Joseph Gordon
@josephwgordon.bsky.social
Associate Professor, University of Prince Edward Island
Heart and Stroke Foundation Canada Provincial Advisory Board for PEI
Heart and Stroke Foundation Canada Provincial Advisory Board for PEI
Reposted by Joseph Gordon
REVIEW: The Impact of Maternal High‐Fat Diet on Stem Cell Programming and Disease Susceptibility in Offspring - Molecular Nutrition & Food Research #DOHaD @Dohadcanada onlinelibrary.wiley.com/doi/abs/10.1...
The Impact of Maternal High‐Fat Diet on Stem Cell Programming and Disease Susceptibility in Offspring
This graphical abstract illustrates that a maternal high-fat diet alters fetal epigenetics, gut microbiota, and molecular and metabolic pathways, thereby disrupting stem cell programming and increasi...
onlinelibrary.wiley.com
January 4, 2026 at 10:51 PM
REVIEW: The Impact of Maternal High‐Fat Diet on Stem Cell Programming and Disease Susceptibility in Offspring - Molecular Nutrition & Food Research #DOHaD @Dohadcanada onlinelibrary.wiley.com/doi/abs/10.1...
Reposted by Joseph Gordon
#2. Feng et al., Nat. Comms., Early-life exercise extends healthspan but not lifespan in mice. #Myoblue tinyurl.com/mwyftnk3
Early-life exercise extends healthspan but not lifespan in mice - Nature Communications
Exercise exerts health benefits, yet the long-term effects of early-life regular exercise on later-life health and lifespan remain poorly understood. Here, the authors show early-life exercise in mice...
tinyurl.com
December 30, 2025 at 1:24 PM
#2. Feng et al., Nat. Comms., Early-life exercise extends healthspan but not lifespan in mice. #Myoblue tinyurl.com/mwyftnk3
Reposted by Joseph Gordon
And now, for the top Muscle Paper of 2025 as voted by all of you. After 70+ votes, the winner is the following: #1. Moreno-Justicia et al., Nat. Comms., Human skeletal muscle fiber heterogeneity beyond myosin heavy chains. #Myoblue tinyurl.com/38v8v2bk
December 31, 2025 at 2:21 PM
And now, for the top Muscle Paper of 2025 as voted by all of you. After 70+ votes, the winner is the following: #1. Moreno-Justicia et al., Nat. Comms., Human skeletal muscle fiber heterogeneity beyond myosin heavy chains. #Myoblue tinyurl.com/38v8v2bk
Reposted by Joseph Gordon
#6. Zhu et al., Nat. Metab., Identification of a resistance-exercise-specific signalling pathway that drives skeletal muscle growth. #Myoblue tinyurl.com/bde3cc9c
https://www.nature.com/articles/s42255-025-01298-7
tinyurl.com
December 28, 2025 at 5:04 PM
#6. Zhu et al., Nat. Metab., Identification of a resistance-exercise-specific signalling pathway that drives skeletal muscle growth. #Myoblue tinyurl.com/bde3cc9c
Reposted by Joseph Gordon
#5. Brorson et al., Nat. Comms., Complementing muscle regeneration—fibro-adipogenic progenitor and macrophage-mediated repair of elderly human skeletal muscle. #Myoblue tinyurl.com/bdebn52s
https://www.nature.com/articles/s41467-025-60627-2
tinyurl.com
December 28, 2025 at 5:04 PM
#5. Brorson et al., Nat. Comms., Complementing muscle regeneration—fibro-adipogenic progenitor and macrophage-mediated repair of elderly human skeletal muscle. #Myoblue tinyurl.com/bdebn52s
Reposted by Joseph Gordon
#4. Wang et al., Cell Stem Cell., Multiomic profiling reveals that prostaglandin E2 reverses aged muscle stem cell dysfunction, leading to increased regeneration and strength. #Myoblue tinyurl.com/yes36epu
Multiomic profiling reveals that prostaglandin E2 reverses aged muscle stem cell dysfunction, leading to increased regeneration and strength
Repair of muscle damage declines with age due to the accumulation of dysfunctional muscle stem cells (MuSCs). Here, we uncover that aged MuSCs have bl…
tinyurl.com
December 29, 2025 at 3:00 PM
#4. Wang et al., Cell Stem Cell., Multiomic profiling reveals that prostaglandin E2 reverses aged muscle stem cell dysfunction, leading to increased regeneration and strength. #Myoblue tinyurl.com/yes36epu
Reposted by Joseph Gordon
#3. Xiang et al., Nat. Aging., Senescent macrophages induce ferroptosis in skeletal muscle and accelerate osteoarthritis-related muscle atrophy. #Myoblue tinyurl.com/ve2nx6mz
https://www.nature.com/articles/s43587-025-00907-0
tinyurl.com
December 29, 2025 at 3:01 PM
#3. Xiang et al., Nat. Aging., Senescent macrophages induce ferroptosis in skeletal muscle and accelerate osteoarthritis-related muscle atrophy. #Myoblue tinyurl.com/ve2nx6mz
Reposted by Joseph Gordon
#8. Ongaro et al., Science., Muscle-derived myostatin is a major endocrine driver of follicle-stimulating hormone synthesis. #Myoblue tinyurl.com/e4due6xb
Muscle-derived myostatin is a major endocrine driver of follicle-stimulating hormone synthesis
Myostatin is a paracrine myokine that regulates muscle mass in a variety of species, including humans. In this work, we report a functional role for myostatin as an endocrine hormone that directly pro...
tinyurl.com
December 27, 2025 at 4:48 PM
#8. Ongaro et al., Science., Muscle-derived myostatin is a major endocrine driver of follicle-stimulating hormone synthesis. #Myoblue tinyurl.com/e4due6xb
Reposted by Joseph Gordon
#7. Ham et al., Nat. Comms., Single-nuclei sequencing of skeletal muscle reveals subsynaptic-specific transcripts involved in neuromuscular junction maintenance. #Myoblue tinyurl.com/hp23esjk
https://www.nature.com/articles/s41467-025-57487-1
tinyurl.com
December 27, 2025 at 4:49 PM
#7. Ham et al., Nat. Comms., Single-nuclei sequencing of skeletal muscle reveals subsynaptic-specific transcripts involved in neuromuscular junction maintenance. #Myoblue tinyurl.com/hp23esjk
Reposted by Joseph Gordon
And now it's time without further ado for my 12th Annual Top 10 Muscle Papers of the Year countdown. This year, we had over 70 votes for the top muscle papers of 2025. Thank you to all participants and authors for an exciting year of muscle biology. #Myoblue
December 26, 2025 at 12:15 PM
And now it's time without further ado for my 12th Annual Top 10 Muscle Papers of the Year countdown. This year, we had over 70 votes for the top muscle papers of 2025. Thank you to all participants and authors for an exciting year of muscle biology. #Myoblue
Reposted by Joseph Gordon
#10. Peng et al., Nat. Comms., Stage-specific and cell-autonomous functions of Delta-like 1 in skeletal muscle stem cells and myogenesis. #Myoblue tinyurl.com/mkxmrjw5
https://www.nature.com/articles/s41467-025-63631-8
tinyurl.com
December 26, 2025 at 12:16 PM
#10. Peng et al., Nat. Comms., Stage-specific and cell-autonomous functions of Delta-like 1 in skeletal muscle stem cells and myogenesis. #Myoblue tinyurl.com/mkxmrjw5
Reposted by Joseph Gordon
#9. Sica et al., Cell Reports., The central clock drives metabolic rhythms in muscle stem cells. #Myoblue tinyurl.com/3v6dyc43
The central clock drives metabolic rhythms in muscle stem cells
Satellite cells (SCs), the skeletal muscle resident stem cells, maintain a state of quiescence yet exhibit robust circadian oscillations at the transc…
tinyurl.com
December 26, 2025 at 12:17 PM
#9. Sica et al., Cell Reports., The central clock drives metabolic rhythms in muscle stem cells. #Myoblue tinyurl.com/3v6dyc43
Reposted by Joseph Gordon
The GDF3–SMAD2/3 axis as a critical driver of age-associated chromatin remodeling adipose tissue macrophage-mediated inflammation and a promising therapeutic target for mitigating macrophage-related inflammation in #aging www.nature.com/articles/s43...
GDF3 promotes adipose tissue macrophage-mediated inflammation via altered chromatin accessibility during aging - Nature Aging
Jang and colleagues demonstrate that GDF3 reshapes the chromatin landscape of inflammatory adipose tissue macrophages and drives endotoxic inflammation with age. Pharmacological inhibition of the GDF3...
www.nature.com
December 15, 2025 at 10:54 AM
The GDF3–SMAD2/3 axis as a critical driver of age-associated chromatin remodeling adipose tissue macrophage-mediated inflammation and a promising therapeutic target for mitigating macrophage-related inflammation in #aging www.nature.com/articles/s43...
Reposted by Joseph Gordon
New athero paper! We only played a minor part but very happy for our @ipekresearch.bsky.social collaborators that this is out now:
www.atherosclerosis-journal.com/article/S002...
www.atherosclerosis-journal.com/article/S002...
Galectin-1 induces macrophage immunometabolic reprogramming, modulates T cell immunity and attenuates atherosclerotic plaque formation
Atherosclerosis is a chronic immunometabolic disease driven by lipid accumulation
and immune cell infiltration. Macrophages and T cells play key roles throughout plaque
development. Galectin-1 (Gal-1)...
www.atherosclerosis-journal.com
December 13, 2025 at 9:00 AM
New athero paper! We only played a minor part but very happy for our @ipekresearch.bsky.social collaborators that this is out now:
www.atherosclerosis-journal.com/article/S002...
www.atherosclerosis-journal.com/article/S002...
Reposted by Joseph Gordon
Previously shared: A study to take to heart
This issue’s cover features work by Jiaxi Guo et al. on the protective role of lipin1 in the heart following ischemic injury via preserving lipid homeostasis: doi.org/10.1172/jci....
This issue’s cover features work by Jiaxi Guo et al. on the protective role of lipin1 in the heart following ischemic injury via preserving lipid homeostasis: doi.org/10.1172/jci....
December 13, 2025 at 2:01 PM
Previously shared: A study to take to heart
This issue’s cover features work by Jiaxi Guo et al. on the protective role of lipin1 in the heart following ischemic injury via preserving lipid homeostasis: doi.org/10.1172/jci....
This issue’s cover features work by Jiaxi Guo et al. on the protective role of lipin1 in the heart following ischemic injury via preserving lipid homeostasis: doi.org/10.1172/jci....
Reposted by Joseph Gordon
Incretin hormones—glucagon-like peptide-1 (GLP-1) & glucose-dependent insulinotropic peptide (GIP)—act as a critical link connecting #digestion, #metabolism, & #cardiovascular function, supporting physiological adaptations to nutrient intake thelancet.com/journals/lan...
#incretins
#MedSky #EndoSky
#incretins
#MedSky #EndoSky
December 13, 2025 at 2:09 PM
Incretin hormones—glucagon-like peptide-1 (GLP-1) & glucose-dependent insulinotropic peptide (GIP)—act as a critical link connecting #digestion, #metabolism, & #cardiovascular function, supporting physiological adaptations to nutrient intake thelancet.com/journals/lan...
#incretins
#MedSky #EndoSky
#incretins
#MedSky #EndoSky
Reposted by Joseph Gordon
Reposted by Joseph Gordon