🔬🧠Brain‑training games for LC cognitive dysfunction? The RECOVER‑NEURO trial shows they don’t address the underlying pathology. Games can’t fix inflammation, microvascular issues, or neuro‑immune dysfunction - we need interventions that understand the biology not candy crush 🍭
November 10, 2025 at 9:25 PM
🔬🧠Brain‑training games for LC cognitive dysfunction? The RECOVER‑NEURO trial shows they don’t address the underlying pathology. Games can’t fix inflammation, microvascular issues, or neuro‑immune dysfunction - we need interventions that understand the biology not candy crush 🍭
REMODEL is fantastic demonstration of what we can do with collaborative effort to perform what Kathy Tuttle calls mechanistic clinical trials!
Semaglutide provides kidney protection via improvements in inflammation and microvascular function. Lots of data to parse going forward. #KidneyWk
Semaglutide provides kidney protection via improvements in inflammation and microvascular function. Lots of data to parse going forward. #KidneyWk
November 7, 2025 at 11:13 PM
REMODEL is fantastic demonstration of what we can do with collaborative effort to perform what Kathy Tuttle calls mechanistic clinical trials!
Semaglutide provides kidney protection via improvements in inflammation and microvascular function. Lots of data to parse going forward. #KidneyWk
Semaglutide provides kidney protection via improvements in inflammation and microvascular function. Lots of data to parse going forward. #KidneyWk
This post is from a scientist with a political agenda, and it is very wrong.
Here‘s what this in vitro model does not have:
❌ any resemblance to the details of a brain! It’s a ball of cells.
Please don’t be fooled by the NAM folks, funded by the right to damage science.
Here‘s what this in vitro model does not have:
❌ any resemblance to the details of a brain! It’s a ball of cells.
Please don’t be fooled by the NAM folks, funded by the right to damage science.
November 4, 2025 at 1:41 PM
This post is from a scientist with a political agenda, and it is very wrong.
Here‘s what this in vitro model does not have:
❌ any resemblance to the details of a brain! It’s a ball of cells.
Please don’t be fooled by the NAM folks, funded by the right to damage science.
Here‘s what this in vitro model does not have:
❌ any resemblance to the details of a brain! It’s a ball of cells.
Please don’t be fooled by the NAM folks, funded by the right to damage science.
This new miBrain model from MIT has it all:
🧠 Neurons, microglia, oligodendroglia, astrocytes, pericytes, & brain microvascular endothelial cells
⚙️ Key features & functions of the human brain
👩👦 Specificity to individual donors
🧬 Customizability via gene editing
📈 Scalability for large projects
🧠 Neurons, microglia, oligodendroglia, astrocytes, pericytes, & brain microvascular endothelial cells
⚙️ Key features & functions of the human brain
👩👦 Specificity to individual donors
🧬 Customizability via gene editing
📈 Scalability for large projects
![Image from the MIT Picower article, "MIT invents human brain model with six major cell types to enable personalized disease research, drug discovery" with the following caption: “Cyan staining shows each of the six major cell types [pericytes, astrocytes, endothelial cells, neurons, oligodendrocytes, and microglia] integrated in a miBrain culture.” The original image appeared in Figure 1 of the PNAS article, “Engineered 3D immuno-glial-neurovascular human miBrain model” (10.1073/pnas.2511596122) by Stanton et al.](https://cdn.bsky.app/img/feed_thumbnail/plain/did:plc:in2pnzujy66a7qnesoxha6ar/bafkreig4udiootxzzdxay4vwclppbwedfythnr36dzzoavgbrzvz2m54va@jpeg)
November 3, 2025 at 7:28 PM
This new miBrain model from MIT has it all:
🧠 Neurons, microglia, oligodendroglia, astrocytes, pericytes, & brain microvascular endothelial cells
⚙️ Key features & functions of the human brain
👩👦 Specificity to individual donors
🧬 Customizability via gene editing
📈 Scalability for large projects
🧠 Neurons, microglia, oligodendroglia, astrocytes, pericytes, & brain microvascular endothelial cells
⚙️ Key features & functions of the human brain
👩👦 Specificity to individual donors
🧬 Customizability via gene editing
📈 Scalability for large projects
Trump's 6 causes of significant diminished mental acuity:
• Microvascular ischemic brain disease
• CVA - at least one, mild-to-moderate sized stroke
• Decades of ongoing cocaine and Adderall abuse
• Hepatic Encephalopathy
• Family history of Alzheimer's Disease
• Dark Tetrad
• Microvascular ischemic brain disease
• CVA - at least one, mild-to-moderate sized stroke
• Decades of ongoing cocaine and Adderall abuse
• Hepatic Encephalopathy
• Family history of Alzheimer's Disease
• Dark Tetrad
October 28, 2025 at 8:11 PM
Trump's 6 causes of significant diminished mental acuity:
• Microvascular ischemic brain disease
• CVA - at least one, mild-to-moderate sized stroke
• Decades of ongoing cocaine and Adderall abuse
• Hepatic Encephalopathy
• Family history of Alzheimer's Disease
• Dark Tetrad
• Microvascular ischemic brain disease
• CVA - at least one, mild-to-moderate sized stroke
• Decades of ongoing cocaine and Adderall abuse
• Hepatic Encephalopathy
• Family history of Alzheimer's Disease
• Dark Tetrad
This is a magnified image of blood vessels being joined together (anastomosed) under the operating microscope. This is for microvascular free flap reconstruction of a head and neck cancer defect.#ENTsecrets #ENT #surgery #surgeon #headandneck 1/2
October 29, 2025 at 4:12 AM
This is a magnified image of blood vessels being joined together (anastomosed) under the operating microscope. This is for microvascular free flap reconstruction of a head and neck cancer defect.#ENTsecrets #ENT #surgery #surgeon #headandneck 1/2
We take skin/muscle/bone tissue from forearm, hip or leg and then connect the blood vessels to branches of the carotid artery and jugular vein in the neck. I did my Facial Plastic and microvascular Reconstructive fellowship in Canada. I miss it very much. 2/2
October 29, 2025 at 4:12 AM
We take skin/muscle/bone tissue from forearm, hip or leg and then connect the blood vessels to branches of the carotid artery and jugular vein in the neck. I did my Facial Plastic and microvascular Reconstructive fellowship in Canada. I miss it very much. 2/2
Dead brain stays dead, and as you get older your neuro plasticity (ability for your brain to adapt to neuro injury) declines.
Similarly, chronic microvascular disease inhibits recovery and creates a sort of “stuttering” decline in cognition. So you test for it regularly.
Similarly, chronic microvascular disease inhibits recovery and creates a sort of “stuttering” decline in cognition. So you test for it regularly.
October 27, 2025 at 12:21 PM
Dead brain stays dead, and as you get older your neuro plasticity (ability for your brain to adapt to neuro injury) declines.
Similarly, chronic microvascular disease inhibits recovery and creates a sort of “stuttering” decline in cognition. So you test for it regularly.
Similarly, chronic microvascular disease inhibits recovery and creates a sort of “stuttering” decline in cognition. So you test for it regularly.
🩸 New #JACCBTS study reveals estrogen’s dual effects on microvascular health differ by sex
⚖️ A balanced ceramide: S1P ratio is 🔑 to endothelial health
🧬 May explain why long-term hormone exposure can 📈 CV risk
🔗 https://bit.ly/43Ct5In
#APSSexDiff2025 #CardioSky #MedSky
⚖️ A balanced ceramide: S1P ratio is 🔑 to endothelial health
🧬 May explain why long-term hormone exposure can 📈 CV risk
🔗 https://bit.ly/43Ct5In
#APSSexDiff2025 #CardioSky #MedSky
October 25, 2025 at 11:05 PM
🩸 New #JACCBTS study reveals estrogen’s dual effects on microvascular health differ by sex
⚖️ A balanced ceramide: S1P ratio is 🔑 to endothelial health
🧬 May explain why long-term hormone exposure can 📈 CV risk
🔗 https://bit.ly/43Ct5In
#APSSexDiff2025 #CardioSky #MedSky
⚖️ A balanced ceramide: S1P ratio is 🔑 to endothelial health
🧬 May explain why long-term hormone exposure can 📈 CV risk
🔗 https://bit.ly/43Ct5In
#APSSexDiff2025 #CardioSky #MedSky
It’s settled. Unless an earlier date opens up, I’ll undergo a minor brain surgery called microvascular decompression on December 16th.
According to my doctor, there’s a 60-70% chance the procedure will provide instant and significant relief. Should be fun. en.wikipedia.org/wiki/Microva...
According to my doctor, there’s a 60-70% chance the procedure will provide instant and significant relief. Should be fun. en.wikipedia.org/wiki/Microva...
October 24, 2025 at 1:44 AM
It’s settled. Unless an earlier date opens up, I’ll undergo a minor brain surgery called microvascular decompression on December 16th.
According to my doctor, there’s a 60-70% chance the procedure will provide instant and significant relief. Should be fun. en.wikipedia.org/wiki/Microva...
According to my doctor, there’s a 60-70% chance the procedure will provide instant and significant relief. Should be fun. en.wikipedia.org/wiki/Microva...
Anyone here know anything about microvascular decompression? My neurosurgeon wants to try that instead of nerve ablation.
October 23, 2025 at 12:17 AM
Anyone here know anything about microvascular decompression? My neurosurgeon wants to try that instead of nerve ablation.
Microfluidic #BloodBrainBarrier
hiPSC Endothelial Cells or primary brain microvascular ECs +primary brain pericytes & astrocytes
A protocol for microscopy-based permeability assay (minutes)
10/40 kD dextran
#NatProtoc 2022
www.nature.com/articles/s41...
hiPSC Endothelial Cells or primary brain microvascular ECs +primary brain pericytes & astrocytes
A protocol for microscopy-based permeability assay (minutes)
10/40 kD dextran
#NatProtoc 2022
www.nature.com/articles/s41...
October 20, 2025 at 7:06 PM
Microfluidic #BloodBrainBarrier
hiPSC Endothelial Cells or primary brain microvascular ECs +primary brain pericytes & astrocytes
A protocol for microscopy-based permeability assay (minutes)
10/40 kD dextran
#NatProtoc 2022
www.nature.com/articles/s41...
hiPSC Endothelial Cells or primary brain microvascular ECs +primary brain pericytes & astrocytes
A protocol for microscopy-based permeability assay (minutes)
10/40 kD dextran
#NatProtoc 2022
www.nature.com/articles/s41...
"Australian researchers unlocking secrets of COVID-19 may have landed on new ways to reduce organ injury from heart attacks and stroke"
SARS-CoV-2 can damage endothelial cells, disrupting blood flow and oxygen delivery. This microvascular injury drives organ damage and Long COVID.
archive.li/AMBdJ
SARS-CoV-2 can damage endothelial cells, disrupting blood flow and oxygen delivery. This microvascular injury drives organ damage and Long COVID.
archive.li/AMBdJ
October 19, 2025 at 11:40 PM
"Australian researchers unlocking secrets of COVID-19 may have landed on new ways to reduce organ injury from heart attacks and stroke"
SARS-CoV-2 can damage endothelial cells, disrupting blood flow and oxygen delivery. This microvascular injury drives organ damage and Long COVID.
archive.li/AMBdJ
SARS-CoV-2 can damage endothelial cells, disrupting blood flow and oxygen delivery. This microvascular injury drives organ damage and Long COVID.
archive.li/AMBdJ
What if ΔPCO₂ in shock is more about acidosis than Haldane effect?
New study shows hydrogen ions dominate the CO₂ gap while flow recovers. #OxyFlo measured jejunal microvascular flow to link perfusion with CO₂ dynamics.
#Shock #CriticalCare #CO2 #LDF #Physiology
link.springer.com/article/10.1...
New study shows hydrogen ions dominate the CO₂ gap while flow recovers. #OxyFlo measured jejunal microvascular flow to link perfusion with CO₂ dynamics.
#Shock #CriticalCare #CO2 #LDF #Physiology
link.springer.com/article/10.1...
Regional venous-to-arterial carbon dioxide pressure and content differences during endotoxemic shock: influence of hydrogen ion accumulation vs. Haldane effect - Intensive Care Medicine Experimental
Background The relationship between carbon dioxide pressures (PCO2) and contents (CCO2) is linked to the Haldane effect. Nevertheless, under shock conditions, hydrogen ion accumulation might strongly ...
link.springer.com
October 20, 2025 at 12:20 PM
What if ΔPCO₂ in shock is more about acidosis than Haldane effect?
New study shows hydrogen ions dominate the CO₂ gap while flow recovers. #OxyFlo measured jejunal microvascular flow to link perfusion with CO₂ dynamics.
#Shock #CriticalCare #CO2 #LDF #Physiology
link.springer.com/article/10.1...
New study shows hydrogen ions dominate the CO₂ gap while flow recovers. #OxyFlo measured jejunal microvascular flow to link perfusion with CO₂ dynamics.
#Shock #CriticalCare #CO2 #LDF #Physiology
link.springer.com/article/10.1...
'This multicellular system with induced pluripotent stem cell-derived neurons, microglia, oligodendroglia, astrocytes, pericytes, and brain microvascular endothelial cells has potential for opening possibilities for disease modeling, drug discovery and development'
#Immunology #Neuroimmunology
#Immunology #Neuroimmunology
Engineered 3D immuno-glial-neurovascular human miBrain model | PNAS
Patient-specific, human-based cellular models integrating a biomimetic blood–brain
barrier, immune, and myelinated neuron components are critically...
www.pnas.org
October 18, 2025 at 5:04 PM
'This multicellular system with induced pluripotent stem cell-derived neurons, microglia, oligodendroglia, astrocytes, pericytes, and brain microvascular endothelial cells has potential for opening possibilities for disease modeling, drug discovery and development'
#Immunology #Neuroimmunology
#Immunology #Neuroimmunology
@navbo.bsky.social 2025 starts this Sunday and the great @leahvanicek.bsky.social will be flying the colours of the @instcardregffm.bsky.social. She will present her work on HFpEF and microvascular cells. Watch out for funky pericyte stuff 💃🏻🤘🏻🫀
@cpi-exstra.bsky.social
@dzhk.de
@sfb1531.bsky.social
@cpi-exstra.bsky.social
@dzhk.de
@sfb1531.bsky.social
October 17, 2025 at 5:05 PM
@navbo.bsky.social 2025 starts this Sunday and the great @leahvanicek.bsky.social will be flying the colours of the @instcardregffm.bsky.social. She will present her work on HFpEF and microvascular cells. Watch out for funky pericyte stuff 💃🏻🤘🏻🫀
@cpi-exstra.bsky.social
@dzhk.de
@sfb1531.bsky.social
@cpi-exstra.bsky.social
@dzhk.de
@sfb1531.bsky.social
Towards an understanding of physical activity-induced post-exertional malaise: Insights into microvascular alterations and immunometabolic interactions in post-COVID condition and myalgic encephalomyelitis/chronic fatigue syndrome
link.springer.com/article/10.1...
link.springer.com/article/10.1...
Towards an understanding of physical activity-induced post-exertional malaise: Insights into microvascular alterations and immunometabolic interactions in post-COVID condition and myalgic encephalomye...
Background A considerable number of patients who contracted SARS-CoV-2 are affected by persistent multi-systemic symptoms, referred to as Post-COVID Condition (PCC). Post-exertional malaise (PEM) has ...
link.springer.com
October 16, 2025 at 8:04 PM
Towards an understanding of physical activity-induced post-exertional malaise: Insights into microvascular alterations and immunometabolic interactions in post-COVID condition and myalgic encephalomyelitis/chronic fatigue syndrome
link.springer.com/article/10.1...
link.springer.com/article/10.1...
Join Now, for the second half of today's Research Symposium - Welcome to Day 2: You can register here: tinyurl.com/BIMW25, then use the same link to login & attend
Donate to Early Career scientists: tinyurl.com/GiveBiM (all links in bio)
Donate to Early Career scientists: tinyurl.com/GiveBiM (all links in bio)
October 15, 2025 at 2:17 PM
Join Now, for the second half of today's Research Symposium - Welcome to Day 2: You can register here: tinyurl.com/BIMW25, then use the same link to login & attend
Donate to Early Career scientists: tinyurl.com/GiveBiM (all links in bio)
Donate to Early Career scientists: tinyurl.com/GiveBiM (all links in bio)
Welcome to Day 2, Black In Micro's Research Symposium is about to begin! Register here: tinyurl.com/BIMW25, then use the same link to login & attend
Donate to Early Career scientists: tinyurl.com/GiveBiM (all links in bio)
Donate to Early Career scientists: tinyurl.com/GiveBiM (all links in bio)
October 15, 2025 at 12:15 PM
Welcome to Day 2, Black In Micro's Research Symposium is about to begin! Register here: tinyurl.com/BIMW25, then use the same link to login & attend
Donate to Early Career scientists: tinyurl.com/GiveBiM (all links in bio)
Donate to Early Career scientists: tinyurl.com/GiveBiM (all links in bio)
New preprint
Authors conclude:
“The increased microclot burden in pediatric LC supports the role of microvascular dysfunction and persistent viral antigens in pathogenesis.”
www.researchsquare.com/article/rs-7...
Authors conclude:
“The increased microclot burden in pediatric LC supports the role of microvascular dysfunction and persistent viral antigens in pathogenesis.”
www.researchsquare.com/article/rs-7...
October 12, 2025 at 7:30 AM
New preprint
Authors conclude:
“The increased microclot burden in pediatric LC supports the role of microvascular dysfunction and persistent viral antigens in pathogenesis.”
www.researchsquare.com/article/rs-7...
Authors conclude:
“The increased microclot burden in pediatric LC supports the role of microvascular dysfunction and persistent viral antigens in pathogenesis.”
www.researchsquare.com/article/rs-7...
#BlackInMicro's Research Symposium is coming this Wedensday. Swipe left to see who's presenting. Come hear from 25 Early Career researchers from around the globe 🌎
Pre-register to attend: tinyurl.com/BIMW25
Donate to Early Career scientists: tinyurl.com/GiveBiM (all links in bio)
Pre-register to attend: tinyurl.com/BIMW25
Donate to Early Career scientists: tinyurl.com/GiveBiM (all links in bio)
October 12, 2025 at 8:35 PM
#BlackInMicro's Research Symposium is coming this Wedensday. Swipe left to see who's presenting. Come hear from 25 Early Career researchers from around the globe 🌎
Pre-register to attend: tinyurl.com/BIMW25
Donate to Early Career scientists: tinyurl.com/GiveBiM (all links in bio)
Pre-register to attend: tinyurl.com/BIMW25
Donate to Early Career scientists: tinyurl.com/GiveBiM (all links in bio)
Follow up. My wife just came out of surgery, a “microvascular decompression” to address her trigeminal neuralgia. She had a massive impingement of a vein on the nerve. She’s just waking up … and the pain (for now) is gone.
I’m surprised that Stephen King never wrote a story about trigeminal neuralgia, because my
<loved one> is dealing with this condition and it’s an effing nightmare. Excruciating phantom pain in your face, triggered by talking, eating, a light wind… what the absolute f*** is this?
<loved one> is dealing with this condition and it’s an effing nightmare. Excruciating phantom pain in your face, triggered by talking, eating, a light wind… what the absolute f*** is this?
October 1, 2025 at 12:25 AM
Follow up. My wife just came out of surgery, a “microvascular decompression” to address her trigeminal neuralgia. She had a massive impingement of a vein on the nerve. She’s just waking up … and the pain (for now) is gone.
“Since its appearance …COVID-19 has been investigated as a respiratory disease, … However…clinical evidence demonstrate[s] its…effects far beyond the lung & employs pathogenesis mechanisms related to endothelial dysfunction, microvascular injury & immune dysregulation”
www.mdpi.com/2673-8112/5/...
www.mdpi.com/2673-8112/5/...
www.mdpi.com
September 26, 2025 at 4:49 PM
“Since its appearance …COVID-19 has been investigated as a respiratory disease, … However…clinical evidence demonstrate[s] its…effects far beyond the lung & employs pathogenesis mechanisms related to endothelial dysfunction, microvascular injury & immune dysregulation”
www.mdpi.com/2673-8112/5/...
www.mdpi.com/2673-8112/5/...
1/1 Anouk Slaghekke - Vortrag auf der ME/CFS-Fachtagung 2025 des Fatigatio e.V. (@fatigatioev.bsky.social):
Muscle Microvascular Abnormalities in Long COVID and ME/CFS"/"Mikrovaskuläre Anomalien in der Skelettmuskulatur bei Long COVID und ME/CFS:
www.youtube.com/watch?v=wAXq...
Muscle Microvascular Abnormalities in Long COVID and ME/CFS"/"Mikrovaskuläre Anomalien in der Skelettmuskulatur bei Long COVID und ME/CFS:
www.youtube.com/watch?v=wAXq...
Anouk Slaghekke - Vortrag auf der ME/CFS-Fachtagung 2025 des Fatigatio e.V. (OmU)
YouTube video by Fatigatio e. V.
www.youtube.com
September 24, 2025 at 5:12 AM
1/1 Anouk Slaghekke - Vortrag auf der ME/CFS-Fachtagung 2025 des Fatigatio e.V. (@fatigatioev.bsky.social):
Muscle Microvascular Abnormalities in Long COVID and ME/CFS"/"Mikrovaskuläre Anomalien in der Skelettmuskulatur bei Long COVID und ME/CFS:
www.youtube.com/watch?v=wAXq...
Muscle Microvascular Abnormalities in Long COVID and ME/CFS"/"Mikrovaskuläre Anomalien in der Skelettmuskulatur bei Long COVID und ME/CFS:
www.youtube.com/watch?v=wAXq...
Anouk Slaghekke presentation on Muscle Microvascular Abnormalities in Long COVID and #ME/CFS (2025)
@fatigatioev.bsky.social
@fatigatioev.bsky.social
Anouk Slaghekke - Vortrag auf der ME/CFS-Fachtagung 2025 des Fatigatio e.V. (OmU)
YouTube video by Fatigatio e. V.
youtube.com
September 24, 2025 at 3:50 AM
Anouk Slaghekke presentation on Muscle Microvascular Abnormalities in Long COVID and #ME/CFS (2025)
@fatigatioev.bsky.social
@fatigatioev.bsky.social