Staphylococcus aureus has undergone metabolic remodeling to adapt to the dairy niche.

Past work has seen over-representation of Staphylococcus aureus clinical isolates in genome and biology studies on staphylococci. Here, we show by a selective plating analysis of municipal wastewater ...

In this work, authors use whole genome tracking in a neonatal intensive care unit to reveal a strong link between Staphylococcus aureus colonization and invasive infection, pinpointing critical new ta...

PhD position (m/f/d) for "Translation of evolutionary principles into antimicrobial treatment"

Philanthropic partners invest $60M to support collaborative research to accelerate the discovery of next-generation antibiotics

Staphylococcus aureus is a leading cause of bloodstream infections causing an estimated 300,000 deaths worldwide. Using a functional genomics approach, our group previously identified that adaptation ...

A survey of the reconstructed gene set of the last eukaryotic common ancestor shows a consistent link between Asgard archaea and the origin of numerous, functionally diverse eukaryotic genes, dem...

Background The nasal microbiome, a dynamic assemblage of commensals and opportunistic pathogens, is crucial to human health. Results Using cross-sectional data from 1,608 adults and longitudinal sampl...

Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...

The human nasal microbiome is a low-diversity ecosystem whose assembly principles and mechanisms of colonization resistance remain poorly understood. In particular, Staphylococcus aureus colonization ...

Type VII secretion system (T7SS) has a range of functions in bacteria, including specific roles in bacterial physiology, including DNA uptake, membrane integrity, and bacterial development. In S. aure...

Antimicrobial resistance (AMR) poses a growing threat to global health, contributing to an estimated 4.95 million deaths in 2019 (1). Methicillin-resistant Staphylococcus aureus (MRSA) is among the most persistent and clinically challenging pathogens, causing infections ranging from bacteremia and pneumonia to osteomyelitis and endocarditis in both healthcare and community settings. MRSA’s ability to evade multiple antibiotic classes, particularly β-lactams, has made it a priority pathogen for new treatment strategies.

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Staphylococcus aureus is a major human pathogen that can cause life-threatening infections in humans. However, treatment options are limited due to the prevalence of antimicrobial-resistant isolates i...

Next-generation sequencing and bioinformatics paved the way in deciphering the human gut microbiome and challenged fundamental postulates on the causal role of the microbiota for health and pathogenesis of infectious and noncommunicable diseases. To exploit the clinical relevance and potential of microbiome diagnostics and therapy, deep metagenomic sequencing with standardized, validated laboratory procedures, aiming at deciphering the microbiome at strain level and applying index-scores to allow classification of individual microbiomes as dysbiotic (associated with disease) or eubiotic (associated with health) should be implemented. By this means, metagenomically informed therapies with live biotherapeutic products, fecal microbiota transfer, pro-, pre-, or postbiotics might become a standard in personalized prevention and treatment of infectious and non-communicable diseases.

The hospital reform has the stated goal of raising patient safety and quality of care in Germany to a higher level.