature Reviews Endocrinology
Consumption of ultra-processed foods (UPF) is increasingly linked to the development of obesity, on both an individual and a global scale. This Review assesses the role of UPF in obesity, examining the epidemiological evidence, biological mechanisms and implications for policymakers.
www.nature.com
October 11, 2025 at 1:31 PM