Daniel Drucker
@danieljdrucker.bsky.social
A clinician scientist at LTRI @sinaihealth studying Glucagon, GIP, GLP-1, GLP-2, diabetes, obesity, metabolism and the gut endocrine system
Thank you to our veterans and active service members, we appreciate your sacrifice
November 11, 2025 at 11:04 AM
Thank you to our veterans and active service members, we appreciate your sacrifice
Some but not all of the remarkable actions of GLP-1 medicines are not strictly dependent on #weightloss findings with real clinical implications #MASH www.novonordisk.com/content/nnco... @aasldnews.bsky.social
November 10, 2025 at 1:53 PM
Some but not all of the remarkable actions of GLP-1 medicines are not strictly dependent on #weightloss findings with real clinical implications #MASH www.novonordisk.com/content/nnco... @aasldnews.bsky.social
Gut barrier function, systemic inflammation and the pathophysiology of metabolic disorders #T2D #obesity journals.physiology.org/doi/abs/10.1...
November 9, 2025 at 12:17 PM
Gut barrier function, systemic inflammation and the pathophysiology of metabolic disorders #T2D #obesity journals.physiology.org/doi/abs/10.1...
Based on preclinical studies with a glucokinase activator the authors propose that targeting immunometabolic pathways may offer a therapeutic strategy to alleviate cardiac dysfunction and reduce infarct vulnerability in #T2D www.biorxiv.org/content/10.1...
November 8, 2025 at 12:04 PM
Based on preclinical studies with a glucokinase activator the authors propose that targeting immunometabolic pathways may offer a therapeutic strategy to alleviate cardiac dysfunction and reduce infarct vulnerability in #T2D www.biorxiv.org/content/10.1...
An update on Teplizumab, a new era for #T1D prevention and management diabetesjournals.org/care/article...
November 6, 2025 at 11:04 PM
An update on Teplizumab, a new era for #T1D prevention and management diabetesjournals.org/care/article...
Studies in mice lead to the proposal that combined treatment with GKA and incretin mimetics may be useful in GCK-MODY and in more common forms of type 2 #diabetes diabetesjournals.org/diabetes/art...
November 6, 2025 at 11:02 PM
Studies in mice lead to the proposal that combined treatment with GKA and incretin mimetics may be useful in GCK-MODY and in more common forms of type 2 #diabetes diabetesjournals.org/diabetes/art...
Eloralintide moves the needle for Amylin agonism #weightloss #obesity in P2 trials investor.lilly.com/news-release... #OW2025
November 6, 2025 at 11:57 AM
Eloralintide moves the needle for Amylin agonism #weightloss #obesity in P2 trials investor.lilly.com/news-release... #OW2025
The exploration of optimal Amylin agonism continues with interrogation of higher doses of Cagrilintide in the RENEW program #Weightloss #Obesity www.novonordisk.com/content/dam/...
November 5, 2025 at 11:42 AM
The exploration of optimal Amylin agonism continues with interrogation of higher doses of Cagrilintide in the RENEW program #Weightloss #Obesity www.novonordisk.com/content/dam/...
The interaction of GLP-1 medicines with the immune system is complex, enabled by direct and indirect actions, including neural inter organ communication. These studies have been led @SinaiHealth by CK Wong. His latest perspective here in the JCI www.jci.org/articles/vie...
November 4, 2025 at 11:56 AM
The interaction of GLP-1 medicines with the immune system is complex, enabled by direct and indirect actions, including neural inter organ communication. These studies have been led @SinaiHealth by CK Wong. His latest perspective here in the JCI www.jci.org/articles/vie...
How do GLP-1 medicines interact with the immune system to reduce #inflammation? From T cells, to the brain, #weightloss and much more, there is no simple unifying one size fits all pathway. "Sometimes we find as many as six impossible things before breakfast" www.jci.org/articles/vie...
November 3, 2025 at 5:50 PM
How do GLP-1 medicines interact with the immune system to reduce #inflammation? From T cells, to the brain, #weightloss and much more, there is no simple unifying one size fits all pathway. "Sometimes we find as many as six impossible things before breakfast" www.jci.org/articles/vie...
Will GLP-1 medicines modify the rates and/or outcomes of one or more #cancers A review on the biology, limitations of the data and the road ahead from @lwellberg.bsky.social and colleagues in JCI www.jci.org/articles/vie...
November 3, 2025 at 5:42 PM
Will GLP-1 medicines modify the rates and/or outcomes of one or more #cancers A review on the biology, limitations of the data and the road ahead from @lwellberg.bsky.social and colleagues in JCI www.jci.org/articles/vie...
A new review series on key aspects of GLP-1 biology from the JCI. First up, Cooper, van Raalte and the kidney www.jci.org/articles/vie...
November 3, 2025 at 5:38 PM
A new review series on key aspects of GLP-1 biology from the JCI. First up, Cooper, van Raalte and the kidney www.jci.org/articles/vie...
New from Prof Tomas @tomaslab-imperial.bsky.social Both basal and agonist-induced GLP-1R phosphorylation are critical for receptor signalling in β-cells www.biorxiv.org/content/10.1...
November 3, 2025 at 10:55 AM
New from Prof Tomas @tomaslab-imperial.bsky.social Both basal and agonist-induced GLP-1R phosphorylation are critical for receptor signalling in β-cells www.biorxiv.org/content/10.1...
Based on adipose tissue transcriptome analysis w/wo #exercise the authors propose
novel molecular pathways regulated by exercise training can lead to therapeutic targets for #obesity and metabolic disease. www.biorxiv.org/content/10.1...
novel molecular pathways regulated by exercise training can lead to therapeutic targets for #obesity and metabolic disease. www.biorxiv.org/content/10.1...
October 31, 2025 at 10:40 AM
Based on adipose tissue transcriptome analysis w/wo #exercise the authors propose
novel molecular pathways regulated by exercise training can lead to therapeutic targets for #obesity and metabolic disease. www.biorxiv.org/content/10.1...
novel molecular pathways regulated by exercise training can lead to therapeutic targets for #obesity and metabolic disease. www.biorxiv.org/content/10.1...
Here the authors propose that inhibition of the serine threonine kinase FAM20C in adipocytes may serve as a potential therapy for #T2D by restoring adipocyte health www.jci.org/articles/vie...
October 28, 2025 at 4:27 PM
Here the authors propose that inhibition of the serine threonine kinase FAM20C in adipocytes may serve as a potential therapy for #T2D by restoring adipocyte health www.jci.org/articles/vie...
Once again.....Real world data reveals #T2D GLP-1RAs and DPP-4is were associated with a small increase in risk of biliary disease, but not of acute pancreatitis compared with SGLT2is diabetesjournals.org/care/article...
October 27, 2025 at 8:32 PM
Once again.....Real world data reveals #T2D GLP-1RAs and DPP-4is were associated with a small increase in risk of biliary disease, but not of acute pancreatitis compared with SGLT2is diabetesjournals.org/care/article...
Here intestinal fructose metabolism drives GLP-1 secretion required to potentiate insulin secretion, thereby establishing a gut-pancreas axis that counter-regulates fructose-induced hyperglycaemia. physoc.onlinelibrary.wiley.com/doi/10.1113/... physoc.onlinelibrary.wiley.com/cms/asset/d1...
October 25, 2025 at 2:12 PM
Here intestinal fructose metabolism drives GLP-1 secretion required to potentiate insulin secretion, thereby establishing a gut-pancreas axis that counter-regulates fructose-induced hyperglycaemia. physoc.onlinelibrary.wiley.com/doi/10.1113/... physoc.onlinelibrary.wiley.com/cms/asset/d1...
#VitaminD deficiency associates with increased risk for a broad range of medical conditions. Yet RCTs of Vitamin D replacement often fail to show therapeutic benefit. Here critical illness and risk of acute kidney injury insight.jci.org/articles/vie...
October 22, 2025 at 4:31 PM
#VitaminD deficiency associates with increased risk for a broad range of medical conditions. Yet RCTs of Vitamin D replacement often fail to show therapeutic benefit. Here critical illness and risk of acute kidney injury insight.jci.org/articles/vie...
Multiple gene therapy approaches are being studied to take on the challenges of extending the duration of GLP-1 medicines. Should they be tunable and/or have a kill/off switch? www.biorxiv.org/content/10.1...
October 19, 2025 at 10:07 AM
Multiple gene therapy approaches are being studied to take on the challenges of extending the duration of GLP-1 medicines. Should they be tunable and/or have a kill/off switch? www.biorxiv.org/content/10.1...
The P3 Retatrutide TRIUMPH trials #obesity dom-pubs.onlinelibrary.wiley.com/doi/10.1111/...
October 15, 2025 at 7:34 PM
The P3 Retatrutide TRIUMPH trials #obesity dom-pubs.onlinelibrary.wiley.com/doi/10.1111/...
β-cell mass does not differ between individuals with and without PBH #Hypoglycemia after RYGB argue against expansion of β-cell mass to explain PBH. diabetesjournals.org/diabetes/art... ada.silverchair-cdn.com/ada/content_...
October 9, 2025 at 8:58 PM
β-cell mass does not differ between individuals with and without PBH #Hypoglycemia after RYGB argue against expansion of β-cell mass to explain PBH. diabetesjournals.org/diabetes/art... ada.silverchair-cdn.com/ada/content_...
Incoming nutritional epidemiology. Low Carbohydrate Diets may not be beneficial for primary prevention of #T2D unless they prioritize plant-based protein, healthy fats, and high-quality carbohydrates. diabetesjournals.org/care/article...
September 30, 2025 at 8:34 PM
Incoming nutritional epidemiology. Low Carbohydrate Diets may not be beneficial for primary prevention of #T2D unless they prioritize plant-based protein, healthy fats, and high-quality carbohydrates. diabetesjournals.org/care/article...
Novel insights into the molecular underpinnings of islet cell dysfunction in #T1D highlighting pathways that may be leveraged to preserve residual β-cell function and modulate α-cell activity @bcellorg.bsky.social www.jci.org/articles/vie...
September 30, 2025 at 4:45 PM
Novel insights into the molecular underpinnings of islet cell dysfunction in #T1D highlighting pathways that may be leveraged to preserve residual β-cell function and modulate α-cell activity @bcellorg.bsky.social www.jci.org/articles/vie...
New from Mark Ruszniak @vubasicsciences.bsky.social An essential role for the GLP-1R in hematopoietic stem cell engraftment academic.oup.com/jimmunol/adv...
September 24, 2025 at 11:37 PM
New from Mark Ruszniak @vubasicsciences.bsky.social An essential role for the GLP-1R in hematopoietic stem cell engraftment academic.oup.com/jimmunol/adv...
Potential Impact of Next-Generation Weight Loss Drugs on Cancer Incidence with 10% #weightloss Projections from the USA pmc.ncbi.nlm.nih.gov/articles/PMC...
September 24, 2025 at 11:08 PM
Potential Impact of Next-Generation Weight Loss Drugs on Cancer Incidence with 10% #weightloss Projections from the USA pmc.ncbi.nlm.nih.gov/articles/PMC...