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NEJM AI
@ai.nejm.org
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NEJM AI, a new monthly journal from the publisher of @nejm.org, explores the cutting-edge applications of artificial intelligence and machine learning in clinical medicine. Online at ai.nejm.org.
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NEJM AI @ai.nejm.org · 9d
In the latest episode of the AI Grand Rounds podcast, Dr. Zak Kohane, editor-in-chief of NEJM AI, explains why this year’s advances in #AI were personal, why it’s spreading fast, and why its most profound theme is values. Full episode: nejm.ai/ep37

#MedSky #MLSky
AI Grand Rounds Episode 37 What Values Are in AI? A Conversation with Dr. Zak Kohane A photo of Dr. Kohane
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Review Article by Soojin Park, MD, Yanwei Li, MS, and Murad Megjhani, PhD: Physiological Signals Boosted by Artificial Intelligence Save Time and Brain Function nejm.ai/4pu5OBD

#AI #MedSky #NeuroSky
Figure 1. Physiological Device Data Sources for Machine Learning Applications in Neurocritical Care. Figure 2. Case 1: Computed Tomography Scan of the Brain on Admission Showing Thick Diffuse Blood (A), Intraventricular Hemorrhage (B), and Hydrocephalus (C). Figure 3. Case 1: Postbleed Day 3.
December 26, 2025 at 1:45 PM
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#AI turned hours into minutes. Dr. Zak Kohane describes how he built his own EHR — showing clinicians what true augmentation looks like on NEJM AI Grand Rounds. Hear more from Dr. Kohane: nejm.ai/ep37

#MedSky #MLSky
December 25, 2025 at 1:30 PM
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A new article presents the development and silent prospective validation of Smart Match, a machine-learning system designed to predict patient-specific perioperative blood transfusion needs. Learn more about this system: nejm.ai/3KAaTc9

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Figure 3. Smart Match Performance on Prospective Data at Different Time Points Relative to Anesthesia Start.
December 24, 2025 at 1:30 PM
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A new study introduces a self-supervised electrocardiogram transformer foundation model that achieves high diagnostic accuracy across multiple cardiac prediction tasks, expanding AI’s potential in complex diagnostic areas. Learn more: nejm.ai/3XvciUi

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Figure 1. Chest Pain Encounters in the United States and Available Noninvasive Testing Modalities.
December 23, 2025 at 2:30 PM
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Original Article by P.J. Lukac et al.: Ambient AI Scribes in Clinical Practice: A Randomized Trial nejm.ai/3MwD0cJ 

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Figure 1. CONSORT-AI Flow Diagram
December 22, 2025 at 6:26 PM
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Perspective by Bilal Irfan, MS, J. Wesley Boyd, MD, PhD, and Roberto Daniel Sirvent, JD, PhD: When Protecting Privacy Means Protecting Health: Foreseeable Health Harms of AI Language Translation and Interpretation Technologies for Immigrant Patients nejm.ai/49PrjYr

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Page 1 of the Perspective "When Protecting Privacy Means Protecting Health: Foreseeable Health Harms of AI Language Translation and Interpretation Technologies for Immigrant Patients" Read the full article at ai.nejm.org.
December 22, 2025 at 2:01 PM
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Editorial by A.K. Manrai et al.: Accelerating Science with Human+AI Review nejm.ai/4rut6bD

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Page 1 of the editorial "Accelerating Science with Human+AI Review" Read the full editorial at ai.nejm.org.
December 19, 2025 at 8:13 PM
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Policy Corner by A. Poddar et al.: Leveraging Artificial Intelligence in Drug and Biological Product Development: An FDA and Clinical Trial Transformation Initiative Workshop Report nejm.ai/4piY05C

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Figure 1. Challenges Associated with the Integration of AI Technology in Drug Development. Figure 2. Recommended Next Steps for the Interested Parties to Successfully Integrate AI in Drug Development.
December 19, 2025 at 2:40 PM
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Editorial by Eileen Kim, MD, Vincent X. Liu, MD, MSc, and Karandeep Singh, MD, MMSc: AI Scribes Are Not Productivity Tools (Yet) nejm.ai/48aLhvx

@kdpsingh.bsky.social #AI #MedSky #MLSky
Page 1 of the editorial "AI Scribes Are Not Productivity Tools (Yet)" Read the full editorial at ai.nejm.org.
December 18, 2025 at 5:20 PM
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This article analyzes how current reimbursement mechanisms hinder the adoption of clinically effective and regulated #AI tools in health care, despite rapid technological progress. Read the full article: nejm.ai/44DVaiY

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Figure 1. The Timeline and Major Reimbursement Events in a Few Health AI Domains with U.S. Food and Drug Administration–Approved Products.
December 18, 2025 at 1:40 PM
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Original Article by M. Afshar et al.: A Pragmatic Randomized Controlled Trial of Ambient Artificial Intelligence to Improve Health Practitioner Well-Being nejm.ai/4onek3X

@majeans2011.bsky.social #AI #MedSky #MLSky
Figure 2. Trial-Averaged Effect of Ambient AI on Primary Outcome of Professional Well-Being (Subcomponents with Professional Fulfillment and Work Exhaustion/Interpersonal Disengagement [Burnout]). Figure 3. Forest Plot for Time-on-Treatment Effect on Primary Outcome of Professional Well-Being (Subcomponents of Professional Fulfillment and Burnout).
December 17, 2025 at 6:41 PM
ai.nejm.org
In the latest episode of the AI Grand Rounds podcast, Dr. Zak Kohane, editor-in-chief of NEJM AI, explains why this year’s advances in #AI were personal, why it’s spreading fast, and why its most profound theme is values. Full episode: nejm.ai/ep37

#MedSky #MLSky
AI Grand Rounds Episode 37 What Values Are in AI? A Conversation with Dr. Zak Kohane A photo of Dr. Kohane
December 17, 2025 at 3:30 PM
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In a new trial evaluating two LLM-powered ambient #AI scribes on a sample of 238 outpatient physicians, one of the tools modestly reduced the time spent writing notes, while both showed potential to improve burnout and task load. Full trial results: nejm.ai/3MwD0cJ

#MedSky #MLSky
Figure 1. CONSORT-AI Flow Diagram
December 16, 2025 at 5:29 PM
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A new Perspective examines the unique challenges of drug development for rare, ultrarare, and hyper-rare diseases, and it highlights strategies to address these obstacles with the advent of AI. Read the full Perspective: nejm.ai/4peikVF

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“More focused collaborative efforts will be essential to address the unique scientific, regulatory, and policy issues associated with the integration of AI into the rare disease space in order to expand the number of effective therapeutic options for patients.” Perspective “Mitigating Limited Data Challenges to Improve Artificial Intelligence Integration in Rare Disease Drug Development” by A. Poddar et al.
December 16, 2025 at 3:39 PM
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The authors of a new editorial describe the invitation-only “Fast Track” process used to review two trials of ambient AI scribes and emphasize the central role of human judgment and values while using AI to accelerate science. Full editorial: nejm.ai/4rut6bD

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“We are encouraged by our first experiences using AI to generate reviews for NEJM AI articles and are proud to publish both randomized controlled trials by Afshar et al. and Lukac et al.” Editorial “Accelerating Science with Human+AI Review” by A.K. Manrai et al.
December 15, 2025 at 6:33 PM
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#AI doesn’t just err — it scales errors. On NEJM AI Grand Rounds, Dr. Laura Zwaan explains why collaboration between humans and machines is the only safeguard. Learn more: nejm.ai/ep36

#MedSky #MLSky
December 15, 2025 at 2:37 PM
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The authors of a new editorial write that #AI scribes for clinical practice show early promise for improved productivity and lay out the conditions under which these tools may substantially improve productivity in the future. Read the full editorial: nejm.ai/48aLhvx

@kdpsingh.bsky.social
“Since AI scribes already have access to the full breadth of clinic visit conversations, they can readily reference shared clinical decision-making and treatment plans, which is valuable context for drafting medical orders and handling prior authorizations.” Editorial “AI Scribes Are Not Productivity Tools (Yet)” by Eileen Kim, M.D., Vincent X. Liu, M.D., M.Sc., and Karandeep Singh, M.D., M.M.Sc.
December 12, 2025 at 8:17 PM
Reposted by NEJM AI
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In a new Perspective, Ziad Obermeyer, MD, writes that today, medical research builds up an understanding of the whole from molecular parts, but #ArtificialIntelligence can revive an approach building down from patient-level data to theory and understanding. Learn more: nej.md/4rWYakP
"Massive datasets of laboratory results and vital signs are pointing to mysterious 'set points' in individual patients’ physiology, with large implications for mortality." Perspective "Bedside to Bench — AI and the New Science of Medicine" by Ziad Obermeyer, M.D.
December 12, 2025 at 5:03 PM
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Drawing on 3 cases, the authors of a new review show how AI-assisted monitoring might enhance decision-making for delayed cerebral ischemia, seizure detection & physiologic trend analysis while outlining the challenges of safely integrating these tools. nejm.ai/4pu5OBD

#AI #MedSky #NeuroSky
Figure 1. Physiological Device Data Sources for Machine Learning Applications in Neurocritical Care.
December 12, 2025 at 1:45 PM
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A new article synthesizes key insights from the Artificial Intelligence in Drug and Biological Product Development workshop and discusses the emerging need for policy development to enhance the integration of #AI in drug and biological product development. nejm.ai/4piY05C

#MedSky #MLSky
Figure 1. Challenges Associated with the Integration of AI Technology in Drug Development.
December 11, 2025 at 4:31 PM
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Humans and machines make the same mistakes — just for different reasons. On NEJM AI Grand Rounds, Dr. Laura Zwaan discusses bias, cognition, and #AI. Full episode: nejm.ai/ep36

#MedSky #MLSky
December 11, 2025 at 1:31 PM
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A new Perspective seeks to indicate how the lack of security in #AI platforms may increase risk in clinical settings, particularly when these tools are used for translation or when patients share sensitive information. Read the full Perspective: nejm.ai/49PrjYr

#MedSky #MLSky
Perspective For undocumented patients whose sociolegal precarity renders information itself a liability, ensuring that confidentiality is maintained is not an abstract ethical principle separable from outcomes — it is a prophylactic intervention. “When Protecting Privacy Means Protecting Health: Foreseeable Health Harms of AI Language Translation and Interpretation Technologies for Immigrant Patients” by Bilal Irfan, M.S., J. Wesley Boyd, M.D., Ph.D., and Roberto Daniel Sirvent, J.D., Ph.D.
December 10, 2025 at 5:15 PM
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In a new study, Afshar and colleagues demonstrate that for health care practitioners, ambient #AI can meaningfully reduce burnout and time spent on notes without compromising documentation quality or billing accuracy. Full study results: nejm.ai/4onek3X

@majeans2011.bsky.social #MedSky #MLSky
A doctor and patient sit facing each other with speech bubbles, conveying conversation. Digital health data overlays represent ambient AI passively capturing the conversation and drafting notes. Original Article | Nov 26, 2025 A Pragmatic Randomized Controlled Trial of Ambient Artificial Intelligence to Improve Health Practitioner Well-Being M. Afshar and Others
December 10, 2025 at 1:30 PM
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Akbarialiabad and colleagues reply to a Letter to the Editor about their Perspective “The Utility of Generative AI in Advancing Global Health.” Read the full response: nejm.ai/43FYYzN

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Page 1 of the letter "Response: Enforceable Safeguards — Verification, Deterrence, and LMIC Agency in Generative AI; A Reply to Rizzo et al." Bottom: Read the full letter at ai.nejm.org.
December 9, 2025 at 3:04 PM
Reposted by NEJM AI
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The editors announce the launch of NEJM Clinician, a new digital publication for clinicians, by clinicians. Read the editorial: nej.md/4roG5vK

#MedSky
Editorial NEJM Clinician — Finding the Medicine That Matters in an Age of Infinite Evidence An illustration of clinicians searching through a tall haystack representing "new medical information."
December 8, 2025 at 3:07 PM