Yasemin Sancak
@yasesancak.bsky.social
Faculty at UW Seattle, interested in mitochondria, calcium signaling, organelles, cancer metabolism.
Reposted by Yasemin Sancak
Genuinely thrilled to share our new story with the world - an amazing collaboration with @profsharona.bsky.social and Bill Zagotta using their innovative FRET technique to study mitofusin conformational changes. Huge credit to Sophie Hurwitz for tackling this project. urldefense.com/v3/__https:/...
Structural insights into GTP-coupled conformational changes in Mfn1 revealed by time-resolved transition metal ion FRET.
Outer mitochondrial membrane fusion is mediated by the mitofusin paralogs Mfn1 and Mfn2. Nucleotide-driven self-assembly and conformational changes are required for regulated membrane fusion activity,...
urldefense.com
October 10, 2025 at 6:31 PM
Genuinely thrilled to share our new story with the world - an amazing collaboration with @profsharona.bsky.social and Bill Zagotta using their innovative FRET technique to study mitofusin conformational changes. Huge credit to Sophie Hurwitz for tackling this project. urldefense.com/v3/__https:/...
Reposted by Yasemin Sancak
Excited to share new work led by outstanding former grad student Kübra Akkaya! We show that Stearoyl-CoA Desaturases (SCDs) regulate intestinal stem and progenitor cell proliferation by balancing fatty acids, sustaining epithelial homeostasis and regeneration.
September 23, 2025 at 12:55 PM
Excited to share new work led by outstanding former grad student Kübra Akkaya! We show that Stearoyl-CoA Desaturases (SCDs) regulate intestinal stem and progenitor cell proliferation by balancing fatty acids, sustaining epithelial homeostasis and regeneration.
Reposted by Yasemin Sancak
Hello! Ever wonder what's "talking to" your favorite transcript, but were too scared to ask? In our review in @cp-cellreports.bsky.social, @mardakheh.bsky.social and I highlight new RNA-focused tools for discovering RNA interactions across organizational scales. Checkit!
tinyurl.com/ydn6e3ac
tinyurl.com/ydn6e3ac
June 30, 2025 at 9:15 PM
Hello! Ever wonder what's "talking to" your favorite transcript, but were too scared to ask? In our review in @cp-cellreports.bsky.social, @mardakheh.bsky.social and I highlight new RNA-focused tools for discovering RNA interactions across organizational scales. Checkit!
tinyurl.com/ydn6e3ac
tinyurl.com/ydn6e3ac
Our paper on regulation of BCAA catabolism by mitochondrial calcium signaling is out!
Mitochondrial calcium signaling regulates branched-chain amino acid catabolism in fibrolamellar carcinoma | Science Advances www.science.org/doi/10.1126/...
Mitochondrial calcium signaling regulates branched-chain amino acid catabolism in fibrolamellar carcinoma | Science Advances www.science.org/doi/10.1126/...
Mitochondrial calcium signaling regulates branched-chain amino acid catabolism in fibrolamellar carcinoma
Mitochondrial Ca2+ signaling regulates branched-chain amino acid catabolism in an adolescent liver cancer.
www.science.org
May 31, 2025 at 6:24 AM
Our paper on regulation of BCAA catabolism by mitochondrial calcium signaling is out!
Mitochondrial calcium signaling regulates branched-chain amino acid catabolism in fibrolamellar carcinoma | Science Advances www.science.org/doi/10.1126/...
Mitochondrial calcium signaling regulates branched-chain amino acid catabolism in fibrolamellar carcinoma | Science Advances www.science.org/doi/10.1126/...
ATTENTION MITO-CALCIUM ENTHUSIASTS: there's a new game in town! This piece highlights a new paper by the Elrod Lab interrogating TMEM65’s role in mitochondrial calcium efflux. The De Stefani and Glancy labs have recently reported similar findings. Congratulations on this important discovery!
NEWS & VIEWS | @yasesancak.bsky.social (U Washington):
A new study shows that the mitochondrial protein TMEM65 has a central role in efflux of calcium ions from the mitochondria.
https://bit.ly/3Sdndzq ?utm_source=bluesky&utm_medium=social&utm_campaign=natmetab
A new study shows that the mitochondrial protein TMEM65 has a central role in efflux of calcium ions from the mitochondria.
https://bit.ly/3Sdndzq ?utm_source=bluesky&utm_medium=social&utm_campaign=natmetab
TMEM65 joins the mitochondrial Ca2+ club - Nature Metabolism
Garbincius et al. show that TMEM65, a mitochondrial transmembrane protein of unknown function, has a central role in efflux of calcium ions from the mitochondria. Mitochondrial calcium efflux is crucial for maintaining mitochondrial calcium levels, which is important for metabolic homeostasis and mitochondrial health.
bit.ly
May 31, 2025 at 5:59 AM
ATTENTION MITO-CALCIUM ENTHUSIASTS: there's a new game in town! This piece highlights a new paper by the Elrod Lab interrogating TMEM65’s role in mitochondrial calcium efflux. The De Stefani and Glancy labs have recently reported similar findings. Congratulations on this important discovery!
Reposted by Yasemin Sancak
It's my great pleasure to present the next big preprint from SheqLab! An exciting application of our O-MAP platform that I hope will transform the study of nuclear architecture.
If you've ever wanted to dissect the subnuclear "neighborhood" around an individual locus, read on! (1/30)
If you've ever wanted to dissect the subnuclear "neighborhood" around an individual locus, read on! (1/30)
November 21, 2024 at 1:27 AM
It's my great pleasure to present the next big preprint from SheqLab! An exciting application of our O-MAP platform that I hope will transform the study of nuclear architecture.
If you've ever wanted to dissect the subnuclear "neighborhood" around an individual locus, read on! (1/30)
If you've ever wanted to dissect the subnuclear "neighborhood" around an individual locus, read on! (1/30)