Karsten Suhre
@ksuhre.bsky.social
Passionate about #GWAS #Metabolomics #Proteomics #Glycomics #Epigenomics, Professor @WeillCornell
Medicine - Qatar, Blog on http://metabolomix.com, http://suhre.fr
Medicine - Qatar, Blog on http://metabolomix.com, http://suhre.fr
Pharma companies take note - human knockouts in bottleneck and consanguineous populations are up and coming.
Plasma Metabolic Outliers Identified in #Estonian Human Knockouts: www.mdpi.com/2218-1989/15...
citing our #Qatar study with @metabolon.bsky.social data:
www.cell.com/cell-genomic...
Plasma Metabolic Outliers Identified in #Estonian Human Knockouts: www.mdpi.com/2218-1989/15...
citing our #Qatar study with @metabolon.bsky.social data:
www.cell.com/cell-genomic...
November 4, 2025 at 1:16 PM
Pharma companies take note - human knockouts in bottleneck and consanguineous populations are up and coming.
Plasma Metabolic Outliers Identified in #Estonian Human Knockouts: www.mdpi.com/2218-1989/15...
citing our #Qatar study with @metabolon.bsky.social data:
www.cell.com/cell-genomic...
Plasma Metabolic Outliers Identified in #Estonian Human Knockouts: www.mdpi.com/2218-1989/15...
citing our #Qatar study with @metabolon.bsky.social data:
www.cell.com/cell-genomic...
I have always been a proponent of hypothesis-free testing of metabolite rations: This paper is just great in how it takes it to the next level:
Untargeted pixel-by- pixel metabolite ratio imaging as a novel tool for biomedical discovery in mass spectrometry imaging
elifesciences.org/articles/96892
Untargeted pixel-by- pixel metabolite ratio imaging as a novel tool for biomedical discovery in mass spectrometry imaging
elifesciences.org/articles/96892
September 14, 2025 at 1:17 PM
I have always been a proponent of hypothesis-free testing of metabolite rations: This paper is just great in how it takes it to the next level:
Untargeted pixel-by- pixel metabolite ratio imaging as a novel tool for biomedical discovery in mass spectrometry imaging
elifesciences.org/articles/96892
Untargeted pixel-by- pixel metabolite ratio imaging as a novel tool for biomedical discovery in mass spectrometry imaging
elifesciences.org/articles/96892
Did you know that DNA methylation can show Mendelian inheritance pattern?
clinicalepigeneticsjournal.biomedcentral.com/articles/10....
clinicalepigeneticsjournal.biomedcentral.com/articles/10....
May 11, 2025 at 2:41 PM
Did you know that DNA methylation can show Mendelian inheritance pattern?
clinicalepigeneticsjournal.biomedcentral.com/articles/10....
clinicalepigeneticsjournal.biomedcentral.com/articles/10....
When one of your first research papers from 30 years back just got cited, and the figures look very similar, you ask yourself where time went - did the research questions change?
Our 1994 paper:
link.springer.com/article/10.1...
Recent 2022 paper:
agupubs.onlinelibrary.wiley.com/doi/10.1029/...
Our 1994 paper:
link.springer.com/article/10.1...
Recent 2022 paper:
agupubs.onlinelibrary.wiley.com/doi/10.1029/...
March 21, 2025 at 12:19 PM
When one of your first research papers from 30 years back just got cited, and the figures look very similar, you ask yourself where time went - did the research questions change?
Our 1994 paper:
link.springer.com/article/10.1...
Recent 2022 paper:
agupubs.onlinelibrary.wiley.com/doi/10.1029/...
Our 1994 paper:
link.springer.com/article/10.1...
Recent 2022 paper:
agupubs.onlinelibrary.wiley.com/doi/10.1029/...
Genome-wide Association Studies of Missing Metabolite Measures: Results From Two Population-based Studies
www.medrxiv.org/content/10.1...
I wonder what a GWAS with imputing missing to zero would yield in comparison.
www.medrxiv.org/content/10.1...
I wonder what a GWAS with imputing missing to zero would yield in comparison.
March 17, 2025 at 2:16 PM
Genome-wide Association Studies of Missing Metabolite Measures: Results From Two Population-based Studies
www.medrxiv.org/content/10.1...
I wonder what a GWAS with imputing missing to zero would yield in comparison.
www.medrxiv.org/content/10.1...
I wonder what a GWAS with imputing missing to zero would yield in comparison.
Interested in joint multiomics data?
Metabolon, Biocrates, Lipidyzer, Chenomx, SOMAscan, Olink, Nightingale, Genos, Exiqon and Illumina genomics (OmniArray, HumanMethylation, RNAseq)
Check out our COMICS server
littleswissriver.shinyapps.io/generate_net...
and BLOG
www.metabolomix.com/comics/
Metabolon, Biocrates, Lipidyzer, Chenomx, SOMAscan, Olink, Nightingale, Genos, Exiqon and Illumina genomics (OmniArray, HumanMethylation, RNAseq)
Check out our COMICS server
littleswissriver.shinyapps.io/generate_net...
and BLOG
www.metabolomix.com/comics/
March 16, 2025 at 1:27 PM
Interested in joint multiomics data?
Metabolon, Biocrates, Lipidyzer, Chenomx, SOMAscan, Olink, Nightingale, Genos, Exiqon and Illumina genomics (OmniArray, HumanMethylation, RNAseq)
Check out our COMICS server
littleswissriver.shinyapps.io/generate_net...
and BLOG
www.metabolomix.com/comics/
Metabolon, Biocrates, Lipidyzer, Chenomx, SOMAscan, Olink, Nightingale, Genos, Exiqon and Illumina genomics (OmniArray, HumanMethylation, RNAseq)
Check out our COMICS server
littleswissriver.shinyapps.io/generate_net...
and BLOG
www.metabolomix.com/comics/
A study associating 5,000 plasma proteins (SOMAscan) with BMI and waist-hip ratio:
Plasma Proteomic Signatures of Adiposity Are Associated With Cardiovascular Risk Factors and Type 2 Diabetes Risk in a Multiethnic Asian Population
diabetesjournals.org/diabetes/art...
Plasma Proteomic Signatures of Adiposity Are Associated With Cardiovascular Risk Factors and Type 2 Diabetes Risk in a Multiethnic Asian Population
diabetesjournals.org/diabetes/art...
March 16, 2025 at 1:17 PM
A study associating 5,000 plasma proteins (SOMAscan) with BMI and waist-hip ratio:
Plasma Proteomic Signatures of Adiposity Are Associated With Cardiovascular Risk Factors and Type 2 Diabetes Risk in a Multiethnic Asian Population
diabetesjournals.org/diabetes/art...
Plasma Proteomic Signatures of Adiposity Are Associated With Cardiovascular Risk Factors and Type 2 Diabetes Risk in a Multiethnic Asian Population
diabetesjournals.org/diabetes/art...
Here a GWAS with MS-proteomics in 700 GTEx samples reporting 1981 cis-pQTLs
Regulation of protein abundance in normal human tissues
www.medrxiv.org/content/10.1...
Interesting link between NAT2 and HMGCR - the locus also associates with statin use in FinnGen (p=2.5e-15)
Regulation of protein abundance in normal human tissues
www.medrxiv.org/content/10.1...
Interesting link between NAT2 and HMGCR - the locus also associates with statin use in FinnGen (p=2.5e-15)
March 12, 2025 at 8:52 AM
Here a GWAS with MS-proteomics in 700 GTEx samples reporting 1981 cis-pQTLs
Regulation of protein abundance in normal human tissues
www.medrxiv.org/content/10.1...
Interesting link between NAT2 and HMGCR - the locus also associates with statin use in FinnGen (p=2.5e-15)
Regulation of protein abundance in normal human tissues
www.medrxiv.org/content/10.1...
Interesting link between NAT2 and HMGCR - the locus also associates with statin use in FinnGen (p=2.5e-15)
A paper addressing discrepancies between Olink and SOMAscan. Most important factor explaining the (non)correlation is the % of LOD samples in Olink:
Comparative studies of 2168 plasma proteins measured by two affinity-based platforms in 4000 Chinese adults
www.nature.com/articles/s41...
Comparative studies of 2168 plasma proteins measured by two affinity-based platforms in 4000 Chinese adults
www.nature.com/articles/s41...
March 9, 2025 at 10:41 AM
A paper addressing discrepancies between Olink and SOMAscan. Most important factor explaining the (non)correlation is the % of LOD samples in Olink:
Comparative studies of 2168 plasma proteins measured by two affinity-based platforms in 4000 Chinese adults
www.nature.com/articles/s41...
Comparative studies of 2168 plasma proteins measured by two affinity-based platforms in 4000 Chinese adults
www.nature.com/articles/s41...
Here a 3D fullerene C60 molecule that I 3D printed starting with a PDB structure file.
Here is how to do it:
makerworld.com/en/models/96...
Here is how to do it:
makerworld.com/en/models/96...
March 7, 2025 at 6:13 AM
Here a 3D fullerene C60 molecule that I 3D printed starting with a PDB structure file.
Here is how to do it:
makerworld.com/en/models/96...
Here is how to do it:
makerworld.com/en/models/96...
Free access to 2,656 metabolites from 9 platforms measured at 56 time points and covering 6 challenges "suffered" by 15 healthy volunteers:
The HuMet Repository - Watching human metabolism at work
www.sciencedirect.com/science/arti...
All data provided in an interactive repository:
humet.org
The HuMet Repository - Watching human metabolism at work
www.sciencedirect.com/science/arti...
All data provided in an interactive repository:
humet.org
March 5, 2025 at 12:58 PM
Free access to 2,656 metabolites from 9 platforms measured at 56 time points and covering 6 challenges "suffered" by 15 healthy volunteers:
The HuMet Repository - Watching human metabolism at work
www.sciencedirect.com/science/arti...
All data provided in an interactive repository:
humet.org
The HuMet Repository - Watching human metabolism at work
www.sciencedirect.com/science/arti...
All data provided in an interactive repository:
humet.org
and this elegant phone stand with engraved Islamic design pattern:
makerworld.com/en/models/11...
Let me know if you have further ideas and suggestions!
makerworld.com/en/models/11...
Let me know if you have further ideas and suggestions!
March 1, 2025 at 8:15 AM
and this elegant phone stand with engraved Islamic design pattern:
makerworld.com/en/models/11...
Let me know if you have further ideas and suggestions!
makerworld.com/en/models/11...
Let me know if you have further ideas and suggestions!
Now with Ramadan coming, 3D printing can also be nice to create some seasonal office decorations, such as this Ramadan-themed door corner art:
makerworld.com/en/models/10...
makerworld.com/en/models/10...
March 1, 2025 at 8:12 AM
Now with Ramadan coming, 3D printing can also be nice to create some seasonal office decorations, such as this Ramadan-themed door corner art:
makerworld.com/en/models/10...
makerworld.com/en/models/10...
and this elegant phone stand with engraved Islamic design pattern:
makerworld.com/en/models/11...
Let me know if you have further ideas and suggestions!
makerworld.com/en/models/11...
Let me know if you have further ideas and suggestions!
March 1, 2025 at 8:07 AM
and this elegant phone stand with engraved Islamic design pattern:
makerworld.com/en/models/11...
Let me know if you have further ideas and suggestions!
makerworld.com/en/models/11...
Let me know if you have further ideas and suggestions!
Happy Ramadan to my Muslim colleagues and friends!
Lately, I got into 3D-printing molecules and proteins. Here a short HowTo for getting from a PDB file to a solid 3D
model:
makerworld.com/en/models/96...
Lately, I got into 3D-printing molecules and proteins. Here a short HowTo for getting from a PDB file to a solid 3D
model:
makerworld.com/en/models/96...
March 1, 2025 at 8:07 AM
Happy Ramadan to my Muslim colleagues and friends!
Lately, I got into 3D-printing molecules and proteins. Here a short HowTo for getting from a PDB file to a solid 3D
model:
makerworld.com/en/models/96...
Lately, I got into 3D-printing molecules and proteins. Here a short HowTo for getting from a PDB file to a solid 3D
model:
makerworld.com/en/models/96...
Solute carriers: The gatekeepers of metabolism
www.cell.com/cell/fulltex...
A nice review on how to use #GWAS with #metabolomics to determine transporter substrates.
Here another one that we experimentally confirmed:
"SLC16A9 is a carnitine efflux transporter"
www.nature.com/articles/nat...
www.cell.com/cell/fulltex...
A nice review on how to use #GWAS with #metabolomics to determine transporter substrates.
Here another one that we experimentally confirmed:
"SLC16A9 is a carnitine efflux transporter"
www.nature.com/articles/nat...
February 22, 2025 at 12:27 PM
Solute carriers: The gatekeepers of metabolism
www.cell.com/cell/fulltex...
A nice review on how to use #GWAS with #metabolomics to determine transporter substrates.
Here another one that we experimentally confirmed:
"SLC16A9 is a carnitine efflux transporter"
www.nature.com/articles/nat...
www.cell.com/cell/fulltex...
A nice review on how to use #GWAS with #metabolomics to determine transporter substrates.
Here another one that we experimentally confirmed:
"SLC16A9 is a carnitine efflux transporter"
www.nature.com/articles/nat...
The key correlation plots are here:
analyticalsciencejournals.onlinelibrary.wiley.com/action/downl...
analyticalsciencejournals.onlinelibrary.wiley.com/action/downl...
February 11, 2025 at 12:19 PM
The key correlation plots are here:
analyticalsciencejournals.onlinelibrary.wiley.com/action/downl...
analyticalsciencejournals.onlinelibrary.wiley.com/action/downl...
For sone time I maintained a sourdough starter using a protocol to make a sourdough bread per day (in a country where this was rare to come by), but getting consistent results was tricky, putting all ingredients into the machine in the evening and programming it for baking the next morning.
January 9, 2025 at 12:37 PM
For sone time I maintained a sourdough starter using a protocol to make a sourdough bread per day (in a country where this was rare to come by), but getting consistent results was tricky, putting all ingredients into the machine in the evening and programming it for baking the next morning.
December 17, 2024 at 1:33 PM
Deletion of beta-fructofuranosidase (invertase) genes is associated with sucrose content in Date Palm fruit
doi.org/10.1002/pld3...
10/12
doi.org/10.1002/pld3...
10/12
December 17, 2024 at 1:33 PM
Deletion of beta-fructofuranosidase (invertase) genes is associated with sucrose content in Date Palm fruit
doi.org/10.1002/pld3...
10/12
doi.org/10.1002/pld3...
10/12
Evidence of Recombination Suppression Blocks on the Y Chromosome of Date Palm (Phoenix dactylifera)
doi.org/10.3389/fpls...
9/12
doi.org/10.3389/fpls...
9/12
December 17, 2024 at 1:33 PM
Evidence of Recombination Suppression Blocks on the Y Chromosome of Date Palm (Phoenix dactylifera)
doi.org/10.3389/fpls...
9/12
doi.org/10.3389/fpls...
9/12
December 17, 2024 at 1:33 PM
December 17, 2024 at 1:33 PM
December 17, 2024 at 1:33 PM