Uri Alon
@urialonlab.bsky.social
The Alon lab explores design principles of biological circuits, focusing on systems medicine, aging, and healthspan.
Why does innovative research necessitate a jump into the unknown? Find out (and much more) in episode 147 of רעב לידע עם אור דניאל (Hungry for Knowledge with Or Daniel)!
www.learntech.co.il/podcast/pod1...
www.learntech.co.il/podcast/pod1...
מדוע מדע חדשני דורש קפיצה אל הלא נודע? | פרופ' אורי אלון | פרק 147 · LearnTech
הכירו את פרופ' אורי אלון, מנהל מעבדת סגול לאריכות ימים במכון ויצמן. בפרק מרתק זה תגלו מדוע תסכול וכישלון הם לא רק חלק מהמחקר אלא המפתח לגילויים פורצי דרך, איך "ענן המחקר" יכול להפוך מאויב למדריך, ומה ...
www.learntech.co.il
May 25, 2025 at 5:39 PM
Why does innovative research necessitate a jump into the unknown? Find out (and much more) in episode 147 of רעב לידע עם אור דניאל (Hungry for Knowledge with Or Daniel)!
www.learntech.co.il/podcast/pod1...
www.learntech.co.il/podcast/pod1...
Sweet moment in life, our 25th lab anniversary. In a circle, we looked at each other, a group of people with shared values and a soft approach, who want each other to succeed and be happy. (1/2)
April 23, 2025 at 12:07 PM
Sweet moment in life, our 25th lab anniversary. In a circle, we looked at each other, a group of people with shared values and a soft approach, who want each other to succeed and be happy. (1/2)
Masterpiece by a masterful scientist
Natural Neuroscience by Nachum Ulanovsky
@mitpress.bsky.social mitpress.mit.edu/978026204499...
Natural Neuroscience by Nachum Ulanovsky
@mitpress.bsky.social mitpress.mit.edu/978026204499...
April 16, 2025 at 8:07 AM
Masterpiece by a masterful scientist
Natural Neuroscience by Nachum Ulanovsky
@mitpress.bsky.social mitpress.mit.edu/978026204499...
Natural Neuroscience by Nachum Ulanovsky
@mitpress.bsky.social mitpress.mit.edu/978026204499...
Our latest on aging, where we reveal an unexpected link between healthspan and equality of lifespans.
By @y1fanyang.bsky.social , out now @naturecomms.bsky.social
www.nature.com/articles/s41...
By @y1fanyang.bsky.social , out now @naturecomms.bsky.social
www.nature.com/articles/s41...
Compression of morbidity by interventions that steepen the survival curve - Nature Communications
Longevity research aims to extend lifespan and reduce sickspan in aging. Here, the authors show that only interventions that steepen survival curves can compress the sickspan relative to lifespan.
www.nature.com
April 11, 2025 at 12:34 PM
Our latest on aging, where we reveal an unexpected link between healthspan and equality of lifespans.
By @y1fanyang.bsky.social , out now @naturecomms.bsky.social
www.nature.com/articles/s41...
By @y1fanyang.bsky.social , out now @naturecomms.bsky.social
www.nature.com/articles/s41...
Now in French and Spanish - our pregnancy paper is highlighted also in @lefigaro.fr and @elpais.com
sante.lefigaro.fr/medecine/com...
elpais.com/salud-y-bien...
sante.lefigaro.fr/medecine/com...
elpais.com/salud-y-bien...
Comment la grossesse chamboule le corps de la future mère, et pourquoi elle ne redevient jamais vraiment elle-même
Une étude menée sur plus de 300 000 femmes révèle les bouleversements visibles dans le sang et l’urine des femmes enceintes. Des résultats qui pourraient aider à mieux prédire les complications de la ...
sante.lefigaro.fr
March 31, 2025 at 2:09 PM
Now in French and Spanish - our pregnancy paper is highlighted also in @lefigaro.fr and @elpais.com
sante.lefigaro.fr/medecine/com...
elpais.com/salud-y-bien...
sante.lefigaro.fr/medecine/com...
elpais.com/salud-y-bien...
Reposted by Uri Alon
Amazing clinical epidemiology! The power of numbers! @urialonlab.bsky.social
www.nature.com/articles/d41...
www.nature.com/articles/d41...
Pregnancy’s true toll on the body: huge birth study paints most detailed picture yet
Data from 300,000 births reveal how essential biological measurements are altered by carrying and delivering a baby.
www.nature.com
March 30, 2025 at 9:39 PM
Amazing clinical epidemiology! The power of numbers! @urialonlab.bsky.social
www.nature.com/articles/d41...
www.nature.com/articles/d41...
Reposted by Uri Alon
We now have our most detailed picture yet of how pregnancy affects the body on a weekly basis from 20 weeks pre-conception to 1.5 years after delivery. Fab work from @urialonlab.bsky.social
Read @newscientist.com.
www.newscientist.com/article/2473...
Read @newscientist.com.
www.newscientist.com/article/2473...
Pregnancy’s lasting effects on different parts of the body revealed
An "unprecedented view" of how the body changes during and after pregnancy has revealed many long-lasting impacts on the liver, kidneys and more
www.newscientist.com
March 28, 2025 at 6:03 PM
We now have our most detailed picture yet of how pregnancy affects the body on a weekly basis from 20 weeks pre-conception to 1.5 years after delivery. Fab work from @urialonlab.bsky.social
Read @newscientist.com.
www.newscientist.com/article/2473...
Read @newscientist.com.
www.newscientist.com/article/2473...
"Pregnancy’s true toll on the body: huge birth study paints most detailed picture yet"
Our study highlighted in @nature.com News
www.nature.com/articles/d41...
Our study highlighted in @nature.com News
www.nature.com/articles/d41...
Pregnancy’s true toll on the body: huge birth study paints most detailed picture yet
Data from 300,000 births reveal how essential biological measurements are altered by carrying and delivering a baby.
www.nature.com
March 30, 2025 at 4:32 PM
"Pregnancy’s true toll on the body: huge birth study paints most detailed picture yet"
Our study highlighted in @nature.com News
www.nature.com/articles/d41...
Our study highlighted in @nature.com News
www.nature.com/articles/d41...
Excited to share our new study revealing the intricate dynamics of pregnancy & postpartum physiology! We analyzed 40M lab tests from 300K pregnancies and 160K women (cross-sectional) and mapped week-by-week changes starting from preconception to months-long postpartum recovery.
March 27, 2025 at 12:44 PM
Excited to share our new study revealing the intricate dynamics of pregnancy & postpartum physiology! We analyzed 40M lab tests from 300K pregnancies and 160K women (cross-sectional) and mapped week-by-week changes starting from preconception to months-long postpartum recovery.
Reposted by Uri Alon
Harnessing huge data from pregnancy natural experiments @urialonlab.bsky.social
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
March 27, 2025 at 3:00 AM
Harnessing huge data from pregnancy natural experiments @urialonlab.bsky.social
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Theory predicted two kinds of fibrosis, hot and cold.
We show in vivo that hot and cold fibrosis describe heart failure, and heart attack, respectively, showing that they are very different disease states. @shovalmiyara.bsky.social @eldadtzahor.bsky.social
We show in vivo that hot and cold fibrosis describe heart failure, and heart attack, respectively, showing that they are very different disease states. @shovalmiyara.bsky.social @eldadtzahor.bsky.social
Our work made it to the cover of @cp-cellsystems.bsky.social ! 🥳
Cold and hot fibrosis define clinically distinct cardiac pathologies
www.cell.com/cell-systems...
Special thanks to Danielle Kimchi for creating this beautiful cover! 🎉
@urialonlab.bsky.social @eldadtzahor.bsky.social
Cold and hot fibrosis define clinically distinct cardiac pathologies
www.cell.com/cell-systems...
Special thanks to Danielle Kimchi for creating this beautiful cover! 🎉
@urialonlab.bsky.social @eldadtzahor.bsky.social
March 24, 2025 at 3:02 PM
Theory predicted two kinds of fibrosis, hot and cold.
We show in vivo that hot and cold fibrosis describe heart failure, and heart attack, respectively, showing that they are very different disease states. @shovalmiyara.bsky.social @eldadtzahor.bsky.social
We show in vivo that hot and cold fibrosis describe heart failure, and heart attack, respectively, showing that they are very different disease states. @shovalmiyara.bsky.social @eldadtzahor.bsky.social
Sagol lecture in longevity research - Myriam Grunewald on vasculature maintenance for longevity
March 18, 2025 at 9:12 AM
Sagol lecture in longevity research - Myriam Grunewald on vasculature maintenance for longevity
Join us at the ICSB in Dublin this October - I will chair the session on aging systems biology
icsb2025.com
icsb2025.com
February 24, 2025 at 9:36 AM
Join us at the ICSB in Dublin this October - I will chair the session on aging systems biology
icsb2025.com
icsb2025.com
Reposted by Uri Alon
It’s finally here! My PhD work, five years in the making, is now published @CellSystems @cellpress.bsky.social 🚨
Cold and hot fibrosis define clinically distinct cardiac pathologies. www.cell.com/cell-systems...
Cold and hot fibrosis define clinically distinct cardiac pathologies. www.cell.com/cell-systems...
Cold and hot fibrosis define clinically distinct cardiac pathologies
Miyara et al. identify two types of fibrosis in cardiac pathologies: “hot fibrosis,”
involving macrophage-myofibroblast interactions in chronic injuries, and acute-injury-driven
“cold fibrosis,” contr...
www.cell.com
February 19, 2025 at 3:52 PM
It’s finally here! My PhD work, five years in the making, is now published @CellSystems @cellpress.bsky.social 🚨
Cold and hot fibrosis define clinically distinct cardiac pathologies. www.cell.com/cell-systems...
Cold and hot fibrosis define clinically distinct cardiac pathologies. www.cell.com/cell-systems...
My brilliant PhD student @Yaelebel.bsky.social gave a talk at the Azrieli Graduate Students forum about her research on using excitable dynamics to explain pulsatile immune phenomena, and how research questions can come from the most unexpected places. Well done Yael!
youtu.be/MdwqWx5emo4
youtu.be/MdwqWx5emo4
Yael Lebel
YouTube video by Azrieli Fellows Program
youtu.be
February 10, 2025 at 3:55 PM
My brilliant PhD student @Yaelebel.bsky.social gave a talk at the Azrieli Graduate Students forum about her research on using excitable dynamics to explain pulsatile immune phenomena, and how research questions can come from the most unexpected places. Well done Yael!
youtu.be/MdwqWx5emo4
youtu.be/MdwqWx5emo4
Will be attending the Quantitative Immunology workshop at the Princeton Center for Theoretical Science later month.
pcts.princeton.edu/events/2025/...
pcts.princeton.edu/events/2025/...
Quantitative Immunology
Organizers: Andrea Graham; Julia Merkenschlager; Alexander Ploss; Colin Scheibner; Ned WingreenThe immune system functions across diverse scales, from the recognition of molecules to the evolution of ...
pcts.princeton.edu
February 9, 2025 at 7:49 PM
Will be attending the Quantitative Immunology workshop at the Princeton Center for Theoretical Science later month.
pcts.princeton.edu/events/2025/...
pcts.princeton.edu/events/2025/...
Why do cortisol-lowering drugs work for Cushing’s but fail in mood disorders & chronic stress?
We propose that the ability of the pituitary and adrenal glands to adjust their functional masses—normally beneficial—counteracts the drug’s effect. Using a math. model, we screened HPA interventions (1/2)
We propose that the ability of the pituitary and adrenal glands to adjust their functional masses—normally beneficial—counteracts the drug’s effect. Using a math. model, we screened HPA interventions (1/2)
February 4, 2025 at 3:53 PM
Why do cortisol-lowering drugs work for Cushing’s but fail in mood disorders & chronic stress?
We propose that the ability of the pituitary and adrenal glands to adjust their functional masses—normally beneficial—counteracts the drug’s effect. Using a math. model, we screened HPA interventions (1/2)
We propose that the ability of the pituitary and adrenal glands to adjust their functional masses—normally beneficial—counteracts the drug’s effect. Using a math. model, we screened HPA interventions (1/2)
Reposted by Uri Alon
@urialonlab.bsky.social lab reveals a hormone circuit that explains why most HPA drugs fail for mood disorders and predicts the few that work ➡️ www.embopress.org/doi/full/10....
February 4, 2025 at 2:20 PM
@urialonlab.bsky.social lab reveals a hormone circuit that explains why most HPA drugs fail for mood disorders and predicts the few that work ➡️ www.embopress.org/doi/full/10....
Reposted by Uri Alon
Really enjoying Uri Alon’s characteristically wonderful lectures on aging:
www.weizmann.ac.il/mcb/alon/cou...
www.weizmann.ac.il/mcb/alon/cou...
Systems Aging (autumn 2024)
Course Theme Song
www.weizmann.ac.il
December 24, 2024 at 5:54 AM
Really enjoying Uri Alon’s characteristically wonderful lectures on aging:
www.weizmann.ac.il/mcb/alon/cou...
www.weizmann.ac.il/mcb/alon/cou...
Videos and lecture notes from my latest course, Systems Aging, are available now at:
www.weizmann.ac.il/mcb/alon/cou...
www.weizmann.ac.il/mcb/alon/cou...
Systems Aging (autumn 2024)
Course Theme Song
www.weizmann.ac.il
January 30, 2025 at 9:00 AM
Videos and lecture notes from my latest course, Systems Aging, are available now at:
www.weizmann.ac.il/mcb/alon/cou...
www.weizmann.ac.il/mcb/alon/cou...
Excited to speak at the Global Conference on Gerophysics, where we'll explore how physics can revolutionize our understanding of aging and mortality. Join us and get 10% off registration with code GCGP10.
See you there, and sign up here: medicine.nus.edu.sg/trp/healthy-...
See you there, and sign up here: medicine.nus.edu.sg/trp/healthy-...
January 28, 2025 at 8:48 AM
Excited to speak at the Global Conference on Gerophysics, where we'll explore how physics can revolutionize our understanding of aging and mortality. Join us and get 10% off registration with code GCGP10.
See you there, and sign up here: medicine.nus.edu.sg/trp/healthy-...
See you there, and sign up here: medicine.nus.edu.sg/trp/healthy-...