Shoval Miyara
@shovalmiyara.bsky.social
Studying fibrosis at the labs of Prof. Uri Alon @urialonlab.bsky.social and Prof. Eldad Tzahor @Weizmann Institute of Science.
Pinned
Shoval Miyara
@shovalmiyara.bsky.social
· Sep 22
A fibroblast-centric network drives cold fibrosis in the tumor microenvironment of lung squamous cell carcinoma
The tumor microenvironment (TME) of chronic inflammation-associated cancers (CIACs) is shaped by cycles of injury and maladaptive repair, yet the principles organizing fibrotic stroma in these tumors ...
www.biorxiv.org
🚨It’s here! Our new preprint is live on bioRxiv🚨
A fibroblast-centric network drives ❄️cold fibrosis in the tumor microenvironment of lung squamous cell carcinoma 🧵
www.biorxiv.org/content/10.1...
A fibroblast-centric network drives ❄️cold fibrosis in the tumor microenvironment of lung squamous cell carcinoma 🧵
www.biorxiv.org/content/10.1...
🚨It’s here! Our new preprint is live on bioRxiv🚨
A fibroblast-centric network drives ❄️cold fibrosis in the tumor microenvironment of lung squamous cell carcinoma 🧵
www.biorxiv.org/content/10.1...
A fibroblast-centric network drives ❄️cold fibrosis in the tumor microenvironment of lung squamous cell carcinoma 🧵
www.biorxiv.org/content/10.1...
A fibroblast-centric network drives cold fibrosis in the tumor microenvironment of lung squamous cell carcinoma
The tumor microenvironment (TME) of chronic inflammation-associated cancers (CIACs) is shaped by cycles of injury and maladaptive repair, yet the principles organizing fibrotic stroma in these tumors ...
www.biorxiv.org
September 22, 2025 at 3:09 PM
🚨It’s here! Our new preprint is live on bioRxiv🚨
A fibroblast-centric network drives ❄️cold fibrosis in the tumor microenvironment of lung squamous cell carcinoma 🧵
www.biorxiv.org/content/10.1...
A fibroblast-centric network drives ❄️cold fibrosis in the tumor microenvironment of lung squamous cell carcinoma 🧵
www.biorxiv.org/content/10.1...
Reposted by Shoval Miyara
🎉 The revised version of CORNETO, our unified Python framework for knowledge-driven network inference from omics data, is published in peer reviewed form
🔗 Paper: www.nature.com/articles/s42...
📖 News & Views: www.nature.com/articles/s42...
💻 Code: corneto.org
🧵 Thread 👇
🔗 Paper: www.nature.com/articles/s42...
📖 News & Views: www.nature.com/articles/s42...
💻 Code: corneto.org
🧵 Thread 👇
July 22, 2025 at 3:23 PM
🎉 The revised version of CORNETO, our unified Python framework for knowledge-driven network inference from omics data, is published in peer reviewed form
🔗 Paper: www.nature.com/articles/s42...
📖 News & Views: www.nature.com/articles/s42...
💻 Code: corneto.org
🧵 Thread 👇
🔗 Paper: www.nature.com/articles/s42...
📖 News & Views: www.nature.com/articles/s42...
💻 Code: corneto.org
🧵 Thread 👇
Had a blast writing this News & Views piece w/ @eldadtzahor.bsky.social
on an interesting study uncovering a role for ARID5A in cardiac #aging, #inflammation & #fibrosis. @natcardiovascres.nature.com
www.nature.com/articles/s44...
on an interesting study uncovering a role for ARID5A in cardiac #aging, #inflammation & #fibrosis. @natcardiovascres.nature.com
www.nature.com/articles/s44...
ARID5A promotes inflammation and fibrosis during cardiac aging - Nature Cardiovascular Research
A systematic biology approach identifies an RNA-binding protein, ARID5A, as a regulator of inflammation and fibrosis in the aging human heart. Inhibition of ARID5A reduced inflammation and fibrosis an...
www.nature.com
May 1, 2025 at 1:09 PM
Had a blast writing this News & Views piece w/ @eldadtzahor.bsky.social
on an interesting study uncovering a role for ARID5A in cardiac #aging, #inflammation & #fibrosis. @natcardiovascres.nature.com
www.nature.com/articles/s44...
on an interesting study uncovering a role for ARID5A in cardiac #aging, #inflammation & #fibrosis. @natcardiovascres.nature.com
www.nature.com/articles/s44...
Reposted by Shoval Miyara
Excited to share our new study revealing the intricate dynamics of pregnancy & postpartum physiology! We analyzed 40M lab tests from 300K pregnancies and 160K women (cross-sectional) and mapped week-by-week changes starting from preconception to months-long postpartum recovery.
March 27, 2025 at 12:44 PM
Excited to share our new study revealing the intricate dynamics of pregnancy & postpartum physiology! We analyzed 40M lab tests from 300K pregnancies and 160K women (cross-sectional) and mapped week-by-week changes starting from preconception to months-long postpartum recovery.
Reposted by Shoval Miyara
Super excited to finally see this published! Our new method to use combinatorial staining and deep learning to push the multiplexing boundaries of spatial proteomics!
High-dimensional imaging using combinatorial channel multiplexing and deep learning go.nature.com/4hGPfO0
High-dimensional imaging using combinatorial channel multiplexing and deep learning - Nature Biotechnology
Protein imaging is multiplexed using combinatorial staining and deep learning decompression.
go.nature.com
March 26, 2025 at 4:12 AM
Super excited to finally see this published! Our new method to use combinatorial staining and deep learning to push the multiplexing boundaries of spatial proteomics!
Reposted by Shoval Miyara
Theory predicted two kinds of fibrosis, hot and cold.
We show in vivo that hot and cold fibrosis describe heart failure, and heart attack, respectively, showing that they are very different disease states. @shovalmiyara.bsky.social @eldadtzahor.bsky.social
We show in vivo that hot and cold fibrosis describe heart failure, and heart attack, respectively, showing that they are very different disease states. @shovalmiyara.bsky.social @eldadtzahor.bsky.social
Our work made it to the cover of @cp-cellsystems.bsky.social ! 🥳
Cold and hot fibrosis define clinically distinct cardiac pathologies
www.cell.com/cell-systems...
Special thanks to Danielle Kimchi for creating this beautiful cover! 🎉
@urialonlab.bsky.social @eldadtzahor.bsky.social
Cold and hot fibrosis define clinically distinct cardiac pathologies
www.cell.com/cell-systems...
Special thanks to Danielle Kimchi for creating this beautiful cover! 🎉
@urialonlab.bsky.social @eldadtzahor.bsky.social
March 24, 2025 at 3:02 PM
Theory predicted two kinds of fibrosis, hot and cold.
We show in vivo that hot and cold fibrosis describe heart failure, and heart attack, respectively, showing that they are very different disease states. @shovalmiyara.bsky.social @eldadtzahor.bsky.social
We show in vivo that hot and cold fibrosis describe heart failure, and heart attack, respectively, showing that they are very different disease states. @shovalmiyara.bsky.social @eldadtzahor.bsky.social
Our work made it to the cover of @cp-cellsystems.bsky.social ! 🥳
Cold and hot fibrosis define clinically distinct cardiac pathologies
www.cell.com/cell-systems...
Special thanks to Danielle Kimchi for creating this beautiful cover! 🎉
@urialonlab.bsky.social @eldadtzahor.bsky.social
Cold and hot fibrosis define clinically distinct cardiac pathologies
www.cell.com/cell-systems...
Special thanks to Danielle Kimchi for creating this beautiful cover! 🎉
@urialonlab.bsky.social @eldadtzahor.bsky.social
March 20, 2025 at 6:42 PM
Our work made it to the cover of @cp-cellsystems.bsky.social ! 🥳
Cold and hot fibrosis define clinically distinct cardiac pathologies
www.cell.com/cell-systems...
Special thanks to Danielle Kimchi for creating this beautiful cover! 🎉
@urialonlab.bsky.social @eldadtzahor.bsky.social
Cold and hot fibrosis define clinically distinct cardiac pathologies
www.cell.com/cell-systems...
Special thanks to Danielle Kimchi for creating this beautiful cover! 🎉
@urialonlab.bsky.social @eldadtzahor.bsky.social
Reposted by Shoval Miyara
How does the #vasculature regulate #immune cell infiltration & function across different brain tumors? 🧠🧪
Excited to share our latest study in #Immunity where we uncover some interesting answers— led by the amazing @lbejarano.bsky.social 🤩👏🏻
🧵
@cp-immunity.bsky.social
www.cell.com/immunity/ful...
Excited to share our latest study in #Immunity where we uncover some interesting answers— led by the amazing @lbejarano.bsky.social 🤩👏🏻
🧵
@cp-immunity.bsky.social
www.cell.com/immunity/ful...
March 20, 2025 at 1:51 PM
How does the #vasculature regulate #immune cell infiltration & function across different brain tumors? 🧠🧪
Excited to share our latest study in #Immunity where we uncover some interesting answers— led by the amazing @lbejarano.bsky.social 🤩👏🏻
🧵
@cp-immunity.bsky.social
www.cell.com/immunity/ful...
Excited to share our latest study in #Immunity where we uncover some interesting answers— led by the amazing @lbejarano.bsky.social 🤩👏🏻
🧵
@cp-immunity.bsky.social
www.cell.com/immunity/ful...
Reposted by Shoval Miyara
Cardiac scars can be classified as "hot" or "cold," each requiring distinct treatments. This discovery could lead to innovative therapies for heart disease and fibrosis in other organs. doi.org/g85hm2
Mending a broken heart: Two types of scars in injured cardiac tissue, two paths to healing
Not all scars are created equal. That's the conclusion of a new study by Weizmann Institute of Science researchers: They found that two distinct types of scars, referred to as "hot" and "cold," can form in the diseased heart, and that these two types call for entirely different treatments.
medicalxpress.com
February 18, 2025 at 5:47 PM
Cardiac scars can be classified as "hot" or "cold," each requiring distinct treatments. This discovery could lead to innovative therapies for heart disease and fibrosis in other organs. doi.org/g85hm2
Reposted by Shoval Miyara
Congrats to @shovalmiyara.bsky.social,Miri Adler, @eldadtzahor.bsky.social & @urialonlab.bsky.social on this great work! We're glad to have supported the translation of findings from theoretical and animal models to human myocardial infarction data using LIANA+ (liana-py.readthedocs.io)
It’s finally here! My PhD work, five years in the making, is now published @CellSystems @cellpress.bsky.social 🚨
Cold and hot fibrosis define clinically distinct cardiac pathologies. www.cell.com/cell-systems...
Cold and hot fibrosis define clinically distinct cardiac pathologies. www.cell.com/cell-systems...
Cold and hot fibrosis define clinically distinct cardiac pathologies
Miyara et al. identify two types of fibrosis in cardiac pathologies: “hot fibrosis,”
involving macrophage-myofibroblast interactions in chronic injuries, and acute-injury-driven
“cold fibrosis,” contr...
www.cell.com
February 25, 2025 at 4:24 PM
Congrats to @shovalmiyara.bsky.social,Miri Adler, @eldadtzahor.bsky.social & @urialonlab.bsky.social on this great work! We're glad to have supported the translation of findings from theoretical and animal models to human myocardial infarction data using LIANA+ (liana-py.readthedocs.io)
Reposted by Shoval Miyara
Happy to share our new preprint: A spatial transcriptomics atlas of live donors reveals unique zonation patterns in the healthy human liver: www.biorxiv.org/content/10.1...
February 24, 2025 at 10:01 AM
Happy to share our new preprint: A spatial transcriptomics atlas of live donors reveals unique zonation patterns in the healthy human liver: www.biorxiv.org/content/10.1...
Reposted by Shoval Miyara
Fantastic work of Shoval and the rest of the team on cardiac fibrosis. I hope the field will follow our categories of cold and hot fibrosis.
It’s finally here! My PhD work, five years in the making, is now published @CellSystems @cellpress.bsky.social 🚨
Cold and hot fibrosis define clinically distinct cardiac pathologies. www.cell.com/cell-systems...
Cold and hot fibrosis define clinically distinct cardiac pathologies. www.cell.com/cell-systems...
Cold and hot fibrosis define clinically distinct cardiac pathologies
Miyara et al. identify two types of fibrosis in cardiac pathologies: “hot fibrosis,”
involving macrophage-myofibroblast interactions in chronic injuries, and acute-injury-driven
“cold fibrosis,” contr...
www.cell.com
February 20, 2025 at 8:05 PM
Fantastic work of Shoval and the rest of the team on cardiac fibrosis. I hope the field will follow our categories of cold and hot fibrosis.
Reposted by Shoval Miyara
🩳 Two types of fibrosis, treatment decision aided by mathematical modeling! 🧬🖥️
📄 The paper is open-access at @cellpress.bsky.social Systems 🔓
🔗 doi.org/10.1016/j.ce... 🧪
▶️ Follow @AdlungLab.com for more systems biology news 🥜
5/5
📄 The paper is open-access at @cellpress.bsky.social Systems 🔓
🔗 doi.org/10.1016/j.ce... 🧪
▶️ Follow @AdlungLab.com for more systems biology news 🥜
5/5
February 20, 2025 at 8:49 AM
🩳 Two types of fibrosis, treatment decision aided by mathematical modeling! 🧬🖥️
📄 The paper is open-access at @cellpress.bsky.social Systems 🔓
🔗 doi.org/10.1016/j.ce... 🧪
▶️ Follow @AdlungLab.com for more systems biology news 🥜
5/5
📄 The paper is open-access at @cellpress.bsky.social Systems 🔓
🔗 doi.org/10.1016/j.ce... 🧪
▶️ Follow @AdlungLab.com for more systems biology news 🥜
5/5
Reposted by Shoval Miyara
🐁 Excitingly, inhibiting TIMP1—a key myofibroblast autocrine growth factor—with neutralizing antibodies reduced cold fibrosis in post-myocardial infarction mice.
🔦 This highlights a novel strategy to mitigate fibrotic remodeling in acute cardiac injuries.
4/5
🔦 This highlights a novel strategy to mitigate fibrotic remodeling in acute cardiac injuries.
4/5
February 20, 2025 at 8:49 AM
🐁 Excitingly, inhibiting TIMP1—a key myofibroblast autocrine growth factor—with neutralizing antibodies reduced cold fibrosis in post-myocardial infarction mice.
🔦 This highlights a novel strategy to mitigate fibrotic remodeling in acute cardiac injuries.
4/5
🔦 This highlights a novel strategy to mitigate fibrotic remodeling in acute cardiac injuries.
4/5
Reposted by Shoval Miyara
🔄 @shovalmiyara.bsky.social et al. from @urialonlab.bsky.social reveal that cold fibrosis is maintained by an autocrine loop in myofibroblasts, offering a new therapeutic target.
🛜 In contrast, hot fibrosis involves persistent immune cell interactions.
3/5
🛜 In contrast, hot fibrosis involves persistent immune cell interactions.
3/5
February 20, 2025 at 8:49 AM
🔄 @shovalmiyara.bsky.social et al. from @urialonlab.bsky.social reveal that cold fibrosis is maintained by an autocrine loop in myofibroblasts, offering a new therapeutic target.
🛜 In contrast, hot fibrosis involves persistent immune cell interactions.
3/5
🛜 In contrast, hot fibrosis involves persistent immune cell interactions.
3/5
Reposted by Shoval Miyara
💬 "Cold" fibrosis emerges from acute injuries like myocardial infarction, while "hot" fibrosis is driven by macrophage-myofibroblast crosstalk in chronic cardiac pathologies.
2/5
2/5
February 20, 2025 at 8:49 AM
💬 "Cold" fibrosis emerges from acute injuries like myocardial infarction, while "hot" fibrosis is driven by macrophage-myofibroblast crosstalk in chronic cardiac pathologies.
2/5
2/5
Reposted by Shoval Miyara
🥵🥶 "You're hot, and you're cold..." 🎶
💔 Did you know that this also applies to a broken heart (aka. cardiac fibrosis 🤓)?
🧵
1/5
💔 Did you know that this also applies to a broken heart (aka. cardiac fibrosis 🤓)?
🧵
1/5
February 20, 2025 at 8:49 AM
🥵🥶 "You're hot, and you're cold..." 🎶
💔 Did you know that this also applies to a broken heart (aka. cardiac fibrosis 🤓)?
🧵
1/5
💔 Did you know that this also applies to a broken heart (aka. cardiac fibrosis 🤓)?
🧵
1/5
Reposted by Shoval Miyara
Very happy to have contributed to this great work! “Hot” and “cold”fibrosis after heart attacks could be affected by targeting myofibroblast’s Timp1. Congratulations @shovalmiyara.bsky.social and @eldadtzahor.bsky.social
It’s finally here! My PhD work, five years in the making, is now published @CellSystems @cellpress.bsky.social 🚨
Cold and hot fibrosis define clinically distinct cardiac pathologies. www.cell.com/cell-systems...
Cold and hot fibrosis define clinically distinct cardiac pathologies. www.cell.com/cell-systems...
Cold and hot fibrosis define clinically distinct cardiac pathologies
Miyara et al. identify two types of fibrosis in cardiac pathologies: “hot fibrosis,”
involving macrophage-myofibroblast interactions in chronic injuries, and acute-injury-driven
“cold fibrosis,” contr...
www.cell.com
February 20, 2025 at 5:06 AM
Very happy to have contributed to this great work! “Hot” and “cold”fibrosis after heart attacks could be affected by targeting myofibroblast’s Timp1. Congratulations @shovalmiyara.bsky.social and @eldadtzahor.bsky.social
Reposted by Shoval Miyara
I heard about this interesting story a couple of years ago at an AHA meeting @ahascience.bsky.social. It's great to see it published @CellSystems. Congratulations @shovalmiyara.bsky.social, @eldadtzahor.bsky.social
@urialonlab.bsky.social et al!
@urialonlab.bsky.social et al!
It’s finally here! My PhD work, five years in the making, is now published @CellSystems @cellpress.bsky.social 🚨
Cold and hot fibrosis define clinically distinct cardiac pathologies. www.cell.com/cell-systems...
Cold and hot fibrosis define clinically distinct cardiac pathologies. www.cell.com/cell-systems...
Cold and hot fibrosis define clinically distinct cardiac pathologies
Miyara et al. identify two types of fibrosis in cardiac pathologies: “hot fibrosis,”
involving macrophage-myofibroblast interactions in chronic injuries, and acute-injury-driven
“cold fibrosis,” contr...
www.cell.com
February 19, 2025 at 7:24 PM
I heard about this interesting story a couple of years ago at an AHA meeting @ahascience.bsky.social. It's great to see it published @CellSystems. Congratulations @shovalmiyara.bsky.social, @eldadtzahor.bsky.social
@urialonlab.bsky.social et al!
@urialonlab.bsky.social et al!
Reposted by Shoval Miyara
A grand project from the one and only @shovalmiyara.bsky.social, redefining what cardiac fibrosis is 🫀❤️🔥
It's been inspiring to see this story take shape
Huge congrats!
It's been inspiring to see this story take shape
Huge congrats!
It’s finally here! My PhD work, five years in the making, is now published @CellSystems @cellpress.bsky.social 🚨
Cold and hot fibrosis define clinically distinct cardiac pathologies. www.cell.com/cell-systems...
Cold and hot fibrosis define clinically distinct cardiac pathologies. www.cell.com/cell-systems...
Cold and hot fibrosis define clinically distinct cardiac pathologies
Miyara et al. identify two types of fibrosis in cardiac pathologies: “hot fibrosis,”
involving macrophage-myofibroblast interactions in chronic injuries, and acute-injury-driven
“cold fibrosis,” contr...
www.cell.com
February 19, 2025 at 3:56 PM
A grand project from the one and only @shovalmiyara.bsky.social, redefining what cardiac fibrosis is 🫀❤️🔥
It's been inspiring to see this story take shape
Huge congrats!
It's been inspiring to see this story take shape
Huge congrats!
It’s finally here! My PhD work, five years in the making, is now published @CellSystems @cellpress.bsky.social 🚨
Cold and hot fibrosis define clinically distinct cardiac pathologies. www.cell.com/cell-systems...
Cold and hot fibrosis define clinically distinct cardiac pathologies. www.cell.com/cell-systems...
Cold and hot fibrosis define clinically distinct cardiac pathologies
Miyara et al. identify two types of fibrosis in cardiac pathologies: “hot fibrosis,”
involving macrophage-myofibroblast interactions in chronic injuries, and acute-injury-driven
“cold fibrosis,” contr...
www.cell.com
February 19, 2025 at 3:52 PM
It’s finally here! My PhD work, five years in the making, is now published @CellSystems @cellpress.bsky.social 🚨
Cold and hot fibrosis define clinically distinct cardiac pathologies. www.cell.com/cell-systems...
Cold and hot fibrosis define clinically distinct cardiac pathologies. www.cell.com/cell-systems...
Reposted by Shoval Miyara
Why do cortisol-lowering drugs work for Cushing’s but fail in mood disorders & chronic stress?
We propose that the ability of the pituitary and adrenal glands to adjust their functional masses—normally beneficial—counteracts the drug’s effect. Using a math. model, we screened HPA interventions (1/2)
We propose that the ability of the pituitary and adrenal glands to adjust their functional masses—normally beneficial—counteracts the drug’s effect. Using a math. model, we screened HPA interventions (1/2)
February 4, 2025 at 3:53 PM
Why do cortisol-lowering drugs work for Cushing’s but fail in mood disorders & chronic stress?
We propose that the ability of the pituitary and adrenal glands to adjust their functional masses—normally beneficial—counteracts the drug’s effect. Using a math. model, we screened HPA interventions (1/2)
We propose that the ability of the pituitary and adrenal glands to adjust their functional masses—normally beneficial—counteracts the drug’s effect. Using a math. model, we screened HPA interventions (1/2)
Reposted by Shoval Miyara
@urialonlab.bsky.social lab reveals a hormone circuit that explains why most HPA drugs fail for mood disorders and predicts the few that work ➡️ www.embopress.org/doi/full/10....
February 4, 2025 at 2:20 PM
@urialonlab.bsky.social lab reveals a hormone circuit that explains why most HPA drugs fail for mood disorders and predicts the few that work ➡️ www.embopress.org/doi/full/10....