Bethan Lloyd-Lewis
@bethlloydlewis.bsky.social
Wellcome Trust Research Fellow, University of Bristol. Epithelial cell fate dynamics during tissue development and cancer. #stemcells #devbio #mammarygland #morphogenesis #microscopy #breastcancer. She/her.
Reposted by Bethan Lloyd-Lewis
Really happy to share a link to our work showing that anti-progestin therapy could help prevent breast cancer before menopause.
Published today in Nature, the study suggests this could be a new way to stop breast cancer before it starts: urldefense.com/v3/__https:/...
Brilliant team science
Published today in Nature, the study suggests this could be a new way to stop breast cancer before it starts: urldefense.com/v3/__https:/...
Brilliant team science
Anti-progestin therapy targets hallmarks of breast cancer risk
Nature - Results of an early-phase breast cancer prevention trial demonstrate the potential for breast cancer prevention in premenopausal women with anti-progestin therapy by inducing...
urldefense.com
November 5, 2025 at 9:07 PM
Really happy to share a link to our work showing that anti-progestin therapy could help prevent breast cancer before menopause.
Published today in Nature, the study suggests this could be a new way to stop breast cancer before it starts: urldefense.com/v3/__https:/...
Brilliant team science
Published today in Nature, the study suggests this could be a new way to stop breast cancer before it starts: urldefense.com/v3/__https:/...
Brilliant team science
Reposted by Bethan Lloyd-Lewis
This was a fun chat. Thanks @jcellsci.bsky.social for featuring me and spotlighting our work.
Check out the special issue on Cilia and Flagella journals.biologists.com/jcs/issue/13....
We have an article on Axonemal Dynein Assembly Factors (DNAAFs) which may be useful for the field.
Check out the special issue on Cilia and Flagella journals.biologists.com/jcs/issue/13....
We have an article on Axonemal Dynein Assembly Factors (DNAAFs) which may be useful for the field.
October 31, 2025 at 8:44 AM
This was a fun chat. Thanks @jcellsci.bsky.social for featuring me and spotlighting our work.
Check out the special issue on Cilia and Flagella journals.biologists.com/jcs/issue/13....
We have an article on Axonemal Dynein Assembly Factors (DNAAFs) which may be useful for the field.
Check out the special issue on Cilia and Flagella journals.biologists.com/jcs/issue/13....
We have an article on Axonemal Dynein Assembly Factors (DNAAFs) which may be useful for the field.
Reposted by Bethan Lloyd-Lewis
Ever wondered how adult organs preserve epithelial barrier integrity while continuously exposed to mechanical stress? We tackled this question in our new preprint – led by our brilliant PhD student Vishnu Krishnakumar! (1/11)
🔗 www.biorxiv.org/content/10.1...
🔗 www.biorxiv.org/content/10.1...
Robust pan-junctional reinforcement preserves the gut epithelial barrier under mechanical stress
Epithelia are specialized tissue barriers that safeguard the organism's internal milieu from the hostile external environment, a function critically dependent on intercellular junctions. In the colon,...
www.biorxiv.org
October 8, 2025 at 9:52 PM
Ever wondered how adult organs preserve epithelial barrier integrity while continuously exposed to mechanical stress? We tackled this question in our new preprint – led by our brilliant PhD student Vishnu Krishnakumar! (1/11)
🔗 www.biorxiv.org/content/10.1...
🔗 www.biorxiv.org/content/10.1...
Reposted by Bethan Lloyd-Lewis
This week has been special for us, marking 100 years of supporting biologists and inspiring biology. We celebrated our achievements at @zoologymuseum.bsky.social last night. We want to thank all our staff, whose continual inspiration and daily support for one another make our work possible.
October 17, 2025 at 1:11 PM
This week has been special for us, marking 100 years of supporting biologists and inspiring biology. We celebrated our achievements at @zoologymuseum.bsky.social last night. We want to thank all our staff, whose continual inspiration and daily support for one another make our work possible.
Reposted by Bethan Lloyd-Lewis
Very sad news, John Gurdon has died.
A developmental biologist's developmental biologist, Nobel prize winner
His work is the foundation of much of today's dev & stem cell bio.
An inspiration to many, including me. Always asking questions & wanting the answers
www.magd.cam.ac.uk/news/profess...
A developmental biologist's developmental biologist, Nobel prize winner
His work is the foundation of much of today's dev & stem cell bio.
An inspiration to many, including me. Always asking questions & wanting the answers
www.magd.cam.ac.uk/news/profess...
Professor Sir John Gurdon FRS (1933-2025) | Magdalene College
Magdalene College is deeply saddened to announce the death of Professor Sir John Gurdon FRS, who served as Master of the College from 1995 to 2002.
www.magd.cam.ac.uk
October 7, 2025 at 4:02 PM
Very sad news, John Gurdon has died.
A developmental biologist's developmental biologist, Nobel prize winner
His work is the foundation of much of today's dev & stem cell bio.
An inspiration to many, including me. Always asking questions & wanting the answers
www.magd.cam.ac.uk/news/profess...
A developmental biologist's developmental biologist, Nobel prize winner
His work is the foundation of much of today's dev & stem cell bio.
An inspiration to many, including me. Always asking questions & wanting the answers
www.magd.cam.ac.uk/news/profess...
Reposted by Bethan Lloyd-Lewis
Thrilled to share the first story from my postdoc! 🎉 A wonderful experiment + simulations collaboration. In the Drosophila wing, we find that 3D cell shapes affect signalling range and fine-tune developmental patterning www.biorxiv.org/content/10.1... Thread below ⬇️
August 11, 2025 at 1:18 PM
Thrilled to share the first story from my postdoc! 🎉 A wonderful experiment + simulations collaboration. In the Drosophila wing, we find that 3D cell shapes affect signalling range and fine-tune developmental patterning www.biorxiv.org/content/10.1... Thread below ⬇️
Reposted by Bethan Lloyd-Lewis
I’m looking for a Postdoc to join my new lab @pdncambridge.bsky.social on an MRC-funded project and explore maternal inter-organ communication with a focus on the mammary gland, using a novel mouse model.
📍 Tenure: 3 years
⏳ Deadline: 15 August 2025
Please RT 🙏
👉 www.jobs.cam.ac.uk/job/51984/
📍 Tenure: 3 years
⏳ Deadline: 15 August 2025
Please RT 🙏
👉 www.jobs.cam.ac.uk/job/51984/
Research Associate (Fixed Term) - Job Opportunities - University of Cambridge
Research Associate (Fixed Term) in the Department of Physiology, Development and Neuroscience at the University of Cambridge.
www.jobs.cam.ac.uk
July 14, 2025 at 6:48 PM
I’m looking for a Postdoc to join my new lab @pdncambridge.bsky.social on an MRC-funded project and explore maternal inter-organ communication with a focus on the mammary gland, using a novel mouse model.
📍 Tenure: 3 years
⏳ Deadline: 15 August 2025
Please RT 🙏
👉 www.jobs.cam.ac.uk/job/51984/
📍 Tenure: 3 years
⏳ Deadline: 15 August 2025
Please RT 🙏
👉 www.jobs.cam.ac.uk/job/51984/
Reposted by Bethan Lloyd-Lewis
Fantastic opportunity to start your independent career at the JIC here. Great startup package. Repost = nice. Thank you!!!
New Independent Fellowship position in Microbiology to launch your lab in our department @johninnescentre.bsky.social (UK). We are conducting a broad search in the area of plant-associated microbial interactions. Message me if you have any questions.
Apply here: www.jic.ac.uk/vacancies/in...
Apply here: www.jic.ac.uk/vacancies/in...
Independent Fellowship in Plant-Associated Microbial Interactions | John Innes Centre
An exciting opportunity for an Independent Fellowship in Plant-Associated Microbial Interactions has arisen at the John Innes Centre. To read the full job description for this role…
www.jic.ac.uk
July 10, 2025 at 6:52 AM
Fantastic opportunity to start your independent career at the JIC here. Great startup package. Repost = nice. Thank you!!!
Reposted by Bethan Lloyd-Lewis
Finally out! 🥳 Our paper showing how a transposable element (TE) insertion can cause developmental phenotypes is now published @natgenet.nature.com 🧬🦠🐁
Below is a brief description of the major findings. Check the full version of the paper for more details: www.nature.com/articles/s41588-025-02248-5
Below is a brief description of the major findings. Check the full version of the paper for more details: www.nature.com/articles/s41588-025-02248-5
Enhancer adoption by an LTR retrotransposon generates viral-like particles, causing developmental limb phenotypes - Nature Genetics
Activation of an LTR retrotransposon inserted upstream of the Fgf8 gene produces viral-like particles in the mouse developing limb, triggering apoptosis and causing limb malformation. This phenotype c...
www.nature.com
July 9, 2025 at 10:05 AM
Finally out! 🥳 Our paper showing how a transposable element (TE) insertion can cause developmental phenotypes is now published @natgenet.nature.com 🧬🦠🐁
Below is a brief description of the major findings. Check the full version of the paper for more details: www.nature.com/articles/s41588-025-02248-5
Below is a brief description of the major findings. Check the full version of the paper for more details: www.nature.com/articles/s41588-025-02248-5
Get in touch if you are interested in applying for an MSCA fellowship to come work with us on the mechanisms regulating epithelial cell fate decisions during mammary gland morphogenesis and cancer. Great environment in a vibrant city!
MSCA opens €404.3 million call for Postdoctoral Fellowships
Postdoctoral Fellowships offer researchers holding a PhD the opportunity to acquire new skills through advanced training and international, interdisciplinary, and inter-sectoral mobility.
marie-sklodowska-curie-actions.ec.europa.eu
July 7, 2025 at 3:49 PM
Get in touch if you are interested in applying for an MSCA fellowship to come work with us on the mechanisms regulating epithelial cell fate decisions during mammary gland morphogenesis and cancer. Great environment in a vibrant city!
Reposted by Bethan Lloyd-Lewis
Could this be the future of cancer prevention?
Walid Khaled, a new ERC Advanced Grant recipient @cam.ac.uk, will work on a preventive vaccine for breast cancer.
Learn more 👉 buff.ly/s6cBCwL
#ERCAdG #CancerResearch #FrontierResearch @wtklab.bsky.social
Walid Khaled, a new ERC Advanced Grant recipient @cam.ac.uk, will work on a preventive vaccine for breast cancer.
Learn more 👉 buff.ly/s6cBCwL
#ERCAdG #CancerResearch #FrontierResearch @wtklab.bsky.social
June 17, 2025 at 11:02 AM
Could this be the future of cancer prevention?
Walid Khaled, a new ERC Advanced Grant recipient @cam.ac.uk, will work on a preventive vaccine for breast cancer.
Learn more 👉 buff.ly/s6cBCwL
#ERCAdG #CancerResearch #FrontierResearch @wtklab.bsky.social
Walid Khaled, a new ERC Advanced Grant recipient @cam.ac.uk, will work on a preventive vaccine for breast cancer.
Learn more 👉 buff.ly/s6cBCwL
#ERCAdG #CancerResearch #FrontierResearch @wtklab.bsky.social
Reposted by Bethan Lloyd-Lewis
Our latest paper from is out! Congratulations to all members the lab that contributed over the years!
No UMAPs in this one!
@phar.cam.ac.uk @scicambridge.bsky.social
Thanks to our funders @cancerresearchuk.org @breastcancernow.bsky.social
No UMAPs in this one!
@phar.cam.ac.uk @scicambridge.bsky.social
Thanks to our funders @cancerresearchuk.org @breastcancernow.bsky.social
CHD8 interacts with BCL11A to induce oncogenic transcription in triple negative breast cancer
@wtklab.bsky.social and collaborators
www.embopress.org/doi/full/10....
@wtklab.bsky.social and collaborators
www.embopress.org/doi/full/10....
May 6, 2025 at 2:22 PM
Our latest paper from is out! Congratulations to all members the lab that contributed over the years!
No UMAPs in this one!
@phar.cam.ac.uk @scicambridge.bsky.social
Thanks to our funders @cancerresearchuk.org @breastcancernow.bsky.social
No UMAPs in this one!
@phar.cam.ac.uk @scicambridge.bsky.social
Thanks to our funders @cancerresearchuk.org @breastcancernow.bsky.social
Reposted by Bethan Lloyd-Lewis
🥳 Thrilled to share our lab's first preprint, led by our talented postdoc Justine Creff! 👩🏻🔬 We tackled a fundamental question: how the epithelium withstands mechanical stress at the interface of cells with distinct geometries and mechanics, such as enterocytes (E) and goblet cells (G) (1/9)
April 6, 2025 at 10:24 PM
🥳 Thrilled to share our lab's first preprint, led by our talented postdoc Justine Creff! 👩🏻🔬 We tackled a fundamental question: how the epithelium withstands mechanical stress at the interface of cells with distinct geometries and mechanics, such as enterocytes (E) and goblet cells (G) (1/9)
Reposted by Bethan Lloyd-Lewis
"Welsh is not a “minority language.” It is an indigenous language of Britain. It’s a language that grew here, shaped by the deep time of these islands – by the millennia it has spent in, and of, this land, shaping it and being shaped by it."
nation.cymru/opinion/wels...
nation.cymru/opinion/wels...
Welsh: the language that shaped Britain
Owen Williams Listen carefully, and you’ll hear it: a language older than the hills, older than the state. The names of rivers and mountains still whisper it – Pen-y-Fan, Penicuik, Aberystwyth, Aberde...
nation.cymru
May 31, 2025 at 7:19 PM
"Welsh is not a “minority language.” It is an indigenous language of Britain. It’s a language that grew here, shaped by the deep time of these islands – by the millennia it has spent in, and of, this land, shaping it and being shaped by it."
nation.cymru/opinion/wels...
nation.cymru/opinion/wels...
Reposted by Bethan Lloyd-Lewis
Pls re-skeet! There's a postdoc job available to join us in Bristol! We're looking for a molecular cell biologist to help us investigate plasma membrane proteostasis in neurons. Apply here by 23 April: www.jobs.ac.uk/job/DMO097/r.... If interested, do contact me and check out grieve-lab.com! Thanks!
April 9, 2025 at 3:42 PM
Pls re-skeet! There's a postdoc job available to join us in Bristol! We're looking for a molecular cell biologist to help us investigate plasma membrane proteostasis in neurons. Apply here by 23 April: www.jobs.ac.uk/job/DMO097/r.... If interested, do contact me and check out grieve-lab.com! Thanks!
Reposted by Bethan Lloyd-Lewis
Check out our latest Comment in Nature Cell Biology on #autophagy (the mechanism that cells of your body use to recycle damaged material and slow ageing). While declining autophagy is often seen as a hallmark of #ageing, we explore emerging exceptions to this idea.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Autophagy does not always decline with ageing - Nature Cell Biology
Autophagy has long been presumed to decline with age, underpinning its designation as a hallmark of ageing. However, emerging evidence challenges this notion, showing tissue-specific variability and, ...
www.nature.com
April 8, 2025 at 10:23 AM
Check out our latest Comment in Nature Cell Biology on #autophagy (the mechanism that cells of your body use to recycle damaged material and slow ageing). While declining autophagy is often seen as a hallmark of #ageing, we explore emerging exceptions to this idea.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Bethan Lloyd-Lewis
A great tribute to David Stevens, a terrific cell biologist and missed by so many of his friends and colleagues. As they say 'one of the good guys'. journals.biologists.com/jcs/article/...
Remembering David Stephens (1971–2024)
In the autumn of 2024, David Stephens, a prominent member of the UK cell biology community and a brilliant scientist, leader and mentor, passed away. With his pragmatism and natural authority, combine...
journals.biologists.com
April 7, 2025 at 4:44 PM
A great tribute to David Stevens, a terrific cell biologist and missed by so many of his friends and colleagues. As they say 'one of the good guys'. journals.biologists.com/jcs/article/...
Reposted by Bethan Lloyd-Lewis
Are you enjoying all the exciting science at #biologists100? Want to spread the love of developmental biology to your friends and family? Together with @bsdb.bsky.social, we've produced a documentary video to showcase the fascinating world of #DevBio:
🎥
🎥
BSDB - The Fascinating World of Developmental Biology (full length)
In this half-hour long documentary we showcase some of the beauty, as well as the translatability, of developmental biology research being undertaken current...
youtu.be
March 25, 2025 at 4:16 PM
Are you enjoying all the exciting science at #biologists100? Want to spread the love of developmental biology to your friends and family? Together with @bsdb.bsky.social, we've produced a documentary video to showcase the fascinating world of #DevBio:
🎥
🎥
Reposted by Bethan Lloyd-Lewis
If you’re a PhD or postdoc developmental biologist in the UK who cares about the field and the community, please nominate yourself to join the BSDB committee. Great opportunity to get involved, have real input and give back to the community @bsdb.bsky.social #biologists100
March 25, 2025 at 5:19 PM
If you’re a PhD or postdoc developmental biologist in the UK who cares about the field and the community, please nominate yourself to join the BSDB committee. Great opportunity to get involved, have real input and give back to the community @bsdb.bsky.social #biologists100
Reposted by Bethan Lloyd-Lewis
We are looking for a doctoral candidate to join the lab! If you are interested in working with human breast tissue samples straight from the clinic and do not fear large data sets, this might just be your dream project ☺️ Apply now ⬇️
ats.talentadore.com/apply/vaitos...
📸 @oonapaavolainen.bsky.social
ats.talentadore.com/apply/vaitos...
📸 @oonapaavolainen.bsky.social
March 20, 2025 at 2:04 PM
We are looking for a doctoral candidate to join the lab! If you are interested in working with human breast tissue samples straight from the clinic and do not fear large data sets, this might just be your dream project ☺️ Apply now ⬇️
ats.talentadore.com/apply/vaitos...
📸 @oonapaavolainen.bsky.social
ats.talentadore.com/apply/vaitos...
📸 @oonapaavolainen.bsky.social
Reposted by Bethan Lloyd-Lewis
Reposted by Bethan Lloyd-Lewis
JOB ALERT
We are seeking a Computational Research Assistant or Research Associate to help drive an ambitious multiomics ageing project part of the NMGN Mouse Ageing Cluster.
www.jobs.cam.ac.uk/job/49939/
@scicambridge.bsky.social @phar.cam.ac.uk @cambridgebiosci.bsky.social
We are seeking a Computational Research Assistant or Research Associate to help drive an ambitious multiomics ageing project part of the NMGN Mouse Ageing Cluster.
www.jobs.cam.ac.uk/job/49939/
@scicambridge.bsky.social @phar.cam.ac.uk @cambridgebiosci.bsky.social
January 15, 2025 at 2:54 PM
JOB ALERT
We are seeking a Computational Research Assistant or Research Associate to help drive an ambitious multiomics ageing project part of the NMGN Mouse Ageing Cluster.
www.jobs.cam.ac.uk/job/49939/
@scicambridge.bsky.social @phar.cam.ac.uk @cambridgebiosci.bsky.social
We are seeking a Computational Research Assistant or Research Associate to help drive an ambitious multiomics ageing project part of the NMGN Mouse Ageing Cluster.
www.jobs.cam.ac.uk/job/49939/
@scicambridge.bsky.social @phar.cam.ac.uk @cambridgebiosci.bsky.social
Reposted by Bethan Lloyd-Lewis
What do we mean by ‘mechanism’ anyway?
@dev-journal.bsky.social Executive Editor @katherine-brown.bsky.social gives her perspective on the recent article "A case for broadening our view of mechanism in developmental biology" by @biyolokum.bsky.social @swathiarur.bsky.social and Mansi Srivastava:
@dev-journal.bsky.social Executive Editor @katherine-brown.bsky.social gives her perspective on the recent article "A case for broadening our view of mechanism in developmental biology" by @biyolokum.bsky.social @swathiarur.bsky.social and Mansi Srivastava:
What do we mean by 'mechanism' anyway? - the Node
The latest issue of Development (vol 152 issue 2) features a Perspective article by Duygu Özpolat, Swathi Arur (one of Development's Academic Editors),
thenode.biologists.com
January 22, 2025 at 10:23 AM
What do we mean by ‘mechanism’ anyway?
@dev-journal.bsky.social Executive Editor @katherine-brown.bsky.social gives her perspective on the recent article "A case for broadening our view of mechanism in developmental biology" by @biyolokum.bsky.social @swathiarur.bsky.social and Mansi Srivastava:
@dev-journal.bsky.social Executive Editor @katherine-brown.bsky.social gives her perspective on the recent article "A case for broadening our view of mechanism in developmental biology" by @biyolokum.bsky.social @swathiarur.bsky.social and Mansi Srivastava:
Reposted by Bethan Lloyd-Lewis
My 3 favourite things about being a scientist: my full time job is to solve mysteries (how cool is that!), constantly being amazed by how beautiful & surprising the natural world is, getting to work w/ people who are smarter than me & have skills I can only dream of having on problems I care about.
November 27, 2024 at 10:31 AM
My 3 favourite things about being a scientist: my full time job is to solve mysteries (how cool is that!), constantly being amazed by how beautiful & surprising the natural world is, getting to work w/ people who are smarter than me & have skills I can only dream of having on problems I care about.
Reposted by Bethan Lloyd-Lewis
We've been awarded a UKRI MRC grant to examine the causes and consequences of #heterochromatin hypomethylation in cancer 🥳. #postdoc opportunity coming in the near future. #epigenetics. Please share with anyone who might be interested.
December 12, 2024 at 4:22 PM
We've been awarded a UKRI MRC grant to examine the causes and consequences of #heterochromatin hypomethylation in cancer 🥳. #postdoc opportunity coming in the near future. #epigenetics. Please share with anyone who might be interested.