Andrea Manca
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amancayork.bsky.social
Andrea Manca
@amancayork.bsky.social
390 followers 420 following 23 posts

Health Economist
@CHE @UniofYork |
Methods & Applied HEOR | HTA |
Economic Evaluation | CEA | Evidence Synthesis | DCE |
Modelling & IPD Analyses | RCTs | RWD | Causal Inference |
Foodie | Skiing | Martial Arts | Travel Personal views | RT not endorsement .. more

Videos
Economics 62%
Mathematics 15%
Posts Replies Media Videos

Reposted by Robert Böhm, Brendan Nyhan, Scott L. Greer , and 15 more

jamiecummins.bsky.social
Jamie Cummins @jamiecummins.bsky.social · Sep 18
Can large language models stand in for human participants?
Many social scientists seem to think so, and are already using "silicon samples" in research.

One problem: depending on the analytic decisions made, you can basically get these samples to show any effect you want.

THREAD 🧵
The threat of analytic flexibility in using large language models to simulate human data: A call to attention
Social scientists are now using large language models to create "silicon samples" - synthetic datasets intended to stand in for human respondents, aimed at revolutionising human subjects research. How...
arxiv.org

amancayork.bsky.social
Andrea Manca @amancayork.bsky.social · Aug 28
Just 2 weeks to go to our residential course on advanced statistical methods in economic evaluation for HTA which will be held in beautiful city of York.

Reposted by David Cutler, Anirban Basu, Andrea Manca , and 1 more

johnmullahy.bsky.social
John Mullahy @johnmullahy.bsky.social · Dec 6
Ten years have elapsed since Will Manning left us.

Early career health economists not familiar with Will and his work might benefit from knowing the significant and enduring contributions Will made to our field.

onlinelibrary.wiley.com/doi/10.1002/...

amancayork.bsky.social
Andrea Manca @amancayork.bsky.social · Jul 12
Do you want to expand your professional competence in HTA? Register to attend the Statistical Methods in Economic Evaluation for HTA - Advanced Course at the University of York🚀 ⁦‪⁦‪@CHEyork‬⁩

www.york.ac.uk/che/courses/...
Statistical Methods in Economic Evaluation for HTA - Advanced
Dates - Tuesday 9th - Thursday 11th September 2025 The course will run from 9:00am to 6:00pm BST (GMT+1) on the first day and from 9:30am to 5:00pm on the next two days.  In-person (University of York...
www.york.ac.uk

Reposted by Torbjørn Wisløff

amancayork.bsky.social
Andrea Manca @amancayork.bsky.social · Jul 8
Please share with your network.

3-day Advanced Course on Statistical Methods in Economic Evaluation for HTA: Advanced Course: September 9-11, 2025!

Now with an updated program including modern methods for causal inference and machine learning.

www.york.ac.uk/che/courses/...
Statistical Methods in Economic Evaluation for HTA - Advanced
Dates - Tuesday 9th - Thursday 11th September 2025 The course will run from 9:00am to 6:00pm BST (GMT+1) on the first day and from 9:30am to 5:00pm on the next two days.  In-person (University of York...
www.york.ac.uk

Reposted by Andrea Manca

lruggiero.bsky.social
Lucia Ruggiero @lruggiero.bsky.social · Jul 1
How do research careers compare across countries? New global database has some answers
Online tool from the Research and Innovation Careers Observatory allows users to compare salary, typical career destinations, and more
www.science.org/content/arti...
How do research careers compare across countries? New global database has some answers
Online tool from the Research and Innovation Careers Observatory allows users to compare salary, typical career destinations, and more
www.science.org

Reposted by Amanda Farrin, Andrea Manca

marionkcampbell.bsky.social
Marion Campbell @marionkcampbell.bsky.social · Jun 16
At #CCR25, we saw some trials use a #CompositeOutcome (an endpoint that combines more than one outcome into a single measure) & also saw some of the problems these can throw up. I have discussed these before but thought it would be useful to revisit 1/9
#MethodologyMonday #120

Reposted by Torbjørn Wisløff

amancayork.bsky.social
Andrea Manca @amancayork.bsky.social · Jun 13
@CHEyork @UoY_BizTraining @UniOfYork short courses are run face to face in beautiful York, where you’ll be able to meet and spend time interacting with our faculty of experts as well as network with other participants from the industry, consultancy and academia
www.york.ac.uk/che/courses/...
Statistical Methods in Economic Evaluation for HTA - Advanced
Dates - Tuesday 9th - Thursday 11th September 2025 The course will run from 9:00am to 6:00pm BST (GMT+1) on the first day and from 9:30am to 5:00pm on the next two days.  In-person (University of York...
www.york.ac.uk

amancayork.bsky.social
Andrea Manca @amancayork.bsky.social · Jun 4
Correct link: www.york.ac.uk/che/courses/...
Statistical Methods in Economic Evaluation for HTA - Advanced
Dates - Tuesday 9th - Thursday 11th September 2025 The course will run from 9:00am to 6:00pm BST (GMT+1) on the first day and from 9:30am to 5:00pm on the next two days.  In-person (University of York...
www.york.ac.uk

amancayork.bsky.social
Andrea Manca @amancayork.bsky.social · Jun 4
📊Unlock the power of data!📊

Join the Statistical Methods in Economic Evaluation for HTA - Advanced short course at the University of York🚀

📅 9-11 September 2025
📍 York, UK

Secure your spot today! 🔗 york.ac.uk/che/courses/st…#DataSciencece#HealthEconomicsc#HTAT#CEAEA
https://york.ac.uk/che/courses/st…

amancayork.bsky.social
Andrea Manca @amancayork.bsky.social · May 30
This work is the result of research collaboration between the Universities of York and Sheffield.

amancayork.bsky.social
Andrea Manca @amancayork.bsky.social · May 30
and another one my colleagues recently presented a report to the German parliament on pharmaceutical pricing.

www.york.ac.uk/che/news/nil...
Professor Nils Gutacker presents report on pharmaceutical pricing to German parliament
Recommendations for fair pricing of innovative products
www.york.ac.uk

amancayork.bsky.social
Andrea Manca @amancayork.bsky.social · May 30
Another piece of research asked “How much should the NHS pay for new drugs when they are used to treat more than one condition?” eepru.sites.sheffield.ac.uk/eepru2-proje...
Pricing models for multi-indication drugs in the UK NHS
Pricing models for multi-indication drugs in the UK NHS
eepru.sites.sheffield.ac.uk

amancayork.bsky.social
Andrea Manca @amancayork.bsky.social · May 30
One of these answer the question “how should we reward pharmaceutical innovation?” www.york.ac.uk/media/che/Ho...
www.york.ac.uk

amancayork.bsky.social
Andrea Manca @amancayork.bsky.social · May 30
interesting article by
@investigate-europe.eu on the price of drugs in the EU, heterogeneity of access across countries and how to negotiate with Pharma www.europeanpressprize.com/article/dead.... Colleagues in York have made important scientific contributions to inform possible negotiations.
Deadly Prices - How Big Pharma Feeds Inequality in Europe - European Press Prize
She is only three years old, but the process is as routine as if she had done it thousands of times before. On this far too warm spring day, Milda, a little girl with a short ponytail, puts on the pin...
www.europeanpressprize.com

Reposted by Andrea Manca

ai.nejm.org
NEJM AI @ai.nejm.org · May 22
This article analyzes how nonexperts perceive AI-generated medical advice, finding that it is often rated as accurate as — or better than — doctor responses, raising concerns about overreliance and potential harm from incorrect guidance. Full article: nejm.ai/43xKDG0

#AI #MedSky #MLSky
People Overtrust AI-Generated Medical Advice despite Low Accuracy
This article presents a comprehensive analysis of how artificial intelligence (AI)–generated medical responses are perceived and evaluated by nonexperts. We conducted a study in which a total of 30...
nejm.ai

amancayork.bsky.social
Andrea Manca @amancayork.bsky.social · May 17
Delighted to offer our residential 3-day course on Statistical Methods in Economic Evaluation for HTA: Advanced Course: September 9-11, 2025!

Now with an updated program including modern methods for causal inference and machine learning.

www.york.ac.uk/che/courses/...
Statistical Methods in Economic Evaluation for HTA - Advanced
Dates - Tuesday 9th - Thursday 11th September 2025 The course will run from 9:00am to 6:00pm BST (GMT+1) on the first day and from 9:30am to 5:00pm on the next two days.  In-person (University of York...
www.york.ac.uk

Reposted by Andrea Manca

aarontay.bsky.social
Aaron Tay @aarontay.bsky.social · Apr 19
[Read] LLM-based relevance assessment still can’t replace
human relevance assessment arxiv.org/pdf/2412.17156. Really interesting paper, challenging the recent idea that one can use LLLM-based relevance assessments to replace human judgements as gold standard,

amancayork.bsky.social
Andrea Manca @amancayork.bsky.social · Mar 25
We are looking to recruit two Research Fellows - Grade 6/7, to work within the Economic Evaluation and Health Technology Assessment team within CHE. Closing Date - 27th April 2025. For further details, visit jobs.york.ac.uk/vacancy/rese...
Jobs - The University of York
jobs.york.ac.uk

amancayork.bsky.social
Andrea Manca @amancayork.bsky.social · Mar 2
'York would be a different city without Rowntree' www.bbc.com/news/article...
How chocolate entrepreneur's values shaped York
Joseph Rowntree's legacy lives on in city where his factory was, 100 years after his death.
www.bbc.com

Reposted by Andrea Manca

erictopol.bsky.social
Eric Topol @erictopol.bsky.social · Feb 27
New example of opportunistic A.I. in medicine
Get a liver diagnosis from an echocardiogram
ai.nejm.org/doi/full/10....
@cedarssinai.bsky.social @ai.nejm.org
Opportunistic Screening of Chronic Liver Disease with Deep-Learning–Enhanced Echocardiography
Chronic liver disease (CLD) affects more than 1.5 billion adults, most of whom are asymptomatic and undiagnosed. Echocardiography is broadly performed and visualizes the liver, but this information...
ai.nejm.org

Reposted by Andrea Manca

Andrew Gelman et al. @statmodeling.bsky.social · Feb 22
“Why don’t machine learning and large language model evaluations report uncertainty?”
statmodeling.stat.columbia.edu/2025/02/22/w...
“Why don’t machine learning and large language model evaluations report uncertainty?” | Statistical Modeling, Causal Inference, and Social Science
statmodeling.stat.columbia.edu

amancayork.bsky.social
Andrea Manca @amancayork.bsky.social · Feb 21
Delighted to offer our residential 3-day course on Statistical Methods in Economic Evaluation for Health Technology Assessment: Advanced Course: September 9-11, 2025!

Discover more at: lnkd.in/eY6UCP_W

Now with an updated program including modern methods for causal inference and machine learning.
HealthEconomics.com | A Scientist.com Company on LinkedIn: The Centre for Health Economics University of York is delighted to offer…
The Centre for Health Economics University of York is delighted to offer its residential 3-day short course on Statistical Methods in Economic Evaluation for…
www.linkedin.com

amancayork.bsky.social
Andrea Manca @amancayork.bsky.social · Feb 21
Evaluation of Medical Devices for Product Development and Health Technology Assessment Course

Date - 7th-9th October 2025
Course Leader - Dr Cynthia Iglesias

You can find further details of the course on the University of York website: bit.ly/41lx4cb
Centre for Health Economics on LinkedIn: 📚 Evaluation of Medical Devices for Product Development and Health…
📚 Evaluation of Medical Devices for Product Development and Health Technology Assessment Course Date - 7th-9th October 2025 Course Leader - Dr Cynthia…
www.linkedin.com

Reposted by Andrea Manca

p-hunermund.com
Paul Hünermund @p-hunermund.com · Feb 21
This is a great paper by Mitsuru Igami framing breakthrough AI algorithms in the familiar logic of structural economic model estimation. doi.org/10.1093/ectj...

But by implication, if structural models behave like board games, such as Chess and Go, how high can their degree of realism really be?

Reposted by Mariacristina De Nardi, Andrea Manca

erictopol.bsky.social
Eric Topol @erictopol.bsky.social · Feb 19
Our lifestyle and environmental exposures are the predominant influencers of healthy aging and premature mortality, compared with polygenic risk, in the first comprehensive assessment
www.nature.com/articles/s41...
open-access
Integrating the environmental and genetic architectures of aging and mortality - Nature Medicine
Based on a systematic analysis of environmental exposures associated with aging and mortality in the UK Biobank, the relative contributions of such exposures and genetic risk for mortality and a range...
www.nature.com

Reposted by Kent Buse, Andrea Manca, Heidi Stöckl

martinmckee.bsky.social
Martin McKee @martinmckee.bsky.social · Jan 28
To our many American friends. The National Academies have assembled a package of resources for researchers facing threats or attacks in the US

www.nationalacademies.org/chr/resource...
www.nationalacademies.org

Reposted by Andrea Manca

profjohndrury.bsky.social
John Drury @profjohndrury.bsky.social · Jan 24
'In an unprecedented move, research-grant reviews have been suspended indefinitely at the world’s largest public funder of biomedical research.'

www.nature.com/articles/d41...
‘Never seen anything like this’: Trump’s team halts NIH meetings and travel
In an unprecedented move, research-grant reviews have been suspended indefinitely at the world’s largest public funder of biomedical research.
www.nature.com

amancayork.bsky.social
Andrea Manca @amancayork.bsky.social · Jan 24
jamanetwork.com/journals/jam...
Evidence Lacking for Many AI Tools Used in Primary Care
This Medical News article is an interview with study author María Villalobos-Quesada, PhD, a researcher at the National eHealth Living Lab at the Leiden University Medical Centre in the Netherlands.
jamanetwork.com

Reposted by Andrea Manca

madhupai.bsky.social
Madhu Pai, MD, PhD @madhupai.bsky.social · Jan 14
Designing effective training programs for applied mathematical modeling

speakingofmedicine.plos.org/2025/01/14/d...
Designing effective training programs for applied mathematical modeling
Applied modeling is a highly cross-disciplinary field, requiring a unique mixture of hard skills, soft skills, and domain knowledge. Successful training programs are those that include hands-on simult...
speakingofmedicine.plos.org