📖 Read all the JAMA, @jamacardiology.com, @jamainternalmed.com, and @jamanetworkopen.com papers presented today at #AHA25.

➡️ ja.ma/43PkF0s

💬 Editorial: While early detection and treatment may help some high-risk youth, the study by Bellows et al suggests broader population approaches to lower LDL-C distribution may offer greater cost-effectiveness.

#AHA25 @ahascience.bsky.social

ja.ma/4hMcFD6

Sequential childhood or early adulthood screening for familial hypercholesterolemia may lower lifetime CVD risk but is unlikely to be cost-effective unless follow-up for elevated cholesterol is widely implemented.

#AHA25 @ahascience.bsky.social

ja.ma/4oAh7rp

From @jamainternalmed.com: A 6-month habit-based group lifestyle intervention added to routine education and activity monitoring improved the proportion of patients with sustained metabolic syndrome remission.

#AHA25 @ahascience.bsky.social

ja.ma/4oI5cHO

💬 Editorial: The GoFresh trial showed home-delivered DASH groceries modestly lowered BP and LDL cholesterol in Black adults, but high costs and diet design limit broader impact.

#AHA25 @ahascience.bsky.social

ja.ma/43kGqFf

Home-delivered, low-sodium Dietary Approaches to Stop Hypertension (DASH) groceries and dietitian support temporarily improved blood pressure and LDL cholesterol in Black adults with high BP versus monetary support.

#AHA25 @ahascience.bsky.social

ja.ma/43lTKt2

💬 Editorial: The CORALreef HeFH trial demonstrated that oral enlicitide achieves robust, sustained reductions in LDL-C and other atherogenic lipids in patients with heterozygous familial hypercholesterolemia already receiving statin therapy.

#AHA25 @ahascience.bsky.social

ja.ma/4hOzaY5

Among adults with HeFH who were already taking statin therapy, treatment with enlicitide was well tolerated and reduced levels of LDL-C, apolipoprotein B, non–HDL-C, and lipoprotein(a).

#AHA25 @ahascience.bsky.social

ja.ma/4nQHAzM

From @jamanetworkopen.com: For neonates with congenital heart defects (CHDs) in Illinois, delayed #prenatal care initiation was associated with a higher probability of delivery at a pediatric #cardiac center, especially for severe CHD.

#AHA25 @ahascience.bsky.social

ja.ma/4hWAVTq

From @jamacardiology.com: Flynn et al find non-DNMT3A clonal hematopoiesis of indeterminate potential (CHIP) mutations most strongly associated with heart failure risk in UK Biobank data, supporting gene-specific risk assessment.

#AHA25 @ahascience.bsky.social

ja.ma/3JFEXmo

From @jamacardiology.com: Non-DNMT3A clonal hematopoiesis of indeterminate potential (CHIP) subtypes—including TET2, ASXL1, JAK2, and spliceosome genes—demonstrated higher association with incident heart failure compared to DNMT3A.

#AHA25 @ahascience.bsky.social

ja.ma/3XiNpLg

From @jamanetworkopen.com: Compared to standard regimens, trastuzumab emtansine exhibited a more favorable cardiotoxicity profile, while other novel and standard therapies demonstrated comparable risks of LVEF decline.

#AHA25 @ahascience.bsky.social

ja.ma/4hUqr6T

📊 Research Summary: Adults with #AFib who drank at least one cup of caffeinated coffee daily after successful cardioversion had a lower risk of recurrence than those who abstained from coffee and caffeine.

#AHA25 @ahascience.bsky.social

ja.ma/4hRnJz2

Patients with #AFib who continued their usual caffeinated coffee intake after cardioversion experienced less recurrence of AF or atrial flutter compared to those who abstained from coffee and caffeine.

#AHA25 @ahascience.bsky.social

ja.ma/47xVRMT