Daniel Drucker
@danieljdrucker.bsky.social
A clinician scientist at LTRI @sinaihealth studying Glucagon, GIP, GLP-1, GLP-2, diabetes, obesity, metabolism and the gut endocrine system
Clinical P1 SAD/MAD evaluation of the long-acting GLP-1R antagonist Imapexitide in healthy human volunteers academic.oup.com/jcem/advance...
December 24, 2025 at 7:49 PM
Clinical P1 SAD/MAD evaluation of the long-acting GLP-1R antagonist Imapexitide in healthy human volunteers academic.oup.com/jcem/advance...
The latest view from Indianapolis-explaining a component of tirzepatide action #weightloss through a CNS hypothalamic leptin sensitization MOA enabling increased energy expenditure in mice www.biorxiv.org/content/10.6...
December 24, 2025 at 1:38 AM
The latest view from Indianapolis-explaining a component of tirzepatide action #weightloss through a CNS hypothalamic leptin sensitization MOA enabling increased energy expenditure in mice www.biorxiv.org/content/10.6...
Studies in mice reveal that the SCoR2 denitrosylase regulates nutrient metabolism, similar to sirtuins, and is a potential drug target for #obesity and #MASLD www.science.org/doi/10.1126/...
The protein denitrosylase SCoR2 regulates lipogenesis and fat storage
Removal of SNO groups from hepatocyte and adipocyte proteins induces lipid synthesis and weight gain.
www.science.org
December 23, 2025 at 10:28 PM
Studies in mice reveal that the SCoR2 denitrosylase regulates nutrient metabolism, similar to sirtuins, and is a potential drug target for #obesity and #MASLD www.science.org/doi/10.1126/...
Amylin activated distributed CNS networks revealed by resting-state fMRI following peripheral amylin administration in wild-type (WT) and receptor-activity modifying protein 1/3 knockout (RAMP1/3 KO) mice
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
December 23, 2025 at 1:08 PM
Amylin activated distributed CNS networks revealed by resting-state fMRI following peripheral amylin administration in wild-type (WT) and receptor-activity modifying protein 1/3 knockout (RAMP1/3 KO) mice
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
The GLP-1 medicine field continues to evolve, offering new effective options for people living with #obesity coming to US distribution channels in January 2026 Higher dose oral semaglutide for weight management now FDA approved #weightloss @novonordisk.bsky.social
www.novonordisk.com/content/nnco...
www.novonordisk.com/content/nnco...
December 22, 2025 at 11:46 PM
The GLP-1 medicine field continues to evolve, offering new effective options for people living with #obesity coming to US distribution channels in January 2026 Higher dose oral semaglutide for weight management now FDA approved #weightloss @novonordisk.bsky.social
www.novonordisk.com/content/nnco...
www.novonordisk.com/content/nnco...
Hitting the gas pedal for better health and longevity #aging #healthspan Scientists uncover the potential of enhanced hydrogen sulfide generation to promote healthy aging @CellMetabolism www.cell.com/cell-metabol...
Enhanced non-enzymatic H2S generation extends lifespan and healthspan in male mice
Cáliz-Molina et al. demonstrate that hydrogen sulfide generators found in garlic extend
lifespan and enhance metabolic, neurocognitive, and locomotor function in male mice.
These molecules induce hepa...
www.cell.com
December 20, 2025 at 12:54 PM
Hitting the gas pedal for better health and longevity #aging #healthspan Scientists uncover the potential of enhanced hydrogen sulfide generation to promote healthy aging @CellMetabolism www.cell.com/cell-metabol...
Amidated gut hormone peptidergic signaling as a determinant of sex-specific metabolic and behavioral states in Drosophila @MolMetab www.sciencedirect.com/science/arti...
December 20, 2025 at 12:36 PM
Amidated gut hormone peptidergic signaling as a determinant of sex-specific metabolic and behavioral states in Drosophila @MolMetab www.sciencedirect.com/science/arti...
The @EASDnews Journal leadership "call on the #diabetes community to join us in our endeavour: to publish robust research grounded in a foundation of strong EDI principles" highlighting that EDI is essential for rigorous science and good for health link.springer.com/article/10.1...
Equity, Diversity and Inclusion is essential for rigorous science and good for health - Diabetologia
Diabetologia -
link.springer.com
December 19, 2025 at 1:14 PM
The @EASDnews Journal leadership "call on the #diabetes community to join us in our endeavour: to publish robust research grounded in a foundation of strong EDI principles" highlighting that EDI is essential for rigorous science and good for health link.springer.com/article/10.1...
48 week P2B data for the GCGR-GLP-1R co-agonist in people with metabolic liver disease #MASH ir.altimmune.com/news-release...
Altimmune Announces that Pemvidutide Achieved Key Measures of Success at 48 Weeks in IMPACT Phase 2b MASH Trial – Altimmune
The Investor Relations website contains information about Altimmune's business for stockholders, potential investors, and financial analysts.
ir.altimmune.com
December 19, 2025 at 1:11 PM
48 week P2B data for the GCGR-GLP-1R co-agonist in people with metabolic liver disease #MASH ir.altimmune.com/news-release...
An allosteric mechanism of GPR120 activation for the treatment of #Alzheimers disease www.nature.com/articles/s43...
Allosteric activation of a cell-type-specific GPR120 inhibits amyloid pathology of Alzheimer’s disease - Nature Aging
He, Wang, Shen, Dong and colleagues find that unsaturated fatty acids enriched in a black rice diet inhibit amyloid pathology, rescue cognition and restore physiological lifespan in mouse models of Al...
www.nature.com
December 19, 2025 at 11:24 AM
An allosteric mechanism of GPR120 activation for the treatment of #Alzheimers disease www.nature.com/articles/s43...
Will GLP-1 medicines eventually support brain health with #aging A look at the evidence to date www.nature.com/articles/s43...
Repurposing glucagon-like peptide-1 receptor agonists for the treatment of neurodegenerative disorders - Nature Aging
The authors discuss the preclinical literature and emerging clinical evidence that support the rationale for investigating the use of glucagon-like peptide-1 receptor agonists to prevent and treat sev...
www.nature.com
December 19, 2025 at 11:15 AM
Will GLP-1 medicines eventually support brain health with #aging A look at the evidence to date www.nature.com/articles/s43...
Are there clinically meaningful metabolic benefits for people with #T2D looking out or through the window to gain increased exposure to natural light? What would Alice think? www.cell.com/cell-metabol...
December 18, 2025 at 4:09 PM
Are there clinically meaningful metabolic benefits for people with #T2D looking out or through the window to gain increased exposure to natural light? What would Alice think? www.cell.com/cell-metabol...
In 2026 @FDA_Gov will review NDA submissions for Cagri-Sema, Retatrutide and Orforglipron, potentially broadening options for use of GLP-1 medicines and achievement of #weightloss in people living with #obesity www.novonordisk.com/content/nnco...
December 18, 2025 at 1:57 PM
In 2026 @FDA_Gov will review NDA submissions for Cagri-Sema, Retatrutide and Orforglipron, potentially broadening options for use of GLP-1 medicines and achievement of #weightloss in people living with #obesity www.novonordisk.com/content/nnco...
GLP-2 exerts rapid effects to improve barrier function yet in our lab, teduglutide does not protect against graft vs host disease. Yet GLP-2R KO mice with GvHD exhibit greater extent of bacteremia and mortality. Free to read #MolecularMetabolism www.sciencedirect.com/science/arti...
December 18, 2025 at 12:55 PM
GLP-2 exerts rapid effects to improve barrier function yet in our lab, teduglutide does not protect against graft vs host disease. Yet GLP-2R KO mice with GvHD exhibit greater extent of bacteremia and mortality. Free to read #MolecularMetabolism www.sciencedirect.com/science/arti...
The #weightloss maintenance data for the small molecule oral GLP-1 medicine orforglipron in the ATTAIN‑MAINTAIN trial has arrived #obesity investor.lilly.com/news-release...
December 18, 2025 at 12:49 PM
The #weightloss maintenance data for the small molecule oral GLP-1 medicine orforglipron in the ATTAIN‑MAINTAIN trial has arrived #obesity investor.lilly.com/news-release...
The long-awaited SURPASS-CVOT is here, just in time for the holidays #T2D #CVD #Tirzepatide www.nejm.org/doi/full/10....
Cardiovascular Outcomes with Tirzepatide versus Dulaglutide in Type 2 Diabetes | NEJM
Tirzepatide, a dual incretin agonist of the glucagon-like peptide-1 and glucose-dependent
insulinotropic polypeptide receptors, has favorable effects on glycemic control and
body weight. The effect...
www.nejm.org
December 17, 2025 at 10:04 PM
The long-awaited SURPASS-CVOT is here, just in time for the holidays #T2D #CVD #Tirzepatide www.nejm.org/doi/full/10....
Strategies to counter clinical hyperinsulinemia #hypoglycemia #genetics #bariatricsurgery include targeting #insulin secretion or insulin or GLP-1 receptor activity. Which option will prove successful for what condition www.cmghjournal.org/article/S235...
DOCK10 Regulates Insulin Hypersecretion in Insulinoma and Serves as a Diagnostic and Therapeutic Target
Insulinomas are rare pancreatic neuroendocrine neoplasms (pan-NENs) characterized
by inappropriate insulin secretion. Despite advances in imaging techniques, the reliable
identification of insulin-sec...
www.cmghjournal.org
December 17, 2025 at 11:33 AM
Strategies to counter clinical hyperinsulinemia #hypoglycemia #genetics #bariatricsurgery include targeting #insulin secretion or insulin or GLP-1 receptor activity. Which option will prove successful for what condition www.cmghjournal.org/article/S235...
A vagal sensory pathway that integrates satiety signals to modulate #sleep www.nature.com/articles/s41...
The gut vagal sensory pathway drives postprandial sleep via activation of PVH-projecting GABAergic neurons in the NTS - Nature Communications
The neural circuits integrating gastrointestinal state and sleep remain largely unexplored. Here, authors show gut vagal sensory neurons detect satiety and drive postprandial sleep via brainstem GABA ...
www.nature.com
December 17, 2025 at 11:22 AM
A vagal sensory pathway that integrates satiety signals to modulate #sleep www.nature.com/articles/s41...
Single-nuclei sequencing, chemogenetics, circuit tracing, and pharmacology resolve how enteric neuron populations can modulate GI motility, secretion, food intake, and #inflammation www.cell.com/cell/abstrac...
In vivo transcriptomic, functional, circuit-based, and translational analyses of enteric neurons
A comprehensive neuronal molecular map spanning the entire murine gastrointestinal
tract enables selective, in vivo investigation of the roles that genetically defined
enteric neuron subtypes play in ...
www.cell.com
December 17, 2025 at 12:34 AM
Single-nuclei sequencing, chemogenetics, circuit tracing, and pharmacology resolve how enteric neuron populations can modulate GI motility, secretion, food intake, and #inflammation www.cell.com/cell/abstrac...
A novel vagal circuit that integrates internal protein status with nutrient-specific cues in mice to guide adaptive #protein appetite and maintain amino acid homeostasis #Diet www.sciencedirect.com/science/arti...
Vagal Sensory Neurons Encode Internal Protein Status to Guide Eating
Animals adaptively adjust nutrient intake based on internal physiological need. Although protein deficiency elicits robust behavioral and endocrine re…
www.sciencedirect.com
December 16, 2025 at 7:59 PM
A novel vagal circuit that integrates internal protein status with nutrient-specific cues in mice to guide adaptive #protein appetite and maintain amino acid homeostasis #Diet www.sciencedirect.com/science/arti...
The accessory protein MRAP2 identified as an important regulator of MC3R function providing further evidence for the crucial role of MRAP2 in energy homeostasis 🧪https://www.science.org/doi/10.1126/scisignal.adu4315
The accessory protein MRAP2 directly interacts with melanocortin-3 receptor to enhance signaling
Signaling mediated by the GPCR MC3R is boosted by a 1:1 association with the accessory protein MRAP2.
www.science.org
December 16, 2025 at 7:53 PM
The accessory protein MRAP2 identified as an important regulator of MC3R function providing further evidence for the crucial role of MRAP2 in energy homeostasis 🧪https://www.science.org/doi/10.1126/scisignal.adu4315
A variety of experimental approaches lead the authors to infer that that decreases in adipocyte NPY1R during #weightloss boost lipolytic capacity and contribute to improved systemic cardiometabolic health #MolecularMetabolism www.sciencedirect.com/science/arti...
Single cell transcriptomics of human weight loss links adipocyte NPY1R to control of lipolysis
Combination of increased physical exercise and hypocaloric diet has long been recognized to improve cardiometabolic health and adipose tissue function…
www.sciencedirect.com
December 16, 2025 at 7:50 PM
A variety of experimental approaches lead the authors to infer that that decreases in adipocyte NPY1R during #weightloss boost lipolytic capacity and contribute to improved systemic cardiometabolic health #MolecularMetabolism www.sciencedirect.com/science/arti...
Beyond setbacks in neurodegenerative diseases, what opportunities and challenges await GLP-1 medicines in a wide range of neuropsychiatric conditions and substance use disorders? @CellRepMed www.cell.com/cell-reports...
Glucagon-like peptide-1 medicines in neurological and psychiatric disorders
Here, Fang et al. highlight emerging and established benefits of GLP-1 medicines in
neurological and psychiatric disorders. These medicines exert direct and indirect
effects on the brain, improving ne...
www.cell.com
December 16, 2025 at 3:38 PM
Beyond setbacks in neurodegenerative diseases, what opportunities and challenges await GLP-1 medicines in a wide range of neuropsychiatric conditions and substance use disorders? @CellRepMed www.cell.com/cell-reports...
An updated look at the therapeutic potential of brown adipose tissue www.nature.com/articles/s41... #weightloss
Brown adipose tissue remains hot - Nature Reviews Endocrinology
Brown adipose tissue is a heat-generating organ and promising therapeutic target for treating obesity and metabolic diseases. Its presence in adults supports metabolic health, whereas its decline with...
www.nature.com
December 16, 2025 at 11:53 AM
An updated look at the therapeutic potential of brown adipose tissue www.nature.com/articles/s41... #weightloss
An update look at the therapeutic potential of brown adipose tissue www.nature.com/articles/s41... #weightloss
Brown adipose tissue remains hot - Nature Reviews Endocrinology
Brown adipose tissue is a heat-generating organ and promising therapeutic target for treating obesity and metabolic diseases. Its presence in adults supports metabolic health, whereas its decline with...
www.nature.com
December 16, 2025 at 11:48 AM
An update look at the therapeutic potential of brown adipose tissue www.nature.com/articles/s41... #weightloss