Smriti Sangwan
@smritisangwan.bsky.social
Asst Prof Northwestern Pharmacology - cryoEM, protein quality control, structure guided drug design.
sites.northwestern.edu/sangwan/
sites.northwestern.edu/sangwan/
Reposted by Smriti Sangwan
We have written up a tutorial on how to run BindCraft, how to prepare your input PDB, how to select hotspots, and various other tips and tricks to get the most out of binder design!
github.com/martinpacesa...
github.com/martinpacesa...
June 30, 2025 at 7:45 PM
We have written up a tutorial on how to run BindCraft, how to prepare your input PDB, how to select hotspots, and various other tips and tricks to get the most out of binder design!
github.com/martinpacesa...
github.com/martinpacesa...
Reposted by Smriti Sangwan
Congratulations to Silvia Ramundo, Group Leader at the GMI, who has been awarded an ASTRA Award from the Austrian Science Fund (FWF) in recognition of her research on chloroplast biology!
Read more: https://thegmi.science/049300
Read more: https://thegmi.science/049300
June 25, 2025 at 5:00 PM
Congratulations to Silvia Ramundo, Group Leader at the GMI, who has been awarded an ASTRA Award from the Austrian Science Fund (FWF) in recognition of her research on chloroplast biology!
Read more: https://thegmi.science/049300
Read more: https://thegmi.science/049300
Reposted by Smriti Sangwan
He resolved that he would not stop either, even though it was a huge sacrifice on his part. I believe this is what we owe our trainees: so long as they are invested in their work, we must be as well, even if it seems like the world is on fire around us, both literally and figuratively. 10/
June 8, 2025 at 7:00 PM
He resolved that he would not stop either, even though it was a huge sacrifice on his part. I believe this is what we owe our trainees: so long as they are invested in their work, we must be as well, even if it seems like the world is on fire around us, both literally and figuratively. 10/
Reposted by Smriti Sangwan
Tip for PhD applicants reaching out to prospective advisors: Don’t use an LLM to write these emails. It’s not a great first impression to express your admiration for a recent paper the faculty member published if that paper does not exist.
June 5, 2025 at 1:27 PM
Tip for PhD applicants reaching out to prospective advisors: Don’t use an LLM to write these emails. It’s not a great first impression to express your admiration for a recent paper the faculty member published if that paper does not exist.
Reposted by Smriti Sangwan
Parts from GE-Cytiva for AKTAs were always ridiculous to begin with….Now look, no time wasted!!!!
May 9, 2025 at 7:35 PM
Parts from GE-Cytiva for AKTAs were always ridiculous to begin with….Now look, no time wasted!!!!
Reposted by Smriti Sangwan
Not long after I started my lab, a prominent scientist told me it was “impossible” to be a successful PI and a mother
Don’t ever let the naysayers tell you it can’t be done - of course it can!
#HappyMothersDay this weekend to all the amazing scientist mamas raising their wonderful kids 🥰
Don’t ever let the naysayers tell you it can’t be done - of course it can!
#HappyMothersDay this weekend to all the amazing scientist mamas raising their wonderful kids 🥰
May 9, 2025 at 6:23 PM
Not long after I started my lab, a prominent scientist told me it was “impossible” to be a successful PI and a mother
Don’t ever let the naysayers tell you it can’t be done - of course it can!
#HappyMothersDay this weekend to all the amazing scientist mamas raising their wonderful kids 🥰
Don’t ever let the naysayers tell you it can’t be done - of course it can!
#HappyMothersDay this weekend to all the amazing scientist mamas raising their wonderful kids 🥰
Reposted by Smriti Sangwan
my sympathies to anyone who is subscribed to the 3dem mailing list in non-digest mode right now... some sort of auto-reply-pocalypse going on...
April 21, 2025 at 5:51 PM
my sympathies to anyone who is subscribed to the 3dem mailing list in non-digest mode right now... some sort of auto-reply-pocalypse going on...
Reposted by Smriti Sangwan
Spatial analysis of mitochondrial gene expression reveals dynamic translation hubs and remodeling in stress | Science Advances www.science.org/doi/10.1126/...
Spatial analysis of mitochondrial gene expression reveals dynamic translation hubs and remodeling in stress
Quantitative imaging of the mitochondrial central dogma identifies translation hubs that are suppressed during stress.
www.science.org
April 18, 2025 at 10:39 PM
Spatial analysis of mitochondrial gene expression reveals dynamic translation hubs and remodeling in stress | Science Advances www.science.org/doi/10.1126/...
Reposted by Smriti Sangwan
I am somehow for the first time ever reviewing for PNAS and their reviewer instructions include this BANGER of a line:
"The purpose of peer review is not to demonstrate proficiency in identifying flaws"
Print it in eleventy point font and hang it from the hillside. Scream it from the rooftops.
"The purpose of peer review is not to demonstrate proficiency in identifying flaws"
Print it in eleventy point font and hang it from the hillside. Scream it from the rooftops.
March 13, 2025 at 2:59 PM
I am somehow for the first time ever reviewing for PNAS and their reviewer instructions include this BANGER of a line:
"The purpose of peer review is not to demonstrate proficiency in identifying flaws"
Print it in eleventy point font and hang it from the hillside. Scream it from the rooftops.
"The purpose of peer review is not to demonstrate proficiency in identifying flaws"
Print it in eleventy point font and hang it from the hillside. Scream it from the rooftops.
Reposted by Smriti Sangwan
Labeling your axes and then explaining them slowly is perhaps the biggest bang for the buck you can get for making your slides more understandable.
March 12, 2025 at 4:38 PM
Labeling your axes and then explaining them slowly is perhaps the biggest bang for the buck you can get for making your slides more understandable.
Reposted by Smriti Sangwan
"The only way out is through" I repeat to myself as I prepare to do this PCR for the fourth time
March 10, 2025 at 7:36 PM
"The only way out is through" I repeat to myself as I prepare to do this PCR for the fourth time
Reposted by Smriti Sangwan
Big news: we are setting up a new non-profit organization to run bioRxiv and medRxiv. It's called openRxiv [no it's not a new preprint server; it's dedicated organization to oversee the servers] openrxiv.org 1/n
Homepage - openRxiv
openRxiv is an independent non-profit, the new organizational home for bioRxiv and medRxiv, enabling researchers to instantly share groundbreaking findings with the global scientific community.
openrxiv.org
March 11, 2025 at 1:20 PM
Big news: we are setting up a new non-profit organization to run bioRxiv and medRxiv. It's called openRxiv [no it's not a new preprint server; it's dedicated organization to oversee the servers] openrxiv.org 1/n
Reposted by Smriti Sangwan
In order to write you have to think.
But also, in order to think you have to write.
At least that’s the lesson I’ve learned with every paper I’ve put together. There is something about the process of formalizing your data and constructing a narrative that leads to better thinking and insights.
But also, in order to think you have to write.
At least that’s the lesson I’ve learned with every paper I’ve put together. There is something about the process of formalizing your data and constructing a narrative that leads to better thinking and insights.
March 10, 2025 at 3:57 PM
In order to write you have to think.
But also, in order to think you have to write.
At least that’s the lesson I’ve learned with every paper I’ve put together. There is something about the process of formalizing your data and constructing a narrative that leads to better thinking and insights.
But also, in order to think you have to write.
At least that’s the lesson I’ve learned with every paper I’ve put together. There is something about the process of formalizing your data and constructing a narrative that leads to better thinking and insights.
Reposted by Smriti Sangwan
I was that woman! I have frequently told the story of how Jeremy responded after my second NIH rejection. He said, “Whatever you do, don’t stop spending. If you run out of startup, we’ll find more money for you.” I didn’t need it in the end, but knowing he had my back was huge. Thank you!
Our first recruit struggled initially to succeed in obtaining NIH funding. But her science was/is terrific and we bridged her along. She subsequent received an HHMI appointment, and then substantial NIH funding. She is now a member of the National Academy and is the current department director
25/n
25/n
March 9, 2025 at 4:14 PM
I was that woman! I have frequently told the story of how Jeremy responded after my second NIH rejection. He said, “Whatever you do, don’t stop spending. If you run out of startup, we’ll find more money for you.” I didn’t need it in the end, but knowing he had my back was huge. Thank you!
Reposted by Smriti Sangwan
I think it's important to reach out to your own community and explain what the funding cuts mean in practice.
March 9, 2025 at 12:24 AM
I think it's important to reach out to your own community and explain what the funding cuts mean in practice.
Reposted by Smriti Sangwan
Interesting! @nytimes.com still hasn’t covered any of the Stand Up for Science protests today, but they made sure to put this important news front and center online. Powerful reporting…
March 8, 2025 at 5:59 AM
Interesting! @nytimes.com still hasn’t covered any of the Stand Up for Science protests today, but they made sure to put this important news front and center online. Powerful reporting…
Reposted by Smriti Sangwan
With everything going on, I needed a pick me. So I went back to the bench to do PCR. It had not worked in the hands of another trainee and I decided to give it a try and it worked. I should do bench work often.😊
March 7, 2025 at 12:59 PM
With everything going on, I needed a pick me. So I went back to the bench to do PCR. It had not worked in the hands of another trainee and I decided to give it a try and it worked. I should do bench work often.😊
Reposted by Smriti Sangwan
I heard some folks try Bluesky, don’t get enough engagement, and go back to Twitter! Be generous with posts you like—it doesn’t cost a dime!
a red heart with the number 994 on it
ALT: a red heart with the number 994 on it
media.tenor.com
March 7, 2025 at 4:57 PM
I heard some folks try Bluesky, don’t get enough engagement, and go back to Twitter! Be generous with posts you like—it doesn’t cost a dime!
Reposted by Smriti Sangwan
#1 use of barad lab website: looking up my own address/phone number....
February 28, 2025 at 12:14 AM
#1 use of barad lab website: looking up my own address/phone number....
Reposted by Smriti Sangwan
I'm going to savor every part of starting a lab in spite of (to spite?) this administration!
Behold, the Mudumbi lab's first full-time member opening our very first box - both arrived today!
Please rest assured that Adriana did not also arrive in a box
Behold, the Mudumbi lab's first full-time member opening our very first box - both arrived today!
Please rest assured that Adriana did not also arrive in a box
February 12, 2025 at 12:13 AM
I'm going to savor every part of starting a lab in spite of (to spite?) this administration!
Behold, the Mudumbi lab's first full-time member opening our very first box - both arrived today!
Please rest assured that Adriana did not also arrive in a box
Behold, the Mudumbi lab's first full-time member opening our very first box - both arrived today!
Please rest assured that Adriana did not also arrive in a box
Reposted by Smriti Sangwan
It’s been a tough few weeks. My 10yo daughter was diagnosed with a very rare, aggressive cancer called interdigitating dendritic cell sarcoma (IDCS). I’m reaching out to identify clinicians/patients who have encountered pediatric IDCS or other (non-LCH) dendritic or histiocytic sarcomas cases.
February 8, 2025 at 9:21 PM
It’s been a tough few weeks. My 10yo daughter was diagnosed with a very rare, aggressive cancer called interdigitating dendritic cell sarcoma (IDCS). I’m reaching out to identify clinicians/patients who have encountered pediatric IDCS or other (non-LCH) dendritic or histiocytic sarcomas cases.
Today I submitted my first grant as a PI. Today marks the first day of the rest of my life 🤦♀️🤦♀️🤦♀️🤦♀️🤦♀️🤦♀️
December 9, 2024 at 11:05 PM
Today I submitted my first grant as a PI. Today marks the first day of the rest of my life 🤦♀️🤦♀️🤦♀️🤦♀️🤦♀️🤦♀️
Reposted by Smriti Sangwan
We need to have a ‘code of conduct’ for reviewing manuscripts, like (1) if you say that something is not novel then provide the reference. (2) If you propose an experiment, state precisely to which claim it is crucial. (3) If you want to say something nasty then sign your name.
November 17, 2024 at 2:47 PM
We need to have a ‘code of conduct’ for reviewing manuscripts, like (1) if you say that something is not novel then provide the reference. (2) If you propose an experiment, state precisely to which claim it is crucial. (3) If you want to say something nasty then sign your name.