Karsten Suhre
@ksuhre.bsky.social
Passionate about #GWAS #Metabolomics #Proteomics #Glycomics #Epigenomics, Professor @WeillCornell
Medicine - Qatar, Blog on http://metabolomix.com, http://suhre.fr
Medicine - Qatar, Blog on http://metabolomix.com, http://suhre.fr
Pinned
Karsten Suhre
@ksuhre.bsky.social
· Mar 16
Interested in joint multiomics data?
Metabolon, Biocrates, Lipidyzer, Chenomx, SOMAscan, Olink, Nightingale, Genos, Exiqon and Illumina genomics (OmniArray, HumanMethylation, RNAseq)
Check out our COMICS server
littleswissriver.shinyapps.io/generate_net...
and BLOG
www.metabolomix.com/comics/
Metabolon, Biocrates, Lipidyzer, Chenomx, SOMAscan, Olink, Nightingale, Genos, Exiqon and Illumina genomics (OmniArray, HumanMethylation, RNAseq)
Check out our COMICS server
littleswissriver.shinyapps.io/generate_net...
and BLOG
www.metabolomix.com/comics/
Pharma companies take note - human knockouts in bottleneck and consanguineous populations are up and coming.
Plasma Metabolic Outliers Identified in #Estonian Human Knockouts: www.mdpi.com/2218-1989/15...
citing our #Qatar study with @metabolon.bsky.social data:
www.cell.com/cell-genomic...
Plasma Metabolic Outliers Identified in #Estonian Human Knockouts: www.mdpi.com/2218-1989/15...
citing our #Qatar study with @metabolon.bsky.social data:
www.cell.com/cell-genomic...
November 4, 2025 at 1:16 PM
Pharma companies take note - human knockouts in bottleneck and consanguineous populations are up and coming.
Plasma Metabolic Outliers Identified in #Estonian Human Knockouts: www.mdpi.com/2218-1989/15...
citing our #Qatar study with @metabolon.bsky.social data:
www.cell.com/cell-genomic...
Plasma Metabolic Outliers Identified in #Estonian Human Knockouts: www.mdpi.com/2218-1989/15...
citing our #Qatar study with @metabolon.bsky.social data:
www.cell.com/cell-genomic...
Reposted by Karsten Suhre
“Our study [in Cancer Discovery] suggests a new therapeutic approach to block metastasis before it starts, and help patients overcome triple negative breast cancer,” said Dr. Vivek Mittal (@MittalLab) from the Meyer Cancer Center and there EIPM.
news.weill.cornell.edu/news/2025/10...
news.weill.cornell.edu/news/2025/10...
October 3, 2025 at 9:37 PM
“Our study [in Cancer Discovery] suggests a new therapeutic approach to block metastasis before it starts, and help patients overcome triple negative breast cancer,” said Dr. Vivek Mittal (@MittalLab) from the Meyer Cancer Center and there EIPM.
news.weill.cornell.edu/news/2025/10...
news.weill.cornell.edu/news/2025/10...
Reposted by Karsten Suhre
🔬Inside the Core Lab: Driving Discovery in #Proteomics
Explore one of the key labs supporting cutting-edge proteomics research in Qatar. Meet the team and discover the advanced technologies driving biomedical breakthroughs.
Featured in the lead-up to #QPC2025 — where innovation meets collaboration.
Explore one of the key labs supporting cutting-edge proteomics research in Qatar. Meet the team and discover the advanced technologies driving biomedical breakthroughs.
Featured in the lead-up to #QPC2025 — where innovation meets collaboration.
October 5, 2025 at 8:28 AM
🔬Inside the Core Lab: Driving Discovery in #Proteomics
Explore one of the key labs supporting cutting-edge proteomics research in Qatar. Meet the team and discover the advanced technologies driving biomedical breakthroughs.
Featured in the lead-up to #QPC2025 — where innovation meets collaboration.
Explore one of the key labs supporting cutting-edge proteomics research in Qatar. Meet the team and discover the advanced technologies driving biomedical breakthroughs.
Featured in the lead-up to #QPC2025 — where innovation meets collaboration.
This Report outlines research Recommendations from the NIDDK’s Working Group of Council on Heterogeneity of #Diabetes, a result of tremendous effort and significant contributions from global investigators and #NIDDK staff.
www.niddk.nih.gov/about-niddk/...
www.niddk.nih.gov/about-niddk/...
Heterogeneity of Diabetes - NIDDK
This Report outlines research Recommendations from the NIDDK’s Working Group of Council on Heterogeneity of Diabetes.
www.niddk.nih.gov
October 2, 2025 at 10:49 AM
This Report outlines research Recommendations from the NIDDK’s Working Group of Council on Heterogeneity of #Diabetes, a result of tremendous effort and significant contributions from global investigators and #NIDDK staff.
www.niddk.nih.gov/about-niddk/...
www.niddk.nih.gov/about-niddk/...
A pretty comprehensive comparison of most actual #proteomics platforms:
Current landscape of plasma proteomics from technical innovations to biological insights and biomarker discovery
www.nature.com/articles/s42...
Current landscape of plasma proteomics from technical innovations to biological insights and biomarker discovery
www.nature.com/articles/s42...
Current landscape of plasma proteomics from technical innovations to biological insights and biomarker discovery - Communications Chemistry
Plasma proteome profiling has surged as a promising avenue for biomarker discovery, yet comprehensive platform comparisons remain scarce. Here, the authors evaluate eight proteomics platforms, revealing key differences and complementary strengths, providing crucial insights for researchers into coverage trade-offs and implicating biomarker discovery and clinical applications.
www.nature.com
October 1, 2025 at 6:13 AM
A pretty comprehensive comparison of most actual #proteomics platforms:
Current landscape of plasma proteomics from technical innovations to biological insights and biomarker discovery
www.nature.com/articles/s42...
Current landscape of plasma proteomics from technical innovations to biological insights and biomarker discovery
www.nature.com/articles/s42...
Reposted by Karsten Suhre
October's #LipidoftheMonth is a sterol that might be causing quite a buzz soon.
www.lipidmaps.org/updates/lipi...
www.lipidmaps.org/updates/lipi...
October 1, 2025 at 6:00 AM
October's #LipidoftheMonth is a sterol that might be causing quite a buzz soon.
www.lipidmaps.org/updates/lipi...
www.lipidmaps.org/updates/lipi...
"A standardized framework for circulating
blood proteomics" ... it summarizes many of the challenges encountered in the field, although I miss any reference to genetic aspects of blood proteomics, i.e. cis-pQTLs to confirm target specificity and epitope effects
www.nature.com/articles/s41...
blood proteomics" ... it summarizes many of the challenges encountered in the field, although I miss any reference to genetic aspects of blood proteomics, i.e. cis-pQTLs to confirm target specificity and epitope effects
www.nature.com/articles/s41...
A standardized framework for circulating blood proteomics
Nature Genetics - The field of blood proteomics faces an upsurge of data with the challenge of cross-study comparisons. This Perspective offers an in-depth analysis and proposes reference materials...
www.nature.com
September 24, 2025 at 12:21 PM
"A standardized framework for circulating
blood proteomics" ... it summarizes many of the challenges encountered in the field, although I miss any reference to genetic aspects of blood proteomics, i.e. cis-pQTLs to confirm target specificity and epitope effects
www.nature.com/articles/s41...
blood proteomics" ... it summarizes many of the challenges encountered in the field, although I miss any reference to genetic aspects of blood proteomics, i.e. cis-pQTLs to confirm target specificity and epitope effects
www.nature.com/articles/s41...
I have always been a proponent of hypothesis-free testing of metabolite rations: This paper is just great in how it takes it to the next level:
Untargeted pixel-by- pixel metabolite ratio imaging as a novel tool for biomedical discovery in mass spectrometry imaging
elifesciences.org/articles/96892
Untargeted pixel-by- pixel metabolite ratio imaging as a novel tool for biomedical discovery in mass spectrometry imaging
elifesciences.org/articles/96892
September 14, 2025 at 1:17 PM
I have always been a proponent of hypothesis-free testing of metabolite rations: This paper is just great in how it takes it to the next level:
Untargeted pixel-by- pixel metabolite ratio imaging as a novel tool for biomedical discovery in mass spectrometry imaging
elifesciences.org/articles/96892
Untargeted pixel-by- pixel metabolite ratio imaging as a novel tool for biomedical discovery in mass spectrometry imaging
elifesciences.org/articles/96892
Reposted by Karsten Suhre
Years ago I asked on Twitter why my heart rate would continue to climb even after I fixed the speed and incline on my treadmill. At the time, no one on Twitter could give me a satisfactory answer.
But now GPT4o was able to answer it and suggested approaches to quantify the phenomenon.
But now GPT4o was able to answer it and suggested approaches to quantify the phenomenon.
August 16, 2025 at 10:42 PM
Years ago I asked on Twitter why my heart rate would continue to climb even after I fixed the speed and incline on my treadmill. At the time, no one on Twitter could give me a satisfactory answer.
But now GPT4o was able to answer it and suggested approaches to quantify the phenomenon.
But now GPT4o was able to answer it and suggested approaches to quantify the phenomenon.
Reposted by Karsten Suhre
(J Proteom Res) [ASAP] Understanding Data Analysis Steps in Mass-Spectrometry-Based Proteomics Is Key to Transparent Reporting: Journal of Proteome ResearchDOI: 10.1021/acs.jproteome.5c00287 #MassSpecRSS
[ASAP] Understanding Data Analysis Steps in Mass-Spectrometry-Based Proteomics Is Key to Transparent Reporting
Journal of Proteome ResearchDOI: 10.1021/acs.jproteome.5c00287
dlvr.it
September 3, 2025 at 11:01 PM
(J Proteom Res) [ASAP] Understanding Data Analysis Steps in Mass-Spectrometry-Based Proteomics Is Key to Transparent Reporting: Journal of Proteome ResearchDOI: 10.1021/acs.jproteome.5c00287 #MassSpecRSS
Reposted by Karsten Suhre
Prefusion gB of HSV bound with a neutralizing nanobody www.nature.com/articles/s41...
A nanobody specific to prefusion glycoprotein B neutralizes HSV-1 and HSV-2 - Nature
A neutralizing nanobody specific to the prefusion conformation of herpes simplex virus glycoprotein B has cross-species activity and offers insights into virus neutralization, possible immunogens and ...
www.nature.com
September 4, 2025 at 5:51 AM
Prefusion gB of HSV bound with a neutralizing nanobody www.nature.com/articles/s41...
Reposted by Karsten Suhre
Excited to share our latest manuscript, "Exposure accumulation drives age-dependent disease architectures and polygenic risk scores," led by Xilin Jiang: www.medrxiv.org/content/10.1...
I am attempting an explainer thread for the first time here:
(I am usually too exhausted to post one)
I am attempting an explainer thread for the first time here:
(I am usually too exhausted to post one)
Exposure accumulation drives age-dependent disease architectures and polygenic risk scores
Our understanding of the dependence of the genetic and environmental architecture of common diseases on age is incomplete. Here, we use longitudinal data to quantify age-dependent genetic and environm...
www.medrxiv.org
September 2, 2025 at 11:08 PM
Excited to share our latest manuscript, "Exposure accumulation drives age-dependent disease architectures and polygenic risk scores," led by Xilin Jiang: www.medrxiv.org/content/10.1...
I am attempting an explainer thread for the first time here:
(I am usually too exhausted to post one)
I am attempting an explainer thread for the first time here:
(I am usually too exhausted to post one)
Reposted by Karsten Suhre
Come and work with us!! 🤩
We have a position for an Assist Prof in Microbial Genomics in our School of III.
Hod Joan Geoghegan will be happy to field questions if you are interested. No specific area of microbial genomics preferred so please do consider it
www.jobs.ac.uk/job/DOO184/a...
Hod Joan Geoghegan will be happy to field questions if you are interested. No specific area of microbial genomics preferred so please do consider it
www.jobs.ac.uk/job/DOO184/a...
Assistant Professor (Research and Education) in Bacterial Genomics at University of Birmingham
Apply now for the Assistant Professor (Research and Education) in Bacterial Genomics role on jobs.ac.uk - the leading job board for higher education jobs. View details.
www.jobs.ac.uk
September 3, 2025 at 8:54 PM
Come and work with us!! 🤩
Reposted by Karsten Suhre
This makes no sense to me.
How does genetically predicted walking speed relate to biological aging (here as telomere length( except as some sort of biomarker of overall health?
www.nature.com/articles/s42...
How does genetically predicted walking speed relate to biological aging (here as telomere length( except as some sort of biomarker of overall health?
www.nature.com/articles/s42...
Investigation of a UK biobank cohort reveals causal associations of self-reported walking pace with telomere length - Communications Biology
Mendelian randomisation analysis of the UK Biobank cohort, supported by analyses of accelerometer-measured activity intensity, reveals that genetically-determined walking pace is associated with longe...
www.nature.com
June 23, 2025 at 3:28 AM
This makes no sense to me.
How does genetically predicted walking speed relate to biological aging (here as telomere length( except as some sort of biomarker of overall health?
www.nature.com/articles/s42...
How does genetically predicted walking speed relate to biological aging (here as telomere length( except as some sort of biomarker of overall health?
www.nature.com/articles/s42...
Reposted by Karsten Suhre
This is great news: UK Biobank Proteomics Project Receives £20M From UK Government for Olink HT characterization of 300k samples
www.genomeweb.com/research-fun...
www.genomeweb.com/research-fun...
UK Biobank Proteomics Project Receives £20M From UK Government
The project, which follows a pilot project profiling 54,000 individuals, will use Olink's Explore HT platform to measure up to 5,400 proteins in 600,000 blood samples.
www.genomeweb.com
June 26, 2025 at 11:01 AM
This is great news: UK Biobank Proteomics Project Receives £20M From UK Government for Olink HT characterization of 300k samples
www.genomeweb.com/research-fun...
www.genomeweb.com/research-fun...
Reposted by Karsten Suhre
Fantastic start to the day here at the 3rd "Human Proteome and Health" Symposium at Rhodes House where Dr Katerina Gospodinova from the ARUK-ODDI and @cmd.ox.ac.uk discussed proteomic profiling of the #matrisome for use a novel therapeutic modality in #Alzheimers Disease 🧠 @arukthamesv.bsky.social
June 25, 2025 at 8:36 AM
Fantastic start to the day here at the 3rd "Human Proteome and Health" Symposium at Rhodes House where Dr Katerina Gospodinova from the ARUK-ODDI and @cmd.ox.ac.uk discussed proteomic profiling of the #matrisome for use a novel therapeutic modality in #Alzheimers Disease 🧠 @arukthamesv.bsky.social
Reposted by Karsten Suhre
#JobAlert! We have an opening for a postdoctoral scientist in #CancerMetabolism in my lab @mrc-lms.bsky.social. If you're interested in the role of metabolism in drug response and resistance in cancer, and would like to work in a fun and friendly team, check it out: lms.mrc.ac.uk/work/vacanci...
MRC Postdoctoral Research Scientist - MRC Laboratory of Medical Sciences
The MRC Laboratory of Medical Sciences (LMS) is a biomedical research institute where scientists and clinicians collaborate to advance the understanding of biology and its application to medicine. LMS...
lms.mrc.ac.uk
June 25, 2025 at 8:57 AM
#JobAlert! We have an opening for a postdoctoral scientist in #CancerMetabolism in my lab @mrc-lms.bsky.social. If you're interested in the role of metabolism in drug response and resistance in cancer, and would like to work in a fun and friendly team, check it out: lms.mrc.ac.uk/work/vacanci...
Reposted by Karsten Suhre
‼️ Job alert 🚨: I have an open 3-year postdoc position in my lab to develop novel crosslinking mass spectrometry workflows. 🧪🧪 So if you want to do cool stuff in protein MS, please apply ! ⬇️ Please RT
www.verwaltung.uni-halle.de/dezern3/Auss...
#Academicsky
#Chemsky
#teammassspec
www.verwaltung.uni-halle.de/dezern3/Auss...
#Academicsky
#Chemsky
#teammassspec
www.verwaltung.uni-halle.de
June 25, 2025 at 12:44 PM
‼️ Job alert 🚨: I have an open 3-year postdoc position in my lab to develop novel crosslinking mass spectrometry workflows. 🧪🧪 So if you want to do cool stuff in protein MS, please apply ! ⬇️ Please RT
www.verwaltung.uni-halle.de/dezern3/Auss...
#Academicsky
#Chemsky
#teammassspec
www.verwaltung.uni-halle.de/dezern3/Auss...
#Academicsky
#Chemsky
#teammassspec
Having worked with #Seer before, this sounds pretty interesting ...
www.globenewswire.com/news-release...
www.globenewswire.com/news-release...
Seer’s Proteograph Platform Enables Unprecedented 20,000-Sample Proteomics Study with Korea University to Develop AI-Driven Diagnostics for Cancers in Young Adults
First-of-its-kind study will use Seer’s next-generation workflow to identify early-onset cancer biomarkers and power deep, unbiased mass spectrometry-based...
www.globenewswire.com
June 2, 2025 at 11:35 AM
Having worked with #Seer before, this sounds pretty interesting ...
www.globenewswire.com/news-release...
www.globenewswire.com/news-release...
please find below our latest paper on #AD
www.nature.com/articles/s41...
Individual bioenergetic capacity as a potential source of resilience to Alzheimer’s disease
www.nature.com/articles/s41...
Individual bioenergetic capacity as a potential source of resilience to Alzheimer’s disease
Individual bioenergetic capacity as a potential source of resilience to Alzheimer’s disease - Nature Communications
Bioenergetic capacity, the ability to maintain energy balance under stress, can be monitored using blood acylcarnitine profiles. Improving this capacity may slow Alzheimer’s disease progression.
www.nature.com
May 29, 2025 at 9:48 AM
please find below our latest paper on #AD
www.nature.com/articles/s41...
Individual bioenergetic capacity as a potential source of resilience to Alzheimer’s disease
www.nature.com/articles/s41...
Individual bioenergetic capacity as a potential source of resilience to Alzheimer’s disease
Reposted by Karsten Suhre
I'm pretty sure this must be due to a underlying large-effect methylation QTL.
May 11, 2025 at 4:26 PM
I'm pretty sure this must be due to a underlying large-effect methylation QTL.
Did you know that DNA methylation can show Mendelian inheritance pattern?
clinicalepigeneticsjournal.biomedcentral.com/articles/10....
clinicalepigeneticsjournal.biomedcentral.com/articles/10....
May 11, 2025 at 2:41 PM
Did you know that DNA methylation can show Mendelian inheritance pattern?
clinicalepigeneticsjournal.biomedcentral.com/articles/10....
clinicalepigeneticsjournal.biomedcentral.com/articles/10....
Reposted by Karsten Suhre
The most famous heuristic in mapping gwas snps to genes is "it's usually the closest gene".
But only slightly less well-known is this: consider the colocalized phenotypes.
That is, a genetic variant seldom disrupts exactly one phenotype.
What else does tugging on that thread do?
But only slightly less well-known is this: consider the colocalized phenotypes.
That is, a genetic variant seldom disrupts exactly one phenotype.
What else does tugging on that thread do?
April 13, 2025 at 6:36 PM
The most famous heuristic in mapping gwas snps to genes is "it's usually the closest gene".
But only slightly less well-known is this: consider the colocalized phenotypes.
That is, a genetic variant seldom disrupts exactly one phenotype.
What else does tugging on that thread do?
But only slightly less well-known is this: consider the colocalized phenotypes.
That is, a genetic variant seldom disrupts exactly one phenotype.
What else does tugging on that thread do?