Aaron and the Hoskins Lab at UW Madison
@uwmadisonrna.bsky.social
Interested in science, RNA, splicing, and single molecule biophysics.
Reposted by Aaron and the Hoskins Lab at UW Madison
Fantastic opportunity for undergraduates pursuing summer research experience! @hhmi.org
Calling all rising juniors & seniors: Interested in biological or biomedical research? Applications for our ’26 Summer Undergraduate Research Experience Program are now open! Nine weeks, hands-on research, & mentorship from some of the nation’s top scientists — learn more: bit.ly/CechFellows
Summer Undergraduate Research Experience | HHMI
The Cech Fellows Program is a paid, nine-week summer research experience empowering the next generation of scientific leaders.
bit.ly
November 21, 2025 at 6:24 PM
Fantastic opportunity for undergraduates pursuing summer research experience! @hhmi.org
Reposted by Aaron and the Hoskins Lab at UW Madison
The Vienna BioCenter Summer School 2026 call is now open for talented undergrads, it's a great opportunity for students who are interested in graduate study in the life sciences. Christa Buecker from Max Perutz Labs Vienna is recruiting! Please share
https://training.vbc.ac.at/summer-school/
https://training.vbc.ac.at/summer-school/
November 21, 2025 at 12:53 PM
The Vienna BioCenter Summer School 2026 call is now open for talented undergrads, it's a great opportunity for students who are interested in graduate study in the life sciences. Christa Buecker from Max Perutz Labs Vienna is recruiting! Please share
https://training.vbc.ac.at/summer-school/
https://training.vbc.ac.at/summer-school/
And here's a follow-up on the limits of biological, magnetic compasses (of the iron protein variety)
elifesciences.org/articles/17210
elifesciences.org/articles/17210
Physical limits to magnetogenetics
Recent reports on the ability of biological molecules to sense magnetic fields are found to be inconsistent with basic physical principles.
elifesciences.org
November 21, 2025 at 12:55 PM
And here's a follow-up on the limits of biological, magnetic compasses (of the iron protein variety)
elifesciences.org/articles/17210
elifesciences.org/articles/17210
New work from the Green and Beckmann labs on how ZAK recognizes collided ribosomes.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
ZAK activation at the collided ribosome - Nature
The kinase ZAK is activated at collided ribosomes to mediate the ribotoxic stress response.
www.nature.com
November 20, 2025 at 3:58 PM
New work from the Green and Beckmann labs on how ZAK recognizes collided ribosomes.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Aaron and the Hoskins Lab at UW Madison
shared the @andyfraser.bsky.social smol-seq paper with some colleagues recently. it's a powerful conceptual advance that could open up a new branch of genomics, slotting nicely alongside advances in single-cell and spatial omics. check it out! www.nature.com/articles/s41...
Quantifying metabolites using structure-switching aptamers coupled to DNA sequencing - Nature Biotechnology
Metabolites can be quantified using a combination of aptamers and DNA barcodes.
www.nature.com
November 17, 2025 at 7:12 PM
shared the @andyfraser.bsky.social smol-seq paper with some colleagues recently. it's a powerful conceptual advance that could open up a new branch of genomics, slotting nicely alongside advances in single-cell and spatial omics. check it out! www.nature.com/articles/s41...
Reposted by Aaron and the Hoskins Lab at UW Madison
Deferred payment option for federal employees
ASBMB is continuing to offer a deferred payment option for #ASBMB26 abstract submissions. Submit now and pay once normal administrative processes catch up.
✅Learn more and submit your abstract by today's deadline: www.asbmb.org/annual-meeti....
ASBMB is continuing to offer a deferred payment option for #ASBMB26 abstract submissions. Submit now and pay once normal administrative processes catch up.
✅Learn more and submit your abstract by today's deadline: www.asbmb.org/annual-meeti....
Abstracts
www.asbmb.org
November 17, 2025 at 9:33 PM
Deferred payment option for federal employees
ASBMB is continuing to offer a deferred payment option for #ASBMB26 abstract submissions. Submit now and pay once normal administrative processes catch up.
✅Learn more and submit your abstract by today's deadline: www.asbmb.org/annual-meeti....
ASBMB is continuing to offer a deferred payment option for #ASBMB26 abstract submissions. Submit now and pay once normal administrative processes catch up.
✅Learn more and submit your abstract by today's deadline: www.asbmb.org/annual-meeti....
@asbmb.bsky.social 2026 meeting abstract deadline is TODAY!
Submit your abstract by 11:59 p.m. EST. Share your research with thousands of researchers using biochemistry and molecular biology to transform our understanding of the world.
www.asbmb.org/annual-meeti...
Submit your abstract by 11:59 p.m. EST. Share your research with thousands of researchers using biochemistry and molecular biology to transform our understanding of the world.
www.asbmb.org/annual-meeti...
Abstracts
www.asbmb.org
November 17, 2025 at 4:54 PM
@asbmb.bsky.social 2026 meeting abstract deadline is TODAY!
Submit your abstract by 11:59 p.m. EST. Share your research with thousands of researchers using biochemistry and molecular biology to transform our understanding of the world.
www.asbmb.org/annual-meeti...
Submit your abstract by 11:59 p.m. EST. Share your research with thousands of researchers using biochemistry and molecular biology to transform our understanding of the world.
www.asbmb.org/annual-meeti...
Reposted by Aaron and the Hoskins Lab at UW Madison
The regular abstract deadline for the 2026 ASBMB Annual Meeting is just two days away!
☑️ Submit your abstract by Nov. 17 to share the impact of your research: l.feathr.co/ESm5YGn8....
☑️ Submit your abstract by Nov. 17 to share the impact of your research: l.feathr.co/ESm5YGn8....
November 15, 2025 at 1:00 PM
The regular abstract deadline for the 2026 ASBMB Annual Meeting is just two days away!
☑️ Submit your abstract by Nov. 17 to share the impact of your research: l.feathr.co/ESm5YGn8....
☑️ Submit your abstract by Nov. 17 to share the impact of your research: l.feathr.co/ESm5YGn8....
@juliebiteenlab.bsky.social is moving into the RNA world now!!!
Now in print: @lortzrodz.bsky.social with @schraderlab.bsky.social found that the stress-induced transition of the material properties of bacterial ribonucleoprotein bodies repurposes them from sites of mRNA decay to reservoirs for mRNA storage.
@natcomms.nature.com
www.nature.com/articles/s41...
@natcomms.nature.com
www.nature.com/articles/s41...
Stress changes the material state of a bacterial biomolecular condensate and shifts its function from mRNA decay to storage - Nature Communications
Bacterial ribonucleoprotein bodies are dynamic biomolecular condensates that play roles in RNA metabolism. Here, Ortiz-Rodríguez et al. show that, under stress, these condensates shift from a liquid s...
www.nature.com
November 14, 2025 at 8:52 PM
@juliebiteenlab.bsky.social is moving into the RNA world now!!!
Awesome paper from Kathy Collins' lab
Different repair pathways support intact or truncated insertions by R2 retrotransposon protein | Science www.science.org/doi/10.1126/...
Different repair pathways support intact or truncated insertions by R2 retrotransposon protein | Science www.science.org/doi/10.1126/...
Different repair pathways support intact or truncated insertions by R2 retrotransposon protein
Non-LTR retrotransposon proteins copy their RNA template into a genome via coordinated nicking and reverse transcriptase activities of target-primed reverse transcription. Mechanisms by which the firs...
www.science.org
November 13, 2025 at 8:05 PM
Awesome paper from Kathy Collins' lab
Different repair pathways support intact or truncated insertions by R2 retrotransposon protein | Science www.science.org/doi/10.1126/...
Different repair pathways support intact or truncated insertions by R2 retrotransposon protein | Science www.science.org/doi/10.1126/...
Reposted by Aaron and the Hoskins Lab at UW Madison
Join us on Monday, Nov. 17 for the Paul Bertics Memorial Lecture, presented by William N. Pappano. Pappano is an alumnus of the Department of Biomolecular Chemistry and works at AbbVie. More info: today.wisc.edu/events/view/...
Biochemistry Colloquium & Bertics Lecture: William Pappano | UW–Madison Events Calendar
today.wisc.edu
November 12, 2025 at 3:46 PM
Join us on Monday, Nov. 17 for the Paul Bertics Memorial Lecture, presented by William N. Pappano. Pappano is an alumnus of the Department of Biomolecular Chemistry and works at AbbVie. More info: today.wisc.edu/events/view/...
Reposted by Aaron and the Hoskins Lab at UW Madison
RESEARCH PAPER: A kinetic ruler controls mRNA poly(A) tail length
By Gabs et al. and Matti Turtola
➡️ https://genesdev.cshlp.org/content/39/21-22/1377.full
#RNAprocessing #mRNA #polyadenylation #ribonucleoprotein #CPAC
By Gabs et al. and Matti Turtola
➡️ https://genesdev.cshlp.org/content/39/21-22/1377.full
#RNAprocessing #mRNA #polyadenylation #ribonucleoprotein #CPAC
November 12, 2025 at 4:01 PM
RESEARCH PAPER: A kinetic ruler controls mRNA poly(A) tail length
By Gabs et al. and Matti Turtola
➡️ https://genesdev.cshlp.org/content/39/21-22/1377.full
#RNAprocessing #mRNA #polyadenylation #ribonucleoprotein #CPAC
By Gabs et al. and Matti Turtola
➡️ https://genesdev.cshlp.org/content/39/21-22/1377.full
#RNAprocessing #mRNA #polyadenylation #ribonucleoprotein #CPAC
Reposted by Aaron and the Hoskins Lab at UW Madison
Are you an early-stage graduate student (2nd or 3rd year) or early-stage postdoc based in the US or Canada, working primarily in Drosophila? Would you like to help improve the experience of all trainees working in Drosophila research? If so, read on.
(Please repost to reach a broad audience.)
(Please repost to reach a broad audience.)
November 12, 2025 at 4:49 AM
Are you an early-stage graduate student (2nd or 3rd year) or early-stage postdoc based in the US or Canada, working primarily in Drosophila? Would you like to help improve the experience of all trainees working in Drosophila research? If so, read on.
(Please repost to reach a broad audience.)
(Please repost to reach a broad audience.)
Interesting paper, although if I'm going to be nit-picky--SF3B1 does not have catalytic activity (it is a RNA binding protein/protein scaffold). In addition, potential non-splicing roles for SF3B1 have been found elsewhere, e.g.,in histone pre-mRNA maturation
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
RNA splicing is required for timely completion of abscission and is modulated by the abscission checkpoint
The abscission checkpoint pauses the progression of cytokinetic abscission at the intercellular bridge when various checkpoint-sustaining errors are sensed. A unique cytoplasmic organelle, the absciss...
www.biorxiv.org
November 11, 2025 at 6:44 PM
Interesting paper, although if I'm going to be nit-picky--SF3B1 does not have catalytic activity (it is a RNA binding protein/protein scaffold). In addition, potential non-splicing roles for SF3B1 have been found elsewhere, e.g.,in histone pre-mRNA maturation
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Aaron and the Hoskins Lab at UW Madison
Beautiful review from J. Rudolph on Histone PARylation factor 1: a review of its role in the DNA damage response url: academic.oup.com/nar/article/...
Histone PARylation factor 1: a review of its role in the DNA damage response
Abstract. Although poly-(ADP ribose) polymerase 1 (PARP1) and PARylation of histones have been known for over 50 years and have been successfully targeted
academic.oup.com
November 11, 2025 at 2:49 PM
Beautiful review from J. Rudolph on Histone PARylation factor 1: a review of its role in the DNA damage response url: academic.oup.com/nar/article/...
Reposted by Aaron and the Hoskins Lab at UW Madison
I am pleased to present our latest pre-print describing our identification of the long-sought triggers for target-directed microRNA degradation (TDMD) of miR-322 and miR-503, work led by Collette LaVigne and Jaeil Han. For more info, read on! 👇
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Plagl1 and Lrrc58 control mammalian body size by triggering target-directed microRNA degradation of miR-322 and miR-503
Precise control of microRNA (miRNA) expression is critical during development. An important mechanism of miRNA regulation is target-directed microRNA degradation (TDMD), a pathway in which the binding...
www.biorxiv.org
July 2, 2025 at 4:17 PM
I am pleased to present our latest pre-print describing our identification of the long-sought triggers for target-directed microRNA degradation (TDMD) of miR-322 and miR-503, work led by Collette LaVigne and Jaeil Han. For more info, read on! 👇
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Aaron and the Hoskins Lab at UW Madison
Congratulations to all authors! Happy to have contributed to the cryo-EM side. It was a lot of fun learning more about the herpesvirus DNA replication process and how clinical drugs inhibit it 🦠💊. Big thanks to @cijilim.bsky.social and Tahir for the support!
New work from Tahirov x Lim collaboration! @qixianghe.bsky.social from my lab contributed the cryo-EM structures for this work. We are excited to help explain how anti-HSV drugs work and to guide their future development.
www.science.org/doi/10.1126/...
@unmc.bsky.social @uwbiochem.bsky.social
www.science.org/doi/10.1126/...
@unmc.bsky.social @uwbiochem.bsky.social
Structural basis of herpesvirus helicase-primase inhibition by pritelivir and amenamevir
Structural studies of HSV-1 helicase-primase revealed how pritelivir and amenamevir bind and block its helicase activity.
www.science.org
November 10, 2025 at 2:49 AM
Congratulations to all authors! Happy to have contributed to the cryo-EM side. It was a lot of fun learning more about the herpesvirus DNA replication process and how clinical drugs inhibit it 🦠💊. Big thanks to @cijilim.bsky.social and Tahir for the support!
Reposted by Aaron and the Hoskins Lab at UW Madison
Control of gene output by intron RNA structure https://www.biorxiv.org/content/10.1101/2025.11.08.687378v1
November 10, 2025 at 3:46 AM
Control of gene output by intron RNA structure https://www.biorxiv.org/content/10.1101/2025.11.08.687378v1
Reposted by Aaron and the Hoskins Lab at UW Madison
Very proud of our recently published work in @narjournal.bsky.social led by senior PhD candidate Julia Warrick. #RNA
academic.oup.com/nar/article/...
academic.oup.com/nar/article/...
An autism spectrum disorder mutation in Topoisomerase 3β causes accumulation of covalent mRNA intermediates by disrupting metal binding within the zinc finger domain
Abstract. The loss and mutation of Topoisomerase 3β (TOP3B), the only known eukaryotic topoisomerase with the ability to catalyze RNA strand passage reacti
academic.oup.com
November 10, 2025 at 12:21 AM
Very proud of our recently published work in @narjournal.bsky.social led by senior PhD candidate Julia Warrick. #RNA
academic.oup.com/nar/article/...
academic.oup.com/nar/article/...
Reposted by Aaron and the Hoskins Lab at UW Madison
Reposted by Aaron and the Hoskins Lab at UW Madison
In immunocompromised people, fungal infections can result in serious illness and even death. New research from @uwmadisonrna.bsky.social's group suggests a promising avenue for treating harmful infections by inhibiting pre-mRNA splicing. Read more: biochem.wisc.edu/2025/11/04/r...
Research Follow-up: Preventing Fungal Infections
New research from the Hoskins and Hull Labs points to a promising new avenue for treating harmful fungal infections.
biochem.wisc.edu
November 10, 2025 at 2:32 PM
In immunocompromised people, fungal infections can result in serious illness and even death. New research from @uwmadisonrna.bsky.social's group suggests a promising avenue for treating harmful infections by inhibiting pre-mRNA splicing. Read more: biochem.wisc.edu/2025/11/04/r...
Reposted by Aaron and the Hoskins Lab at UW Madison
Applications are open for the NIH-sponsored undergraduate Research Opportunities HIV RNA (ROHR) program for Summer 2026. Successful applicants will get to carry out a research project at a major university and attend a conference at the NIH. Please spread the word!
sites.google.com/a/umich.edu/...
sites.google.com/a/umich.edu/...
November 10, 2025 at 3:47 PM
Applications are open for the NIH-sponsored undergraduate Research Opportunities HIV RNA (ROHR) program for Summer 2026. Successful applicants will get to carry out a research project at a major university and attend a conference at the NIH. Please spread the word!
sites.google.com/a/umich.edu/...
sites.google.com/a/umich.edu/...
Reposted by Aaron and the Hoskins Lab at UW Madison
Cool new bioorthogonal reaction: malononitrile addition to azodicarboxylate
www.nature.com/articles/s41...
www.nature.com/articles/s41...
A catalyst-free bioorthogonal reaction for malononitrile addition to azodicarboxylates - Nature Communications
Developing bioorthogonal reactions that enable investigation of biological processes is an important aim in chemical biology. Here, the authors report the malononitrile addition to azodicarboxylate (M...
www.nature.com
November 9, 2025 at 5:14 PM
Cool new bioorthogonal reaction: malononitrile addition to azodicarboxylate
www.nature.com/articles/s41...
www.nature.com/articles/s41...