Nate Sherer
@natesherer.bsky.social
University of Wisconsin-Madison McArdle Laboratory for Cancer Research and Institute for Molecular Virology. Viruses and cells. Opinions my own.
Reposted by Nate Sherer
Virus taxonomy increasingly rests on phylogenetic hypotheses, but the trees, alignments, and assumptions behind them are often ephemeral.
This post explores what it might look like to make that phylogenetic basis transparent and reproducible, using retroviruses as a case study.
shorturl.at/s9aft
This post explores what it might look like to make that phylogenetic basis transparent and reproducible, using retroviruses as a case study.
shorturl.at/s9aft
Making Phylogeny-backed Virus Taxonomy Reproducible
A Retrovirus Case Study Using GLUE
shorturl.at
January 5, 2026 at 12:45 PM
Virus taxonomy increasingly rests on phylogenetic hypotheses, but the trees, alignments, and assumptions behind them are often ephemeral.
This post explores what it might look like to make that phylogenetic basis transparent and reproducible, using retroviruses as a case study.
shorturl.at/s9aft
This post explores what it might look like to make that phylogenetic basis transparent and reproducible, using retroviruses as a case study.
shorturl.at/s9aft
Reposted by Nate Sherer
A tribute to Stuart Kornfeld, pioneering #glycotime scientist whose work on mannose-6-phosphate receptor lysosomal trafficking (among many other contributions) was highly influential to our work 🫡
www.jci.org/articles/vie...
www.jci.org/articles/vie...
JCI -
A tribute to Stuart A. Kornfeld (1936–2025)
www.jci.org
January 3, 2026 at 3:08 AM
A tribute to Stuart Kornfeld, pioneering #glycotime scientist whose work on mannose-6-phosphate receptor lysosomal trafficking (among many other contributions) was highly influential to our work 🫡
www.jci.org/articles/vie...
www.jci.org/articles/vie...
Reposted by Nate Sherer
Happy to see @joelrc.bsky.social's paper identifying cellular heterogeneity in basal OASL expression as a major determinant of interferon induction during influenza virus infection out in its final form:
www.pnas.org/doi/10.1073/...
Happy new year, hope everyone's 2026 is better than 2025!
www.pnas.org/doi/10.1073/...
Happy new year, hope everyone's 2026 is better than 2025!
PNAS
Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...
www.pnas.org
January 1, 2026 at 12:42 AM
Happy to see @joelrc.bsky.social's paper identifying cellular heterogeneity in basal OASL expression as a major determinant of interferon induction during influenza virus infection out in its final form:
www.pnas.org/doi/10.1073/...
Happy new year, hope everyone's 2026 is better than 2025!
www.pnas.org/doi/10.1073/...
Happy new year, hope everyone's 2026 is better than 2025!
Reposted by Nate Sherer
Today I made a small but momentous start to work in 2026 by changing a single number.
I renamed the file “Papers to write and submit in 2025” to “Papers to write and submit in 2026”.
Stay tuned for more file updates on 1st January 2027.
I renamed the file “Papers to write and submit in 2025” to “Papers to write and submit in 2026”.
Stay tuned for more file updates on 1st January 2027.
January 1, 2026 at 4:26 PM
Today I made a small but momentous start to work in 2026 by changing a single number.
I renamed the file “Papers to write and submit in 2025” to “Papers to write and submit in 2026”.
Stay tuned for more file updates on 1st January 2027.
I renamed the file “Papers to write and submit in 2025” to “Papers to write and submit in 2026”.
Stay tuned for more file updates on 1st January 2027.
Reposted by Nate Sherer
🚨 Alarm!!! 🚨
AI/ML course for microscopy image analysis!!! 🧐
In 2026 at Janelia (@hhmijanelia.bsky.social), no tuition, housing and meals provided! Isn’t that borderline unbelievable?!?
20 students, ~14 TAs and lecturers
🗓️ June 4-18 2026
✍️ Jan 15 2026 ✍️
🔁 pls!!
www.janelia.org/you-janelia/...
AI/ML course for microscopy image analysis!!! 🧐
In 2026 at Janelia (@hhmijanelia.bsky.social), no tuition, housing and meals provided! Isn’t that borderline unbelievable?!?
20 students, ~14 TAs and lecturers
🗓️ June 4-18 2026
✍️ Jan 15 2026 ✍️
🔁 pls!!
www.janelia.org/you-janelia/...
Deep Learning for Microscopy Image Analysis
Topics The following will be covered extensively during lectures, exercises, and project work: Image denoising and restoration (fully supervised and self-supervised) Image translation (e.g.,
www.janelia.org
December 28, 2025 at 7:06 PM
🚨 Alarm!!! 🚨
AI/ML course for microscopy image analysis!!! 🧐
In 2026 at Janelia (@hhmijanelia.bsky.social), no tuition, housing and meals provided! Isn’t that borderline unbelievable?!?
20 students, ~14 TAs and lecturers
🗓️ June 4-18 2026
✍️ Jan 15 2026 ✍️
🔁 pls!!
www.janelia.org/you-janelia/...
AI/ML course for microscopy image analysis!!! 🧐
In 2026 at Janelia (@hhmijanelia.bsky.social), no tuition, housing and meals provided! Isn’t that borderline unbelievable?!?
20 students, ~14 TAs and lecturers
🗓️ June 4-18 2026
✍️ Jan 15 2026 ✍️
🔁 pls!!
www.janelia.org/you-janelia/...
Reposted by Nate Sherer
Proud to be in a class with some seriously impressive up-and-comers. Inaugural class here: journals.asm.org/journal/jvi/...
I'll be penning an article with colleague and friend @hanckslab.bsky.social on mitochondrial proteins that moonlight to execute immune responses
@jvico-eics.bsky.social
I'll be penning an article with colleague and friend @hanckslab.bsky.social on mitochondrial proteins that moonlight to execute immune responses
@jvico-eics.bsky.social
December 19, 2025 at 6:48 PM
Proud to be in a class with some seriously impressive up-and-comers. Inaugural class here: journals.asm.org/journal/jvi/...
I'll be penning an article with colleague and friend @hanckslab.bsky.social on mitochondrial proteins that moonlight to execute immune responses
@jvico-eics.bsky.social
I'll be penning an article with colleague and friend @hanckslab.bsky.social on mitochondrial proteins that moonlight to execute immune responses
@jvico-eics.bsky.social
Reposted by Nate Sherer
New preprint! We found that the flavin-dependent halogenase RebH catalyzes sequence-tolerant Trp bromination in peptides 🧪https://www.biorxiv.org/content/10.64898/2025.12.17.694899v1
December 21, 2025 at 3:58 AM
New preprint! We found that the flavin-dependent halogenase RebH catalyzes sequence-tolerant Trp bromination in peptides 🧪https://www.biorxiv.org/content/10.64898/2025.12.17.694899v1
Reposted by Nate Sherer
New in ACS SynBio: led by Dennis Bolshakov, we used the awesome power of yeast to define how expression levels, noise, and sequence program the dynamics of synthetic protein waves, allowing us to genetically encode new cellular timescales stable over generations!
pubs.acs.org/doi/full/10....
pubs.acs.org/doi/full/10....
December 17, 2025 at 3:24 PM
New in ACS SynBio: led by Dennis Bolshakov, we used the awesome power of yeast to define how expression levels, noise, and sequence program the dynamics of synthetic protein waves, allowing us to genetically encode new cellular timescales stable over generations!
pubs.acs.org/doi/full/10....
pubs.acs.org/doi/full/10....
Reposted by Nate Sherer
The Akhtar Lab @manneresearch.bsky.social and Northwestern University @nufeinbergmed.bsky.social is hiring a full time RESEARCH TECHNICIAN. If you want to study neonatal HSV pathogenesis please send me a message and apply for the position here:
luriechildrens.wd1.myworkdayjobs.com/externalport...
luriechildrens.wd1.myworkdayjobs.com/externalport...
December 23, 2025 at 3:38 PM
The Akhtar Lab @manneresearch.bsky.social and Northwestern University @nufeinbergmed.bsky.social is hiring a full time RESEARCH TECHNICIAN. If you want to study neonatal HSV pathogenesis please send me a message and apply for the position here:
luriechildrens.wd1.myworkdayjobs.com/externalport...
luriechildrens.wd1.myworkdayjobs.com/externalport...
Reposted by Nate Sherer
Best two minutes of your day.
Trust me.
Trust me.
December 21, 2025 at 12:27 AM
Best two minutes of your day.
Trust me.
Trust me.
Reposted by Nate Sherer
Please consider joining us on the Editorial Board of JGV !
Details within 👇
Please pass on to any appropriate colleagues.
Details within 👇
Please pass on to any appropriate colleagues.
📢 Voluntary opportunity
Journal of General Virology is looking for Editors to support peer review and editorial decisions. This unpaid role contributes to journal strategy and community engagement in virology.
More info: Voluntary Opportunities 👉 microb.io/Vacancies
Journal of General Virology is looking for Editors to support peer review and editorial decisions. This unpaid role contributes to journal strategy and community engagement in virology.
More info: Voluntary Opportunities 👉 microb.io/Vacancies
Jobs
View the current job vacancies at the Microbiology Society.
microb.io
December 20, 2025 at 9:39 PM
Please consider joining us on the Editorial Board of JGV !
Details within 👇
Please pass on to any appropriate colleagues.
Details within 👇
Please pass on to any appropriate colleagues.
Reposted by Nate Sherer
🧵 Thread on our new @natcomms.nature.com paper: TLDR -- ADP-ribosylation inhibits viral replication and represents a previously under-appreciated arm of innate immunity during flu infection. Read along for the details…. (1/11) www.nature.com/articles/s41...
Global remodeling of ADP-ribosylation by PARP1 suppresses influenza A virus infection - Nature Communications
Influenza A virus infection causes a dramatic upregulation of ADP-ribosylation that as part of the cellular antiviral response, a process that is counteracted by the viral NS1 protein.
www.nature.com
December 19, 2025 at 9:52 PM
🧵 Thread on our new @natcomms.nature.com paper: TLDR -- ADP-ribosylation inhibits viral replication and represents a previously under-appreciated arm of innate immunity during flu infection. Read along for the details…. (1/11) www.nature.com/articles/s41...
Reposted by Nate Sherer
Unfortunately the drop in ESI funding rates is not paired with changes in funding required to get tenure. It’s not just the next three years of our labs at risk, but the rest of our careers. We are also the cohort that started in the COVID pandemic- it’s been nothing but “unprecedented times”…
December 19, 2025 at 2:16 AM
Unfortunately the drop in ESI funding rates is not paired with changes in funding required to get tenure. It’s not just the next three years of our labs at risk, but the rest of our careers. We are also the cohort that started in the COVID pandemic- it’s been nothing but “unprecedented times”…
New work led by Madison Bandini out in @pnas.org using live cell imaging to show how HIV targets the cell cycle to double viral genomes and increase transcription. Awesome collaboration with cell cycle heroes in Suzuki lab @mcardlelab.bsky.social @uwmadison.bsky.social. www.pnas.org/doi/10.1073/...
December 18, 2025 at 11:13 PM
New work led by Madison Bandini out in @pnas.org using live cell imaging to show how HIV targets the cell cycle to double viral genomes and increase transcription. Awesome collaboration with cell cycle heroes in Suzuki lab @mcardlelab.bsky.social @uwmadison.bsky.social. www.pnas.org/doi/10.1073/...
Reposted by Nate Sherer
Awesome to see Ye's work from my lab featured on the cover of @rnajournal.bsky.social 's January issue! It's an awesome story about 3' splice selection and how Prp8 and Prp22 may communicate with one another! The structure shown is @maxewilkinson.bsky.social 's P complex (9DTR)
December 16, 2025 at 4:12 PM
Awesome to see Ye's work from my lab featured on the cover of @rnajournal.bsky.social 's January issue! It's an awesome story about 3' splice selection and how Prp8 and Prp22 may communicate with one another! The structure shown is @maxewilkinson.bsky.social 's P complex (9DTR)
Reposted by Nate Sherer
Put a perspective piece together on how fever may have driven the evolution of antiviral genes: rupress.org/jem/article/...
Does fever drive the evolution of antiviral genes? | Journal of Experimental Medicine | Rockefeller University Press
Fever is an evolutionary conserved response to pathogens. In this Perspective, Langlois hypothesizes that antiviral genes are selected for their function a
rupress.org
December 15, 2025 at 3:20 PM
Put a perspective piece together on how fever may have driven the evolution of antiviral genes: rupress.org/jem/article/...
Reposted by Nate Sherer
youtu.be/ra0WKNhQZ0U
Refreshingly, this pulls zero punches, and lands them squarely on the liars, grifters and frauds responsible for the lab leak hoax and the authoritarian persecution of science and scientists.
Refreshingly, this pulls zero punches, and lands them squarely on the liars, grifters and frauds responsible for the lab leak hoax and the authoritarian persecution of science and scientists.
COVID Origins: Debunking the Grift, Pseudoscience, and Politics of the Lab Leak Theory
YouTube video by Professor Dave Explains
youtu.be
December 13, 2025 at 2:27 PM
youtu.be/ra0WKNhQZ0U
Refreshingly, this pulls zero punches, and lands them squarely on the liars, grifters and frauds responsible for the lab leak hoax and the authoritarian persecution of science and scientists.
Refreshingly, this pulls zero punches, and lands them squarely on the liars, grifters and frauds responsible for the lab leak hoax and the authoritarian persecution of science and scientists.
Reposted by Nate Sherer
Haven’t posted for a while but @jezcarlton.bsky.social opening up the annual UK membrane trafficking meeting #UKMT seems like an appropriate reason to post!
Great line up - as ever - with organisers Jez and Chris Stefan introducing a poster session too 🤓
Great line up - as ever - with organisers Jez and Chris Stefan introducing a poster session too 🤓
December 15, 2025 at 9:43 AM
Haven’t posted for a while but @jezcarlton.bsky.social opening up the annual UK membrane trafficking meeting #UKMT seems like an appropriate reason to post!
Great line up - as ever - with organisers Jez and Chris Stefan introducing a poster session too 🤓
Great line up - as ever - with organisers Jez and Chris Stefan introducing a poster session too 🤓
Hooray for Dr. Bandini!!
December 14, 2025 at 3:14 PM
Hooray for Dr. Bandini!!
Reposted by Nate Sherer
Tenure-Track Faculty Position in Microbiology
Come and join great students and colleagues at Hofstra Biology. Please apply using the link below and/or spread the word!
hofstra.peopleadmin.com/postings/6542
Come and join great students and colleagues at Hofstra Biology. Please apply using the link below and/or spread the word!
hofstra.peopleadmin.com/postings/6542
December 12, 2025 at 4:53 PM
Tenure-Track Faculty Position in Microbiology
Come and join great students and colleagues at Hofstra Biology. Please apply using the link below and/or spread the word!
hofstra.peopleadmin.com/postings/6542
Come and join great students and colleagues at Hofstra Biology. Please apply using the link below and/or spread the word!
hofstra.peopleadmin.com/postings/6542
Reposted by Nate Sherer
Our paper "Ecosystem health shapes viral ecology in peatland soils" is out in Nature Microbiology!
We show that peatland health strongly structures viral communities, shaping virus–host networks, and carbon and nutrient cycling. Please share.
www.nature.com/articles/s41...
#phagesky #Microsky
We show that peatland health strongly structures viral communities, shaping virus–host networks, and carbon and nutrient cycling. Please share.
www.nature.com/articles/s41...
#phagesky #Microsky
Ecosystem health shapes viral ecology in peatland soils - Nature Microbiology
Metagenomics shows that viral diversity and community structure are shaped by geography and ecosystem health status, positioning viruses as unexpected players in peatland restoration.
www.nature.com
December 12, 2025 at 12:04 AM
Our paper "Ecosystem health shapes viral ecology in peatland soils" is out in Nature Microbiology!
We show that peatland health strongly structures viral communities, shaping virus–host networks, and carbon and nutrient cycling. Please share.
www.nature.com/articles/s41...
#phagesky #Microsky
We show that peatland health strongly structures viral communities, shaping virus–host networks, and carbon and nutrient cycling. Please share.
www.nature.com/articles/s41...
#phagesky #Microsky
Reposted by Nate Sherer
We are recruiting a tenure track professor in the broader area of molecular biology @zmbh.uni-heidelberg.de at Heidelberg University! www.nature.com/naturecareer... Please share and apply!
Tenure Track Professorship (W1 with Tenure Track to W3) in “Molecular Biology" (f/m/d) - Heidelberg job with Universität Heidelberg | 12850668
The Center for Molecular Biology of Heidelberg University (ZMBH) and the Faculty of Biosciences invite applications for a Tenure Track Professors...
www.nature.com
December 9, 2025 at 6:11 PM
We are recruiting a tenure track professor in the broader area of molecular biology @zmbh.uni-heidelberg.de at Heidelberg University! www.nature.com/naturecareer... Please share and apply!
Reposted by Nate Sherer
My tenth ASCB/ Cell Bio meeting; my first meeting as a PI. I love the amazing community I have and am so excited for our new and future labs 🥰
Until next time! #CellBio2025
Until next time! #CellBio2025
December 10, 2025 at 5:08 PM
My tenth ASCB/ Cell Bio meeting; my first meeting as a PI. I love the amazing community I have and am so excited for our new and future labs 🥰
Until next time! #CellBio2025
Until next time! #CellBio2025
Reposted by Nate Sherer
The Gonzalez Lab at Columbia University is seeking a scientific leader!
Join us in a Research Scientist position, driving single-molecule, structural, and biochemical studies of translation, translational control, and other RNA-based processes.
Apply: apply.interfolio.com/176949
Join us in a Research Scientist position, driving single-molecule, structural, and biochemical studies of translation, translational control, and other RNA-based processes.
Apply: apply.interfolio.com/176949
December 10, 2025 at 12:16 PM
The Gonzalez Lab at Columbia University is seeking a scientific leader!
Join us in a Research Scientist position, driving single-molecule, structural, and biochemical studies of translation, translational control, and other RNA-based processes.
Apply: apply.interfolio.com/176949
Join us in a Research Scientist position, driving single-molecule, structural, and biochemical studies of translation, translational control, and other RNA-based processes.
Apply: apply.interfolio.com/176949