Karsten Suhre
@ksuhre.bsky.social
Passionate about #GWAS #Metabolomics #Proteomics #Glycomics #Epigenomics, Professor @WeillCornell
Medicine - Qatar, Blog on http://metabolomix.com, http://suhre.fr
Medicine - Qatar, Blog on http://metabolomix.com, http://suhre.fr
Pinned
Karsten Suhre
@ksuhre.bsky.social
· Dec 3
A genome-wide association study of mass spectrometry proteomics using a nanoparticle enrichment platform - Nature Genetics
Genome-wide association analyses of blood plasma samples using a mass spectrometry-based platform illustrate the complementarity of different proteomics approaches for identifying protein quantitative...
www.nature.com
Read our latest paper just published in Nature Genetics :
A genome-wide association study of mass spectrometry proteomics using a nanoparticle enrichment platform
www.nature.com/articles/s41...
A genome-wide association study of mass spectrometry proteomics using a nanoparticle enrichment platform
www.nature.com/articles/s41...
Come and join me for a GenomeWeb webinar supported by Seer on
"Unbiased Plasma Proteomics Expands GWAS Insights"
Wednesday, March 11, 2026
12:00 PM Eastern Daylight Time
Register here:
event.on24.com/wcc/r/521498...
More details:
www.genomeweb.com/events
"Unbiased Plasma Proteomics Expands GWAS Insights"
Wednesday, March 11, 2026
12:00 PM Eastern Daylight Time
Register here:
event.on24.com/wcc/r/521498...
More details:
www.genomeweb.com/events
A genome-wide association study of mass spectrometry proteomics using a nanoparticle enrichment platform - Nature Genetics
Genome-wide association analyses of blood plasma samples using a mass spectrometry-based platform illustrate the complementarity of different proteomics approaches for identifying protein quantitative...
www.nature.com
February 17, 2026 at 7:03 AM
Come and join me for a GenomeWeb webinar supported by Seer on
"Unbiased Plasma Proteomics Expands GWAS Insights"
Wednesday, March 11, 2026
12:00 PM Eastern Daylight Time
Register here:
event.on24.com/wcc/r/521498...
More details:
www.genomeweb.com/events
"Unbiased Plasma Proteomics Expands GWAS Insights"
Wednesday, March 11, 2026
12:00 PM Eastern Daylight Time
Register here:
event.on24.com/wcc/r/521498...
More details:
www.genomeweb.com/events
Using @somalogic.bsky.social affinity #proteomics data from three cohorts and #pQTL association strength as a readout we identify protein signatures reflecting latent variation in aptamer-based affinity proteomics.
Learn how HSP90 can act as a proxy for cell-lysis.
pubs.acs.org/doi/full/10....
Learn how HSP90 can act as a proxy for cell-lysis.
pubs.acs.org/doi/full/10....
Identification of Protein Signatures Reflecting Latent Variation in Aptamer-Based Affinity Proteomics
Accurate quantification of circulating proteins is critical for assessing biological variation and integrating proteomics with other omics to understand biological processes and disease mechanisms. Pr...
pubs.acs.org
February 17, 2026 at 6:48 AM
Using @somalogic.bsky.social affinity #proteomics data from three cohorts and #pQTL association strength as a readout we identify protein signatures reflecting latent variation in aptamer-based affinity proteomics.
Learn how HSP90 can act as a proxy for cell-lysis.
pubs.acs.org/doi/full/10....
Learn how HSP90 can act as a proxy for cell-lysis.
pubs.acs.org/doi/full/10....
Reposted by Karsten Suhre
Quantifying the ∼75–95% of Peptides in DIA-MS Data Sets that Were Not Previously Quantified #JProteomeRes pubs.acs.org/doi/10.1021/...
Quantifying the ∼75–95% of Peptides in DIA-MS Data Sets that Were Not Previously Quantified
We have developed a novel algorithm termed GoldenHaystack (GH) that was designed for enhanced peptide quantification of data-independent acquisition liquid-mass spectrometry (DIA-LC-MS) data files reg...
pubs.acs.org
February 5, 2026 at 10:19 AM
Quantifying the ∼75–95% of Peptides in DIA-MS Data Sets that Were Not Previously Quantified #JProteomeRes pubs.acs.org/doi/10.1021/...
Our paper is now available in the print edition of Proteomics:
"Comparative Analysis Between Olink-PEA and Alamar-NULISA Proteomic Technologies Applied to a Critically Ill COVID-19 Cohort"
dx.doi.org/10.1002/pmic...
"Comparative Analysis Between Olink-PEA and Alamar-NULISA Proteomic Technologies Applied to a Critically Ill COVID-19 Cohort"
dx.doi.org/10.1002/pmic...
December 15, 2025 at 2:11 PM
Our paper is now available in the print edition of Proteomics:
"Comparative Analysis Between Olink-PEA and Alamar-NULISA Proteomic Technologies Applied to a Critically Ill COVID-19 Cohort"
dx.doi.org/10.1002/pmic...
"Comparative Analysis Between Olink-PEA and Alamar-NULISA Proteomic Technologies Applied to a Critically Ill COVID-19 Cohort"
dx.doi.org/10.1002/pmic...
Reposted by Karsten Suhre
A study on 1.7 million people in Hong Kong shows superior hybrid immunity to Covid in people who got vaccinated before infection vs. people who got infected first. "Our findings are a direct rebuttal to arguments for natural immunity," the authors write. doi.org/10.1016/j.va...
Redirecting
doi.org
December 6, 2025 at 5:02 PM
A study on 1.7 million people in Hong Kong shows superior hybrid immunity to Covid in people who got vaccinated before infection vs. people who got infected first. "Our findings are a direct rebuttal to arguments for natural immunity," the authors write. doi.org/10.1016/j.va...
Here a tutorial on how to easily 3D-print proteins and other macro-molecules:
makerworld.com/en/models/96...
makerworld.com/en/models/96...
Howto 3D-print proteins and molecules from the PDB by KS MakerWorld: Download Free 3D Models
How to print 3D protein and molecular structures - from virtual to physicalThis is a 3D print of an antibody bound to a protein, i.e. PDGF-B blocking antibody bound to PDGF-BB. Blue and red are two su...
makerworld.com
December 4, 2025 at 5:08 PM
Here a tutorial on how to easily 3D-print proteins and other macro-molecules:
makerworld.com/en/models/96...
makerworld.com/en/models/96...
Faecal metabolites as a readout of habitual diet capture dietary interactions with the gut microbiome.
By integrating faecal metabolomics, metagenomics, and dietary data Falchi et al. show that faecal metabolites capture mediations between diet and the gut microbiome
www.nature.com/articles/s41...
By integrating faecal metabolomics, metagenomics, and dietary data Falchi et al. show that faecal metabolites capture mediations between diet and the gut microbiome
www.nature.com/articles/s41...
Faecal metabolites as a readout of habitual diet capture dietary interactions with the gut microbiome - Nature Communications
Here, by integrating faecal metabolomics, metagenomics, and habitual dietary data of two large human cohorts, the authors show that faecal metabolites reflect diet and gut microbiome interactions, pre...
www.nature.com
December 4, 2025 at 11:10 AM
Faecal metabolites as a readout of habitual diet capture dietary interactions with the gut microbiome.
By integrating faecal metabolomics, metagenomics, and dietary data Falchi et al. show that faecal metabolites capture mediations between diet and the gut microbiome
www.nature.com/articles/s41...
By integrating faecal metabolomics, metagenomics, and dietary data Falchi et al. show that faecal metabolites capture mediations between diet and the gut microbiome
www.nature.com/articles/s41...
Read our latest paper just published in Nature Genetics :
A genome-wide association study of mass spectrometry proteomics using a nanoparticle enrichment platform
www.nature.com/articles/s41...
A genome-wide association study of mass spectrometry proteomics using a nanoparticle enrichment platform
www.nature.com/articles/s41...
A genome-wide association study of mass spectrometry proteomics using a nanoparticle enrichment platform - Nature Genetics
Genome-wide association analyses of blood plasma samples using a mass spectrometry-based platform illustrate the complementarity of different proteomics approaches for identifying protein quantitative...
www.nature.com
December 3, 2025 at 11:43 AM
Read our latest paper just published in Nature Genetics :
A genome-wide association study of mass spectrometry proteomics using a nanoparticle enrichment platform
www.nature.com/articles/s41...
A genome-wide association study of mass spectrometry proteomics using a nanoparticle enrichment platform
www.nature.com/articles/s41...
Honestly - these days the most interesting part is often the exchange with the reviewers - great idea to make these public: our paper has 67 pages, they can be found here: static-content.springer.com/esm/art%3A10...
static-content.springer.com
November 28, 2025 at 3:06 PM
Honestly - these days the most interesting part is often the exchange with the reviewers - great idea to make these public: our paper has 67 pages, they can be found here: static-content.springer.com/esm/art%3A10...
Suspense !
Our new #GWAS with MS #proteomics paper has been scheduled for publication in Nature Genetics on 27 November 2025 at 10:00 (London time) and will be available at the following URL: www.nature.com/articles/s41...
Our new #GWAS with MS #proteomics paper has been scheduled for publication in Nature Genetics on 27 November 2025 at 10:00 (London time) and will be available at the following URL: www.nature.com/articles/s41...
www.nature.com
November 27, 2025 at 7:10 AM
Suspense !
Our new #GWAS with MS #proteomics paper has been scheduled for publication in Nature Genetics on 27 November 2025 at 10:00 (London time) and will be available at the following URL: www.nature.com/articles/s41...
Our new #GWAS with MS #proteomics paper has been scheduled for publication in Nature Genetics on 27 November 2025 at 10:00 (London time) and will be available at the following URL: www.nature.com/articles/s41...
Genomics of drug target prioritization for complex diseases - a Nature Reviews Genetics review:
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Genomics of drug target prioritization for complex diseases - Nature Reviews Genetics
In this Review, Chen et al. discuss how the advancement and integration of large-scale genetic resources, multi-omics data and sophisticated computational tools are improving drug development pipeline...
www.nature.com
November 16, 2025 at 6:28 AM
Genomics of drug target prioritization for complex diseases - a Nature Reviews Genetics review:
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Recommendations from the NIDDK’s Working Group of Council on Heterogeneity of Diabetes:
www.niddk.nih.gov/about-niddk/...
www.niddk.nih.gov/about-niddk/...
Heterogeneity of Diabetes - NIDDK
This Report outlines research Recommendations from the NIDDK’s Working Group of Council on Heterogeneity of Diabetes.
www.niddk.nih.gov
November 16, 2025 at 6:27 AM
Recommendations from the NIDDK’s Working Group of Council on Heterogeneity of Diabetes:
www.niddk.nih.gov/about-niddk/...
www.niddk.nih.gov/about-niddk/...
Pharma companies take note - human knockouts in bottleneck and consanguineous populations are up and coming.
Plasma Metabolic Outliers Identified in #Estonian Human Knockouts: www.mdpi.com/2218-1989/15...
citing our #Qatar study with @metabolon.bsky.social data:
www.cell.com/cell-genomic...
Plasma Metabolic Outliers Identified in #Estonian Human Knockouts: www.mdpi.com/2218-1989/15...
citing our #Qatar study with @metabolon.bsky.social data:
www.cell.com/cell-genomic...
November 4, 2025 at 1:16 PM
Pharma companies take note - human knockouts in bottleneck and consanguineous populations are up and coming.
Plasma Metabolic Outliers Identified in #Estonian Human Knockouts: www.mdpi.com/2218-1989/15...
citing our #Qatar study with @metabolon.bsky.social data:
www.cell.com/cell-genomic...
Plasma Metabolic Outliers Identified in #Estonian Human Knockouts: www.mdpi.com/2218-1989/15...
citing our #Qatar study with @metabolon.bsky.social data:
www.cell.com/cell-genomic...
Reposted by Karsten Suhre
“Our study [in Cancer Discovery] suggests a new therapeutic approach to block metastasis before it starts, and help patients overcome triple negative breast cancer,” said Dr. Vivek Mittal (@MittalLab) from the Meyer Cancer Center and there EIPM.
news.weill.cornell.edu/news/2025/10...
news.weill.cornell.edu/news/2025/10...
October 3, 2025 at 9:37 PM
“Our study [in Cancer Discovery] suggests a new therapeutic approach to block metastasis before it starts, and help patients overcome triple negative breast cancer,” said Dr. Vivek Mittal (@MittalLab) from the Meyer Cancer Center and there EIPM.
news.weill.cornell.edu/news/2025/10...
news.weill.cornell.edu/news/2025/10...
Reposted by Karsten Suhre
🔬Inside the Core Lab: Driving Discovery in #Proteomics
Explore one of the key labs supporting cutting-edge proteomics research in Qatar. Meet the team and discover the advanced technologies driving biomedical breakthroughs.
Featured in the lead-up to #QPC2025 — where innovation meets collaboration.
Explore one of the key labs supporting cutting-edge proteomics research in Qatar. Meet the team and discover the advanced technologies driving biomedical breakthroughs.
Featured in the lead-up to #QPC2025 — where innovation meets collaboration.
October 5, 2025 at 8:28 AM
🔬Inside the Core Lab: Driving Discovery in #Proteomics
Explore one of the key labs supporting cutting-edge proteomics research in Qatar. Meet the team and discover the advanced technologies driving biomedical breakthroughs.
Featured in the lead-up to #QPC2025 — where innovation meets collaboration.
Explore one of the key labs supporting cutting-edge proteomics research in Qatar. Meet the team and discover the advanced technologies driving biomedical breakthroughs.
Featured in the lead-up to #QPC2025 — where innovation meets collaboration.
This Report outlines research Recommendations from the NIDDK’s Working Group of Council on Heterogeneity of #Diabetes, a result of tremendous effort and significant contributions from global investigators and #NIDDK staff.
www.niddk.nih.gov/about-niddk/...
www.niddk.nih.gov/about-niddk/...
Heterogeneity of Diabetes - NIDDK
This Report outlines research Recommendations from the NIDDK’s Working Group of Council on Heterogeneity of Diabetes.
www.niddk.nih.gov
October 2, 2025 at 10:49 AM
This Report outlines research Recommendations from the NIDDK’s Working Group of Council on Heterogeneity of #Diabetes, a result of tremendous effort and significant contributions from global investigators and #NIDDK staff.
www.niddk.nih.gov/about-niddk/...
www.niddk.nih.gov/about-niddk/...
A pretty comprehensive comparison of most actual #proteomics platforms:
Current landscape of plasma proteomics from technical innovations to biological insights and biomarker discovery
www.nature.com/articles/s42...
Current landscape of plasma proteomics from technical innovations to biological insights and biomarker discovery
www.nature.com/articles/s42...
Current landscape of plasma proteomics from technical innovations to biological insights and biomarker discovery - Communications Chemistry
Plasma proteome profiling has surged as a promising avenue for biomarker discovery, yet comprehensive platform comparisons remain scarce. Here, the authors evaluate eight proteomics platforms, revealing key differences and complementary strengths, providing crucial insights for researchers into coverage trade-offs and implicating biomarker discovery and clinical applications.
www.nature.com
October 1, 2025 at 6:13 AM
A pretty comprehensive comparison of most actual #proteomics platforms:
Current landscape of plasma proteomics from technical innovations to biological insights and biomarker discovery
www.nature.com/articles/s42...
Current landscape of plasma proteomics from technical innovations to biological insights and biomarker discovery
www.nature.com/articles/s42...
Reposted by Karsten Suhre
October's #LipidoftheMonth is a sterol that might be causing quite a buzz soon.
www.lipidmaps.org/updates/lipi...
www.lipidmaps.org/updates/lipi...
October 1, 2025 at 6:00 AM
October's #LipidoftheMonth is a sterol that might be causing quite a buzz soon.
www.lipidmaps.org/updates/lipi...
www.lipidmaps.org/updates/lipi...
"A standardized framework for circulating
blood proteomics" ... it summarizes many of the challenges encountered in the field, although I miss any reference to genetic aspects of blood proteomics, i.e. cis-pQTLs to confirm target specificity and epitope effects
www.nature.com/articles/s41...
blood proteomics" ... it summarizes many of the challenges encountered in the field, although I miss any reference to genetic aspects of blood proteomics, i.e. cis-pQTLs to confirm target specificity and epitope effects
www.nature.com/articles/s41...
A standardized framework for circulating blood proteomics
Nature Genetics - The field of blood proteomics faces an upsurge of data with the challenge of cross-study comparisons. This Perspective offers an in-depth analysis and proposes reference materials...
www.nature.com
September 24, 2025 at 12:21 PM
"A standardized framework for circulating
blood proteomics" ... it summarizes many of the challenges encountered in the field, although I miss any reference to genetic aspects of blood proteomics, i.e. cis-pQTLs to confirm target specificity and epitope effects
www.nature.com/articles/s41...
blood proteomics" ... it summarizes many of the challenges encountered in the field, although I miss any reference to genetic aspects of blood proteomics, i.e. cis-pQTLs to confirm target specificity and epitope effects
www.nature.com/articles/s41...
I have always been a proponent of hypothesis-free testing of metabolite rations: This paper is just great in how it takes it to the next level:
Untargeted pixel-by- pixel metabolite ratio imaging as a novel tool for biomedical discovery in mass spectrometry imaging
elifesciences.org/articles/96892
Untargeted pixel-by- pixel metabolite ratio imaging as a novel tool for biomedical discovery in mass spectrometry imaging
elifesciences.org/articles/96892
September 14, 2025 at 1:17 PM
I have always been a proponent of hypothesis-free testing of metabolite rations: This paper is just great in how it takes it to the next level:
Untargeted pixel-by- pixel metabolite ratio imaging as a novel tool for biomedical discovery in mass spectrometry imaging
elifesciences.org/articles/96892
Untargeted pixel-by- pixel metabolite ratio imaging as a novel tool for biomedical discovery in mass spectrometry imaging
elifesciences.org/articles/96892
Reposted by Karsten Suhre
Years ago I asked on Twitter why my heart rate would continue to climb even after I fixed the speed and incline on my treadmill. At the time, no one on Twitter could give me a satisfactory answer.
But now GPT4o was able to answer it and suggested approaches to quantify the phenomenon.
But now GPT4o was able to answer it and suggested approaches to quantify the phenomenon.
August 16, 2025 at 10:42 PM
Years ago I asked on Twitter why my heart rate would continue to climb even after I fixed the speed and incline on my treadmill. At the time, no one on Twitter could give me a satisfactory answer.
But now GPT4o was able to answer it and suggested approaches to quantify the phenomenon.
But now GPT4o was able to answer it and suggested approaches to quantify the phenomenon.
Reposted by Karsten Suhre
(J Proteom Res) [ASAP] Understanding Data Analysis Steps in Mass-Spectrometry-Based Proteomics Is Key to Transparent Reporting: Journal of Proteome ResearchDOI: 10.1021/acs.jproteome.5c00287 #MassSpecRSS
[ASAP] Understanding Data Analysis Steps in Mass-Spectrometry-Based Proteomics Is Key to Transparent Reporting
Journal of Proteome ResearchDOI: 10.1021/acs.jproteome.5c00287
dlvr.it
September 3, 2025 at 11:01 PM
(J Proteom Res) [ASAP] Understanding Data Analysis Steps in Mass-Spectrometry-Based Proteomics Is Key to Transparent Reporting: Journal of Proteome ResearchDOI: 10.1021/acs.jproteome.5c00287 #MassSpecRSS
Reposted by Karsten Suhre
Prefusion gB of HSV bound with a neutralizing nanobody www.nature.com/articles/s41...
A nanobody specific to prefusion glycoprotein B neutralizes HSV-1 and HSV-2 - Nature
A neutralizing nanobody specific to the prefusion conformation of herpes simplex virus glycoprotein B has cross-species activity and offers insights into virus neutralization, possible immunogens and ...
www.nature.com
September 4, 2025 at 5:51 AM
Prefusion gB of HSV bound with a neutralizing nanobody www.nature.com/articles/s41...