Rachel M. Kratofil
@rachelkratofil.bsky.social
Helen Hay Whitney Fellow at Icahn School of Medicine at Mount Sinai.
Fascinated by biology. Loves microscopy 🔬
Fascinated by biology. Loves microscopy 🔬
Reposted by Rachel M. Kratofil
New discovery in ulcerative colitis: a bacterial toxin that kills macrophages and increases inflammation, which could be the foundation for a new treatment
science.org/doi/10.1126/...
science.org/doi/10.1126/...
@science.org
science.org/doi/10.1126/...
science.org/doi/10.1126/...
@science.org
A bacterial toxin disarms gut defenses against inflammation
Macrophage-toxic bacteria from patients with ulcerative colitis worsen gut inflammation in mice
science.org
November 20, 2025 at 7:25 PM
New discovery in ulcerative colitis: a bacterial toxin that kills macrophages and increases inflammation, which could be the foundation for a new treatment
science.org/doi/10.1126/...
science.org/doi/10.1126/...
@science.org
science.org/doi/10.1126/...
science.org/doi/10.1126/...
@science.org
Reposted by Rachel M. Kratofil
For solving a 50-year mystery by uncovering the machinery behind BMP, a molecule with protective effects against various disorders, Uche Medoh is the winner of the 2025 Science & SciLifeLab Prize for Young Scientists.
🎉 Learn more about the work: https://scim.ag/4qVpK1a
🎉 Learn more about the work: https://scim.ag/4qVpK1a
November 13, 2025 at 8:34 PM
For solving a 50-year mystery by uncovering the machinery behind BMP, a molecule with protective effects against various disorders, Uche Medoh is the winner of the 2025 Science & SciLifeLab Prize for Young Scientists.
🎉 Learn more about the work: https://scim.ag/4qVpK1a
🎉 Learn more about the work: https://scim.ag/4qVpK1a
Reposted by Rachel M. Kratofil
Reposted by Rachel M. Kratofil
When Macrophages Disappear, Skin Blood Vessels Age!
Check out our new study @nature.com that uncovers how the loss of capillary-associated macrophages with age blocks vessel repair and blood flow, revealing a new cellular trigger of tissue aging. #Aging #Immunology
👇👇
www.nature.com/articles/s41...
Check out our new study @nature.com that uncovers how the loss of capillary-associated macrophages with age blocks vessel repair and blood flow, revealing a new cellular trigger of tissue aging. #Aging #Immunology
👇👇
www.nature.com/articles/s41...
Niche-specific dermal macrophage loss promotes skin capillary ageing - Nature
Capillary-associated macrophages are selectively lost over time, contributing to impaired vascular repair and reduced tissue perfusion in older mice.
www.nature.com
October 15, 2025 at 3:52 PM
When Macrophages Disappear, Skin Blood Vessels Age!
Check out our new study @nature.com that uncovers how the loss of capillary-associated macrophages with age blocks vessel repair and blood flow, revealing a new cellular trigger of tissue aging. #Aging #Immunology
👇👇
www.nature.com/articles/s41...
Check out our new study @nature.com that uncovers how the loss of capillary-associated macrophages with age blocks vessel repair and blood flow, revealing a new cellular trigger of tissue aging. #Aging #Immunology
👇👇
www.nature.com/articles/s41...
Reposted by Rachel M. Kratofil
UChicago Microbiology is searching for tenured or tenure-track faculty working in host-pathogens interactions, viral and bacterial pathogenesis, and emerging infectious diseases. Come join our vibrant Department! microbiology.uchicago.edu
Apply here apply.interfolio.com/174404
Apply here apply.interfolio.com/174404
Apply - Interfolio
{{$ctrl.$state.data.pageTitle}} - Apply - Interfolio
apply.interfolio.com
October 5, 2025 at 12:03 PM
UChicago Microbiology is searching for tenured or tenure-track faculty working in host-pathogens interactions, viral and bacterial pathogenesis, and emerging infectious diseases. Come join our vibrant Department! microbiology.uchicago.edu
Apply here apply.interfolio.com/174404
Apply here apply.interfolio.com/174404
Reposted by Rachel M. Kratofil
"Among all bacterial species, S. aureus ranks second only to E. coli in the number of scientific publications."
It was a pleasure to contribute to this review, with @pinholab.bsky.social and Friedrich Götz
journals.asm.org/doi/10.1128/...
It was a pleasure to contribute to this review, with @pinholab.bsky.social and Friedrich Götz
journals.asm.org/doi/10.1128/...
Staphylococcus aureus: a model for bacterial cell biology and pathogenesis | Journal of Bacteriology
When talking about Staphylococcus aureus, one usually has in mind the diseases that can be caused by this bacterium, ranging
from mild skin and soft tissue infections, such as abscesses and furuncles,...
journals.asm.org
July 28, 2025 at 10:48 AM
"Among all bacterial species, S. aureus ranks second only to E. coli in the number of scientific publications."
It was a pleasure to contribute to this review, with @pinholab.bsky.social and Friedrich Götz
journals.asm.org/doi/10.1128/...
It was a pleasure to contribute to this review, with @pinholab.bsky.social and Friedrich Götz
journals.asm.org/doi/10.1128/...
Congrats @ruthfranklinlab.bsky.social and lab! So much we don't know yet about macrophages!
#Macrophage-derived oncostatin M repairs the #lung epithelial barrier during inflammatory damage | @science.org www.science.org/doi/10.1126/...
#Macrophage-derived oncostatin M repairs the #lung epithelial barrier during inflammatory damage | @science.org www.science.org/doi/10.1126/...
Macrophage-derived oncostatin M repairs the lung epithelial barrier during inflammatory damage
Tissue repair programs must function alongside antiviral immunity to restore the lung epithelial barrier following infection. We found that macrophage-derived oncostatin M (OSM) counteracted the patho...
www.science.org
July 10, 2025 at 9:37 PM
Congrats @ruthfranklinlab.bsky.social and lab! So much we don't know yet about macrophages!
#Macrophage-derived oncostatin M repairs the #lung epithelial barrier during inflammatory damage | @science.org www.science.org/doi/10.1126/...
#Macrophage-derived oncostatin M repairs the #lung epithelial barrier during inflammatory damage | @science.org www.science.org/doi/10.1126/...
I had an amazing time organizing the GRS Tissue Repair and Regeneration conference this week along with my co-chair Robyn Allen. We have an incredible community who are so passionate for science, and equally supportive for one another!
June 7, 2025 at 6:29 PM
I had an amazing time organizing the GRS Tissue Repair and Regeneration conference this week along with my co-chair Robyn Allen. We have an incredible community who are so passionate for science, and equally supportive for one another!
Improved humanized mouse model of Staphylococcus aureus infection - Mucosal Immunology @daneparkerlab.com www.mucosalimmunology.org/article/S193...
Improved humanized mouse model of Staphylococcus aureus infection
Staphylococcus aureus is a significant cause of pulmonary infections, but existing
mouse models fail to recapitulate human-specific responses. In this study, we developed
a novel mouse model of S. aur...
www.mucosalimmunology.org
May 14, 2025 at 6:45 PM
Improved humanized mouse model of Staphylococcus aureus infection - Mucosal Immunology @daneparkerlab.com www.mucosalimmunology.org/article/S193...
Reposted by Rachel M. Kratofil
🫁"Lung Immune Cell Type ‘Quietly’ Controls Inflammation in COVID-19". Congrats @payalyokota.bsky.social, @khannakm.bsky.social, and colleagues!
nyulangone.org/news/lung-im...
nyulangone.org/news/lung-im...
Lung Immune Cell Type ‘Quietly’ Controls Inflammation in COVID-19
NYU Langone study shows a type of immune cell in the lungs may help prevent inflammation from spiraling out of control during COVID-19. Learn more.
nyulangone.org
April 29, 2025 at 7:34 PM
🫁"Lung Immune Cell Type ‘Quietly’ Controls Inflammation in COVID-19". Congrats @payalyokota.bsky.social, @khannakm.bsky.social, and colleagues!
nyulangone.org/news/lung-im...
nyulangone.org/news/lung-im...
Reposted by Rachel M. Kratofil
🔬 A new probe developed by Janelia researchers & collaborators that enables visualization of extracellular matrix structure in live tissues could also be useful in studying diseases linked to changes in the extracellular matrix and in diagnostic imaging ➡️ www.janelia.org/news/looking...
April 29, 2025 at 3:55 PM
🔬 A new probe developed by Janelia researchers & collaborators that enables visualization of extracellular matrix structure in live tissues could also be useful in studying diseases linked to changes in the extracellular matrix and in diagnostic imaging ➡️ www.janelia.org/news/looking...
Reposted by Rachel M. Kratofil
Excited to share our latest study
@cp-immunity.bsky.social. Heartfelt thanks to the editorial and review teams , to my co-first @yeungadventures.bsky.social, our co-authors, and to @khannakm.bsky.social
for his outstanding mentorship throughout! Pls read/share!👇
www.cell.com/immunity/ful...
@cp-immunity.bsky.social. Heartfelt thanks to the editorial and review teams , to my co-first @yeungadventures.bsky.social, our co-authors, and to @khannakm.bsky.social
for his outstanding mentorship throughout! Pls read/share!👇
www.cell.com/immunity/ful...
Nerve- and airway-associated interstitial macrophages mitigate SARS-CoV-2 pathogenesis via type I interferon signaling
The local immunoregulatory mechanisms that safeguard the host from excessive lung
infection inflammation remain unclear. Yeung, Yokota et al. uncover the essential
role of nerve- and airway-associated...
www.cell.com
April 25, 2025 at 2:38 PM
Excited to share our latest study
@cp-immunity.bsky.social. Heartfelt thanks to the editorial and review teams , to my co-first @yeungadventures.bsky.social, our co-authors, and to @khannakm.bsky.social
for his outstanding mentorship throughout! Pls read/share!👇
www.cell.com/immunity/ful...
@cp-immunity.bsky.social. Heartfelt thanks to the editorial and review teams , to my co-first @yeungadventures.bsky.social, our co-authors, and to @khannakm.bsky.social
for his outstanding mentorship throughout! Pls read/share!👇
www.cell.com/immunity/ful...
Reposted by Rachel M. Kratofil
Congrats to superstar Joe Daccache on his NIH F31 NOA! He aims to define tissue-wide disease memory in inflammatory conditions to develop next-generation therapies. #Naiklab #Ruggleslab @sinaiimmuno.bsky.social
April 15, 2025 at 3:27 PM
Congrats to superstar Joe Daccache on his NIH F31 NOA! He aims to define tissue-wide disease memory in inflammatory conditions to develop next-generation therapies. #Naiklab #Ruggleslab @sinaiimmuno.bsky.social
Reposted by Rachel M. Kratofil
Toronto is aiming high with the hiring of 100 new scientists!
🇨🇦💪
🇨🇦💪
Today UHN launches the Canada Leads 100 Challenge! 🇨🇦💯
We’re making an ambitious investment to recruit 100 world-leading scientists. Together, we'll drive the future of health research and position Canada as a leader in global innovation!
Learn more:
www.uhn.ca/corporate/Ab...
We’re making an ambitious investment to recruit 100 world-leading scientists. Together, we'll drive the future of health research and position Canada as a leader in global innovation!
Learn more:
www.uhn.ca/corporate/Ab...
April 7, 2025 at 11:40 PM
Toronto is aiming high with the hiring of 100 new scientists!
🇨🇦💪
🇨🇦💪
Reposted by Rachel M. Kratofil
Today UHN launches the Canada Leads 100 Challenge! 🇨🇦💯
We’re making an ambitious investment to recruit 100 world-leading scientists. Together, we'll drive the future of health research and position Canada as a leader in global innovation!
Learn more:
www.uhn.ca/corporate/Ab...
We’re making an ambitious investment to recruit 100 world-leading scientists. Together, we'll drive the future of health research and position Canada as a leader in global innovation!
Learn more:
www.uhn.ca/corporate/Ab...
April 7, 2025 at 4:00 PM
Today UHN launches the Canada Leads 100 Challenge! 🇨🇦💯
We’re making an ambitious investment to recruit 100 world-leading scientists. Together, we'll drive the future of health research and position Canada as a leader in global innovation!
Learn more:
www.uhn.ca/corporate/Ab...
We’re making an ambitious investment to recruit 100 world-leading scientists. Together, we'll drive the future of health research and position Canada as a leader in global innovation!
Learn more:
www.uhn.ca/corporate/Ab...
Reposted by Rachel M. Kratofil
"Pregnancy’s true toll on the body: huge birth study paints most detailed picture yet"
Our study highlighted in @nature.com News
www.nature.com/articles/d41...
Our study highlighted in @nature.com News
www.nature.com/articles/d41...
Pregnancy’s true toll on the body: huge birth study paints most detailed picture yet
Data from 300,000 births reveal how essential biological measurements are altered by carrying and delivering a baby.
www.nature.com
March 30, 2025 at 4:32 PM
"Pregnancy’s true toll on the body: huge birth study paints most detailed picture yet"
Our study highlighted in @nature.com News
www.nature.com/articles/d41...
Our study highlighted in @nature.com News
www.nature.com/articles/d41...
Growth of the maternal intestine during reproduction: Cell www.cell.com/cell/fulltex...
Growth of the maternal intestine during reproduction
In mice, pregnancy elongates the maternal small intestine and its villi. Reproductive
remodeling is distinct from diet- or microbiota-induced changes and involves SGLT3a-driven
progenitor expansion, r...
www.cell.com
March 19, 2025 at 9:49 PM
Growth of the maternal intestine during reproduction: Cell www.cell.com/cell/fulltex...
Reposted by Rachel M. Kratofil
A tissue-scale strategy for sensing threats in barrier organs https://www.biorxiv.org/content/10.1101/2025.03.19.644134v1
March 19, 2025 at 9:17 PM
A tissue-scale strategy for sensing threats in barrier organs https://www.biorxiv.org/content/10.1101/2025.03.19.644134v1
Reposted by Rachel M. Kratofil
Immune cells in the skin ‘cauterize’ open wounds and create ‘band-aids’ to prevent the spread of harmful bacteria and foreign molecules from injury sites.
https://go.nature.com/4kw1RKx
https://go.nature.com/4kw1RKx
Immune cells ‘bandage’ wounds with bacteria-trapping goo
Cells called neutrophils form gooey rings around sites where skin is punctured, study in mice shows.
go.nature.com
March 19, 2025 at 4:21 PM
Immune cells in the skin ‘cauterize’ open wounds and create ‘band-aids’ to prevent the spread of harmful bacteria and foreign molecules from injury sites.
https://go.nature.com/4kw1RKx
https://go.nature.com/4kw1RKx
Reposted by Rachel M. Kratofil
1/2 New publication from the lab from the talented postdoc Dr. Andy Perrault in collaboration with Dr. Alejandro Pironti! pubmed.ncbi.nlm.nih.gov/39977318/
Enterobacter hormaechei replaces virulence with carbapenem resistance via porin loss - PubMed
Pathogenic <i>Enterobacter</i> species are of increasing clinical concern due to the multidrug-resistant nature of these bacteria, including resistance to carbapenem antibiotics. Our understanding of ...
pubmed.ncbi.nlm.nih.gov
February 22, 2025 at 3:42 PM
1/2 New publication from the lab from the talented postdoc Dr. Andy Perrault in collaboration with Dr. Alejandro Pironti! pubmed.ncbi.nlm.nih.gov/39977318/
Reposted by Rachel M. Kratofil
Congrats to the Plikus lab on this exciting work on fibroblasts in skin wounds!
www.jidonline.org/article/S002...
www.jidonline.org/article/S002...
Integrated Single-Cell Analysis Reveals Spatially and Temporally Dynamic Heterogeneity in Fibroblast States during Wound Healing
Wound healing is a dynamic process over temporal and spatial scales. Key to repair
outcomes are fibroblasts; yet, how they modulate healing across time and in different
wound regions remains incomplet...
www.jidonline.org
February 21, 2025 at 3:35 PM
Congrats to the Plikus lab on this exciting work on fibroblasts in skin wounds!
www.jidonline.org/article/S002...
www.jidonline.org/article/S002...
Reposted by Rachel M. Kratofil
Intravital imaging of pulmonary lymphatics in inflammation and metastatic cancer @jem.org @simoncleary.bsky.social
doi.org/10.1084/jem....
doi.org/10.1084/jem....
February 20, 2025 at 2:37 AM
Intravital imaging of pulmonary lymphatics in inflammation and metastatic cancer @jem.org @simoncleary.bsky.social
doi.org/10.1084/jem....
doi.org/10.1084/jem....
Only 1 week left to submit your abstract for a presentation at the 2025 GRS Tissue Repair and Regeneration - due Feb23!!
Our theme this year is "Tissue Adaptations to Maintain Form and Function" and our keynote speaker for the weekend will be @ophirklein.bsky.social!
www.grc.org/tissue-repai...
Our theme this year is "Tissue Adaptations to Maintain Form and Function" and our keynote speaker for the weekend will be @ophirklein.bsky.social!
www.grc.org/tissue-repai...
2025 Tissue Repair and Regeneration (GRS) Seminar GRC
The 2025 Gordon Research Seminar on Tissue Repair and Regeneration (GRS) will be held in New London, New Hampshire. Apply today to reserve your spot.
www.grc.org
February 17, 2025 at 6:27 PM
Only 1 week left to submit your abstract for a presentation at the 2025 GRS Tissue Repair and Regeneration - due Feb23!!
Our theme this year is "Tissue Adaptations to Maintain Form and Function" and our keynote speaker for the weekend will be @ophirklein.bsky.social!
www.grc.org/tissue-repai...
Our theme this year is "Tissue Adaptations to Maintain Form and Function" and our keynote speaker for the weekend will be @ophirklein.bsky.social!
www.grc.org/tissue-repai...
Reposted by Rachel M. Kratofil
Delighted to share our new study. A collaboration with the Thurlow lab. Antibiotic resistance rapidly emerges and thrives in diabetic mice. A worrying coming together of two major and growing health problems worldwide www.science.org/doi/10.1126/...
Diabetes potentiates the emergence and expansion of antibiotic resistance
Diabetic infections are a reservoir for the emergence and proliferation of antibiotic resistance in Staphylococcus aureus.
www.science.org
February 13, 2025 at 11:48 AM
Delighted to share our new study. A collaboration with the Thurlow lab. Antibiotic resistance rapidly emerges and thrives in diabetic mice. A worrying coming together of two major and growing health problems worldwide www.science.org/doi/10.1126/...