Jonathan Zuckerman MD PhD
@jzrenalpath.bsky.social
Service Chief, Renal Pathology, UCLA Department of Pathology and Laboratory Medicine. Views are my own.
Intimate contact between endothelial cell and mesangial cell cytoplasm. A reminder that no GBM separates the blood space from the mesangium. I wonder what secrets they are sharing. #renalpath #pathsky #nephsky
October 31, 2025 at 5:09 PM
Intimate contact between endothelial cell and mesangial cell cytoplasm. A reminder that no GBM separates the blood space from the mesangium. I wonder what secrets they are sharing. #renalpath #pathsky #nephsky
Severe vascular rejection hiding in the IF tissue. Fibrinoid necrosis really pops on the H&E and further confirmed by fibrinogen IF. #renalpath #pathsky #nephsky
October 31, 2025 at 5:04 PM
Severe vascular rejection hiding in the IF tissue. Fibrinoid necrosis really pops on the H&E and further confirmed by fibrinogen IF. #renalpath #pathsky #nephsky
Reposted by Jonathan Zuckerman MD PhD
Laser microdissection followed by mass spectrometry (LMD/MS) shows promise as a more sensitive approach to tissue diagnosis of PLA2R-associated membranous nephropathy. Read more in #ASNKidneyNews kidney.pub/KN1710-09
October 27, 2025 at 2:00 PM
Laser microdissection followed by mass spectrometry (LMD/MS) shows promise as a more sensitive approach to tissue diagnosis of PLA2R-associated membranous nephropathy. Read more in #ASNKidneyNews kidney.pub/KN1710-09
Reposted by Jonathan Zuckerman MD PhD
📽️✨An inside look at life in the UCLA Pathology Residency Program!
We’re excited to share the moments that shape our residents -
from the microscope to mentorship, and everything in between.
Watch the full video ➨ youtu.be/Yfw39_U9_Hg
#pathology #PathSky #PathMatch26 #PathMatch #Match2026
We’re excited to share the moments that shape our residents -
from the microscope to mentorship, and everything in between.
Watch the full video ➨ youtu.be/Yfw39_U9_Hg
#pathology #PathSky #PathMatch26 #PathMatch #Match2026
UCLA Pathology & Laboratory Medicine Residency Program
YouTube video by UCLA Department of Pathology & Laboratory Medicine
youtu.be
October 22, 2025 at 4:00 PM
📽️✨An inside look at life in the UCLA Pathology Residency Program!
We’re excited to share the moments that shape our residents -
from the microscope to mentorship, and everything in between.
Watch the full video ➨ youtu.be/Yfw39_U9_Hg
#pathology #PathSky #PathMatch26 #PathMatch #Match2026
We’re excited to share the moments that shape our residents -
from the microscope to mentorship, and everything in between.
Watch the full video ➨ youtu.be/Yfw39_U9_Hg
#pathology #PathSky #PathMatch26 #PathMatch #Match2026
Teenager with nephrotic syndrome. Biopsy revealed unusual case of membranous nephropathy in a peds patient. PLA2R positive (IHC). PLA2R most common antigen in peds MN. EXT1/2 also common, SEMA3B less common. (pubmed.ncbi.nlm.nih.gov/38025223/) #renalpath #pathsky #nephsky
October 13, 2025 at 1:56 PM
Teenager with nephrotic syndrome. Biopsy revealed unusual case of membranous nephropathy in a peds patient. PLA2R positive (IHC). PLA2R most common antigen in peds MN. EXT1/2 also common, SEMA3B less common. (pubmed.ncbi.nlm.nih.gov/38025223/) #renalpath #pathsky #nephsky
A startling biopsy. Severe acute TMA in a pt with suspected scleroderma renal crisis. Massive vascular thrombosis, mucoid intimal edema, and early onion skin change associated with severe cortical necrosis. #renalpath #nephsky #pathsky
October 9, 2025 at 3:08 AM
A startling biopsy. Severe acute TMA in a pt with suspected scleroderma renal crisis. Massive vascular thrombosis, mucoid intimal edema, and early onion skin change associated with severe cortical necrosis. #renalpath #nephsky #pathsky
Bx for nephrotic syndrome in an IV drug user with multiple infections. LM was all medulla, but good enough to make a diagnosis. AA amyloidosis; very common bx result in this clinical setting. #renalpath #pathsky #nephsky
October 7, 2025 at 5:32 PM
Bx for nephrotic syndrome in an IV drug user with multiple infections. LM was all medulla, but good enough to make a diagnosis. AA amyloidosis; very common bx result in this clinical setting. #renalpath #pathsky #nephsky
Bx for new onset NS in an older adult. Serologic work up including SPEP/UPEP IFE negative. Bx shows membranous pattern with few double contours. IgG3-k restriction and mottle EM deposits c/w PGNMID with membranous predominant pattern. PLA2R- #renalpath #pathsky #nephsky
October 5, 2025 at 3:30 PM
Bx for new onset NS in an older adult. Serologic work up including SPEP/UPEP IFE negative. Bx shows membranous pattern with few double contours. IgG3-k restriction and mottle EM deposits c/w PGNMID with membranous predominant pattern. PLA2R- #renalpath #pathsky #nephsky
Kidney txp biopsy for AKI (~6 post txp). Tubular injury associated with granular and ropey trichome positive casts. IHC confirmed myoglobin cast nephropathy. CK found to be very high; thought to be due to statin related myopathy. #renalpath #pathsky #nephsky
October 4, 2025 at 5:17 PM
Kidney txp biopsy for AKI (~6 post txp). Tubular injury associated with granular and ropey trichome positive casts. IHC confirmed myoglobin cast nephropathy. CK found to be very high; thought to be due to statin related myopathy. #renalpath #pathsky #nephsky
Heavy Chains, Heavy Consequences: A Case of Concomitant Heavy Chain Amyloidosis and Heavy Chain Deposition Disease. Fibrils and powdery deposits. #renalpath #nephsky #pathsky www.sciencedirect.com/science/arti...
September 17, 2025 at 6:13 PM
Heavy Chains, Heavy Consequences: A Case of Concomitant Heavy Chain Amyloidosis and Heavy Chain Deposition Disease. Fibrils and powdery deposits. #renalpath #nephsky #pathsky www.sciencedirect.com/science/arti...
Reposted by Jonathan Zuckerman MD PhD
🔬 We are now recruiting a Renal Pathologist! #pathology #path2path #PathSky #renalpath
Join our team today! ➨ bit.ly/46CqsrU
Join our team today! ➨ bit.ly/46CqsrU
September 17, 2025 at 4:33 PM
🔬 We are now recruiting a Renal Pathologist! #pathology #path2path #PathSky #renalpath
Join our team today! ➨ bit.ly/46CqsrU
Join our team today! ➨ bit.ly/46CqsrU
Multiple diagnoses not uncommon in kidney biopsies. This case showed nodular diabetic nephropathy, a mostly chronic ANCA associated GN, and to top it off some interstitial ALECT2 amyloidosis. #renalpath #nephsky #pathsky
September 11, 2025 at 5:21 PM
Multiple diagnoses not uncommon in kidney biopsies. This case showed nodular diabetic nephropathy, a mostly chronic ANCA associated GN, and to top it off some interstitial ALECT2 amyloidosis. #renalpath #nephsky #pathsky
Lupus nephritis case with prominent podocyte cytoplasmic vacuolization on LM with myelin figures revealed by EM. Probably HCQ effect but given its prominence genetic etiologies should be excluded (e.g., Fabry, LMX1B). #renalpath #pathsky #nephsky
September 8, 2025 at 11:06 PM
Lupus nephritis case with prominent podocyte cytoplasmic vacuolization on LM with myelin figures revealed by EM. Probably HCQ effect but given its prominence genetic etiologies should be excluded (e.g., Fabry, LMX1B). #renalpath #pathsky #nephsky
Interesting case of AL-amyloidosis. Massive vascular deposits, even in hilar arterioles with glomerular sparring. Patient had minimal proteinuria given lack of glomerular amyloid. #renalpath #pathsky #nephsky
September 4, 2025 at 11:14 PM
Interesting case of AL-amyloidosis. Massive vascular deposits, even in hilar arterioles with glomerular sparring. Patient had minimal proteinuria given lack of glomerular amyloid. #renalpath #pathsky #nephsky
Nice example of urate crystals in gouty tophi involving the medulla. Polarizable crystals can be see using unstained sections from the IF tissue. #renalpath #pathsky #nephsky
August 28, 2025 at 7:04 PM
Nice example of urate crystals in gouty tophi involving the medulla. Polarizable crystals can be see using unstained sections from the IF tissue. #renalpath #pathsky #nephsky
Another example of an 'incidental' finding next to the tumor in a nephrectomy specimen. Amyloidosis (probably LECT2). Reminder not too overlook the non-neoplastic tissue. #renalpath #pathsky #nephsky
August 20, 2025 at 4:55 PM
Another example of an 'incidental' finding next to the tumor in a nephrectomy specimen. Amyloidosis (probably LECT2). Reminder not too overlook the non-neoplastic tissue. #renalpath #pathsky #nephsky
Reposted by Jonathan Zuckerman MD PhD
ANCA GN Working Group Meeting
More info for EUVAS Florence Working Group - Symposium on ANCA GN Classification-Scoring Systems, click link
👉https://vasculitis.org/
Register: app.donorfy.com/form/ZU81NH9...
@brixsilke.bsky.social & Ingeborg Bajema #renalpath #vasculitis #pathsky #nephsky
More info for EUVAS Florence Working Group - Symposium on ANCA GN Classification-Scoring Systems, click link
👉https://vasculitis.org/
Register: app.donorfy.com/form/ZU81NH9...
@brixsilke.bsky.social & Ingeborg Bajema #renalpath #vasculitis #pathsky #nephsky
August 18, 2025 at 10:12 PM
ANCA GN Working Group Meeting
More info for EUVAS Florence Working Group - Symposium on ANCA GN Classification-Scoring Systems, click link
👉https://vasculitis.org/
Register: app.donorfy.com/form/ZU81NH9...
@brixsilke.bsky.social & Ingeborg Bajema #renalpath #vasculitis #pathsky #nephsky
More info for EUVAS Florence Working Group - Symposium on ANCA GN Classification-Scoring Systems, click link
👉https://vasculitis.org/
Register: app.donorfy.com/form/ZU81NH9...
@brixsilke.bsky.social & Ingeborg Bajema #renalpath #vasculitis #pathsky #nephsky
Multi-focal severe necrotizing arteritis in a kidney biopsy with an ANCA vasculitis. Interestingly, foci of arteritis were only present in IF/EM tissue. Illustrating how even when severe arteritis can be easily missed due to sampling in a small biopsy. #renalpath #nephsky #pathsky
August 15, 2025 at 3:35 PM
Multi-focal severe necrotizing arteritis in a kidney biopsy with an ANCA vasculitis. Interestingly, foci of arteritis were only present in IF/EM tissue. Illustrating how even when severe arteritis can be easily missed due to sampling in a small biopsy. #renalpath #nephsky #pathsky
Great work by our chief resident @clilleymd.bsky.social on charactering microscopic tubulo-venous communications in kidney biopsies. www.kidneymedicinejournal.org/article/S259... . Here's another nice example (x.com/JZRenalPath/...) #renalpath #pathsky #nephsky
Microscopic Tubulovenous Communications in Nonneoplastic Kidneys: A Single-Center Case Series and Review of the Literature
Pathological connection between the kidney tubules and veins is known as a microscopic
tubulovenous communication we refer to as a tubulovenous fistula (TVF). This finding
has been reported in a few s...
www.kidneymedicinejournal.org
August 14, 2025 at 5:40 PM
Great work by our chief resident @clilleymd.bsky.social on charactering microscopic tubulo-venous communications in kidney biopsies. www.kidneymedicinejournal.org/article/S259... . Here's another nice example (x.com/JZRenalPath/...) #renalpath #pathsky #nephsky
Kidney txp biopsy with histologic features of acute pyelonephritis. Neutrophilic tubulitis, neutrophilic casts, and tubules which seem to explode out. Cellular rejection typically is not neutrophilic and inflammation hits the tubules from the outside in. #renalpath #nephsky #pathsky
August 11, 2025 at 5:28 PM
Kidney txp biopsy with histologic features of acute pyelonephritis. Neutrophilic tubulitis, neutrophilic casts, and tubules which seem to explode out. Cellular rejection typically is not neutrophilic and inflammation hits the tubules from the outside in. #renalpath #nephsky #pathsky
Reposted by Jonathan Zuckerman MD PhD
The August issue of CJASN is now available online! Topics covered this month include:
- GLP-1 receptor antagonists in patients receiving dialysis
- Transportation access and dialysis outcomes
- and more
Check out the issue here: journals.lww.com/cja...
#ASNCJASN
Cover by @JZRenalpath et al.
- GLP-1 receptor antagonists in patients receiving dialysis
- Transportation access and dialysis outcomes
- and more
Check out the issue here: journals.lww.com/cja...
#ASNCJASN
Cover by @JZRenalpath et al.
August 8, 2025 at 3:00 PM
The August issue of CJASN is now available online! Topics covered this month include:
- GLP-1 receptor antagonists in patients receiving dialysis
- Transportation access and dialysis outcomes
- and more
Check out the issue here: journals.lww.com/cja...
#ASNCJASN
Cover by @JZRenalpath et al.
- GLP-1 receptor antagonists in patients receiving dialysis
- Transportation access and dialysis outcomes
- and more
Check out the issue here: journals.lww.com/cja...
#ASNCJASN
Cover by @JZRenalpath et al.
Reposted by Jonathan Zuckerman MD PhD
🔬 We are now recruiting a Renal Pathologist! #pathology #path2path #PathSky #renalpath
Join our team today! ➨ bit.ly/4ll8K09
Join our team today! ➨ bit.ly/4ll8K09
August 7, 2025 at 7:16 PM
🔬 We are now recruiting a Renal Pathologist! #pathology #path2path #PathSky #renalpath
Join our team today! ➨ bit.ly/4ll8K09
Join our team today! ➨ bit.ly/4ll8K09
Wide variety of morphologies in this case of crystalline light chain proximal tubulopathy: mottle lysosomes, crystals, and fibrils. #renalpath #nephsky #pathsky
August 6, 2025 at 9:32 PM
Wide variety of morphologies in this case of crystalline light chain proximal tubulopathy: mottle lysosomes, crystals, and fibrils. #renalpath #nephsky #pathsky
One of the more subtle amyloid cases I have seen. Just a few deposits in 2 gloms by LM. Just enough congo red staining. Glad to catch it in the EM as well. #renalpath #nephsky #pathsky
July 31, 2025 at 6:19 PM
One of the more subtle amyloid cases I have seen. Just a few deposits in 2 gloms by LM. Just enough congo red staining. Glad to catch it in the EM as well. #renalpath #nephsky #pathsky
Some well formed "eye lashes" on these capillary loops in a case of AL-amyloidosis. Podocytes getting skewered by the spicules in the EM. #renalpath #pathsky #nephsky.
July 24, 2025 at 10:21 PM
Some well formed "eye lashes" on these capillary loops in a case of AL-amyloidosis. Podocytes getting skewered by the spicules in the EM. #renalpath #pathsky #nephsky.