Andreas Müller
@andimicroscopy.bsky.social
Scientist at Paul Langerhans Institute Dresden. Interested in the structural features of pancreatic beta cell function and signaling. 🔬
Pinned
Ok, let's start this thing here with my favorite 3D animation connected to our recent paper on structure and interactions of beta cell primary cilia. www.nature.com/articles/s41...
Still super ecited about cilia-axon contacts in the pancreas.
Still super ecited about cilia-axon contacts in the pancreas.
Reposted by Andreas Müller
AI based analysis of human pancreatic histology provides a foundation for future research into relevant diagnostic and therapeutic targets, refining several hypotheses regarding tissue alterations associated with #T2D www.nature.com/articles/s41...
February 10, 2026 at 11:20 AM
AI based analysis of human pancreatic histology provides a foundation for future research into relevant diagnostic and therapeutic targets, refining several hypotheses regarding tissue alterations associated with #T2D www.nature.com/articles/s41...
Reposted by Andreas Müller
There are just a few days (and spots!) left to apply to this EM course with a focus on marine samples 🌊 do not miss it!
Don’t forget to apply to this beautiful Electron Microscopy course at @szndohrn.bsky.social in Napoli, Italy by February 12th! 🌊 ☀️ Stay tuned for the preliminary program, in the meantime take a look here: www.szn.it/index.php/it...
February 9, 2026 at 2:49 PM
There are just a few days (and spots!) left to apply to this EM course with a focus on marine samples 🌊 do not miss it!
Reposted by Andreas Müller
🌍 Cilia2027 | Mar 8–12, 2027 | 📍 Stresa, Lake Maggiore, Italy
Join the global cilia community for science, collaboration & discovery (+ fun!!).
#Cilia2027 #CiliaBiology
Join the global cilia community for science, collaboration & discovery (+ fun!!).
#Cilia2027 #CiliaBiology
December 16, 2025 at 3:29 PM
🌍 Cilia2027 | Mar 8–12, 2027 | 📍 Stresa, Lake Maggiore, Italy
Join the global cilia community for science, collaboration & discovery (+ fun!!).
#Cilia2027 #CiliaBiology
Join the global cilia community for science, collaboration & discovery (+ fun!!).
#Cilia2027 #CiliaBiology
Reposted by Andreas Müller
Villin-SNAP25 interaction regulates insulin secretion downstream of ICA512 signaling https://www.biorxiv.org/content/10.64898/2026.01.13.699220v1
January 14, 2026 at 4:30 AM
Villin-SNAP25 interaction regulates insulin secretion downstream of ICA512 signaling https://www.biorxiv.org/content/10.64898/2026.01.13.699220v1
Reposted by Andreas Müller
🔬🔦Our latest ‘Imaging spotlight’, by @carlesbosch.bsky.social, Ana Diaz, @adrianawanner.bsky.social & @andreas-t-schaefer.bsky.social, highlights the non-destructive X-ray tomography pipeline that the authors developed to map mouse brain ultrastructure & considers future applications & developments.
Imaging spotlight: Revealing mouse brain ultrastructure using non-destructive X-ray tomography - FocalPlane
Imaging spotlight: Revealing mouse brain ultrastructure using non-destructive X-ray tomography - News
focalplane.biologists.com
January 14, 2026 at 11:15 AM
🔬🔦Our latest ‘Imaging spotlight’, by @carlesbosch.bsky.social, Ana Diaz, @adrianawanner.bsky.social & @andreas-t-schaefer.bsky.social, highlights the non-destructive X-ray tomography pipeline that the authors developed to map mouse brain ultrastructure & considers future applications & developments.
Reposted by Andreas Müller
Microscopy Bat signal!
I want to compile a list of biological samples that demonstrate microscope capabilities, including the reagents to generate them. Please send me anything you know of!! Beads are great for QC, but there's a different teaching benefit with biology. 1/n
I want to compile a list of biological samples that demonstrate microscope capabilities, including the reagents to generate them. Please send me anything you know of!! Beads are great for QC, but there's a different teaching benefit with biology. 1/n
December 8, 2025 at 2:27 PM
Microscopy Bat signal!
I want to compile a list of biological samples that demonstrate microscope capabilities, including the reagents to generate them. Please send me anything you know of!! Beads are great for QC, but there's a different teaching benefit with biology. 1/n
I want to compile a list of biological samples that demonstrate microscope capabilities, including the reagents to generate them. Please send me anything you know of!! Beads are great for QC, but there's a different teaching benefit with biology. 1/n
Reposted by Andreas Müller
20-plex volumetric super-resolution imaging of cellular ultrastructure. Preprint, led by @seweryn-galecki.bsky.social, dropping soon.
January 1, 2026 at 11:10 PM
20-plex volumetric super-resolution imaging of cellular ultrastructure. Preprint, led by @seweryn-galecki.bsky.social, dropping soon.
Reposted by Andreas Müller
Surprise mother$#@%er!
Q: What does this mean for neural systems to understand them?
A: We absolutely need the wiring diagram. All synapses, chemical and electrical.
#Connectomics
Q: What does this mean for neural systems to understand them?
A: We absolutely need the wiring diagram. All synapses, chemical and electrical.
#Connectomics
Evidence suggests that transcriptionally similar cells can be functionally diverse
go.nature.com/3N4lT2d
go.nature.com/3N4lT2d
Does a cell’s gene expression always reflect its function?
Transcriptionally similar neurons can be functionally diverse.
go.nature.com
January 1, 2026 at 6:55 AM
Surprise mother$#@%er!
Q: What does this mean for neural systems to understand them?
A: We absolutely need the wiring diagram. All synapses, chemical and electrical.
#Connectomics
Q: What does this mean for neural systems to understand them?
A: We absolutely need the wiring diagram. All synapses, chemical and electrical.
#Connectomics
Happy that we could contribute to this amazing study.
New from The Tomas Lab Key pathways linking GLP-1R signaling to regulate β-cell mitochondrial remodelling and function #islets #diabetes www.nature.com/articles/s41... @tomaslab-imperial.bsky.social
GLP-1R associates with VAPB and SPHKAP at ERMCSs to regulate β-cell mitochondrial remodelling and function - Nature Communications
Following its internalisation, active endosomal GLP-1R engages with VAPB and SPHKAP at ER membrane contact sites to assemble a local cAMP/PKA condensate for the control of MICOS complex phosphorylatio...
www.nature.com
December 13, 2025 at 1:07 PM
Happy that we could contribute to this amazing study.
Reposted by Andreas Müller
💥I am excited to present our first research paper from the lab about caveolae lipid trafficking 🎉 Led by my fantastic PhD candidate @estherocket.bsky.social
Here we looked into caveolae mediated dietary lipid uptake and how this process is mechanistically facilitated 👇 1/n
Here we looked into caveolae mediated dietary lipid uptake and how this process is mechanistically facilitated 👇 1/n
Lipid-induced Caveolin1-Lipid droplet trafficking is associated with lipid droplet growth https://www.biorxiv.org/content/10.64898/2025.12.10.693432v1
December 11, 2025 at 7:08 AM
💥I am excited to present our first research paper from the lab about caveolae lipid trafficking 🎉 Led by my fantastic PhD candidate @estherocket.bsky.social
Here we looked into caveolae mediated dietary lipid uptake and how this process is mechanistically facilitated 👇 1/n
Here we looked into caveolae mediated dietary lipid uptake and how this process is mechanistically facilitated 👇 1/n
Reposted by Andreas Müller
Our Method of the Year 2025 is...drumroll please...EM-based connectomics!!
Our Editorial introduces our choice and highlights six Comments and other related content in this special issue. Please join us in celebrating EM-based connectomics! 🎉🧠🔬
www.nature.com/articles/s41...
Our Editorial introduces our choice and highlights six Comments and other related content in this special issue. Please join us in celebrating EM-based connectomics! 🎉🧠🔬
www.nature.com/articles/s41...
Method of the Year 2025: electron microscopy-based connectomics - Nature Methods
A large network of interconnected neurons serves as the basis of brain function and of behavior. Methodological advances have enabled the reconstruction of large-scale and even whole-brain connectomes...
www.nature.com
December 8, 2025 at 4:59 PM
Our Method of the Year 2025 is...drumroll please...EM-based connectomics!!
Our Editorial introduces our choice and highlights six Comments and other related content in this special issue. Please join us in celebrating EM-based connectomics! 🎉🧠🔬
www.nature.com/articles/s41...
Our Editorial introduces our choice and highlights six Comments and other related content in this special issue. Please join us in celebrating EM-based connectomics! 🎉🧠🔬
www.nature.com/articles/s41...
Reposted by Andreas Müller
The TUD has made a very nice video in their "Kurze Frage" series featuring PLID member Andreas Müller where he explains how insulin is produced by the beta cells of the pancreas and why this is important in diabetes (German only)
#TUDresden #DiabetesResearch #PLID #HelmholztzMunich
#TUDresden #DiabetesResearch #PLID #HelmholztzMunich
Wie wird Insulin produziert? 🩸 | Kurze Frage über Diabetesforschung & Betazellen
YouTube video by TU Dresden entdecken
www.youtube.com
December 3, 2025 at 12:24 PM
The TUD has made a very nice video in their "Kurze Frage" series featuring PLID member Andreas Müller where he explains how insulin is produced by the beta cells of the pancreas and why this is important in diabetes (German only)
#TUDresden #DiabetesResearch #PLID #HelmholztzMunich
#TUDresden #DiabetesResearch #PLID #HelmholztzMunich
Here is a short video by @tudresden.bsky.social (in German) of me explaining what beta cells do and talking about our research on investigating the structural features of their function and dysfunction.
Wie wird #Insulin produziert? Was passiert bei #Diabetes im Körper? 🩸 In der »Kurzen Frage« spricht @andimicroscopy.bsky.social vom Paul Langerhans Institut von @helmholtzmunich.bsky.social & #TUDresden über seine Forschung an den Betazellen der Bauchspeicheldrüse. Zum Video ➡️ youtu.be/KAeSulc4Neo
December 3, 2025 at 11:28 AM
Here is a short video by @tudresden.bsky.social (in German) of me explaining what beta cells do and talking about our research on investigating the structural features of their function and dysfunction.
Reposted by Andreas Müller
Interested in applying U-ExM to cells, tissues, organoids, or cryo-sections? Our EMBO workshop is open for applications!
🧫🔬 Deadline: 12 Jan 2026 — don’t miss it!
🧫🔬 Deadline: 12 Jan 2026 — don’t miss it!
Have you applied for 'Ultrastructure expansion microscopy: from cells to tissue' yet? #EMBOExM
🔬 Advance your microscopy skills by joining us to explore U-ExM techniques and gain hands-on expertise in applying this powerful approach to mammalian cells.
Apply now: s.embl.org/uex26-01-bl
🔬 Advance your microscopy skills by joining us to explore U-ExM techniques and gain hands-on expertise in applying this powerful approach to mammalian cells.
Apply now: s.embl.org/uex26-01-bl
December 2, 2025 at 3:13 PM
Interested in applying U-ExM to cells, tissues, organoids, or cryo-sections? Our EMBO workshop is open for applications!
🧫🔬 Deadline: 12 Jan 2026 — don’t miss it!
🧫🔬 Deadline: 12 Jan 2026 — don’t miss it!
Reposted by Andreas Müller
Do you have 2D-to-3D image registration challenges? Let me know about them here
forum.image.sc/t/toward-bet...
forum.image.sc/t/toward-bet...
Toward better 2D - 3D registration in BigWarp
BigWarp has so far focused on 2D-2D or 3D-3D registration, and not on 2D-3D registration. After a conversation with @Christian_Tischer , we thought some simple UI changes could make the support for 2...
forum.image.sc
November 29, 2025 at 6:03 PM
Do you have 2D-to-3D image registration challenges? Let me know about them here
forum.image.sc/t/toward-bet...
forum.image.sc/t/toward-bet...
Reposted by Andreas Müller
Our new paper showcasing molecular connectomics with pan-expansion microscopy is out in @natbiotech.nature.com! www.nature.com/articles/s41...
This wonderful collaboration with @bewersdorflab.bsky.social was led by Ons M'Saad (now founder/CEO of Panluminate) and @allisonphysics.bsky.social. (1/5)
This wonderful collaboration with @bewersdorflab.bsky.social was led by Ons M'Saad (now founder/CEO of Panluminate) and @allisonphysics.bsky.social. (1/5)
November 27, 2025 at 4:40 AM
Our new paper showcasing molecular connectomics with pan-expansion microscopy is out in @natbiotech.nature.com! www.nature.com/articles/s41...
This wonderful collaboration with @bewersdorflab.bsky.social was led by Ons M'Saad (now founder/CEO of Panluminate) and @allisonphysics.bsky.social. (1/5)
This wonderful collaboration with @bewersdorflab.bsky.social was led by Ons M'Saad (now founder/CEO of Panluminate) and @allisonphysics.bsky.social. (1/5)
Reposted by Andreas Müller
#Cilia and #Centrosome friends- tomorrow is the big day!! 🎉 🎉
Organoids for #PCD, #CryoET of the base of motile cilia, TZ organization in #IRDs, macrophages & cystic niches in #PKD, how pro-inflammatory lipids & #adipogenesis AND cilia as signal-sending organelles shedding #EVs! 🤩 😍 Join us!!
Organoids for #PCD, #CryoET of the base of motile cilia, TZ organization in #IRDs, macrophages & cystic niches in #PKD, how pro-inflammatory lipids & #adipogenesis AND cilia as signal-sending organelles shedding #EVs! 🤩 😍 Join us!!
🎆 Join us for an unmissable finale to 2025! 🎆 We're thrilled to bring our #cilia & #centrosome community together 25/11/2025 15:00-17:45 GMT! Our 53rd @bscb-official.bsky.social @gensocuk.bsky.social @ukcilianetwork.bsky.social e-symposium schedule is live: www.eventbrite.co.uk/e/bscb-genso... /1
November 24, 2025 at 11:04 AM
#Cilia and #Centrosome friends- tomorrow is the big day!! 🎉 🎉
Organoids for #PCD, #CryoET of the base of motile cilia, TZ organization in #IRDs, macrophages & cystic niches in #PKD, how pro-inflammatory lipids & #adipogenesis AND cilia as signal-sending organelles shedding #EVs! 🤩 😍 Join us!!
Organoids for #PCD, #CryoET of the base of motile cilia, TZ organization in #IRDs, macrophages & cystic niches in #PKD, how pro-inflammatory lipids & #adipogenesis AND cilia as signal-sending organelles shedding #EVs! 🤩 😍 Join us!!
Reposted by Andreas Müller
Scientific journals: we don’t want you using generative AI because it makes shit up.
Same journal: here is an AI summary or evaluation of this paper. This might be more useful than the actual abstract or paper that the authors freaking wrote
Same journal: AI cover art which makes no sense? Oooh!
Same journal: here is an AI summary or evaluation of this paper. This might be more useful than the actual abstract or paper that the authors freaking wrote
Same journal: AI cover art which makes no sense? Oooh!
November 23, 2025 at 1:51 AM
Scientific journals: we don’t want you using generative AI because it makes shit up.
Same journal: here is an AI summary or evaluation of this paper. This might be more useful than the actual abstract or paper that the authors freaking wrote
Same journal: AI cover art which makes no sense? Oooh!
Same journal: here is an AI summary or evaluation of this paper. This might be more useful than the actual abstract or paper that the authors freaking wrote
Same journal: AI cover art which makes no sense? Oooh!
Reposted by Andreas Müller
Calling on my #science network! TeamNDF is #hiring a postdoc to start in 2026!
Are you fascinated by metabolism and the brain? Do you want to dig into life long impacts and the molecular cause?
Learn more about the team and our research here: www.dife.de/en/research/...
Please share! 🧠 🍔 💉
Are you fascinated by metabolism and the brain? Do you want to dig into life long impacts and the molecular cause?
Learn more about the team and our research here: www.dife.de/en/research/...
Please share! 🧠 🍔 💉
November 22, 2025 at 12:15 PM
Calling on my #science network! TeamNDF is #hiring a postdoc to start in 2026!
Are you fascinated by metabolism and the brain? Do you want to dig into life long impacts and the molecular cause?
Learn more about the team and our research here: www.dife.de/en/research/...
Please share! 🧠 🍔 💉
Are you fascinated by metabolism and the brain? Do you want to dig into life long impacts and the molecular cause?
Learn more about the team and our research here: www.dife.de/en/research/...
Please share! 🧠 🍔 💉
Reposted by Andreas Müller
New on bioRxiv! 🚨
“Pericyte and Endothelial Primary Cilia and Centrioles have Disparate Organization Across the Brain Microvasculature”
This project studying #microvascular cells took an unexpected turn when we discovered that #pericytes have primary #cilia!
🔗 www.biorxiv.org/content/10.1...
🧪 🧵1/8
“Pericyte and Endothelial Primary Cilia and Centrioles have Disparate Organization Across the Brain Microvasculature”
This project studying #microvascular cells took an unexpected turn when we discovered that #pericytes have primary #cilia!
🔗 www.biorxiv.org/content/10.1...
🧪 🧵1/8
November 20, 2025 at 9:04 PM
New on bioRxiv! 🚨
“Pericyte and Endothelial Primary Cilia and Centrioles have Disparate Organization Across the Brain Microvasculature”
This project studying #microvascular cells took an unexpected turn when we discovered that #pericytes have primary #cilia!
🔗 www.biorxiv.org/content/10.1...
🧪 🧵1/8
“Pericyte and Endothelial Primary Cilia and Centrioles have Disparate Organization Across the Brain Microvasculature”
This project studying #microvascular cells took an unexpected turn when we discovered that #pericytes have primary #cilia!
🔗 www.biorxiv.org/content/10.1...
🧪 🧵1/8
Reposted by Andreas Müller
We just released a new major version of TrackMate (v8), the cell and organelle tracking plugin of Fiji.
It ships many new features, detailed below, but that are articulated around the following:
It ships many new features, detailed below, but that are articulated around the following:
November 20, 2025 at 11:42 AM
We just released a new major version of TrackMate (v8), the cell and organelle tracking plugin of Fiji.
It ships many new features, detailed below, but that are articulated around the following:
It ships many new features, detailed below, but that are articulated around the following:
Reposted by Andreas Müller
My new ImageJ / Fiji toolkit is out 🔥! The goal is to make image handling & visualization easy, with an intuitive interface! Install it on Fiji with the "Image Viewer" update site
#microscopy #ImageJ #FluorescenceFriday #microscopyMonday
imagej.net/plugins/imag...
#microscopy #ImageJ #FluorescenceFriday #microscopyMonday
imagej.net/plugins/imag...
November 4, 2025 at 10:40 PM
My new ImageJ / Fiji toolkit is out 🔥! The goal is to make image handling & visualization easy, with an intuitive interface! Install it on Fiji with the "Image Viewer" update site
#microscopy #ImageJ #FluorescenceFriday #microscopyMonday
imagej.net/plugins/imag...
#microscopy #ImageJ #FluorescenceFriday #microscopyMonday
imagej.net/plugins/imag...
Reposted by Andreas Müller
As a neuroscientist, I’d suggest there is a profound disconnect between what *some* computer scientists think is representative of “intelligence”, cognitive ability, or descriptions of consciousness from some in AI work.
LLMs are not how neural systems process information, nor how brains function.
LLMs are not how neural systems process information, nor how brains function.
November 6, 2025 at 5:19 PM
As a neuroscientist, I’d suggest there is a profound disconnect between what *some* computer scientists think is representative of “intelligence”, cognitive ability, or descriptions of consciousness from some in AI work.
LLMs are not how neural systems process information, nor how brains function.
LLMs are not how neural systems process information, nor how brains function.
Reposted by Andreas Müller
We are looking for motivated #postdocs to join the lab! Biochemistry/microbiology/cryo-EM experience? Excited by #cryo-EM/ET, #chromatin? ❄️🧬🧫
Interdisciplinary projects, top EMBL facilities!
Email CV + short cover letter → svetlana.dodonova@embl.de
Info about the group: www.embl.org/groups/dodon...
Interdisciplinary projects, top EMBL facilities!
Email CV + short cover letter → svetlana.dodonova@embl.de
Info about the group: www.embl.org/groups/dodon...
Dodonova Group – Organisational principles and 3D architecture of archaeal chromatin
www.embl.org
October 15, 2025 at 10:38 AM
We are looking for motivated #postdocs to join the lab! Biochemistry/microbiology/cryo-EM experience? Excited by #cryo-EM/ET, #chromatin? ❄️🧬🧫
Interdisciplinary projects, top EMBL facilities!
Email CV + short cover letter → svetlana.dodonova@embl.de
Info about the group: www.embl.org/groups/dodon...
Interdisciplinary projects, top EMBL facilities!
Email CV + short cover letter → svetlana.dodonova@embl.de
Info about the group: www.embl.org/groups/dodon...
Reposted by Andreas Müller
Everything you wanted to know about #cilia & #signaling in one big beautiful poster format from field thought leaders @wachtenlab.bsky.social & @sorentc.bsky.social- from our just live @jcellsci.bsky.social Special Issue… 🤩🤩🤩
I’m excited to share this collaborative work with Prof. Dagmar Wachten (@wachtenlab.bsky.social), providing an accessible overview of primary cilia signalling and recent advances in cellular signaling in health and disease. Many thanks to Dagmar for a fantastic collaboration! doi.org/10.1242/jcs....
Primary cilia signalling at a glance
Summary: We explore the primary cilium as a master regulator of cellular communication that integrates diverse signalling pathways to guide development and maintain homeostasis. Its dysfunction trigge...
doi.org
October 30, 2025 at 1:11 PM
Everything you wanted to know about #cilia & #signaling in one big beautiful poster format from field thought leaders @wachtenlab.bsky.social & @sorentc.bsky.social- from our just live @jcellsci.bsky.social Special Issue… 🤩🤩🤩