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JAMA is an international peer-reviewed general medical journal and a member of the JAMA Network family of journals.

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The numbers are in.

This year's most popular JAMA content spans a range of topics, from coffee and #AFib to #osteoporosis to #SepticShock. What was your favorite article in 2025—and did other readers agree?

🔗 ja.ma/3KYLUQ6
📌 Editor’s Choice from this week's issue of #JAMA:

➡️ #Pregnancy Outcomes After Prepregnancy #GLP-1 RA Use,
➡️ Liberal vs Restrictive Transfusion in High-Risk #Cardiac #Surgery,
➡️ Continuous #Glucose Monitoring, and more.

ja.ma/4eRp9GH
December 25, 2025 at 4:00 PM
💬 Editorial: While restrictive transfusion remains standard, TOP trial results indicate some cardiac patients may benefit from a tailored approach based on clinical factors.

ja.ma/4p90DFW
December 25, 2025 at 3:00 PM
The numbers are in.

This year's most popular JAMA content spans a range of topics, from coffee and #AFib to #osteoporosis to #SepticShock. What was your favorite article in 2025—and did other readers agree?

🔗 ja.ma/3MSqrsD
December 25, 2025 at 1:00 PM
The numbers are in.

This year's most popular JAMA content spans a range of topics, from coffee and #AFib to #osteoporosis to #SepticShock. What was your favorite article in 2025—and did other readers agree?

🔗 ja.ma/3YaBWy6
December 24, 2025 at 5:00 PM
Newborn #nirsevimab immunization was associated with lower risks of RSV-related hospitalization and severe outcomes compared to maternal #RSVpreF vaccination.

ja.ma/45b5jEc
December 24, 2025 at 4:00 PM
💬 Editorial: Maya et al show prior #GLP-1RA use is associated with increased gestational weight gain and higher risks of some adverse pregnancy outcomes compared to matched controls, but does not raise congenital anomaly risk.

ja.ma/496FVR9
December 24, 2025 at 3:00 PM
#GLP-1 receptor agonist exposure with discontinuation before or during early #pregnancy was associated with greater gestational weight gain and increased risk of preterm delivery, gestational #diabetes, and hypertensive disorders.

ja.ma/49aip60
December 24, 2025 at 2:00 PM
Superficial vein thrombosis is a condition in which blood clots develop within the superficial veins, typically in the legs or arms.

This JAMA Patient Page describes its risk factors, symptoms, diagnosis, and treatments.

ja.ma/3YI4b7j
December 24, 2025 at 1:00 PM
📌 Editor’s Choice from this week's issue of #JAMA:

➡️ #Pregnancy Outcomes After Prepregnancy #GLP-1 RA Use,
➡️ Liberal vs Restrictive Transfusion in High-Risk #Cardiac #Surgery,
➡️ Continuous #Glucose Monitoring, and more.

ja.ma/4eRp9GH
December 23, 2025 at 6:00 PM
💬 Editorial: Automated insulin delivery systems increase time in pregnancy-specific glucose targets and are associated with lower rates of hyperglycemia-related complications in pregnant individuals with type 1 #diabetes.

ja.ma/4pRDZDr
December 23, 2025 at 5:30 PM
Pregnant women with type 1 #diabetes using closed-loop systems spent 3 more hours per day in target glucose range, supporting their use for improved glycemic control during pregnancy.

ja.ma/3Y5aVMq
December 23, 2025 at 5:00 PM
The numbers are in.

This year's most popular JAMA content spans a range of topics, from coffee and #AFib to #osteoporosis to #SepticShock. What was your favorite article in 2025—and did other readers agree?

🔗 ja.ma/3KYLUQ6
December 23, 2025 at 4:00 PM
📊 Research Summary: In adults with #tuberculosis and daily tobacco use, an mHealth intervention delivering motivational and behavioral support via text message led to higher quit rates at 6 months compared to written advice.

ja.ma/45p7LXI
December 23, 2025 at 1:00 PM
Among adults with newly diagnosed, drug-sensitive #tuberculosis in high-burden countries, an mHealth program delivering text messages for tobacco cessation was associated with higher quit rates and lower short-term mortality than written advice alone.

ja.ma/3MSeyms
December 23, 2025 at 12:00 PM
Reposted by JAMA
NEW: Paper in @jama.com (me, Glenn Cohen, & @drsinhaesq.bsky.social) discusses FDA plan to approve leucovorin for new indication based on "case reports" and "mechanistic data"

1. Departure from FDA's evidentiary standards

2. May harm patients and set bad precedent

jamanetwork.com/journals/jam...
December 22, 2025 at 5:35 PM
💬 Viewpoint: California’s SB 243 is the first law to regulate #AI companion #chatbots, requiring user disclosures, youth protections, and suicide crisis protocols but leaves key gaps in emotional safety standards.

ja.ma/4qkSCyQ
December 22, 2025 at 5:15 PM
💬 Viewpoint: Approval of leucovorin for cerebral folate deficiency based on limited evidence raises concerns about weakening FDA drug approval standards and public trust.

ja.ma/4asLxYh
December 22, 2025 at 5:00 PM
Superficial vein thrombosis is a condition in which blood clots develop within the superficial veins, typically in the legs or arms.

This JAMA Patient Page describes its risk factors, symptoms, diagnosis, and treatments.

ja.ma/3L27Ycz
December 22, 2025 at 4:45 PM
Newborn #nirsevimab immunization was associated with lower risks of RSV-related hospitalization and severe outcomes compared to maternal #RSVpreF vaccination.

ja.ma/44GMGI6
December 22, 2025 at 4:35 PM
📊 Research Summary: In adults with #tuberculosis and daily tobacco use, an mHealth intervention delivering motivational and behavioral support via text message led to higher quit rates at 6 months compared to written advice.

ja.ma/3Y3sZXl
December 22, 2025 at 4:25 PM
💬 Editorial: A mobile health text-based program tripled quit rates and reduced mortality in patients with #tuberculosis who smoke, supporting immediate integration in high-burden regions.

ja.ma/4snJ2NA
December 22, 2025 at 4:20 PM
Among adults with newly diagnosed, drug-sensitive #tuberculosis in high-burden countries, an mHealth program delivering text messages for tobacco cessation was associated with higher quit rates and lower short-term mortality than written advice alone.

ja.ma/4s4h2yp
December 22, 2025 at 4:15 PM
JAMA+ AI Editor in Chief Roy Perlis, MD, MSc, and Associate Editor Yulin Hswen, ScD, MPH, discuss some of the most cited #AI papers in 2025 across the JAMA Network.

🎧 Listen now: ja.ma/4qdc68y
December 22, 2025 at 3:00 PM
#COVID19 vaccination before or during pregnancy was associated with lower risks of hospitalization, ICU admission, and preterm birth among those infected with SARS-CoV-2 in Canada.

ja.ma/3Y53PYo
December 22, 2025 at 2:00 PM
💬 Editor's Note: JAMA+ AI Editor in Chief Roy Perlis, MD, MSc, speaks with insitro’s Chief eXploration Officer, Ajamete Kaykas, PhD, about using machine learning and wet lab research to accelerate new therapeutic development.

ja.ma/44CAPL6
AI in the Lab—Will AI Really Change Drug Discovery?
In this episode of JAMA+ AI Conversations, I interview Ajamete Kaykas, PhD, chief exploration officer at insitro, a biotech company aiming to combine machine learning with wet lab work to identify new treatments. We discuss everything from the future of scientists in the AI era to whether AI will...
ja.ma
December 22, 2025 at 1:00 PM