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Staphylococcus aureus is a major human pathogen that can cause life-threatening infections in humans. However, treatment options are limited due to the prevalence of antimicrobial-resistant isolates i...

Next-generation sequencing and bioinformatics paved the way in deciphering the human gut microbiome and challenged fundamental postulates on the causal role of the microbiota for health and pathogenesis of infectious and noncommunicable diseases. To exploit the clinical relevance and potential of microbiome diagnostics and therapy, deep metagenomic sequencing with standardized, validated laboratory procedures, aiming at deciphering the microbiome at strain level and applying index-scores to allow classification of individual microbiomes as dysbiotic (associated with disease) or eubiotic (associated with health) should be implemented. By this means, metagenomically informed therapies with live biotherapeutic products, fecal microbiota transfer, pro-, pre-, or postbiotics might become a standard in personalized prevention and treatment of infectious and non-communicable diseases.

The hospital reform has the stated goal of raising patient safety and quality of care in Germany to a higher level.

Two treatments for the sexually transmitted disease are expected to become available soon

YouTube video by CMFI - Cluster of Excellence

Five outstanding researchers were elected to the Executive Board at the general meeting of the German Center for Infection Research (DZIF). Prof. Dirk Busch, Prof.

Staphylococcus aureus is a leading cause of both community and hospital-acquired infection worldwide. In addition, S. aureus is resistant to many commonly used antibiotics, which make the treatment of bacteremia, infective endocarditis, and other invasive diseases more challenging. It is essential to obtain a basic understanding of how S. aureus survives in a variety of host niches, including those niches where S. aureus is dependent upon amino acid catabolism. We hypothesize that arginine acquisition is critical for S. aureus pathogenesis; therefore, identifying these transporters is essential for the development of novel therapeutic strategies.

The cell death effector Gasdermin A is only known to be activated by Streptococcus pyogenes. This work discovers a mechanism for its activation by Staphylococcus aureus, and shows a conserved role in ...

Abstract. The human nasal microbiome can serve as a reservoir for pathogens. In particular, the opportunistic pathogen Staphylococcus aureus can be a membe

Abstract. The human nasal microbiome can serve as a reservoir for pathogens. In particular, the opportunistic pathogen Staphylococcus aureus can be a membe

YouTube video by CMFI - Cluster of Excellence

PhD Project - Molecular dissection of Staphylococcus aureus in Atopic Dermatitis Using a Human Skin Organoid model at University of Edinburgh, listed on FindAPhD.com

PhD Project - EASTBIO How do transporters promote the fitness of Staphylococcus aureus in different host-species ? at University of Edinburgh, listed on FindAPhD.com