Anupam Patgiri
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apatgiri.bsky.social
Anupam Patgiri
@apatgiri.bsky.social
1.8K followers 1.7K following 230 posts
Assistant Professor @EmoryMedicine passionate about #mitochondria #metabolism and #chemicalbiology | PhD @aroralabnyu, Postdoc @VamsiMootha | Amateur Photographer | Lab website: patgirilab.org | 🇮🇳🇺🇸
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Reposted by Anupam Patgiri
frezzalab.bsky.social
Good morning, all. A great selection of papers in #cancermetabolism and #mitochondrialbiology is waiting for you here: biomed.news/bims-camemi/... @biomednews.bsky.social #keepreading

"Calm down. Both your sins and your good deeds will be lost in oblivion." - Czesław Miłosz
November 30, 2025 at 6:22 AM
Reposted by Anupam Patgiri
cvasilescu.bsky.social
#mitochondrialdisease collection of papers from #week48! 📚
biomed.news/bims-mitdis/...

@biomednews.bsky.social @gavinmcstay.bsky.social @mitoscientist.bsky.social @mitoscientists.bsky.social

Inhibition of oligomeric BAX by an anti-apoptotic dimer
Newman et al
https://www.cell.com/cell/abstract/S0092-8674(25)01242-5?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS0092867425012425%3Fshowall%3Dtrue
November 30, 2025 at 12:38 PM
apatgiri.bsky.social
Innate immune and metabolic signals induce mitochondria-dependent membrane lysis via mitoxyperiosis

www.cell.com/cell/abstrac...
Innate immune and metabolic signals induce mitochondria-dependent membrane lysis via mitoxyperiosis
Wang et al. identify a new lytic cell death pathway, mitoxyperilysis, triggered by the synergy of innate immune activation and metabolic stress. This process is regulated by mTORC2 and involves persis...
www.cell.com
November 28, 2025 at 4:18 PM
Reposted by Anupam Patgiri
manu-lera.bsky.social
#OpenCloning is a an Open Source alternative to SnapGene/Benchling that supports automation and integration with other software

✅ Free
🔓 Open Source
🧬 More cloning methods than SnapGene
🤖 Can be automated with python
👨‍🔬 Built by a researcher — for researchers!

👉 Check it out at opencloning.org
A cloning strategy as depicted in the OpenCloning website
November 24, 2025 at 4:57 PM
apatgiri.bsky.social
Grateful for the wonderful people and amazing opportunities in my life - and the simple joy of homemade food and slowing down. Wishing everyone a warm and joyful Thanksgiving! 🍂🦃

#ThanksgivingEve #Thanksgiving #Gratitude #Thankful #HomemadeFood #TurkeyTime #HolidayCooking #FoodLove #MadeWithLove
November 26, 2025 at 2:37 PM
Reposted by Anupam Patgiri
elife.bsky.social
Evidence from 14 research funding programmes confirms that early winners tend to keep winning (Matthew effect). But the idea that an early setback makes you stronger later doesn’t replicate widely.
buff.ly/UEtcRd4
eLife Assessment This important study reports the results of efforts to replicate two phenomena of significant interest to early-career scientists and scientific policymakers: the Matthew effect and the early-career setback effect. Several previous studies of these effects have focused on early-career researchers with grant proposals that fell just below or just above a funding threshold. Those just above the threshold were more likely to be successful when they applied for funding later in the career (an example of the well-known Matthew effect), while those just below were more likely to go on to have stronger publication records (the early-career setback effect). In this study the Matthew effect was found to be robust across funders, and to generalize from those close to the funding threshold to the whole population. The early-career setback effect was not robust across funders and did not generalize to the whole population. The evidence reported is convincing.
November 25, 2025 at 11:02 AM
Reposted by Anupam Patgiri
pride-ebi.bsky.social
PXD062734 🚨

Proteomic analysis of binding partners of the OMM anchored ubiquitin-fusion degradation substrate

🚨 New dataset alert! 🚨
November 24, 2025 at 11:00 AM
Reposted by Anupam Patgiri
shoshana.bsky.social
Boston's Mayor Wu playing with Yo-Yo Ma at Symphony Hall
November 23, 2025 at 5:11 AM
Reposted by Anupam Patgiri
ryanlab.bsky.social
📢Last 2 weeks of #immunometabolism discoveries @biomednews.bsky.social ⬇️⬇️

biomed.news/bims-imicid/...
biomed.news/bims-imicid/...

Exciting to have a paper in the collection!

An inherited mitochondrial DNA mutation remodels inflammatory cytokine responses in macrophages and in vivo in mice
November 23, 2025 at 1:05 PM
Reposted by Anupam Patgiri
frezzalab.bsky.social
Good Sunday, all. What a great week for #cancermetabolism and #mitochondrialbiology. Find here a selection of groundbreaking discoveries: biomed.news/bims-camemi/... @biomednews.bsky.social #keepreading

"Trying to define yourself is like trying to bite your own teeth."-Alan Watts
November 23, 2025 at 6:51 AM
Reposted by Anupam Patgiri
sculpturatus.bsky.social
The chemotypes within FDA approvals so far this year are quite diverse. Most of the 2025 small molecule approvals are chiral with four covalent electrophiles.
November 23, 2025 at 12:58 AM
Reposted by Anupam Patgiri
pride-ebi.bsky.social
PXD068737 🚨

LC-MS/MS analysis of lactylated proteins in C2C12 cells

🚨 New dataset alert! 🚨
November 22, 2025 at 11:00 PM
apatgiri.bsky.social
Bacterial CipB is an exogenous receptor to drive the mitophagy-TFEB axis and promote pathogenesis rupress.org/jcb/article-...
Bacterial CipB is an exogenous receptor to drive the mitophagy-TFEB axis and promote pathogenesis
Liu et al. discover that pathogenic bacteria use a shared strategy to exploit the host’s cellular recycling process, mitophagy. Through an effector protein
rupress.org
November 22, 2025 at 6:08 PM
Reposted by Anupam Patgiri
dplamartin.bsky.social
link.springer.com/epdf/10.1007...
Mitochondria quality control: preserving the cells’ command center
link.springer.com
November 22, 2025 at 12:27 PM
apatgiri.bsky.social
The metabolic engine of cognition: microglia–neuron interactions in health, ageing and disease www.nature.com/articles/s42...
The metabolic engine of cognition: microglia–neuron interactions in health, ageing and disease - Nature Metabolism
This Review highlights how metabolic interactions between microglia and neurons shape brain health, and how their disruption in ageing and disease contributes to cognitive decline.
www.nature.com
November 22, 2025 at 12:07 AM
Reposted by Anupam Patgiri
ryanlab.bsky.social
Very excited to announce that the first paper from the lab is now live @natcomms.nature.com #mitochondria #immunometabolism

This work was led by postdoc Eloise marques with many important contributions from all of our co-authors.

Please check it out!

www.nature.com/articles/s41...
An inherited mitochondrial DNA mutation remodels inflammatory cytokine responses in macrophages and in vivo in mice - Nature Communications
Inherited mitochondrial DNA mutations can result in diverse clinical phenotypes. Here, the authors characterise a heteroplasmic tRNAAla mutation (m.5019A>G) in mice and demonstrate that macrophages...
www.nature.com
November 20, 2025 at 4:09 PM
Reposted by Anupam Patgiri
elife.bsky.social
Toxoplasma gondii carefully balances calcium between its organelles. This study shows the ER, via the SERCA pump, is central to controlling Ca²⁺ in the cytosol and mitochondria.

🔗 buff.ly/RFgcZgE
November 20, 2025 at 11:28 PM
Reposted by Anupam Patgiri
willoremus.com
every company in 2025
comic strip with call and response text. who are we? CEOs what do we want? AI! AI to do what? We don't know! When do we want it? Right now!
November 12, 2025 at 5:59 PM
apatgiri.bsky.social
An inherited mitochondrial DNA mutation remodels inflammatory cytokine responses in macrophages and in vivo in mice
www.nature.com/articles/s41...
An inherited mitochondrial DNA mutation remodels inflammatory cytokine responses in macrophages and in vivo in mice - Nature Communications
Inherited mitochondrial DNA mutations can result in diverse clinical phenotypes. Here, the authors characterise a heteroplasmic tRNAAla mutation (m.5019A>G) in mice and demonstrate that macrophages...
www.nature.com
November 20, 2025 at 3:42 PM
apatgiri.bsky.social
Missing the magic of New England’s fall colors! I captured this shot of Sleepy Hollow Farm in Vermont back in 2019.
#FallVibes #AutumnColors #FallFoliage #FallMagic #PeakFoliage #NaturePhotography #LandscapePhotography #NewEngland #Vermont
November 20, 2025 at 12:13 PM
Reposted by Anupam Patgiri
ryanlab.bsky.social
Last week's #immunometabolism discoveries @biomednews.bsky.social ⬇️⬇️⬇️

biomed.news/bims-imicid/...

Interesting finding:

Intracellular Salmonella hijacks the mitochondrial citrate carrier to evade host oxidative defenses
November 10, 2025 at 9:23 AM
Reposted by Anupam Patgiri
frezzalab.bsky.social
www.nature.com/articles/s42...
Glycerol-3-phosphate activates ChREBP, FGF21 transcription and lipogenesis in citrin deficiency

@charlesmbrenner.bsky.social congratulations!
Glycerol-3-phosphate activates ChREBP, FGF21 transcription and lipogenesis in citrin deficiency - Nature Metabolism
In a mouse model of the rare disease citrin deficiency, the authors discovered that the accumulation of glycerol-3-phosphate leads to ChREBP activation and FGF21 induction. The study identifies glycer...
www.nature.com
November 16, 2025 at 7:21 AM
Reposted by Anupam Patgiri
frezzalab.bsky.social
Good Sunday!. A wonderful selection of papers in #cancermetabolism and #mitochondrialbiology is waiting for you here: biomed.news/bims-camemi/... @biomednews.bsky.social #keepreading

"99.9 per cent of everything you think, and of everything you do, is for yourself—and there isn't one."
-Wei Wu Wei
November 16, 2025 at 7:04 AM
Reposted by Anupam Patgiri
frisophagy.bsky.social
Only good papers on mitophagy this week!

biomed.news/bims-tofagi/...

Highlights:
-The bottleneck for maternal transmission of mtDNA is linked to purifying selection by autophagy
-Piecemeal Mitochondrial degradation in plants
-Allophagy?!

Thanks to @biomednews.bsky.social
Altered bottleneck and mitochondrial turnover affect mtDNA mutation load and selection efficiency. (A) Mutational burden was quantified as the total number of mtDNA variants detected per animal. (B) For each animal, the mtDNA N/S ratio was calculated by dividing the number of nonsynonymous variants, normalized to the number of possible nonsynonymous variants in the mitochondrial genome, by the number of synonymous variants, normalized to the number of possible synonymous sites. For (A) and (B): dashed line, median value of the Polg+/+ control group; dotted line, modal value of the Polg+/+ control group; gray, Polg+/+ control group; orange, Polg+/+ Tfam+/− group; blue, Polg+/+ Tfam+/OE group; green, Polg+/+ Bcl2l13−/− group; and pink, Polg+/+ Ulk2−/− group.
November 16, 2025 at 10:53 AM
apatgiri.bsky.social
Metabolic Messengers: itaconate www.nature.com/articles/s42...
Metabolic Messengers: itaconate - Nature Metabolism
McGettrick et al. provide a succinct yet broad overview of the immunometabolite itaconate as an immunomodulatory molecule.
www.nature.com
November 15, 2025 at 7:13 PM