@sebastianbaatz.bsky.social
Nephrology, ERKNet, Nephrogenetic, ADPKD, Leipzig UKL
Reposted
Review by Anthony Bleyer et al:
Autosomal Dominant Tubulointerstitial Kidney Disease: A Review
bit.ly/3VgPMNS (FREE)
Autosomal Dominant Tubulointerstitial Kidney Disease: A Review
bit.ly/3VgPMNS (FREE)
November 16, 2025 at 11:00 PM
Review by Anthony Bleyer et al:
Autosomal Dominant Tubulointerstitial Kidney Disease: A Review
bit.ly/3VgPMNS (FREE)
Autosomal Dominant Tubulointerstitial Kidney Disease: A Review
bit.ly/3VgPMNS (FREE)
Reposted
November 16, 2025 at 11:00 AM
Reposted
BAFF and APRIL represent pre-HIT 1 in #IgAN
#Nephpearls #NephSky
Antigen-driven immune activation within lymphoid tissues leads to the release of BAFF and APRIL, which bind to those receptors and promote B-cell survival and production of IgA
👉🏼 pubmed.ncbi.nlm.nih.gov/38362118/
#Nephpearls #NephSky
Antigen-driven immune activation within lymphoid tissues leads to the release of BAFF and APRIL, which bind to those receptors and promote B-cell survival and production of IgA
👉🏼 pubmed.ncbi.nlm.nih.gov/38362118/
November 15, 2025 at 8:36 AM
BAFF and APRIL represent pre-HIT 1 in #IgAN
#Nephpearls #NephSky
Antigen-driven immune activation within lymphoid tissues leads to the release of BAFF and APRIL, which bind to those receptors and promote B-cell survival and production of IgA
👉🏼 pubmed.ncbi.nlm.nih.gov/38362118/
#Nephpearls #NephSky
Antigen-driven immune activation within lymphoid tissues leads to the release of BAFF and APRIL, which bind to those receptors and promote B-cell survival and production of IgA
👉🏼 pubmed.ncbi.nlm.nih.gov/38362118/
Reposted
Reposted
The KDIGO 2024 Clinical Practice Guideline for the Evaluation and Management of Chronic Kidney Disease recommends using equations that include both creatinine and cystatin C for more accurate GFR estimation and risk assessment in CKD.
ja.ma/43QS5vy
ja.ma/43QS5vy
November 5, 2025 at 4:30 PM
The KDIGO 2024 Clinical Practice Guideline for the Evaluation and Management of Chronic Kidney Disease recommends using equations that include both creatinine and cystatin C for more accurate GFR estimation and risk assessment in CKD.
ja.ma/43QS5vy
ja.ma/43QS5vy
Reposted
Finally, a large group of patients are those with heterozygous COL4A3 and COL4A4 variants who do well long term with only microscopic hematuria. The problem is that you don't know which patients will fall into this bucket and which will fall into the buckets above by genotyping alone. #KidneyWk
November 6, 2025 at 6:39 PM
Finally, a large group of patients are those with heterozygous COL4A3 and COL4A4 variants who do well long term with only microscopic hematuria. The problem is that you don't know which patients will fall into this bucket and which will fall into the buckets above by genotyping alone. #KidneyWk
Reposted
VEXAS syndrome is a severe, adult-onset autoinflammatory condition characterized by vacuoles in blood-forming and immune cells.
Here, Zhigang Cai & team show neutrophil-specific loss of Uba1 results in VEXAS-like symptoms in mice: www.jci.org/articles/vie...
Here, Zhigang Cai & team show neutrophil-specific loss of Uba1 results in VEXAS-like symptoms in mice: www.jci.org/articles/vie...
November 5, 2025 at 5:15 PM
VEXAS syndrome is a severe, adult-onset autoinflammatory condition characterized by vacuoles in blood-forming and immune cells.
Here, Zhigang Cai & team show neutrophil-specific loss of Uba1 results in VEXAS-like symptoms in mice: www.jci.org/articles/vie...
Here, Zhigang Cai & team show neutrophil-specific loss of Uba1 results in VEXAS-like symptoms in mice: www.jci.org/articles/vie...
Reposted
November 3, 2025 at 5:03 PM
Reposted
Interesting case from the Skeleton Key Group which just keeps pumping out the #FOAMed
www.renalfellow.org/2025/09/28/s...
www.renalfellow.org/2025/09/28/s...
Skeleton Key Group Case #40: Cosmetic Calcium
Author: Nikitha (Niki) Cherayil, MD A. The Stem A middle-aged woman with chronic kidney disease stage 3 in the setting of hypertension and recurrent kidney st
www.renalfellow.org
September 29, 2025 at 3:09 AM
Interesting case from the Skeleton Key Group which just keeps pumping out the #FOAMed
www.renalfellow.org/2025/09/28/s...
www.renalfellow.org/2025/09/28/s...
Reposted
somewhat related
www.sciencedirect.com/science/arti... in @kireports.bsky.social
see how less often do we think of TKD (4%) but how often it turns out to be (19%)
#NephSky
www.sciencedirect.com/science/arti... in @kireports.bsky.social
see how less often do we think of TKD (4%) but how often it turns out to be (19%)
#NephSky
September 8, 2025 at 5:12 PM
somewhat related
www.sciencedirect.com/science/arti... in @kireports.bsky.social
see how less often do we think of TKD (4%) but how often it turns out to be (19%)
#NephSky
www.sciencedirect.com/science/arti... in @kireports.bsky.social
see how less often do we think of TKD (4%) but how often it turns out to be (19%)
#NephSky
Reposted
📖 This weekend don't miss our @kireports.bsky.social #ISNFridaySelection: Early determination of tacrolimus concentration-dose ratio identifies risk of allograft loss in kidney transplantation www.kireports.org/ar...
June 20, 2025 at 6:00 AM
📖 This weekend don't miss our @kireports.bsky.social #ISNFridaySelection: Early determination of tacrolimus concentration-dose ratio identifies risk of allograft loss in kidney transplantation www.kireports.org/ar...
Reposted
Should GLP-1 receptor agonist therapy be used to treat obesity in Bardet-Biedl syndrome? buff.ly/3KaQiPj
Jeremy W Tomlinson provides a Commentary on Singh et al. (buff.ly/4F0fcqZ)
Jeremy W Tomlinson provides a Commentary on Singh et al. (buff.ly/4F0fcqZ)
June 20, 2025 at 1:20 PM
Should GLP-1 receptor agonist therapy be used to treat obesity in Bardet-Biedl syndrome? buff.ly/3KaQiPj
Jeremy W Tomlinson provides a Commentary on Singh et al. (buff.ly/4F0fcqZ)
Jeremy W Tomlinson provides a Commentary on Singh et al. (buff.ly/4F0fcqZ)
Reposted
Postoperative 20% Albumin Infusion and Acute Kidney Injury in High-Risk Cardiac Surgery Patients - The ALBICS AKI Randomized Clinical Trial by Drs. Shehabi, Pakavakis et al.
jamanetwork.com/journals/jam...
Infusion of 20% albumin increased the risk of AKI.
jamanetwork.com/journals/jam...
Infusion of 20% albumin increased the risk of AKI.
June 17, 2025 at 8:17 PM
Postoperative 20% Albumin Infusion and Acute Kidney Injury in High-Risk Cardiac Surgery Patients - The ALBICS AKI Randomized Clinical Trial by Drs. Shehabi, Pakavakis et al.
jamanetwork.com/journals/jam...
Infusion of 20% albumin increased the risk of AKI.
jamanetwork.com/journals/jam...
Infusion of 20% albumin increased the risk of AKI.
Reposted
Reposted
7/
📣 To the #nephrology community:
We invite all clinicians, geneticists, pathologists & data scientists to:
✅ Use CKDx in your practice & research
✅ Share cases where h/g flags made a difference
✅ Tell us what metadata would help refine diagnostics further
📣 To the #nephrology community:
We invite all clinicians, geneticists, pathologists & data scientists to:
✅ Use CKDx in your practice & research
✅ Share cases where h/g flags made a difference
✅ Tell us what metadata would help refine diagnostics further
June 13, 2025 at 2:14 PM
7/
📣 To the #nephrology community:
We invite all clinicians, geneticists, pathologists & data scientists to:
✅ Use CKDx in your practice & research
✅ Share cases where h/g flags made a difference
✅ Tell us what metadata would help refine diagnostics further
📣 To the #nephrology community:
We invite all clinicians, geneticists, pathologists & data scientists to:
✅ Use CKDx in your practice & research
✅ Share cases where h/g flags made a difference
✅ Tell us what metadata would help refine diagnostics further
Reposted
Antibody-mediated Rejection - Treatment Standard by Drs. Böhmig, Budde et al.
academic.oup.com/ndt/article/...
An expert opinion paper about Treatment Standard by ABMR.
academic.oup.com/ndt/article/...
An expert opinion paper about Treatment Standard by ABMR.
Antibody-mediated Rejection - Treatment Standard
Abstract. Antibody-mediated rejection (AMR) remains a major cause of graft failure, with significant health and economic burden. Despite being recognized &
academic.oup.com
June 4, 2025 at 5:41 PM
Antibody-mediated Rejection - Treatment Standard by Drs. Böhmig, Budde et al.
academic.oup.com/ndt/article/...
An expert opinion paper about Treatment Standard by ABMR.
academic.oup.com/ndt/article/...
An expert opinion paper about Treatment Standard by ABMR.
Reposted
Interesting case of dual occurrence of fibrillary GN and lupus nephritis. Full house staining and mixture of many typical IC deposits with fibrils. #renalpath #pathskyr #nephsky www.sciencedirect.com/science/arti...
May 1, 2025 at 5:24 PM
Interesting case of dual occurrence of fibrillary GN and lupus nephritis. Full house staining and mixture of many typical IC deposits with fibrils. #renalpath #pathskyr #nephsky www.sciencedirect.com/science/arti...
Reposted
ADPKD Risk calculator.
This looks well done: halbritter-lab.github.io/adpkd-risk/
This looks well done: halbritter-lab.github.io/adpkd-risk/
Loading...
ADPKD Risk Calculator is a web-based tool designed to assess Autosomal Dominant Polycystic Kidney Disease (ADPKD) progression risk using the Mayo Imaging Classification and PROPKD Score.
halbritter-lab.github.io
April 13, 2025 at 6:56 PM
ADPKD Risk calculator.
This looks well done: halbritter-lab.github.io/adpkd-risk/
This looks well done: halbritter-lab.github.io/adpkd-risk/
Reposted
Also published today
The Boston first in human kidney xenotransplantation case report
@nejm.org #ISNWCN
www.nejm.org/doi/full/10....
The Boston first in human kidney xenotransplantation case report
@nejm.org #ISNWCN
www.nejm.org/doi/full/10....
February 7, 2025 at 9:56 AM
Also published today
The Boston first in human kidney xenotransplantation case report
@nejm.org #ISNWCN
www.nejm.org/doi/full/10....
The Boston first in human kidney xenotransplantation case report
@nejm.org #ISNWCN
www.nejm.org/doi/full/10....
Reposted
In the REGENCY trial, obinutuzumab, a humanized type II anti-CD20 monoclonal antibody, plus standard therapy provided significantly better renal responses than standard therapy alone in patients with lupus nephritis. Full trial results: nej.md/3Eq6gxV
#ISNWCN | @theisn.org
#ISNWCN | @theisn.org
Efficacy and Safety of Obinutuzumab in Active Lupus Nephritis | NEJM
Obinutuzumab, a humanized type II anti-CD20 monoclonal antibody, provided significantly
better renal responses than placebo in a phase 2 trial involving patients with lupus
nephritis receiving stan...
nej.md
February 7, 2025 at 2:15 PM
In the REGENCY trial, obinutuzumab, a humanized type II anti-CD20 monoclonal antibody, plus standard therapy provided significantly better renal responses than standard therapy alone in patients with lupus nephritis. Full trial results: nej.md/3Eq6gxV
#ISNWCN | @theisn.org
#ISNWCN | @theisn.org
Reposted
17/
I'm very curious how others (e.g., @kidney_boy @Nephro_Sparks) think through this. It's hard to find articles directly addressing this exact question...
I'm very curious how others (e.g., @kidney_boy @Nephro_Sparks) think through this. It's hard to find articles directly addressing this exact question...
November 18, 2024 at 9:33 AM
17/
I'm very curious how others (e.g., @kidney_boy @Nephro_Sparks) think through this. It's hard to find articles directly addressing this exact question...
I'm very curious how others (e.g., @kidney_boy @Nephro_Sparks) think through this. It's hard to find articles directly addressing this exact question...
Reposted
Here comes gene therapy for hemophilia
Factor VIII gene was introduced into hematopoietic stem cells in men with hemophilia. The annualized bleeding rate went from 10 to 0. No worrisome gene integrations were seen. Read the full correspondence: nej.md/3PIZ4iX
#MedSky #Hematology
#MedSky #Hematology
Platelet-Targeted Gene Therapy for Hemophilia A with Inhibitor History | NEJM
Factor VIII gene was introduced into hematopoietic stem cells in men with hemophilia.
The annualized bleeding rate went from 10 to 0. No worrisome gene integrations were
seen.
nej.md
January 26, 2025 at 2:48 PM
Here comes gene therapy for hemophilia
Reposted
Hypokalemia: Diagnostic algorithm
#Nephpearls #NephSky
☑️ Urine K
☑️ Serum Mg
☑️ Serum CO2
☑️ Blood Pressure
☑️ Urine Chloride
☑️ Renin, Aldosterone
👉 pubmed.ncbi.nlm.nih.gov/18813287/
#Nephpearls #NephSky
☑️ Urine K
☑️ Serum Mg
☑️ Serum CO2
☑️ Blood Pressure
☑️ Urine Chloride
☑️ Renin, Aldosterone
👉 pubmed.ncbi.nlm.nih.gov/18813287/
January 26, 2025 at 5:10 AM
Hypokalemia: Diagnostic algorithm
#Nephpearls #NephSky
☑️ Urine K
☑️ Serum Mg
☑️ Serum CO2
☑️ Blood Pressure
☑️ Urine Chloride
☑️ Renin, Aldosterone
👉 pubmed.ncbi.nlm.nih.gov/18813287/
#Nephpearls #NephSky
☑️ Urine K
☑️ Serum Mg
☑️ Serum CO2
☑️ Blood Pressure
☑️ Urine Chloride
☑️ Renin, Aldosterone
👉 pubmed.ncbi.nlm.nih.gov/18813287/
Reposted
🚨 ADPKD 2025 guidelines are finally out! Huge congrats to Amy Early and the @kdigo.org team, to our chairs Olivier Devuyst & Vicente Torres, to Reem Mustafa, to the evidence review team, and to all the coauthors. Special thoughts go out to Tess Harris. kdigo.org/guidelines/a...
Autosomal Dominant Polycystic Kidney Disease (ADPKD) – KDIGO
kdigo.org
January 21, 2025 at 2:55 PM
🚨 ADPKD 2025 guidelines are finally out! Huge congrats to Amy Early and the @kdigo.org team, to our chairs Olivier Devuyst & Vicente Torres, to Reem Mustafa, to the evidence review team, and to all the coauthors. Special thoughts go out to Tess Harris. kdigo.org/guidelines/a...