Daniel Drucker
@danieljdrucker.bsky.social
A clinician scientist at LTRI @sinaihealth studying Glucagon, GIP, GLP-1, GLP-2, diabetes, obesity, metabolism and the gut endocrine system
In a cohort study of women with benign uterine pathology or endometrial hyperplasia, combined GLP-1RA and progestin was associated with reduced Endometrial #Cancer risk jamanetwork.com/journals/jam...
GLP-1 Receptor Agonists Plus Progestins and Endometrial Cancer Risk
This cohort study compares the associations of glucagon-like peptide-1 (GLP-1) receptor agonists and of progestins with risk of endometrial cancer among US women with endometrial hyperplasia or other ...
jamanetwork.com
February 11, 2026 at 12:45 AM
In a cohort study of women with benign uterine pathology or endometrial hyperplasia, combined GLP-1RA and progestin was associated with reduced Endometrial #Cancer risk jamanetwork.com/journals/jam...
Topline data on Ribupatide an oral GLP-1R-GIPR medicine with a focus on double digit #weightloss at 26 weeks www.kailera.com/press-releas...
Kailera Therapeutics and Hengrui Pharma Report Positive Topline Data from Phase 2 Obesity Trial of Oral Ribupatide - Kailera
Shanghai, China and Waltham, Mass., USA, February 10, 2026 — Hengrui Pharma (Hengrui), a global pharmaceutical company focused on scientific and technological innovation, and Kailera Therapeutics, Inc...
www.kailera.com
February 10, 2026 at 8:59 PM
Topline data on Ribupatide an oral GLP-1R-GIPR medicine with a focus on double digit #weightloss at 26 weeks www.kailera.com/press-releas...
New studies developing the model of Human Jejunal Enteroids HJEs in preclinical for L cell biology, GLP-1 secretion and enteroendocrine dysfunction. #diabetes www.nature.com/articles/s41...
Characterization of jejunal enteroids in human obesity; a model for studying GLP-1 cells - International Journal of Obesity
International Journal of Obesity - Characterization of jejunal enteroids in human obesity; a model for studying GLP-1 cells
www.nature.com
February 10, 2026 at 11:32 AM
New studies developing the model of Human Jejunal Enteroids HJEs in preclinical for L cell biology, GLP-1 secretion and enteroendocrine dysfunction. #diabetes www.nature.com/articles/s41...
A spotlight on pancreatic exocrine fibrosis and #T2D @diabetologiajnl.bsky.social
link.springer.com/article/10.1... #islets
link.springer.com/article/10.1... #islets
The emerging role of pancreatic exocrine fibrosis as a common aetiological driver of islet dysfunction and diabetes: opportunities for novel disease-modifying interventions - Diabetologia
Three diseases primarily affecting the exocrine pancreas—chronic pancreatitis, cystic fibrosis and pancreatic ductal adenocarcinoma—are all associated with a high incidence of diabetes. Together, they...
link.springer.com
February 10, 2026 at 11:29 AM
A spotlight on pancreatic exocrine fibrosis and #T2D @diabetologiajnl.bsky.social
link.springer.com/article/10.1... #islets
link.springer.com/article/10.1... #islets
Partitioned polygenic risk scores offer a promising approach for early risk stratification, personalised prevention and improved management for #T2D #hypertension www.nature.com/articles/s41... #genetics
Partitioned polygenic scores show mechanistic heterogeneity in type 2 diabetes and hypertension comorbidity - Nature Communications
Type 2 diabetes and hypertension often co-occur, suggesting shared biological mechanisms. Here, Pascat et al. use partitioned polygenic scores to show distinct biological processes link both condition...
www.nature.com
February 10, 2026 at 11:24 AM
Partitioned polygenic risk scores offer a promising approach for early risk stratification, personalised prevention and improved management for #T2D #hypertension www.nature.com/articles/s41... #genetics
AI based analysis of human pancreatic histology provides a foundation for future research into relevant diagnostic and therapeutic targets, refining several hypotheses regarding tissue alterations associated with #T2D www.nature.com/articles/s41...
February 10, 2026 at 11:20 AM
AI based analysis of human pancreatic histology provides a foundation for future research into relevant diagnostic and therapeutic targets, refining several hypotheses regarding tissue alterations associated with #T2D www.nature.com/articles/s41...
Observational cohort data from All of Us suggest that prior Rx for GLP-1RAs may reduce alcohol consumption by decreasing use frequency. www.medrxiv.org/content/10.6...
February 9, 2026 at 11:00 AM
Observational cohort data from All of Us suggest that prior Rx for GLP-1RAs may reduce alcohol consumption by decreasing use frequency. www.medrxiv.org/content/10.6...
The intersection of #genetics susceptibility, childhood red meat consumption and risk of #T1D #nutritionalepiemiology link.springer.com/article/10.1...
Red meat intake during pregnancy and childhood and risk of type 1 diabetes: findings from the ABIS birth cohort - Diabetologia
Aims/hypothesis The role of red meat in type 1 diabetes risk remains unclear. We examined whether maternal and early-life red meat intake is associated with the development of type 1 diabetes and whet...
link.springer.com
February 9, 2026 at 10:52 AM
The intersection of #genetics susceptibility, childhood red meat consumption and risk of #T1D #nutritionalepiemiology link.springer.com/article/10.1...
An overview of The Physiology Of the WEight Reduced State (POWERS) study #weightloss www.nature.com/articles/s41...
The Physiology Of the WEight Reduced State (POWERS) study: strategies for the analysis of biological specimens - International Journal of Obesity
International Journal of Obesity - The Physiology Of the WEight Reduced State (POWERS) study: strategies for the analysis of biological specimens
www.nature.com
February 6, 2026 at 10:33 AM
An overview of The Physiology Of the WEight Reduced State (POWERS) study #weightloss www.nature.com/articles/s41...
Here the authors identify the prostratin and aPKC/GLUT1 signalling pathways as putative targets for treating #diabetes through enhancing intestinal glucose excretion www.nature.com/articles/s41...
Atypical protein kinase C activation drives intestinal glucose excretion in diabetes mellitus - Nature Communications
Intestinal glucose excretion is a gut-based mechanism contributing to improved glycemic control after weight-loss surgery. Here, the authors describe a signaling pathway that drives intestinal glucose...
www.nature.com
February 6, 2026 at 10:25 AM
Here the authors identify the prostratin and aPKC/GLUT1 signalling pathways as putative targets for treating #diabetes through enhancing intestinal glucose excretion www.nature.com/articles/s41...
Here the authors identify the prostratin and aPKC/GLUT1 signalling pathways as putative targets for treating #diabetes through enhancing intestinal glucose excretion www.nature.com/articles/s41...
Atypical protein kinase C activation drives intestinal glucose excretion in diabetes mellitus - Nature Communications
Intestinal glucose excretion is a gut-based mechanism contributing to improved glycemic control after weight-loss surgery. Here, the authors describe a signaling pathway that drives intestinal glucose...
www.nature.com
February 6, 2026 at 10:24 AM
Here the authors identify the prostratin and aPKC/GLUT1 signalling pathways as putative targets for treating #diabetes through enhancing intestinal glucose excretion www.nature.com/articles/s41...
Making gut epithelium, an update from the maestro @HansClevers www.cell.com/cell/fulltex... #stemcells @cellcellpress.bsky.social
Shifting paradigms in tissue stem cell biology: Insights from the intestine
This review provides a comprehensive overview of the intestinal crypt and its diverse
cell types, highlighting their roles in nutrient absorption, mucus production, antimicrobial
defense, and GLP-1-re...
www.cell.com
February 5, 2026 at 4:27 PM
Making gut epithelium, an update from the maestro @HansClevers www.cell.com/cell/fulltex... #stemcells @cellcellpress.bsky.social
Here the authors highlight the therapeutic potential of a ketogenic diet and microbiome modulation for the treatment of sepsis. www.cell.com/cell-metabol...
Ketogenic diet alleviates septic lung injury via microbial gut-lung axis
Wei et al. show that a ketogenic diet protects against sepsis-induced lung injury
via a gut-lung axis. Specific gut lactobacilli convert dietary oleic acid into azelaic
acid, which translocates to the...
www.cell.com
February 5, 2026 at 4:17 PM
Here the authors highlight the therapeutic potential of a ketogenic diet and microbiome modulation for the treatment of sepsis. www.cell.com/cell-metabol...
Studies in cells and mice reveal that the human GLP1R A316T variant exhibits characteristics of constitutive activation but dampened GLP-1RA responses www.science.org/doi/10.1126/...
In vivo functional profiling and structural characterization of the human GLP1R A316T variant
The GLP1R A316T missense variant displays improved glucose tolerance but impaired pharmacological incretin responses in vivo.
www.science.org
February 4, 2026 at 9:22 PM
Studies in cells and mice reveal that the human GLP1R A316T variant exhibits characteristics of constitutive activation but dampened GLP-1RA responses www.science.org/doi/10.1126/...
Expanding evidence that the brain controls peripheral immune responses. A bidirectional tumour–brain communication network involving Npy2r vagal sensory input and sympathetic output that cooperatively regulate anti-cancer immunity www.nature.com/articles/s41...
Tumour–brain crosstalk restrains cancer immunity via a sensory–sympathetic axis - Nature
Mouse models demonstrate that vagal sensory neurons transmit signals from lung adenocarcinoma to the brain, increasing sympathetic efferent activity in the tumour microenvironment and thereb...
www.nature.com
February 4, 2026 at 5:09 PM
Expanding evidence that the brain controls peripheral immune responses. A bidirectional tumour–brain communication network involving Npy2r vagal sensory input and sympathetic output that cooperatively regulate anti-cancer immunity www.nature.com/articles/s41...
As the #obesity #weightloss medicine market matures, @novonordisk looks to the pipeline including the unimolecular Amycretin entering P3 trials #TD assets.main.pro2.maf.media-server.com/da6ae6453818...
February 4, 2026 at 12:14 PM
As the #obesity #weightloss medicine market matures, @novonordisk looks to the pipeline including the unimolecular Amycretin entering P3 trials #TD assets.main.pro2.maf.media-server.com/da6ae6453818...
As the orforglipron clinical trials portfolio expands #weightloss #T2D #obesity #CVD two notable trials in cardiovascular disease and peripheral artery disease are now highlighted investor.lilly.com/static-files...
February 4, 2026 at 12:06 PM
As the orforglipron clinical trials portfolio expands #weightloss #T2D #obesity #CVD two notable trials in cardiovascular disease and peripheral artery disease are now highlighted investor.lilly.com/static-files...
Health care registry data from Ontario with 10 yr F/U reveals that maternal #diabetes particularly #T1D and #T2D is associated with a small increased epilepsy risk in offspring publications.aap.org/pediatrics/a...
February 4, 2026 at 11:14 AM
Health care registry data from Ontario with 10 yr F/U reveals that maternal #diabetes particularly #T1D and #T2D is associated with a small increased epilepsy risk in offspring publications.aap.org/pediatrics/a...
A new look at the development of ILC lineages with perspectives on links to NK and T cells #inflammation www.nature.com/articles/s41...
The development of innate lymphoid cells - Nature Immunology
In this Review, Bhandoola et al. discuss recent advances in understanding early developmental stages of innate lymphoid cells originating from lymphoid progenitors in mice.
www.nature.com
February 4, 2026 at 11:06 AM
A new look at the development of ILC lineages with perspectives on links to NK and T cells #inflammation www.nature.com/articles/s41...
Alcohol use disorders and use of GLP-1 medicines after bariatric surgery. A real world perspective jamanetwork.com/journals/jam...
Incretin-Based Therapies and Post–Bariatric Surgery Alcohol Use Disorder
This cohort study evaluates whether incretin-based therapy after bariatric surgery is associated with a lower risk of new-onset alcohol use disorder and initiation of medications for alcohol use disor...
jamanetwork.com
February 4, 2026 at 10:59 AM
Alcohol use disorders and use of GLP-1 medicines after bariatric surgery. A real world perspective jamanetwork.com/journals/jam...
Dissecting the importance of the murine GCGR vs the GLP-1R for the CNS and #weightloss actions of survodutide @MolMetab www.sciencedirect.com/science/arti...
February 3, 2026 at 11:06 AM
Dissecting the importance of the murine GCGR vs the GLP-1R for the CNS and #weightloss actions of survodutide @MolMetab www.sciencedirect.com/science/arti...
A microphysiological system (MPS) featuring multicellular human hepatic spheroids physically integrated with self-organized microvascular networks for studies of #insulin resistance www.nature.com/articles/s41...
A vascularized liver microphysiological system captures key features of hepatic insulin resistance and monocyte infiltration - Nature Communications
To humanize models of liver metabolic disease research, authors develop a microfluidic platform leveraging human hepatic spheroids integrated with microvasculature and circulating monocytes to model h...
www.nature.com
February 3, 2026 at 10:56 AM
A microphysiological system (MPS) featuring multicellular human hepatic spheroids physically integrated with self-organized microvascular networks for studies of #insulin resistance www.nature.com/articles/s41...
#Diabetes remission occurred earlier and more frequently in young vs. older adults within the first 5 years after RYGB link.springer.com/article/10.1...
Type 2 diabetes remission and metabolic outcomes 5 years after Roux-en-Y gastric bypass in young vs older adults: a multicentre matched cohort study - Diabetologia
Aims/hypothesis Timely metabolic surgery improves glycaemic control and reduces cardiovascular risk for patients with type 2 diabetes. Young age is a known predictor of favourable metabolic outcome, b...
link.springer.com
January 30, 2026 at 11:30 AM
#Diabetes remission occurred earlier and more frequently in young vs. older adults within the first 5 years after RYGB link.springer.com/article/10.1...
Reposted by Daniel Drucker
GLP-1 drugs might do what food policy can’t — change the way we eat. The desire for smaller portions and fewer junk foods is affecting what the food industry is selling us, by @tamarhaspel.bsky.social www.washingtonpost.com/food/2026/01... via @postopinions.bsky.social
Column | GLP-1 drugs might do what food policy can’t — change the way we eat
The desire for smaller portions and fewer junk foods is affecting what the food industry is selling us.
www.washingtonpost.com
January 29, 2026 at 5:46 PM
GLP-1 drugs might do what food policy can’t — change the way we eat. The desire for smaller portions and fewer junk foods is affecting what the food industry is selling us, by @tamarhaspel.bsky.social www.washingtonpost.com/food/2026/01... via @postopinions.bsky.social
Here, chronic alcohol consumption in humans or mice was associated with decreased GLP-1R gene expression in brain regions involved in the reinforcing effects of ethanol www.nature.com/articles/s41...
January 30, 2026 at 11:26 AM
Here, chronic alcohol consumption in humans or mice was associated with decreased GLP-1R gene expression in brain regions involved in the reinforcing effects of ethanol www.nature.com/articles/s41...