Daniel Drucker
@danieljdrucker.bsky.social
A clinician scientist at LTRI @sinaihealth studying Glucagon, GIP, GLP-1, GLP-2, diabetes, obesity, metabolism and the gut endocrine system
Pinned
Reassessment of antibody-based detection of the murine T cell GLP-1 receptor
Glucagon-like peptide 1 receptor (GLP-1R) agonists exhibit anti-inflammatory actions,
yet the importance of direct immune cell GLP-1R signaling remains uncertain. Although
T cells respond to GLP-1, lo...
www.cell.com
Our latest assessment of 3 widely used GLP-1R antisera independently with @daveyboyhod Some are useful, others not fit for purpose. Use of non-validated antisera sows confusion in the field and creates problems that are difficult to later rectify www.cell.com/cell-metabol...
P2B 24 week data for the GCGR-GLP-1R co-agonist Pemvidutide #MASH resolution without worsening of fibrosis at 24 weeks but not fibrosis improvement without worsening of MASH www.thelancet.com/journals/lan...
Safety and efficacy of weekly pemvidutide versus placebo for metabolic dysfunction-associated steatohepatitis (IMPACT): 24-week results from a multicentre, randomised, double-blind, phase 2b study
Pemvidutide treatment met the primary endpoint of MASH resolution without worsening
of fibrosis at 24 weeks but did not meet the other primary endpoint of fibrosis improvement
without worsening of MAS...
www.thelancet.com
November 11, 2025 at 2:41 PM
P2B 24 week data for the GCGR-GLP-1R co-agonist Pemvidutide #MASH resolution without worsening of fibrosis at 24 weeks but not fibrosis improvement without worsening of MASH www.thelancet.com/journals/lan...
The latest review on #MASH and an overview of resmetirom and semaglutide for moderate to advanced fibrosis jamanetwork.com/journals/jam...
Metabolic Dysfunction–Associated Steatotic Liver Disease in Adults: A Review
This Review summarizes the pathogenesis, epidemiology, diagnosis, treatment, and prognosis for adults with metabolic dysfunction–associated steatotic liver disease.
jamanetwork.com
November 11, 2025 at 11:26 AM
The latest review on #MASH and an overview of resmetirom and semaglutide for moderate to advanced fibrosis jamanetwork.com/journals/jam...
Distinguishing features of autoantibody-negative and autoantibody-positive type 1 #diabetes link.springer.com/article/10.1...
Clinical, immunogenetic and metabolic characteristics of autoantibody-negative and autoantibody-positive type 1 diabetes - Diabetologia
Aims/hypothesis Autoantibody-negative type 1 diabetes is an idiopathic subtype with unclear aetiology. We aimed to characterise and compare the clinical, immune, genetic and metabolic characteristics ...
link.springer.com
November 11, 2025 at 11:19 AM
Distinguishing features of autoantibody-negative and autoantibody-positive type 1 #diabetes link.springer.com/article/10.1...
Diet associations with sarcopenic #obesity from NHANES www.nature.com/articles/s41...
Association between adherence to EAT-Lancet diet and risk of sarcopenia and sarcopenic obesity in adults - International Journal of Obesity
International Journal of Obesity - Association between adherence to EAT-Lancet diet and risk of sarcopenia and sarcopenic obesity in adults
www.nature.com
November 11, 2025 at 11:14 AM
Diet associations with sarcopenic #obesity from NHANES www.nature.com/articles/s41...
New insights into the oxidative proinsulin folding and suppression of the proinsulin aggregation inside quality control granules, essential for secretion of #insulin www.nature.com/articles/s41...
Ca2+-driven PDIA6 biomolecular condensation ensures proinsulin folding - Nature Cell Biology
Lee et al. show that Ca²⁺ triggers condensates enriched with PDIA6, an ER-resident disulfide isomerase and chaperone, along with other protein disulfide isomerase family proteins and some chaperones t...
www.nature.com
November 11, 2025 at 11:09 AM
New insights into the oxidative proinsulin folding and suppression of the proinsulin aggregation inside quality control granules, essential for secretion of #insulin www.nature.com/articles/s41...
Thank you to our veterans and active service members, we appreciate your sacrifice
November 11, 2025 at 11:04 AM
Thank you to our veterans and active service members, we appreciate your sacrifice
Deadlines are approaching (some next week!) for @keystoneSymposia.bsky.social #IsletBiology & #Diabetes : #BetaCell Compensation, Failure & Recovery, this March in Breckenridge! See scholarship, abstract and discount reg dates: keysym.us/KSDiabetes26 #KSDiabetes26
Islet Biology and Diabetes: Beta Cell Compensation, Failure and Recovery | Keystone Symposia
Join us at the Keystone Symposia on Islet Biology and Diabetes: Beta Cell Compensation, Failure and Recovery, March 2026, in Breckenridge, with field leaders!
keysym.us
November 10, 2025 at 10:59 PM
Deadlines are approaching (some next week!) for @keystoneSymposia.bsky.social #IsletBiology & #Diabetes : #BetaCell Compensation, Failure & Recovery, this March in Breckenridge! See scholarship, abstract and discount reg dates: keysym.us/KSDiabetes26 #KSDiabetes26
Some but not all of the remarkable actions of GLP-1 medicines are not strictly dependent on #weightloss findings with real clinical implications #MASH www.novonordisk.com/content/nnco... @aasldnews.bsky.social
November 10, 2025 at 1:53 PM
Some but not all of the remarkable actions of GLP-1 medicines are not strictly dependent on #weightloss findings with real clinical implications #MASH www.novonordisk.com/content/nnco... @aasldnews.bsky.social
A CNS mode of action for liraglutide in experimental #PCOS in rats dom-pubs.pericles-prod.literatumonline.com/doi/10.1111/...
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dom-pubs.pericles-prod.literatumonline.com
November 10, 2025 at 11:48 AM
A CNS mode of action for liraglutide in experimental #PCOS in rats dom-pubs.pericles-prod.literatumonline.com/doi/10.1111/...
More insights in the enduring pursuit of the molecular mechanisms of metformin action www.nature.com/articles/s41...
Hydrophilic metformin and hydrophobic biguanides inhibit mitochondrial complex I by distinct mechanisms - Nature Structural & Molecular Biology
He, Teng and Yang et al. report how metformin, the widely used antidiabetic drug, inhibit its target, the respiratory complex I, through a distinct state-dependent, inhibitor trapping mechanism, thus ...
www.nature.com
November 10, 2025 at 11:41 AM
More insights in the enduring pursuit of the molecular mechanisms of metformin action www.nature.com/articles/s41...
New concepts linking ketohexokinase to fructose metabolism, GLP-1, alcohol intake and liver injury in mice www.nature.com/articles/s42...
Identification of a common ketohexokinase-dependent link driving alcohol intake and alcohol-associated liver disease in mice - Nature Metabolism
Ethanol-induced fructose metabolism, mediated by KHK-A/C, drives excessive alcohol consumption and pathogenesis of alcoholic liver disease.
www.nature.com
November 10, 2025 at 11:37 AM
New concepts linking ketohexokinase to fructose metabolism, GLP-1, alcohol intake and liver injury in mice www.nature.com/articles/s42...
Gut barrier function, systemic inflammation and the pathophysiology of metabolic disorders #T2D #obesity journals.physiology.org/doi/abs/10.1...
November 9, 2025 at 12:17 PM
Gut barrier function, systemic inflammation and the pathophysiology of metabolic disorders #T2D #obesity journals.physiology.org/doi/abs/10.1...
Cardiorenal outcomes and safety for use of SGLT2i vs. DPP4i in PPL in Ontario with #T2D and #dementia Real world administrative data @diabetologiajnl.bsky.social link.springer.com/article/10.1...
Cardiovascular effectiveness and safety of SGLT2 inhibitors vs DPP4 inhibitors by dementia status: a cohort study of older adults with diabetes - Diabetologia
Aims/hypothesis People with dementia are at a higher risk of inappropriate medication use; however, limited data inform clinical outcomes of sodium–glucose cotransporter 2 inhibitor (SGLT2i) use in pe...
link.springer.com
November 8, 2025 at 12:52 PM
Cardiorenal outcomes and safety for use of SGLT2i vs. DPP4i in PPL in Ontario with #T2D and #dementia Real world administrative data @diabetologiajnl.bsky.social link.springer.com/article/10.1...
Based on preclinical studies with a glucokinase activator the authors propose that targeting immunometabolic pathways may offer a therapeutic strategy to alleviate cardiac dysfunction and reduce infarct vulnerability in #T2D www.biorxiv.org/content/10.1...
November 8, 2025 at 12:04 PM
Based on preclinical studies with a glucokinase activator the authors propose that targeting immunometabolic pathways may offer a therapeutic strategy to alleviate cardiac dysfunction and reduce infarct vulnerability in #T2D www.biorxiv.org/content/10.1...
Here studies in mice demonstrate that #probiotic mediated GLP-1 modulation can bypass dietary fiber requirements to maintain gut homeostasis www.science.org/doi/10.1126/...
Engineered probiotic restores GLP-1 signaling to ameliorate fiber-deficiency exacerbated colitis
Engineered probiotic delivers bacterial peptide that enhances GLP-1 and restores barrier integrity in diet-modulated colitis.
www.science.org
November 8, 2025 at 11:47 AM
Here studies in mice demonstrate that #probiotic mediated GLP-1 modulation can bypass dietary fiber requirements to maintain gut homeostasis www.science.org/doi/10.1126/...
Results from the evoke trials with oral semaglutide #Alzheimersdisease are imminent. The real world data continues to arrive for GLP-1 medicines and #T2D cardiab.biomedcentral.com/articles/10....
Neurodegeneration onset with glucagon-like peptide-1 receptor agonists in people with type 2 diabetes: a real-world multinational cohort study - Cardiovascular Diabetology
Background Type 2 diabetes (T2D), affecting approximately 12% of the global population and over 30% of older adults, is among the most prevalent and fast-growing risk factors for neurodegenerative dis...
cardiab.biomedcentral.com
November 8, 2025 at 11:43 AM
Results from the evoke trials with oral semaglutide #Alzheimersdisease are imminent. The real world data continues to arrive for GLP-1 medicines and #T2D cardiab.biomedcentral.com/articles/10....
More synthetic gene switches in mice. Here melatonin regulated GLP-1 expression as a therapeutic output exclusively secreted during nighttime, highlighting potential as an experimental cell therapy for #obesity dependent type-2 #diabetes #circadian www.nature.com/articles/s41...
Regulation of therapeutic protein release in response to circadian biomarkers - Nature Communications
Circadian clocks integrate external environmental and internal physiological cues to generate oscillations of secreted endocrine signals. Here the authors build a melatonin-based circadian biomarker-d...
www.nature.com
November 7, 2025 at 11:43 AM
More synthetic gene switches in mice. Here melatonin regulated GLP-1 expression as a therapeutic output exclusively secreted during nighttime, highlighting potential as an experimental cell therapy for #obesity dependent type-2 #diabetes #circadian www.nature.com/articles/s41...
Here the authors propose that AQP7 is a key regulator of adipose homeostasis and a potential therapeutic target for reducing fat accumulation and metabolic imbalances associated with high glucose exposure. www.nature.com/articles/s44...
AQP7 deficiency drives adipose tissue remodeling and disrupts homeostasis - npj Metabolic Health and Disease
npj Metabolic Health and Disease - AQP7 deficiency drives adipose tissue remodeling and disrupts homeostasis
www.nature.com
November 7, 2025 at 11:36 AM
Here the authors propose that AQP7 is a key regulator of adipose homeostasis and a potential therapeutic target for reducing fat accumulation and metabolic imbalances associated with high glucose exposure. www.nature.com/articles/s44...
An update on Teplizumab, a new era for #T1D prevention and management diabetesjournals.org/care/article...
November 6, 2025 at 11:04 PM
An update on Teplizumab, a new era for #T1D prevention and management diabetesjournals.org/care/article...
Studies in mice lead to the proposal that combined treatment with GKA and incretin mimetics may be useful in GCK-MODY and in more common forms of type 2 #diabetes diabetesjournals.org/diabetes/art...
November 6, 2025 at 11:02 PM
Studies in mice lead to the proposal that combined treatment with GKA and incretin mimetics may be useful in GCK-MODY and in more common forms of type 2 #diabetes diabetesjournals.org/diabetes/art...
New from the Scherer lab @utsw The microprotein adipogenin (Adig) identified as a key cofactor that modulates seipin function, lipid droplet biology and fat storage in adipose tissue www.science.org/doi/10.1126/...
Adipogenin promotes the development of lipid droplets by binding a dodecameric seipin complex
The microprotein adipogenin (Adig) is predominantly expressed in adipose tissues. Here, we found that Adig interacts with seipin to form a stable, rigid complex. We present the structure of the seipin...
www.science.org
November 6, 2025 at 7:11 PM
New from the Scherer lab @utsw The microprotein adipogenin (Adig) identified as a key cofactor that modulates seipin function, lipid droplet biology and fat storage in adipose tissue www.science.org/doi/10.1126/...
Studies in mice identify a lipid metabolic circuit between bacteria and host that is disrupted by diet and can be targeted therapeutically #microbiota #weightloss #ceramides www.cell.com/cell-metabol...
Dietary fat disrupts a commensal-host lipid network that promotes metabolic health
Klag et al. identified that Turicibacter, a spore-forming bacteria, promotes leanness
by producing unique lipids that suppress host ceramides and reduce fat uptake. High-fat
diets lower Turicibacter l...
www.cell.com
November 6, 2025 at 4:24 PM
Studies in mice identify a lipid metabolic circuit between bacteria and host that is disrupted by diet and can be targeted therapeutically #microbiota #weightloss #ceramides www.cell.com/cell-metabol...
Insights on downstream immunity from blood methylome signatures in children exposed to maternal type 1 diabetes #T1D #Genetics #Epigenetics www.nature.com/articles/s42...
Blood methylome signatures in children exposed to maternal type 1 diabetes are linked to protection against islet autoimmunity - Nature Metabolism
Through an epigenome-wide blood analysis in children of mothers with or without type 1 diabetes, the authors identify epigenetic modifications of type 1 diabetes susceptibility loci through which mate...
www.nature.com
November 6, 2025 at 12:06 PM
Insights on downstream immunity from blood methylome signatures in children exposed to maternal type 1 diabetes #T1D #Genetics #Epigenetics www.nature.com/articles/s42...
Eloralintide moves the needle for Amylin agonism #weightloss #obesity in P2 trials investor.lilly.com/news-release... #OW2025
November 6, 2025 at 11:57 AM
Eloralintide moves the needle for Amylin agonism #weightloss #obesity in P2 trials investor.lilly.com/news-release... #OW2025