UW–Madison Department of Biochemistry
@uwbiochem.bsky.social
Official Bluesky account of the world-renowned biochemistry research & teaching department at UW–Madison.
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Biochemistry at UW–Madison
YouTube video by UW-Madison Department of Biochemistry
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Scientists @uwbiochem.bsky.social are doing innovative research that positively impacts everything from human health to environmental sustainability by exploring the forms, functions, and interactions of biomolecules. Learn more in our new video: www.youtube.com/watch?v=FdJh...
In July 2026, Department Chair Brian Fox will begin a six month fellowship at the Stellenbosch Institute for Advanced Study. As a Fellow, Fox will bring his knowledge of enzyme function and structure to enhance capabilities for pandemic preparedness. Read more: biochem.wisc.edu/2025/11/06/f...
Fox Receives Stellenbosch Institute for Advanced Study Fellowship
Fox's residency at STIAS will combine their expertise in genome sequencing with his knowledge of enzyme function and AlphaFold structure prediction.
biochem.wisc.edu
November 13, 2025 at 5:18 PM
In July 2026, Department Chair Brian Fox will begin a six month fellowship at the Stellenbosch Institute for Advanced Study. As a Fellow, Fox will bring his knowledge of enzyme function and structure to enhance capabilities for pandemic preparedness. Read more: biochem.wisc.edu/2025/11/06/f...
Join us on Monday, Nov. 17 for the Paul Bertics Memorial Lecture, presented by William N. Pappano. Pappano is an alumnus of the Department of Biomolecular Chemistry and works at AbbVie. More info: today.wisc.edu/events/view/...
Biochemistry Colloquium & Bertics Lecture: William Pappano | UW–Madison Events Calendar
today.wisc.edu
November 12, 2025 at 3:46 PM
Join us on Monday, Nov. 17 for the Paul Bertics Memorial Lecture, presented by William N. Pappano. Pappano is an alumnus of the Department of Biomolecular Chemistry and works at AbbVie. More info: today.wisc.edu/events/view/...
In immunocompromised people, fungal infections can result in serious illness and even death. New research from @uwmadisonrna.bsky.social's group suggests a promising avenue for treating harmful infections by inhibiting pre-mRNA splicing. Read more: biochem.wisc.edu/2025/11/04/r...
Research Follow-up: Preventing Fungal Infections
New research from the Hoskins and Hull Labs points to a promising new avenue for treating harmful fungal infections.
biochem.wisc.edu
November 10, 2025 at 2:32 PM
In immunocompromised people, fungal infections can result in serious illness and even death. New research from @uwmadisonrna.bsky.social's group suggests a promising avenue for treating harmful infections by inhibiting pre-mRNA splicing. Read more: biochem.wisc.edu/2025/11/04/r...
Reposted by UW–Madison Department of Biochemistry
New work from Tahirov x Lim collaboration! @qixianghe.bsky.social from my lab contributed the cryo-EM structures for this work. We are excited to help explain how anti-HSV drugs work and to guide their future development.
www.science.org/doi/10.1126/...
@unmc.bsky.social @uwbiochem.bsky.social
www.science.org/doi/10.1126/...
@unmc.bsky.social @uwbiochem.bsky.social
Structural basis of herpesvirus helicase-primase inhibition by pritelivir and amenamevir
Structural studies of HSV-1 helicase-primase revealed how pritelivir and amenamevir bind and block its helicase activity.
www.science.org
November 10, 2025 at 12:14 AM
New work from Tahirov x Lim collaboration! @qixianghe.bsky.social from my lab contributed the cryo-EM structures for this work. We are excited to help explain how anti-HSV drugs work and to guide their future development.
www.science.org/doi/10.1126/...
@unmc.bsky.social @uwbiochem.bsky.social
www.science.org/doi/10.1126/...
@unmc.bsky.social @uwbiochem.bsky.social
Join us on Nov. 10 for Biochemistry Colloquium with Barry Stoddard @fredhutch.org. The Stoddard Lab characterizes the structure/function relationships of enzymatic catalysts at the atomic level. More info: today.wisc.edu/events/view/...
Biochemistry Colloquium: Barry Stoddard | UW–Madison Events Calendar
today.wisc.edu
November 5, 2025 at 3:55 PM
Join us on Nov. 10 for Biochemistry Colloquium with Barry Stoddard @fredhutch.org. The Stoddard Lab characterizes the structure/function relationships of enzymatic catalysts at the atomic level. More info: today.wisc.edu/events/view/...
Reposted by UW–Madison Department of Biochemistry
RPA, long known for its role in DNA replication and repair, is now shown to boost telomerase activity!
Big congrats to @cijilim.bsky.social's lab for this milestone achievement!
Glad our lab (via Michael O’Connor) could contribute to this collaboration!
Big congrats to @cijilim.bsky.social's lab for this milestone achievement!
Glad our lab (via Michael O’Connor) could contribute to this collaboration!
Our paper in Science is out! @souravagrawal.bsky.social, @rlynn.bsky.social, @susvirkar.bsky.social, and the rest of the team show human RPA is a telomerase processivity factor essential for telomere maintenance. This reshapes our thinking about telomerase regulation. www.science.org/doi/10.1126/...
Human RPA is an essential telomerase processivity factor for maintaining telomeres
Telomerase counteracts telomere shortening by repeatedly adding DNA repeats to chromosome ends. We identified the replication protein A (RPA) heterotrimer as a telomerase processivity factor critical ...
www.science.org
November 1, 2025 at 7:15 PM
RPA, long known for its role in DNA replication and repair, is now shown to boost telomerase activity!
Big congrats to @cijilim.bsky.social's lab for this milestone achievement!
Glad our lab (via Michael O’Connor) could contribute to this collaboration!
Big congrats to @cijilim.bsky.social's lab for this milestone achievement!
Glad our lab (via Michael O’Connor) could contribute to this collaboration!
Reposted by UW–Madison Department of Biochemistry
New findings from @cijilim.bsky.social in @uwbiochem.bsky.social identify a protein essential to maintaining the end-caps on chromosomes — helping doctors around the world connect a genetic mutation to their patients' illnesses. biochem.wisc.edu/2025/10/30/r...
Researchers Link Mutations in RPA Protein to Cancer, Other Diseases
Researchers in the Lim Lab reveal that dysfunction in a protein essential to maintaining stability in our chromosomes may be responsible for serious diseases.
biochem.wisc.edu
October 30, 2025 at 9:32 PM
New findings from @cijilim.bsky.social in @uwbiochem.bsky.social identify a protein essential to maintaining the end-caps on chromosomes — helping doctors around the world connect a genetic mutation to their patients' illnesses. biochem.wisc.edu/2025/10/30/r...
Research from Professor Ci Ji Lim's (@cijilim.bsky.social) lab, published today in @science.org, could provide patients and doctors with new protein mutations to test for certain cancers and bone marrow diseases. Read more: biochem.wisc.edu/2025/10/30/r...
Researchers Link Mutations in RPA Protein to Cancer, Other Diseases
Researchers in the Lim Lab reveal that dysfunction in a protein essential to maintaining stability in our chromosomes may be responsible for serious diseases.
biochem.wisc.edu
October 30, 2025 at 7:35 PM
Research from Professor Ci Ji Lim's (@cijilim.bsky.social) lab, published today in @science.org, could provide patients and doctors with new protein mutations to test for certain cancers and bone marrow diseases. Read more: biochem.wisc.edu/2025/10/30/r...
Join us on Nov. 3 for the Green Lecture in Enzyme Chemistry, given by Karen Allen. The Allen Group investigates the structure, function, mechanisms of catalysis and evolution of enzymes. More info: today.wisc.edu/events/view/...
Biochemistry Colloquium & Green Lecture: Karen Allen | UW–Madison Events Calendar
today.wisc.edu
October 29, 2025 at 1:27 PM
Join us on Nov. 3 for the Green Lecture in Enzyme Chemistry, given by Karen Allen. The Allen Group investigates the structure, function, mechanisms of catalysis and evolution of enzymes. More info: today.wisc.edu/events/view/...
Today's seminar has been canceled. We apologize for any inconvenience!
Join us on Monday Oct. 27 for Biochemistry Colloquium with James Berger. The Berger Lab focuses on molecular mechanisms & cellular functions of multisubunit assemblies that control the organization, preservation & flow of genetic information. More info: today.wisc.edu/events/view/...
Biochemistry Colloquium: James Berger | UW–Madison Events Calendar
today.wisc.edu
October 27, 2025 at 3:30 PM
Today's seminar has been canceled. We apologize for any inconvenience!
Reposted by UW–Madison Department of Biochemistry
Happy to share our latest work, led by Sierra Love and in collaboration with Melissa Jurica's lab at UCSC and @danglab.bsky.social at U. Minnesota-Twin Cities. This work was funded by the Edward P. Evans Foundation/EvansMDS.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
A Yeast-Based High-Throughput Screening Platform for the Discovery of Novel pre-mRNA Splicing Modulators
Pre-mRNA splicing is a crucial process in eukaryotic gene expression, and splicing dysregulation has been linked to various diseases. However, very few small molecules have been discovered that can mo...
www.biorxiv.org
October 21, 2025 at 8:43 PM
Happy to share our latest work, led by Sierra Love and in collaboration with Melissa Jurica's lab at UCSC and @danglab.bsky.social at U. Minnesota-Twin Cities. This work was funded by the Edward P. Evans Foundation/EvansMDS.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Join us on Monday Oct. 27 for Biochemistry Colloquium with James Berger. The Berger Lab focuses on molecular mechanisms & cellular functions of multisubunit assemblies that control the organization, preservation & flow of genetic information. More info: today.wisc.edu/events/view/...
Biochemistry Colloquium: James Berger | UW–Madison Events Calendar
today.wisc.edu
October 23, 2025 at 1:01 PM
Join us on Monday Oct. 27 for Biochemistry Colloquium with James Berger. The Berger Lab focuses on molecular mechanisms & cellular functions of multisubunit assemblies that control the organization, preservation & flow of genetic information. More info: today.wisc.edu/events/view/...
Reposted by UW–Madison Department of Biochemistry
Andrea A. Putnam, a UW School of Medicine and Public Health assistant professor of biomolecular chemistry, has been named a 2025 Packard Foundation Fellow in Science and Engineering. Congratulations, Dr. Putnam!
Andrea Putnam awarded 2025 Packard Fellowship - School of Medicine and Public Health
www.med.wisc.edu
October 16, 2025 at 7:12 PM
Andrea A. Putnam, a UW School of Medicine and Public Health assistant professor of biomolecular chemistry, has been named a 2025 Packard Foundation Fellow in Science and Engineering. Congratulations, Dr. Putnam!
Biochemistry Colloquium on Oct. 20 will be given by Jessica Anna. The Anna Group studies the photochemistry and photophysics of natural light harvesting complexes, model systems and photocatalysts. More info: today.wisc.edu/events/view/...
Biochemistry Colloquium: Jessica Anna | UW–Madison Events Calendar
today.wisc.edu
October 15, 2025 at 4:09 PM
Biochemistry Colloquium on Oct. 20 will be given by Jessica Anna. The Anna Group studies the photochemistry and photophysics of natural light harvesting complexes, model systems and photocatalysts. More info: today.wisc.edu/events/view/...
Reposted by UW–Madison Department of Biochemistry
Hey, that's us! 😀
Join us on Monday Oct. 13 for Biochemistry Colloquium with Aaron Smith! Research in Smith's lab focuses on understanding the structure and function of metalloproteins involved in crucial biological processes. More info: today.wisc.edu/events/view/...
Biochemistry Colloquium: Aaron T. Smith | UW–Madison Events Calendar
today.wisc.edu
October 8, 2025 at 3:26 PM
Hey, that's us! 😀
Join us on Monday Oct. 13 for Biochemistry Colloquium with Aaron Smith! Research in Smith's lab focuses on understanding the structure and function of metalloproteins involved in crucial biological processes. More info: today.wisc.edu/events/view/...
Biochemistry Colloquium: Aaron T. Smith | UW–Madison Events Calendar
today.wisc.edu
October 8, 2025 at 1:38 PM
Join us on Monday Oct. 13 for Biochemistry Colloquium with Aaron Smith! Research in Smith's lab focuses on understanding the structure and function of metalloproteins involved in crucial biological processes. More info: today.wisc.edu/events/view/...
Reposted by UW–Madison Department of Biochemistry
The long-term goal of @cijilim.bsky.social's research group is to understand how mammalian telomeres safeguard the genome. #WARF100 @uwchancellor.bsky.social @uwbiochem.bsky.social https://www.warf.org/commercialize/uw-madison-inventor-profiles/ip_lim/
October 5, 2025 at 6:02 PM
The long-term goal of @cijilim.bsky.social's research group is to understand how mammalian telomeres safeguard the genome. #WARF100 @uwchancellor.bsky.social @uwbiochem.bsky.social https://www.warf.org/commercialize/uw-madison-inventor-profiles/ip_lim/
Join us on Oct. 6 for Biochemistry Colloquium with Brian Hie! @brianhie.bsky.social's lab conducts research at the intersection of biology and machine learning. This seminar is sponsored by Thermo Fisher Scientific. @hkws.bsky.social More info: today.wisc.edu/events/view/...
Biochemistry Colloquium: Brian Hie | UW–Madison Events Calendar
today.wisc.edu
October 1, 2025 at 1:13 PM
Join us on Oct. 6 for Biochemistry Colloquium with Brian Hie! @brianhie.bsky.social's lab conducts research at the intersection of biology and machine learning. This seminar is sponsored by Thermo Fisher Scientific. @hkws.bsky.social More info: today.wisc.edu/events/view/...
Reposted by UW–Madison Department of Biochemistry
Very excited about next week's RNA Maxigroup seminar from Kristen Lynch @upenn.edu ! Thanks to @rnasociety.bsky.social , @uwbiochem.bsky.social, and the CMB program for sponsoring!
September 29, 2025 at 7:16 PM
Very excited about next week's RNA Maxigroup seminar from Kristen Lynch @upenn.edu ! Thanks to @rnasociety.bsky.social , @uwbiochem.bsky.social, and the CMB program for sponsoring!
Reposted by UW–Madison Department of Biochemistry
Brian Fox studies enzymes and their functions, using synthetic biology techniques to discover new enzymes that can break down recalcitrant polysaccharides. #WARF100 @uwchancellor.bsky.social @uwbiochem.bsky.social https://www.warf.org/commercialize/uw-madison-inventor-profiles/ip_fox/
September 26, 2025 at 10:13 PM
Brian Fox studies enzymes and their functions, using synthetic biology techniques to discover new enzymes that can break down recalcitrant polysaccharides. #WARF100 @uwchancellor.bsky.social @uwbiochem.bsky.social https://www.warf.org/commercialize/uw-madison-inventor-profiles/ip_fox/
Join us for Biochemistry Colloquium on Sept. 29 with Dr. Nancy Sullivan. Sullivan is an international leader in viral immunology, emerging diseases prevention, and infectious disease research. More info: today.wisc.edu/events/view/...
Biochemistry Colloquium: Nancy Sullivan | UW–Madison Events Calendar
today.wisc.edu
September 24, 2025 at 1:26 PM
Join us for Biochemistry Colloquium on Sept. 29 with Dr. Nancy Sullivan. Sullivan is an international leader in viral immunology, emerging diseases prevention, and infectious disease research. More info: today.wisc.edu/events/view/...
This year, the Biophysics Instrumentation Facility in the Department of Biochemistry upgraded their equipment to keep the facility on the cutting edge of biochemical research and accommodate increased demands from labs across campus. Learn more: biochem.wisc.edu/2025/09/03/b...
Biophysics Instrumentation Facility Gets an Upgrade
With new and updated equipment, the facility expands on ways researchers can explore interactions among and properties of biological molecules.
biochem.wisc.edu
September 23, 2025 at 12:39 PM
This year, the Biophysics Instrumentation Facility in the Department of Biochemistry upgraded their equipment to keep the facility on the cutting edge of biochemical research and accommodate increased demands from labs across campus. Learn more: biochem.wisc.edu/2025/09/03/b...
Congratulations to Chad Rienstra, who was named the Evelyn Mercer Professor in Biochemical Sciences @uwmadisoncals.bsky.social! More info: biochem.wisc.edu/2025/09/16/c...
Chad Rienstra is Named Evelyn Mercer Professor in Biochemical Sciences
Rienstra is among 10 faculty members in CALS selected this academic year to receive college and department professorships or chairships.
biochem.wisc.edu
September 22, 2025 at 2:40 PM
Congratulations to Chad Rienstra, who was named the Evelyn Mercer Professor in Biochemical Sciences @uwmadisoncals.bsky.social! More info: biochem.wisc.edu/2025/09/16/c...
Join us for Biochemistry Colloquium on Sept. 22 with Stephen Bell. The Bell Lab studies the assembly of multi-enzyme replisomes that replicate animal chromosomes and how events are regulated during the cell cycle to ensure genome maintenance. More info: today.wisc.edu/events/view/...
Biochemistry Colloquium: Stephen Bell | UW–Madison Events Calendar
today.wisc.edu
September 18, 2025 at 1:46 PM
Join us for Biochemistry Colloquium on Sept. 22 with Stephen Bell. The Bell Lab studies the assembly of multi-enzyme replisomes that replicate animal chromosomes and how events are regulated during the cell cycle to ensure genome maintenance. More info: today.wisc.edu/events/view/...
Reposted by UW–Madison Department of Biochemistry
New from Niko's lab along with @uwbiochem.bsky.social 's Tim Grant and Kevin Zhang
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Improved cryo-EM reconstruction of sub-50 kDa complexes using 2D template matching
Visualizing the structures of small proteins and complexes has been a longstanding challenge in single-particle cryo-EM. Some of these targets have been successfully resolved by binding to antibody fr...
www.biorxiv.org
September 17, 2025 at 1:47 PM
New from Niko's lab along with @uwbiochem.bsky.social 's Tim Grant and Kevin Zhang
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...